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PubMed2003

Neurophysiological characterization of transitory global amnesia syndrome.

A total of 27 patients with transitory global amnesia (TGA) in the acute and late (from 7 days) periods and 31 patients with dyscirculatory encephalopathy and subjective memory impairments (control group) were studied. EEG data and assessment of the P300 cognitive evoked potential wave established differences in the nature of beta1 activity between these groups. The extent of beta1 activity on the EEG showed different relationships with the latent period of the P300 wave: in the control group, there were increases in beta1 activity with increases in the latent period (r = 0.43). while beta1 activity in TGA decreased with increases in latent period (r = -0.23). These changes were most marked in the frontocentral areas. The authors believe that these patterns of changes in EEG and cognitive evoked potentials in the acute period of TGA and at later periods, as well as in the control group, provide evidence of the functional nature of TGA syndrome, which is not related to any damaged brain structure.

Aged↗
PubMed1989

Directed forgetting and posthypnotic amnesia: information processing and social contexts.

In three experiments we compared posthypnotic amnesia (PHA) with directed forgetting (DF), evaluating subjects' hypnotic susceptibility, hypnotized or not. Experiment 1 suggested that the memory processes in PHA and DF were not the same. Low and high susceptibility subjects responded differently in the two contexts. Experiment 2 demonstrated a context effect for highly susceptible subjects: They showed the usual DF response outside hypnosis but not during hypnosis. Experiment 3 showed that high and low susceptibility subjects responded similarly to DF instructions outside hypnosis, eliminating the susceptibility as an important variable in the DF response. We concluded: (a) The interaction of context and susceptibility was the important determinant of unusual DF responses for high susceptibles, and (b) information processing concepts are too limited to explain PHA and perhaps DF. Theories that include interactions appear necessary for an accurate understanding of hypnotic phenomena and perhaps some phenomena usually focused on by cognitive psychology.

Amnesia↗
PubMed1983

Disrupted retrieval in directed forgetting: a link with posthypnotic amnesia.

Certain reliable findings from research on directed forgetting seem difficult to accommodate in terms of the theoretical processes, such as selective rehearsal or storage differentiation, that have been put forward to account for directed-forgetting phenomena. Some kind of "missing mechanism" appears to be involved. In order to circumvent the methodological constraints that have limited the conclusions investigators could draw from past experiments, a new paradigm is introduced herein that includes a mixture of intentional and incidental learning. With this paradigm, a midlist instruction to forget the first half of a list was found to reduce later recall of the items learned incidentally as well as those learned intentionally. This result suggests that a cue to forget can lead to a disruption of retrieval processes as well as to the alteration of encoding processes postulated in prior theories. The results also provide a link between intentional forgetting and the literature on posthypnotic amnesia, in which disrupted retrieval has been implicated. With each of these procedures, the information that can be remembered is typically recalled out of order and often with limited recollection for when the information had been presented. It therefore was concluded here that retrieval inhibition plays a significant role in nonhypnotic as well as in hypnotic instances of directed forgetting. The usefulness of retrieval inhibition as a mechanism for memory updating was also discussed.

Amnesia↗
PubMed1988

Pragmatics of measuring recognition memory: applications to dementia and amnesia.

