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[Urea and its therapeutic possibilities].

Origin of epidermal urea and the therapeutical possibilities are shown: the waterbinding, keratolytic, epidermal thinning, antipruriginous, and the penetrating-supporting effects. Our clinical studies revealed mild to moderate eczemas and psoriasis capitis to be treated with a 10% urea-, 1% hydrocortisone cream. A 10% urea cream is well indicated for mild palmar and plantar hyperkeratotic dermatitis, the after treatment of contact dermatitis, and senile atrophic skin. Serious hyperkeratotic palmar dermatitis gives better results when handled alternately with triamcinolone-acetonid cream and a 10% urea cream.

Adult↗

[Clinical variations of keratoacanthomas].

Clinical variants of Keratoacanthomas are, besides the very frequent crateriform types, and the plate-shaped ones, Keratoacanthoma marginatum centrifugum, aggregated Keratoacanthomas, successive multiple Keratoacanthomas, and rare special forms like multiple eruptive Keratoakanthomas and Keratoacanthomas combined with Hyperplasia of sebaceous glands and epitheliomas. A detailed description of the different types is derived from their growth and their origin from supraseboglandular epithelium of hair follicles.

Diagnosis, Differential↗

Treatment of pustulosis palmaris et plantaris with oral doses of colchicine.

The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to 0.5 to 1 mg daily in responsive patients. Thirteen patients showed complete clearing of pustulation, and 14 patients showed a remarkable reduction in pustule formation after two to eight weeks of treatment. One patient did not respond and four discontinued treatment because of nausea or diarrhea. During a three-month follow-up evaluation after treatment was stopped, relapse occurred in eight cases. Colchicine appears to be effective in the suppression of acute exacerbations of pustulosis palmaris et plantaris.

Administration, Oral↗