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[Mucinous cystadenoma of ileocecal appendix].

We present two patients with mucinous cystadenoma and mucinous cystadenocarcinoma of the appendix, respectively. These are very uncommon lesions in that localization. We point out the lack of specificity of the term "mucocele" and also the need of strict criteria to define this type of lesions in order to establish the adequate treatment. Usually the diagnosis is not possible before surgery. The treatment consists of simple appendectomy for the benign lesions and right hemicolectomy for mucinous carcinoma.

Adult↗

[Levels of serum immunoglobulins in patients with acute and chronic inflammation of the appendix].

The author analyzes, based on examinations of IgA, IgG and IgM immunoglobulin levels in a group of 130 patients with acute and chronic appendicitis the possibility to improve diagnosis of the disease based on changes of the above values. The investigation of these levels was stimulated by the hypothesis that the appendix in mammals plays a similar role as Fabricius' bursa in birds. The assembled results do not confirm that reduced values of these immunoglobulins are one of the causes of appendicitis and the method is not asset as regards improvement of diagnostic possibilities.

Acute Disease↗

[2 cases of villous tumor of the appendix].

Villous tumors of the vermiform appendix are uncommon with two cases and a review of the literature, the authors indicate the lack in specific clinical sign, and lay stress on the importance of the pathologic study on the therapeutic management.

Adenoma↗

[Peritoneal pseudomyxoma secondary to mucinous cystadenocarcinoma of the appendix].

A new case is presented of peritoneal pseudomyxoma secondary to a mucinous cystadenocarcinoma of the appendix discovered in the course of repair of a strangulated umbilical hernia. This is an uncommon entity which is only exceptionally diagnosed before operation and has a controversial treatment. The evolution and prognosis are unpredictable and are directly related to the degree of cellular differentiation.

Adult↗

Carcinoid tumors of the appendix in children younger than 16 years. A retrospective clinical and pathologic study.

Eighteen cases of appendiceal carcinoid in children aged 4 to 15 years, 14 of them girls, are reviewed. Most (73%) of the tumors were located in the distal third of the appendix. Tumor size, measured in histologic sections, ranged from 0.1 to 1.2 cm. In three cases the tumor had invaded the mesoappendix. No metastases were found. Standard appendectomy was performed in all cases as the only surgical procedure. The preoperative clinical diagnosis in 15 cases was acute appendicitis, which was histologically confirmed in 53%. At follow-up 2.2 to 29.3 years postoperatively (mean 16.4 years), all the patients were alive and without suspected or verified recurrence of carcinoid.

Adolescent↗

[Involvement of the appendix in the inflammatory process in severe nonspecific chronic ulcerative colitis in children].

The authors examined appendix tissues taken from 16 children and adolescents who had undergone colectomy for severe chronic ulcerative colitis. Fourteen patients had the mucosa and submucous layer involved in the chronic inflammatory process that is typical of ulcerative colitis, 5 patients showed inflammation in the muscular and subserous layers. The clinical symptomatology of appendicitis was absent.

Adolescent↗

Infection of an abdominal aortic aneurysm from an appendix abscess.

We report a case of gram negative anaerobic infection developing in an abdominal aortic aneurysm due to direct involvement by an appendix abscess. Diagnosis, management and successful treatment of this unusual and often lethal condition are discussed.

Aneurysm, Infected↗

Adenocarcinoid of the appendix presenting as bilateral Krukenberg's tumor of the ovaries. Immunohistochemical and ultrastructural studies and literature review.

A patient with an adenocarcinoid of the appendix presented with bilateral Krukenberg's tumors of the ovaries. Immunohistochemical and ultrastructural studies revealed a selective ability of the mucinous (goblet cell) component of the appendiceal neoplasm to metastasize. A review of the literature has revealed nine previously published cases of appendiceal adenocarcinoid metastatic to the ovaries. All showed involvement of both ovaries, but none provided unequivocal evidence of a metastatic proliferating carcinoid element. As the appendiceal lesion is often grossly inconspicuous, it may be overlooked in cases presenting initially with ovarian tumors. Routine appendectomy is therefore recommended in such patients where no grossly obvious primary tumor is evident.

Adenocarcinoma↗

Mucinous carcinoid tumor of the appendix presenting as bilateral ovarian tumors.

