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PubMed2001

Laboratory investigations of the survivability of bacteria in hypervelocity impacts.

It is now well established that material naturally moves around the Solar System, even from planetary surface to planetary surface. Accordingly, the idea that life is distributed throughout space and did not necessarily originate on the Earth but migrated here from elsewhere (Panspermia) is increasingly deemed worthy of consideration. If life arrived at the Earth from space, its relative speed will typically be of order many km s-1, and the resulting collision with the Earth and its atmosphere will be in the hypervelocity regime. A mechanism for the bacteria to survive such an impact is required. Therefore a programme of hypervelocity impacts in the laboratory at (4.5 +/- 0.6) km s-1 was carried out using bacteria (Rhodococcus) laden projectiles. After impacts on a variety of target materials (rock, glass and metal) attempts were made to culture Rhodococcus from the surface of the resulting craters and also from the target material ejected during crater formation. Control shots with clean projectiles yielded no evidence for Rhodococcus growth from any crater surface or ejecta. When projectiles doped with Rhodococcus were used no impact crater surface yielded colonies of Rhodococcus. However, for four shots of bacteria into rock (two on chalk and two on granite) the ejecta was afterwards found to give colonies of Rhodococcus. This was not true for shots onto glass. In addition, shots into aerogel (density 96 kg m-3) were also carried out (two with clean projectiles and two with projectiles with Rhodococcus). This crudely simulated aero-capture in a planetary atmosphere. No evidence for Rhodococcus growth was found from the projectiles captured in the aerogel from any of the four shots.

Earth, Planet↗
PubMed2001

Study of the peptide prebiotic synthesis in context of exobiological investigations on earth orbit.

Dry films of amino acids mixtures glycine+ tryptophan and tryptophan were exposed on the surface of "Mir" station. Similar films were irradiated by vacuum ultra violet (145 nm) and ultra violet (254 nm) in the laboratory experiments. Gly-Gly, Trp-Gly, Gly-Trp, Tpr-Trp and Trp-Trp-Trp were the main reaction products for the experimental mixture glycine + tryptophan and Tpr-Trp and Trp-Trp-Trp for tryptophan. The presence of Lunar soil both in flight and in laboratory experiments increases the reaction yield by 1.5-2.0 times. Therefore, the hypothesis concerning the possibility of safe delivery of peptides and amino acids required for the emergence of life and associated with mineral have got yet another approval.

Evolution, Molecular↗
PubMed2001

Limits of photosynthesis in extrasolar planetary systems for earth-like planets.

We present a general modeling scheme for investigating the possibility of photosynthesis-based life on extrasolar planets. The scheme focuses on the identification of the habitable zone in main-sequence-star planetary systems with planets of Earth mass and size. Our definition of habitability is based on the long-term possibility of photosynthetic biomass production as a function of mean planetary surface temperature and atmospheric CO2-content. All the astrophysical, climatological, biogeochemical, and geodynamic key processes involved in the generation of photosynthesis-driven life conditions are taken into account. Implicitly, a co-genetic origin of the central star and the orbiting planet is assumed. The numerical solution of an advanced geodynamic model yields realistic look-up diagrams for determining the limits of photosynthesis in extrasolar planetary systems, assuming minimum CO2 levels set by the demand of C4 photosynthesis.

Atmosphere↗
PubMed2001

Differentiation of Dictyostelium discoideum vegetative cells into spores during Earth orbit in space.

We reported previously that emerged amoebae of Dictyostelium (D.) discoideum grew, aggregated and differentiated to fruiting bodies with normal morphology in space. Here, we investigated the effects of space radiation and/or microgravity on the number, viability, kinetics of germination, growth rate and mutation frequency of spores formed in space in a radiation-sensitive strain, gamma s13, and the parental strain, NC4. In gamma s13, there were hardly spores in the fruiting bodies formed in space. In NC4, we found a decrease in the number of spores, a delay in germination of the spores and delayed start of cell growth of the spores formed in space when compared to the ground control. However, the mutation frequency of the NC4 spores formed in space was similar to that of the ground control. We conclude that the depression of spore formation might be induced by microgravity and/or space radiation through the depression of some stage(s) of DNA repair during cell differentiation in the slime mold.

Animals↗
PubMed2002

Lifetime total radiation risk of cosmonauts for orbital and interplanetary flights.

