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At least 109 records · Page 6Linked to original sources

Future prospects for Alzheimer's disease therapy: ethical and policy issues for the international community.

In addition to being driven by basic scientific research and the preclinical and clinical evaluation of promising new compounds, the development of drugs for patients with Alzheimer's disease (AD) must also be guided by public policy and ethical considerations. More carefully coordinated efforts should be devoted to reducing caregiver burden and providing community-based health care services for patients with chronic as opposed to acute diseases. Important ethical issues include the appropriate duration of double-blind, placebo-controlled clinical trials, the determination of the meaning of "informed consent" when dealing with patients with dementia, the establishment of outcome goals for various stages of the disease process, and the provision of appropriate hospice-type care. The establishment of the International Working Group on Harmonization of Dementia Drug Guidelines is an important step in the process of achieving an international approach toward the development and evaluation of drugs for patients with AD.

Alzheimer Disease↗

[Active music therapy for senile depression].

68 cases with senile depression were divided randomly into two groups--test group and control group. Patients of both groups received same antidepressive drugs while for the patients in the test group active music therapy was provided everyday in addition and the course of music therapy was 8 weeks. Patients in the test group showed improvement of their symptoms at the end of first week while most patients in the control group were getting somewhat better at the 3rd-4th week. The effectiveness of combined treatment in the test group is better than that in the control group. Patients in the test group became calm and active and the atmosphere on the ward appeared to be somewhat harmonized so that it was beneficial to the nursing care.

Aged↗

Initial assessment and stabilization of the critically injured child.

The care that the child receives during the initial resuscitation and stabilization of a life-threatening injury makes a critical difference in long-term outcome. Children who die as a result of a traumatic injury usually do so because of airway compromise, irreparable CNS injury, or bleeding. Hypoxia is the final common event by which these three kill children. If hypoxia is prevented or recognized and treated early, its effects can be reversed before they become permanent. The potential for a good outcome is maximized by expert nursing care for the critically injured child. Expert nursing care includes rapid and accurate assessment and interventions during both the primary and secondary surveys. Knowledge of the anatomic and physiologic differences between children and adults guides the nurse in holistic care of pediatric trauma victims; the nurse must also understand and address the emotional needs of the patients and their families.

Adolescent↗

Mechanical cardiopulmonary resuscitation.

Mechanical cardiopulmonary resuscitation is used by prehospital and intrahospital personnel to provide basic and advanced life support. It has several advantages over manual CPR. Major advances have been made to produce convenient portable units that provide reliable, improved ventilation and cardiac compression. More sophisticated techniques under development would effect changes in prehospital emergency care procedures because they require endotracheal intubation. Mechanical CPR will logically be important in implementing these techniques.

Emergency Medical Services↗

[Audit and standardization of allergologic practices for urticaria].

In November 1997, by the initiative of allergists and ANAICE commissions of harmonization and allergy practice were created to improve the quality of care. The summary of the results is reported of one of the commissions, that on urticaria. The common attitudes and disagreements between the allergists from different faculties and who worked in different towns are presented. The work has also shown the importance of interactions between urticaria and mind in chronic urticaria in adults and has analysed invalidated indications. The work has obtained the support of the principal representative structures of liberal allergy: the SNAF, ANAFORCAL and ANAICE. It needs to be followed by scientific and rigorous methodology, like the audits of ambulatory medical practice. The harmonization commissions have done preliminary work which is indispensable for introduction of audits in the different sectors of activity in allergy.

Acute Disease↗

Harmonizing cancer control in Europe.

Harmonizing cancer control in Europe should be a win situation not only for the cancer patients, but also for the different cancer research organizations. With the common vision of European oncology it will be possible to formulate strategic goals. One of these goals is the establishment of comprehensive cancer centers, either cancer hospitals or coordinated comprehensive cancer centers. It is important to identify the necessary structures needed to increase the innovation potential, and this includes not only care and diagnostic technologies but also prevention. We need to establish a harmonized evaluation procedure. Positive outcome measurements are important to demonstrate the effects of research on the treatment of our patients. For optimal innovation the establishment of translational research environments at the cancer centers are mandatory. In order to avoid fragmentation both in care and research, European collaboration must increase.

Delivery of Health Care↗

The Latin American guide for psychiatric diagnosis. A cultural overview.

