Demonstration of double allelic expression (allelic inclusion) of rabbit kappa light chain allotypes on heterozygous lymphocytes by double allotype sequential stimulation.
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The results of immunoglobulin typing of 268 Tuvinians for G1m (f, z, a, and x), G3m (b, 0, 1, 3, 5, c3, 5, g, s, t and v), A2m (1 and 2) and Km (1) indicate these southern Siberians to have the Caucasian haplotype Gmf; bAm1 (0.100), the Oriental haplotypes Gmf, a; bAm1 (0.022), Gmf, a; bAm2 (0.040), Gmz, a; b, s, tAm1 (0.027) and Gmz, a; b, s, tAm2 (0.107). The haplotypes distribution for Gmz, a; gAm1 (0.279), Gmz, a; gAm2 (0.065), Gmz, a; x, gAm1 (0.101) and Gmz, a, x; gAm2 (0.030) are similar to those found in oriental populations. The striking feature of this population is the presence of Gmz, a; bAm1 (0.108) and Gmz, a; bAm2 (0.122) previously thought to be characteristic of African or Papuan populations, indicating that a third focus of the Gmz; a; b haplotypes exists in Central Asia. The Km1 frequency observed (0.125) is intermediate between Caucasian and previously studied northern Oriental populations.
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