This paper presents results of calculations of total radiation risk for cosmonauts over their lifetimes and assessments of possible shortening of life expectancy on the basis of generalized doses calculated for cosmonauts after a long term interplanetary and orbital space missions on "MIR" station and International Space Station with the use of mathematical expressions coming from a model of change mortality rate of mammals after irradiation. Tumor risk assessments for cosmonauts over lifetime after flights are also given. Dependences of the delayed radiation consequences mentioned above on flight duration, spacecraft shielding thicknesses, solar activity and cosmonauts' age are analyzed.

Age Factors↗
PubMed2002

The dependence of solar energetic particle fluxes in the Earth-Mars-Earth route on solar activity period.

This report presents the results of analyzing the relative importance of particle fluxes of different origin in the Earth-Mars-Earth route during different solar activity periods. The analysis has been made in terms of the galactic cosmic ray and solar energetic particle flux models developed at Moscow State University. The results demonstrate the extreme importance of the high-energy solar particle fluxes in interplanetary space even during the years of "quiet" Sun.

Cosmic Radiation↗
PubMed2002

Estimation of a cosmonaut's radiation hazard during long-term space missions on the basis of a generalized dosimetric function.

This paper presents a new concept of radiation hazard assessment for spacecraft crew members during long term space missions on the basis of a generalized dosimetric function. This new dosimetric function enables a complicated nature of space radiation exposure to be reduced to the conditions of a standard irradiation. It can be obtained on the basis of mean-tissue equivalent dose values calculated for each space radiation source and transmission coefficients describing the influence of the complex spatial and temporal distribution of the absorbed dose in the cosmonaut's body on the radiobiological effects. The combination of cosmic ionizing radiation with other non-radiation nature factors in flight can also be accounted for. In terms of the generalized dose, it is possible to assess the nature and extent of lowering a crew working capacity, as well as radiation risk, both during a flight and post flight period.

Aerospace Medicine↗
PubMed2002

Prebiotic synthesis of nucleotides at the Earth orbit in presence of Lunar soil.

Modern studies now favor the fact that extraterrestrial organic molecules served as an important source of biological important substances on the primitive Earth. It is presumed that these space-made organic molecules could be transported safely to the Earth surface being associated with mineral grains. It is important to test whether nucleotides synthesized in Earth orbit could be protected by lunar surface regolite. The phosphorylation of adenosine, uridine and thymidine has been studied with respect of their further transformations and degradation in presence of mineral bed. After retrieval, HPLC analysis is used to identify all the mononucleotides of certain nucleosides. It has been shown, that exposure of the investigated nucleosides as dry films in space conditions in the presence of Lunar soil increases the yield of synthesized nucleotides in 1.1-3.0 times as compared with the exposure of the same samples in absence of Lunar soil. To identify and evaluate the principal source of energy in open space responsible for nucleotide synthesis reaction laboratory experiments were performed. It has been shown, that vacuum ultra violet (VUV 145 nm) radiation promotes nucleotide synthesis more effectively than ultra violet (UV 254 nm) while the presence of Lunar soil increases reaction yield in 1.5-2.0 times. Formation of 5'-mononucleotides seemed to be the most effective reaction both in flight and in laboratory experiments. Protective action of lunar soil on synthesized nucleotides against UV radiation has been shown in open Space conditions.

Adenosine Monophosphate↗
PubMed2002

Stability of nucleic acid under the effect of UV radiation.

Nucleic acids (combined with protein molecules) are essential constituents of the living systems playing an important role in the early evolution of life as well. A specific feature of these molecules has been found and directly confirmed recently: under the influence of short-wavelength UV radiation bipyrimidine photoproducts (cyclobutane dimers and 6-4 bipyrimidines) are induced and the reversion of them can be provoked by the same photons. However, reversion is preferred by the shorter wavelengths. With increasing ratio of the longer wavelength components of the radiation (using artificial UV sources and solar light on the Earth's surface) the impact of the reversible photoproducts in the harmful biological effect decreases and other photoproducts are dominant. Assuming the photoinduced reactions (dimerisation and reversion) are statistical events, during the irradiation the chance for a number of nucleoprotein molecules to survive the radiation damage can be reality. The theoretical and experimental basis of these assumptions will be discussed in the case of bacteriophage T7 nucleoprotein.

