Microbiological determination of drug partitioning. 3. Partition coefficient profiles of several antimicrobial agents.
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Benzalkonium Compounds↗
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Microbiological determination of drug partitioning. IV. Drug-protein interactions.
The protein binding characteristics of chloramphenicol, furazolium chloride, benzalkonium chloride, and phenylmercuric nitrate were described from their partitioning behavior in gelatin-acacia complex coacervate systems. Although the partitioning was determined by two different methods (microbiological and chemical), the microbiological method was more reliable for this type of investigation. Drug-protein parameters were calculated for the four antimicrobials. The advantages of the coacervate systems over other models for protein binding studies of drugs are discussed.
Bacteria↗
Rates of recovery of irreversibly inhibited monoamine oxidases: a measure of enzyme protein turnover.
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Animals↗
[Damage to the nervous system due to nitrofurans in the rat].
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Animals↗
A new screening assay for antigiardial compounds: effects of various drugs on the adherence of Giardia duodenalis to Caco2 cells.
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Animals↗
Toxic dilatation of the colon complicating pseudomembranous enterocolitis.
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Anti-Bacterial Agents↗
Management of enteric fever in children.
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Ampicillin↗
Triple-quadrupole LC-MS-MS for quantitative determination of nitrofuran metabolites in complex food matrixes.
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Animals↗
Nitrofurans and enzyme systems of the neonatal animal.
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Animals↗
Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo.
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Adolescent↗
Inhibitory effects of some anti-inflammatory and other analgesics and nitrofurans on the induction of -galactosidase synthesis in Klebsiella aerogenes.
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Acetaminophen↗
Reduction of niridazole by rat liver santhine oxidase.
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Adenine↗
Hepatic disposition of clinically useful 5-nitrofurans.
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Animals↗
Origin of urinary tyramine and tryptamine.
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Anti-Bacterial Agents↗
Possible roles for pyruvate:ferredoxin oxidoreductase and thiol-dependent peroxidase and reductase activities in resistance to nitroheterocyclic drugs in Giardia intestinalis.
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Animals↗
The prevention of ascending, catheter-induced infections of the urinary tract.
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Adolescent↗
In vitro studies with E. Coli from piglets and calves. Development of resistance to antibiotics.
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Ampicillin↗
Resistance studies of Salmonella Typhimurium in chicks on a tylosin feed.
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Animals↗