This article has two purposes. The first is to describe four theoretical models of yes-no recognition memory and present their associated measures of discrimination and response bias. These models are then applied to a set of data from normal subjects to determine which pairs of discrimination and bias indices show independence between discrimination and bias. The following models demonstrated independence: a two-high-threshold model, a signal detection model with normal distributions using d' and C (rather than beta), and a signal detection model with logistic distributions and a bias measure analogous to C. C is defined as the distance of criterion from the intersection of the two underlying distributions. The second purpose is to use the indices from the acceptable models to characterize recognition memory deficits in dementia and amnesia. Young normal subjects, Alzheimer's disease patients, and parkinsonian dementia patients were tested with picture recognition tasks with repeated study-test trials. Huntington's disease patients, mixed etiology amnesics, and age-matched normals were tested by Butters, Wolfe, Martone, Granholm, and Cermak (1985) using the same paradigm with word stimuli. Demented and amnesic patients produced distinctly different patterns of abnormal memory performance. Both groups of demented patients showed poor discrimination and abnormally liberal response bias for words (Huntington's disease) and pictures (Alzheimer's disease and parkinsonian dementia), whereas the amnesic patients showed the worst discrimination but normal response bias for words. Although both signal detection theory and two-high-threshold discrimination parameters showed identical results, the bias measure from the two-high-threshold model was more sensitive to change than the bias measure (C) from signal detection theory. Three major points are emphasized. First, any index of recognition memory performance assumes an underlying model. Second, even acceptable models can lead to different conclusions about patterns of learning and forgetting. Third, efforts to characterize and ameliorate abnormal memory should address both discrimination and bias deficits.

Adult↗
PubMed1998

The offset of childhood amnesia: memory for events that occurred before age 3.

Adult memory for the events surrounding the birth of a sibling was examined in 69 adults. The authors identified a steep offset for childhood amnesia for this event before the child reaches age 2 1/2 years. The authors also examined the accuracy of information recalled. Although the majority of the answers were accurate, false memories were a consistent feature of the data. Alternative explanations of the authors' data were considered by examining the amount of information an additional 57 adults had about a family birth for which they could have no memory. The pattern of results did not support the view that participants might be unable to differentiate between memories and knowledge about the event.

Adult↗
PubMed1991

Unaware learning versus preserved learning in pharmacologic amnesia: similarities and differences.

The differences between learning in lorazepam (LOR)--or scopolamine (SCOP)--induced amnesia and learning in unaware drug-free normal subjects were examined. The drugs produced impairment in free recall, but did not affect digit span or word retrieval. In a verbal version, but not a motor version, of the serial reaction time task, the subjects who received SCOP or higher dose LOR showed impairment of sequence-specific learning. Subjects who received placebo had no such impairment. In the stem completion paradigm, higher dose LOR, but not SCOP, impaired performance. In a tachistoscopic word identification task, neither drug interfered with repetition priming. Unaware learning and drug-induced amnesic learning were thus dissociable. These findings disconfirm the hypothesis that unaware learning and drug-induced amnesic learning are analogous.

Adolescent↗
PubMed1991

Normal acquisition of novel verbal information in amnesia.

Amnesic patients (n = 9) and normal subjects (n = 12) read lists of unique words, repeated words, unique nonwords, and repeated nonwords as quickly as possible. In the first experiment both groups of subjects read the lists of repeated items faster than the lists of unique items and improved at the same rate within each list. In the second experiment, subjects read four new lists of items and then reread the same four lists after a 10-min delay. The results replicated the findings from the first experiment and demonstrated in addition that the facilitated reading speed persisted across the delay. These results show that the acquisition of novel verbal information can be supported by nondeclarative (implicit) memory. It is suggested that facilitated reading speed for words and nonwords reflects changes in early-stage perceptual systems and that these changes occur independently of the brain structures damaged in amnesia.

Aged↗
PubMed1999

Rate of forgetting in amnesia: I. Recall and recognition of prose.

Three experiments explored the rate at which amnesic participants' free recall, cued recall, and recognition of prose declined over short filled delays. In Experiment 1, after performance had been matched to that of controls at 15s, amnesics showed accelerated forgetting over delays of up to 10 min in a free-recall condition, whereas recognition performance declined normally over delays of up to 1 hr. This pattern of results was replicated in Experiment 2, which showed that amnesic rate of forgetting on a test of cued recall was influenced by level of cuing. Experiment 3 showed that excessive sensitivity to interference was unlikely to be the cause of the amnesic patients' accelerated forgetting rate, which is instead explained in terms of storage deficit accounts of amnesia.