Bacteriophage T7↗
PubMed2002

Survival of microorganisms in space protected by meteorite material: results of the experiment 'EXOBIOLOGIE' of the PERSEUS mission.

During the early evolution of life on Earth, before the formation of a protective ozone layer in the atmosphere, high intensities of solar UV radiation of short wavelengths could reach the surface of the Earth. Today the full spectrum of solar UV radiation is only experienced in space, where other important space parameters influence survival and genetic stability additionally, like vacuum, cosmic radiation, temperature extremes, microgravity. To reach a better understanding of the processes leading to the origin, evolution and distribution of life we have performed space experiments with microorganisms. The ability of resistant life forms like bacterial spores to survive high doses of extraterrestrial solar UV alone or in combination with other space parameters, e.g. vacuum, was investigated. Extraterrestrial solar UV was found to have a thousand times higher biological effectiveness than UV radiation filtered by stratospheric ozone concentrations found today on Earth. The protective effects of anorganic substances like artificial or real meteorites were determined on the MIR station. In the experiment EXOBIOLOGIE of the French PERSEUS mission (1999) it was found that very thin layers of anorganic material did not protect spores against the deleterious effects of energy-rich UV radiation in space to the expected amount, but that layers of UV radiation inactivated spores serve as a UV-shield by themselves, so that a hypothetical interplanetary transfer of life by the transport of microorganisms inside rocks through the solar system cannot be excluded, but requires the shielding of a substantial mass of anorganic substances.

Aluminum Silicates↗
PubMed2002

A review of solar proton events during the 22nd solar cycle.

Solar cycle 22 had significant, large fluence, energetic particle events on a scale reminiscent of the 19th solar cycle. Examination of the characteristics of these large events suggests that some of the old concepts of spectral form, intensity-time envelope and energy extrapolations, used to estimate the dose from large events that occurred during previous solar cycles should be re-evaluated. There has also been a dramatic change in perspective regarding the source of solar protons observed in interplanetary space. Very large fluence events are associated with powerful fast interplanetary shocks. The elemental composition and charge state of these events is suggestive of a dominate source in the solar corona and not from a very hot plasma. Furthermore, there is a strong suggestion that the intensity-time profile observed in space is dominated by the connection of the observer to an interplanetary shock source rather than to a unique location near the surface of the sun. These concepts will be examined from the perspective of energetic particles contributing to the dose experienced by an astronaut on an interplanetary space mission.

Anisotropy↗
PubMed2003

Radiation risk and human space exploration.

Radiation protection is essential to enable humans to live and work safely in space. Predictions about the nature and magnitude of the risks posed by space radiation are subject to very large uncertainties. Prudent use of worst-case scenarios may impose unacceptable constraints on shielding mass for spacecraft or habitats, tours of duty of crews on Space Station, and on the radius and duration of sorties on planetary surfaces. The NASA Space Radiation Health Program has been devised to develop the knowledge required to accurately predict and to efficiently manage radiation risk. The knowledge will be acquired by means of a peer-reviewed, largely ground-based and investigator-initiated, basic science research program. The NASA Strategic Plan to accomplish these objectives in a manner consistent with the high priority assigned to the protection and health maintenance of crews will be presented.

Aerospace Medicine↗
PubMed2003

Planetary protection and the search for life beneath the surface of Mars.

The search for traces of extinct and extant life on Mars will be extended to beneath the surface of the planet. Current data from Mars missions suggesting the presence of liquid water early in Mars' history and mathematical modeling of the fate of water on Mars imply that liquid water may exist deep beneath the surface of Mars. This leads to the hypothesis that life may exist deep beneath the Martian surface. One possible scenario to look for life on Mars involves a series of unmanned missions culminating with a manned mission drilling deep into the Martian subsurface (approximately 3Km), collecting samples, and conducting preliminary analyses to select samples for return to earth. This mission must address both forward and back contamination issues, and falls under planetary protection category V. Planetary protection issues to be addressed include provisions stating that the inevitable deposition of earth microbes by humans should be minimized and localized, and that earth microbes and organic material must not contaminate the Martian subsurface. This requires that the drilling equipment be sterilized prior to use. Further, the collection, containment and retrieval of the sample must be conducted such that the crew is protected and that any materials returning to earth are contained (i.e., physically and biologically isolated) and the chain of connection with Mars is broken.

