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At least 1,081 records · Page 60Linked to original sources
PubMed1976

A comparative clinical evaluation of a new topical steroid 'halcinonide' and hydrocortisone in steroid-responsive dermatoses.

Fifty patients with symmetrical, bilateral lesions of psoriasis, eczematous dermatitis, atopic dermatitis, or neurodermatitis participated in a double-blind paired comparison study in which 0-1% halcinonide (in a cream formulation containing also neomycin and nystatin) was applied to the lesions on one side of the body and 1% hydrocortisone cream to those on the opposite side for two to three weeks. The number of excellent responses to therapy showed the halcinonide combination to be significantly superior (p less than 0-01) to the control cream in all diagnostic categories if considered collectively, and in psoriasis if the responses were grouped according to diagnosis. No adverse reactions occurred during the trial.

Administration, Topical↗
PubMed1979

A double-blind controlled trial of betamethasone dipropionate 0.05% (Diproderm) in comparison with fluocinolone acetonide 0.025% (Synalar) in psoriasis and other steroid-responsive dermatoses.

In a double-blind randomized study, sixty-two patients suffering from psoriasis or eczema were treated, twice daily for three weeks, either with 0.05% betamethasone 17, 21-dipropionate cream or with 0.025% fluocinolone acetonide cream. The results showed that both topical corticosteroid preparations were effective, well tolerated and cosmetically acceptable. Fifty-seven per cent of the patients treated with betamethasone dipropionate were rated as being 'much better' in the overall assessment of response at the end of the trial period compared to only 25% of those in the fluocinolone acetonide group.

Adolescent↗
PubMed2000

Inflammatory and immune reactions associated with stratum corneum and neutrophils in sterile pustular dermatoses.

In this review we present our own experimental findings as well as those from the literature related to the pathomechanisms for the inflammatory changes in psoriasis and its related diseases. A growing body of evidence has indicated that T cell-mediated immunity plays an important role in triggering and maintenance of psoriatic lesions. It has been revealed that lymphokines produced by activated T cells in psoriatic lesions have a strong influence on the proliferation of the epidermis. Characteristic neutrophil accumulation under the stratum corneum can be observed in the highly inflamed areas of psoriatic lesions. These neutrophils are chemotactically attracted and activated there by synergistic action of chemokines, IL-8 and Gro-alpha released by stimulated keratinocytes, and particularly by C5a/C5a des arg produced via the alternative complement pathway activation. We demonstrated that the infiltrating neutrophils adhere to iC3b-opsonized corneocytes to produce active oxygen and probably lysosomal enzymes. From a close relationship observed between neutrophil accumulation and high mitotic ratio of the lesional epidermis, we think that these stimulated neutrophils influence the growth and differentiation of epidermal keratinocytes. Aberrant expression of HLA-DR on neutrophils suggests their activation of infiltrating T cells in the presence of bacterial superantigen. These T cells in turn influence the transepidermal neutrophil migration through the effect of their cytokines on the keratinocyte production of proinflammatory mediators including IL-8 and C3. In this review we discuss the pivotal roles played by stratum corneum and neutrophils in several skin diseases, where neutrophils accumulate beneath the stratum corneum in a sterile condition.

Dermatitis↗
PubMed2002

[Identification of causative species in malassezia-associated dermatoses].

The Tween test was used to identify Malassezia species isolated from patients with pityriasis versicolor and seborrhoeic dermatitis, and suckling infants with seborrhoeic dermatitis. The most common species isolated from cases of pityriasis versicolor was M. globosa (55%), and this species was surmised to be the principal causative organism of this disease. In both adult and suckling infant cases of seborrhoeic dermatitis, M. globosa and M. furfur were isolated at high incidences compared with the healthy control subjects, indicating the possibility that one or both of these species are the causative organisms of these diseases. In addition, scales were collected from lesions of pityriasis versicolor for use as the template, and the involved Malassezia species were identified by the PCR method using the DNA sequences of nuclear ribosomal internal transcribed spacer l. The most commonly detected species was M. globosa, found in 97% of the cases, and this was followed in frequency by M. restricta (79%) and M. sympodialis (68%). It was also elucidated that multiple Malassezia species can be detected in the same specimen.

Adolescent↗