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An unusual case of peripheral odontogenic fibroma, presenting as a swelling on gingiva involving hard palate in a 3-year-old female child, is described. Even with cellular stroma and unencapsulation these tumors behave in a benign fashion. To the best of our knowledge, cartilagenous differentiation of stroma as observed in this case has not been reported in English literature so far.
The authors describe a case of very rare neoplasm fibroma proper in the region subglottic of larynx. Operative treatment by tracheostomy, thyroidotomy and complete extirpation of the tumor.
The authors describe the autopsy finding of two fibromas within the left ventricular wall of a five-day-old newborn. Histochemistry and immunohistochemistry showed the lesion as a purely fibroblastic proliferation, with intense elastic fibers formation and secondary morphological alteration and biological damage of the pre-existing muscular fibers. The authors, on the basis of the phases of the cardiac metamers development and of myocardial tissue differentiation, exclude any relationship with disembryogenetic factors, and hence the hamartomatous origin of the lesion, despite their onset in the first months of intrauterine growth.
A young man presented with desmoplastic fibroma in the proximal ulna. This rare tumour was treated by curettage and bone grafting.
The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands digested with Bam HI and Eco RI were approximately 8.8 kbp and 15 kbp, respectively. Thus the lesional HPV DNA was different from HPV types used as probes and was probably integrated into host cell chromosomal DNA judging by the off-size high molecular weight bands. Considering the contaminating mesenchymal region and uninfected epithelial cells as well as the evidently limited homology with probe HPV DNAs, the virus copy number in infected cells was poorly defined. In situ antigen staining signals were widely detected in the hyperplastic epithelial layer.
Localized fibroma represents a rare entity arising from the pleura. Currently its histogenesis and clinical behaviour are still controversial. A case of a 64-year-old male is here presented; clinical and histopathological features are then discussed on the basis of a review of the Literature. At present, an en-bloc resection of the tumor, including wide margins of the surrounding lung tissue, seems to be the most appropriate surgical choice.
An 11-year-old boy presented with a lytic lesion in the proximal humeral metaphysis. In spite of an aggressively reactive appearance on plain radiography and MR imaging, this lesion proved to be a non-ossifying fibroma. Fracture of the cortical shell probably contributed to the relatively wide zone of transition and periosteal reaction on plain radiography and the reactive change on MR imaging.
The clinical and histological features of the peripheral odontogenic fibroma are briefly outlined. A case arising from the attached lingual gingiva between the mandibular right permanent first molar and the second molar in a 67 year old Indian female is reported here. The unusual occurrence of marked clear cell differentiation within the odontogenic epithelial component, and histogenetic link to the clear cell rests of the dental lamina and surface epithelium are discussed.
A patient prescribed oxymetazoline hydrochloride nasal drops presented with recurrent ventricular tachycardia of fascicular origin. Cardiac ultrasound showed a calcified lesion, presumably a fibroma arising from the interventricular septum. Fascicular tachycardia related to the lesion and provoked by the use of a sympathomimetic agent is postulated.
A case of serious, recurrent enterorrhagia is reported. The cause could not be identified with normal diagnostic tools and was discovered only after explorative laparotomy. The finding was benign ulcerated tumour of the small intestine, histologically defined as fibroma with fluorishing cellularity.
The author presented a clinico-pathological analysis of the data concerning 41 patients with fibroma of the ovaries, treated at the N.N. Petrov Research Institute of Oncology of the USSR Ministry of Health from 1926 to 1974. A method of the "dynamic analysis" was used in studying 10-year survival rates which made 96.9%. Recurrences were observed among patients under a long-term follow-up, despite various scope of surgery employed. The author made a conclusion on the possibility to remove the adnexa only in women of childbearing age.
This article describes a case of peripheral ossifying fibroma. The lesion is presented with respect to its clinical, radiographic, and histologic characteristics. Recommendations for proper diagnosis and treatment are suggested.
Twenty-two patients with large nonossifying fibromas (NOFs) in weight-bearing bones were studied to evaluate risk of pathologic fracture. Previous reports suggest an absolute size threshold for NOFs beyond which there is a reasonable chance of impending fracture. In this series, 13 (59%) large NOFs had not had pathologic fracture despite exceeding the previously established size threshold. Four of the patients had fractures of the long bone in which the NOF was located without the fracture involving the lesion. In the nine (41%) patients in whom pathologic fracture occurred, healing was uneventful after closed reduction and cast immobilization. Whereas absolute size parameters may be useful in predicting pathologic fracture rate, they do not imply a requirement for prophylactic curettage and bone grafting. The majority of patients with large NOFs can be monitored without surgical intervention, and fractures can be successfully managed with nonoperative treatment.
A case of peripheral odontogenic fibroma is reported and its epidemiology, clinical aspects and etiopathogenesis are discussed. It is supposed that the epithelial component may be related to odontogenic embrionary tissue inclusions: These inclusions may stimulate a local mesenchymal reaction giving place to a proliferative lesion, as observed.
Three cases of demoplastic fibroma of bone are presented. Thirty six cases already reported in the world literature are reviewed, making the present total thirty nine cases. The extreme rarity of the tumor is emphasised, and its clinical, radiographic, morphological and pathological aspects discussed. Though the absence of metastases or histologically abnormal cells attest to its benign nature it has a definite tendency to local recurrence. Differential diagnosis and treatment are discussed.
A 10-year-old girl with negative T wave in leads I, II, III, aVF, and V2-6 in the ECG was examined. The two-dimensional echocardiogram and the MRI revealed that she had a tumor in the free wall near the apex of the left ventricle. We removed the intramural fibroma (50 x 35 x 30 mm) of the left ventricle under cardiopulmonary bypass very carefully not to perforate the left ventricular cavity. After the removal, the defect was repaired by the sutures of the myocardial layers so that the volume inside the left ventricle could be kept and its shape could be maintained. She has been doing well without any trouble for 5 months after the operation.
Fine-needle aspiration biopsy of an ameloblastic fibroma, an unusual odontogenic tumor related to ameloblastoma, was performed on a 38-yr-old man with a slowly enlarging left facial mass. Aspiration of the tumor yielded a cellular sample composed of a mixture of mesenchymal and epithelial cells, arranged, respectively, in thick mats and complex solid structures outlined by columnar cells with central regions reminiscent of stellate reticulum. A diagnosis of odontogenic tumor was conferred, and the lesion was surgically biopsied and then resected. The key cytologic feature distinguishing this lesion from other odontogenic tumors was fragments of hypercellular stroma. The differential diagnosis includes ameloblastoma, ameloblastic fibrosarcoma, other odontogenic tumors, intraosseous adenoid cystic carcinoma, trabecular adenoma, and basal-cell carcinoma.
A 25-yr-old female presented with a slowly progressive swelling, occurring over an 8-yr period, in the right lower leg. The swelling was tender and fixed to the underlying bone. Clinical and radiological diagnosis was giant cell tumor (GCT) of the bone. Aspiration cytology smears were cellular showing an admixture of chondroid, stellate, and fibrocytic cells against a chondroid background. On cytomorphology, a diagnosis of chondromyxoid fibroma (CMF) was made. It was confirmed on histologic examination.