Adult↗
PubMed1993

Intact acquisition and long-term retention of mirror-tracing skill in Alzheimer's disease and in global amnesia.

The ability of patients with Alzheimer's disease (AD) or global amnesia (AMN) to acquire skill for tracing a pattern seen in mirror-reversed view and to retain that skill over 24-h intervals was examined. Both patient groups had poor recall and recognition of their mirror-tracing experience, but they acquired and retained mirror-tracing skill as well as normal control subjects. One AMN patient (H.M.) retained the skill over a year-long interval. Furthermore, the patients transferred their skill normally to an alternate pattern. These results indicate that the memory system underlying mirror-tracing skill learning is separable from medial-temporal structures compromised in AMN and AD and from neocortical areas compromised in AD. Brain regions relatively spared in early AD, such as the basal ganglia or cerebellum, may mediate critical aspects of the learning of novel sensorimotor associations that underlie skilled mirror tracing.

Aged↗
PubMed1995

Intact delay-eyeblink classical conditioning in amnesia.

The status of classical conditioning in human amnesia was examined by comparing conditioning of the eyeblink response (the unconditional response) to a tone conditioned stimulus (CS) paired with an airpuff unconditioned stimulus (US) in the delay paradigm between 7 amnesic and 7 age- and education-matched normal control participants. Amnesic patients exhibited normal baseline performance in pseudoconditioning and normal acquisition and extinction of conditioned responses in terms of the number, latency, and magnitude of eyeblinks. These results indicate that in humans, as in rabbits, brain structures critical for declarative memory are not essential for the acquisition of elementary CS-US associations.

Adult↗
PubMed1995

On the acquisition of new declarative knowledge in amnesia.

In 2 experiments, the acquisition of new declarative knowledge was examined in amnesic patients and in 7 groups of controls, with a study-only procedure that delayed testing until the conclusion of training. The study-only procedure was compared with a standard procedure in which study and test trials alternated (study-test). The amnesic patients acquired new factual (declarative) knowledge at an abnormally slow rate, learning more with the study-only procedure than with the study-test procedure. Controls exhibited the opposite pattern. The advantage of the study-only procedure for amnesic patients was related to the presence of frontal lobe dysfunction. The 2 groups exhibited a similar ability to use their knowledge flexibly, suggesting that the information acquired by amnesic patients was based on their residual capacity for declarative memory. In addition, the capacity for factual learning in amnesia was proportional to the capacity to recollect specific events in the learning session.

Aged↗
PubMed1996

Involvement of entorhinal cortex or parietal cortex in long-term spatial discrimination memory in rats: retrograde amnesia.

Twenty-four rats assigned to 1 of 3 matched groups (control, entorhinal cortex [EC], and parietal cortex [PC]) were trained on 6 successive discrimination problems (2 in an 8-arm for pretraining and 4 in a 12-arm radial maze for training per se). The training on the 12-arm maze started 6, 4, 2, and 0.5 weeks before surgery. On the day after the rats learned the last problem, they were given surgery according to groups. Postoperative retention was measured by presenting 16 trials per session for each of the problems during 4 sessions. Results indicate that the EC lesions produced a retention deficit for problems learned immediately and up to 4 weeks before surgery, but not for the problem acquired 6 weeks before the lesions. The PC lesions produced a significant retrograde amnesia that was not temporally graded. Results demonstrate that the EC and PC make important, albeit distinct, contributions to spatial memory storage and retrieval in rats.

Amnesia, Retrograde↗
PubMed1997

Intact and impaired conceptual memory processes in amnesia.