Mucinous carcinoid tumor of the vermiform appendix, an uncommon variant of appendiceal carcinoid, may present clinically with ovarian metastases. We studied a tumor by immunohistochemistry and electron microscopy and reviewed eight similar cases from the literature. The primary and metastatic tumors in our case were composed of mucin-producing cells and small argyrophilic cells arranged in cords and acini. Tumor cells in both primary and metastatic sites exhibited identical patterns of immunoreactivity for epithelial antigens (epithelial membrane antigen, carcinoembryonic antigen) and neuroendocrine antigens (serotonin, vasoactive intestinal polypeptide, adrenocorticotropic hormone). Ultrastructurally, the cells contained either mucin vacuoles or dense-core neurosecretory granules; rare individual cells contained both types of inclusions. When bilateral solid mucinous ovarian tumors are discovered at laparotomy, diagnostic appendectomy is indicated if no obvious extraovarian primary tumor can be found.

Adrenocorticotropic Hormone↗

Radionuclide imaging of sequential torsions of the appendix testis.

Radionuclide imaging is the diagnostic procedure of choice for evaluation of acute disorders of the scrotum, permitting rapid differentiation of torsion of the spermatic cord from inflammatory processes. The method is less successful in diagnosing torsion of the testicular appendages. In the majority of reported cases of torsion of the appendix testis the scan appears normal. In a very limited number of cases increased perfusion to the affected side has been noted. We report a case of metachronous torsion of both the appendices testis. In each instance, there was decreased tracer uptake on the affected side, suggestive of early torsion of the testicle. The sequential involvement of each testis with a nine month interval between respective torsions provides a unique example where each testis serves, sequentially, as a normal control for the torsed contralateral appendage.

Child↗

[Retrocecal mucus-secreting tumors of the appendix (mucoceles). Apropos of 3 radiologically diagnosed cases].

The term of appendiceal mucocele has been applied to a group of lesions distending the lumen of the appendix; filled with mucus. About 15% of these lesions are malignant tumors (cystadenocarcinomas). All these lesions may lead to pseudomyxoma peritonei, but only the peritoneal involvement due to a malignant tumor (adenocarcinoma) has multiple recurrences and poor prognosis. Benign lesions are cured by appendicectomy, even if a peritoneal "gelatinous" effusion is present. These lesions can usually be early diagnosed by US and CT features if the mucocele extends behind the cecum in the retroperitoneal space, especially if the wall is calcified. A colic examination (with barium enema or colonoscopy) must be taken event if the diagnosis is made by US or CT means, because of the significant association of mucocele with other colonic tumors.

Adult↗

Non-random acquisition of ethionine resistance by Chinese hamster fibroblasts. Appendix: acquisition of thermoresistance.

When cells from a single culture are physically separated into cultures exposed and unexposed to the drug, respectively, the cells in the unexposed culture acquire drug resistance at a rate that is much higher than that predicted by Poisson's law. The results are in conflict with the spontaneous mutation hypothesis of Luria and Delbrück. Appendix: cells grown at 37 degrees C acquire temperature resistance when their close relatives are exposed to a high temperature in separate cultures.

Animals↗

[Goblet cell carcinoid of the appendix].

A 50-year-old man was admitted with a diagnosis of acute appendicitis on January, 5, 1984 and an appendectomy was performed on the same day. The acutely inflamed appendix measured 7 cm in length, and a gross tumor, was seen at the apex. Histologic examination of the gross tumor, which was 1.7 cm in diameter, revealed a neoplasm representing a goblet cell carcinoid. Silver impregnation by both the Grimelius and Masson-Fontana methods disclosed a positive reaction in some neoplastic cells. Electron microscopically, endocrine granules with both limiting membranes and ahlos, 100-210 nm in diameter, were present in the neoplastic cells, Because of the relatively large size of the tumor and neoplastic invasion to the mesoappedix in this case and, in addition, the possible malignant nature of carcinoid tumor, ileoascendocolectomy was performed as an additional operation.

Appendectomy↗

Double tumours of the appendix: a rare entity. A case report.

A 73-year-old man was admitted with the suspicion of appendiceal abscess. Emergency appendectomy was done. Histology revealed two tumours, an adenocarcinoma and a carcinoid. Tumours of the appendix are seldom diagnosed preoperatively and often first at microscopic examination. All specimens should therefore be histologically examined.

Adenocarcinoma↗