Containment of Biohazards↗
PubMed2003

Evaluation of the dynamic cutoff rigidity model using dosimetry data from the STS-28 flight.

We have a developed a dynamic cutoff rigidity model based on computed world grids of vertical cutoff rigidities derived from employing the Tsyganenko magnetospheric model. The dynamic range of this model covers all magnetic activity levels specified by integer values of the Kp magnetic index. We present comparisons of the measured dose observed on the space shuttle during the August 1989 solar proton event with the dose computed from solar particles predicted to be allowed through the magnetosphere to the space shuttle position. We find a one-to-one correspondence between the portion of the orbit predicted to be subjected to solar protons and the portion of the orbit where solar particle dose measurements were obtained.

Cosmic Radiation↗
PubMed2004

Survey of current situation in radiation belt modeling.

The study of Earth's radiation belts is one of the oldest subjects in space physics. Despite the tremendous progress made in the last four decades, we still lack a complete understanding of the radiation belts in terms of their configurations, dynamics, and detailed physical accounts of their sources and sinks. The static nature of early empirical trapped radiation models, for examples, the NASA AP-8 and AE-8 models, renders those models inappropriate for predicting short-term radiation belt behaviors associated with geomagnetic storms and substorms. Due to incomplete data coverage, these models are also inaccurate at low altitudes (e.g., <1000 km) where many robotic and human space flights occur. The availability of radiation data from modern space missions and advancement in physical modeling and data management techniques have now allowed the development of new empirical and physical radiation belt models. In this paper, we will review the status of modern radiation belt modeling.

Atmosphere↗
PubMed1997

From the interstellar clouds, through the inner to the outer solar system: a universally distributed complex organic chemistry. Preface.

High molecular weight organic compounds are involved in the chemistry and physics of many astrophysical and planetary objects. They are or should be present in interstellar dust, in comets and meteorites, in the Giant planets and Titan, in asteroids Triton and icy satellites. They represent a class of very complex organic material, part of which may have played a role in the origin of life on Earth. Thus they directly concern prebiotic chemistry and exobiology.

Cosmic Dust↗
PubMed1997

Complex organics in laboratory simulations of interstellar/cometary ices.

We present the photochemical and thermal evolution of both non-polar and polar ices representative of interstellar and pre-cometary grains. Ultraviolet photolysis of the non-polar ices comprised of O2, N2, and CO produces CO2, N2O, O3, CO3, HCO, H2CO, and possibly NO and NO2. When polar ice analogs (comprised of H2O, CH3OH, CO, and NH3) are exposed to UV radiation, simple molecules are formed including: H2, H2CO, CO2, CO, CH4, and HCO (the formyl radical). Warming produces moderately complex species such as CH3CH2OH (ethanol), HC(=O)NH2 (formamide), CH3C(=O)NH2 (acetamide), R-CN and/or R-NC (nitriles and/or isonitriles). Several of these are already known to be in the interstellar medium, and their presence indicates the importance of grain processing. Infrared spectroscopy, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, and gas chromatography-mass spectrometry demonstrate that after warming to room temperature what remains is an organic residue composed primarily of hexamethylenetetramine (HMT, C6H12N4) and other complex organics including the amides above and polyoxymethylene (POM) and its derivatives. The formation of these organic species from simple starting mixtures under conditions germane to astrochemistry may have important implications for the organic chemistry of interstellar ice grains, comets and the origins of life.

Astronomical Phenomena↗
PubMed1997

Complex organic molecules in space: the carriers of the interstellar infrared emission features.

The Unidentified Infrared Bands (UIR bands) are a complex family of infrared emission features which are observed in a variety of astronomical sources. While these features have been known for more than twenty years, a satisfactory identification of the carriers remains elusive. While the gross appearance of the emission spectrum indicates that the molecular carriers are aromatic compounds, differences in detail between the astronomical spectra and the available laboratory spectra have prevented a more complete description of the identity and physical state of these compounds. In this paper we present the first detailed comparison between the astronomical emission spectra and the spectra of ionized polycyclic aromatic hydrocarbons (PAHs) measured in the laboratory. These spectra are found to provide the best fit to date of the astronomical spectra and demonstrate that the positions and intensities of the UIR bands are entirely consistent with the emission from a gas-phase mixture of PAH molecules dominated by PAH cations.

Cations↗