To examine the status of conceptual memory processes in amnesia, a conceptual memory task with implicit or explicit task instructions was given to amnesic and control groups. After studying a list of category exemplars, participants saw category labels and were asked to generate as many exemplars as possible (an implicit memory task) or to generate exemplars that had been in the prior study list (an explicit memory task). After incidental deep or shallow encoding of exemplars, amnesic patients showed normal implicit memory performance (priming), a normal levels-of-processing effect on priming, and impaired explicit memory performance. After intentional encoding of exemplars, amnesic patients showed impaired implicit and explicit memory performance. Results suggest that although amnesic patients can show impairments on implicit and explicit conceptual memory tasks, their deficit does not generalize to all conceptual memory tasks.

Adult↗
PubMed1998

Font-specific priming following global amnesia and occipital lobe damage.

Font-specificity in visual word-stem completion priming was examined in patients with global amnesia and Patient M.S., who had a right-occipital lobectomy. Word-stems appeared in the same or different font as study words. Amnesic patients showed normal font-specific priming (greater priming for words studied in the same than different font as test), despite impaired word-stem cued recall. Patient M.S. failed to exhibit font-specific priming, despite preserved declarative memory. Therefore, perceptual specificity in visual priming depends on visual processes mediated by the right-occipital lobe rather than medial temporal and diencephalic regions involved in declarative memory.

Adult↗
PubMed2004

On Common Ground: Jost's (1897) law of forgetting and Ribot's (1881) law of retrograde amnesia.

T. Ribot's (1881) law of retrograde amnesia states that brain damage impairs recently formed memories to a greater extent than older memories, which is generally taken to imply that memories need time to consolidate. A. Jost's (1897) law of forgetting states that if 2 memories are of the same strength but different ages, the older will decay more slowly than the younger. The main theoretical implication of this venerable law has never been worked out, but it may be the same as that implied by Ribot's law. A consolidation interpretation of Jost's law implies an interference theory of forgetting that is altogether different from the cue-overload view that has dominated thinking in the field of psychology for decades.

Amnesia, Retrograde↗
PubMed2005

Emotion-induced retrograde amnesia and trait anxiety.

Emotional arousal can both enhance and impair memory. Considering that both emotional memory and trait anxiety (TA) have been associated with adrenergic activity, the authors investigated whether there is an association between 2 opposite emotional memory biases and the TA. The authors used a procedure recently put forward by B. A. Strange, R. Hurlemann, and R. J. Dolan (2003) to elicit an emotion-induced retrograde amnesia (ERA) coupled to an emotional memory enhancement (EME). The authors contrasted the association between these emotional memory biases and the TA in several conditions involving different levels of encoding and types of recall. The results presented here indicated a significant interaction of the TA with EME and ERA and the dependency of these biases on the consciously controlled use of memory.

Adult↗
PubMed2004

Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease.

Remote memory was assessed in persons with HIV-associated dementia (HIV-D), probable Alzheimer's disease (AD), and Huntington's disease (HD) and in healthy controls. The clinical groups were similar in overall dementia severity. Each clinical group exhibited impairments on remote memory tests relative to controls; however, temporally graded memory loss with selective preservation of older information was observed in the AD group but not the HD or HIV-D group. Analysis of cued retrieval indicated a preferential cuing benefit for the HIV-D and HD groups relative to the AD group. The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D. The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage.

AIDS Dementia Complex↗
PubMed2005

Impaired implicit memory for gist information in amnesia.

In 2 experiments using a converging associates paradigm, the authors evaluated implicit memory for gist information in amnesic patients. In Experiment 1, participants saw multiple sets of associates, each converging on a nonpresented theme word, and were then tested using an implicit word stem completion test and an explicit cued recall test. Amnesic patients showed intact implicit and impaired explicit memory for studied words, but memory for nonpresented lures was impaired, regardless of retrieval instructions. To evaluate whether impaired implicit memory for lures was due to accelerated forgetting of gist information, short study lists were used in Experiment 2, each consisting of a single set of associates. Amnesics' implicit memory for lures was again impaired. These results point to an inability to encode robust gist representations as the cause of impaired gist memory in amnesia.

Aged↗