The ICD-10 Classification of Mental and Behavioral Disorders is being accepted by most countries and by the World Psychiatric Association as the international standard in the field for statistical reporting and for clinical care and research. Emerging now, however, is the need to harmonize international communication with recognition of cultural diversity and specific local requirements. Latin American psychiatrists hold a long-standing commitment to the formulation of a reliable and valid diagnostic system in international psychiatry. Examples of important Latin American contributions include the pioneering use of explicit operational criteria in diagnostic methodology by Horwitz and Marconi in Chile, and the proposal of a multiaxial diagnostic formulation by Leme-Lopes in Brazil. In recent times, two main Latin American efforts at developing diagnostic adaptations to the international classification in psychiatry have emerged. One is the Cuban Glossary of Psychiatry, already in its third edition, and the second is a more ambitious project to develop the Latin American Guide for Psychiatric Diagnosis (GLADP). Departing from the experience gained by the Cuban psychiatry and keeping ICD-10 as the basis for nosological organization of mental disorders, the GLADP is being developed with the contributions of psychiatrists and other mental health professionals from most countries in Latin America. The GLADP comprises 4 parts: (I) historical and cultural framework of Latin American psychiatry; (II) a comprehensive diagnostic process and formulation, (III) psychiatric nosology (including ICD-10 major classes of disorders and Latin American cultural syndromes); and (IV) appendixes (including, a lexicologic glossary, concepts and proposals for future study, and bibliography). This is an overview of the basic principles and dimensions for psychiatric diagnosis in Latin America, with an emphasis on its cultural framework.

Adult↗

Static conductivity imaging using variational gradient Bz algorithm in magnetic resonance electrical impedance tomography.

A new image reconstruction algorithm is proposed to visualize static conductivity images of a subject in magnetic resonance electrical impedance tomography (MREIT). Injecting electrical current into the subject through surface electrodes, we can measure the induced internal magnetic flux density B = (Bx, By, Bz) using an MRI scanner. In this paper, we assume that only the z-component Bz is measurable due to a practical limitation of the measurement technique in MREIT. Under this circumstance, a constructive MREIT imaging technique called the harmonic Bz algorithm was recently developed to produce high-resolution conductivity images. The algorithm is based on the relation between inverted delta2Bz and the conductivity requiring the computation of inverted delta2Bz. Since twice differentiations of noisy Bz data tend to amplify the noise, the performance of the harmonic Bz algorithm is deteriorated when the signal-to-noise ratio in measured Bz data is not high enough. Therefore, it is highly desirable to develop a new algorithm reducing the number of differentiations. In this work, we propose the variational gradient Bz algorithm where Bz is differentiated only once. Numerical simulations with added random noise confirmed its ability to reconstruct static conductivity images in MREIT. We also found that it outperforms the harmonic Bz algorithm in terms of noise tolerance. From a careful analysis of the performance of the variational gradient Bz algorithm, we suggest several methods to further improve the image quality including a better choice of basis functions, regularization technique and multilevel approach. The proposed variational framework utilizing only Bz will lead to different versions of improved algorithms.

Algorithms↗

Life-sustaining treatment. A legal-ethical dilemma.

The U.S. Supreme Court decision in Cruzan by Cruzan v. Harmon will have a major impact on how we will care for patients in a persistent vegetative state. Each healthcare institution will need to review its life-sustaining treatment policies to match the guidelines established by the Supreme Court. Nurse executives also need to develop strategies to manage staff morale in coping with the conflicts surrounding the issues of preservation of life, quality of life, and patient/family choice regarding treatment.

Adult↗

The evolving horizon of drug registration--Europe and beyond.

The thalidomide tragedy gave rise to national drug regulation without thought to international harmonization. Thus from the early days of the European Community (EC), there has been a barrier to the free movement of medicinal products. Previous attempts have failed to resolve the problem and the European Commission is currently involved in attempting to establish Community drug legislation which will remove these barriers and create a single internal market. The Commission advocates two procedures (a centralized and a decentralized) largely under the control of the Committee for Proprietary Medicinal Products (CPMP) within the framework of a new European Agency for the Evaluation of Medicinal Products. The present authority of the Commission to make decisions binding on all 12 Member States will be utilized by the CPMP. While the present draft legislation should create significant improvement towards the goal of a single market, it contains some areas of potential concern. That this major venture should be a success is not only critical to the EC economy, its research-based pharmaceutical industry and the health care of its citizens but also to the achievement of global harmonization for pharmaceutical marketing authorization for which there is much evidence of enthusiasm and desire.

European Union↗

[Korea's health care policy of the twentieth century].

This article analyzes the social transformation of Korea's health care policy in the twentieth century from a historical perspective. The whole period under the research is divided into four stages. In the first stage (1900 - 1945), two major health care policies, public hygiene and population control, were a part of political strategy for consolidating Japanese colonial dominion over Korea. The second stage (1945 - 1960) is characterized by the division of Korean peninsula and Korean war that resulted in the vicious cycle between massive poverty and social disease. In the third stage (1961 - 1991), military governments considered the health care system as a 'carrot' for enhancing national security and reinforcing legitimacy of the regime. In the final stage (1992 - 1999), the state and civil society have been influential agents in shaping forms and contents of health care policy, with the organized medicine relatively neglected. Globalization will have more influence on the arena of health care policy in which three grants would have to negotiate one another. In addition, the organized medicine will have to consider a variety of non-governmental organizations (NGOs) as an inevitable counterpart of policy-making process in harmonizing the conflicts between public deliberation and professional interests. In the next century, health care policy, along with social welfare, environment and labor policy agendas would constitute a health-related policy regime in which all the participants have to accomplish not medicalization of life but socialization of health care and to diminish the inequity in health among a variety of social class.

Health Policy↗