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[Spanish adaptation and validation of an anxiety scale derived from the AMDP (AMDP-AT) system. I: Adaptation and convergent validity].

The Spanish translation and adaptation of the 17-item Scale extracted from the francophone extension of the AMPD scales, the AMPD-AT, has been filled out in 120 anxious, depressed and other psychiatric patients along with numerous other rating scales measuring anxiety (Hamilton, Zung, STAI, VAS), depression (Hamilton, VAS), and global psychopathology (AMPD-SY, CGI). The results point to a higher correlation with psychic anxiety than with somatic anxiety and with state anxiety than with trait anxiety. The correlations are lower with depression scales than with anxiety scales. The AMPD-AT shows as an special advantage the possibility to be used into the AMPD-System (in order to extract a score of anxiety in the context of a psychopathological profile) or independently as a scale of psychic anxiety.

Adolescent↗
PubMed1994

[Validity of an ELISA test for CD4+ T lymphocyte count and validity of total lymphocyte count in the assessment of immunodeficiency status in HIV infection].

A newly available commercial ELISA (TRAx CD4, T Cell Diagnostics USA) for enumerating CD4+ T lymphocytes has been evaluated with blood samples of 105 HIV seropositive and 6 seronegative subjects. Results from the flow cytometric analysis were used as reference. The sensitivity and specificity of the ELISA to identify HIV seropositive subjects having less than 200 CD4+ T lymphocytes/microliters were assessed and studied using the ROC curve. The reproducibility of the ELISA test was analyzed on 40 samples. The results of the ELISA correlated well with these of the flow cytometric analysis (r = 0.79, p < 0.001). However, the ELISA test tends to overestimate the true CD4 count in HIV seropositives. This overestimation could not be explained by the aspecific contribution of monocytic CD4. The threshold for identifying HIV seropositive subjects with less than 200 CD4+ T lymphocytes with a maximum sensitivity and specificity was determined with ROC curve and equalled 400 cell equivalents with the ELISA (sensitivity and specificity were equal to 80%) and 1,450 lymphocytes/microliters with the total absolute lymphocyte count (sensitivity and specificity were equal to 75%). Using this curve, a threshold of 300 cell equivalents for the ELISA test and of 1,100 lymphocytes/microliters for the absolute lymphocyte count was shown to maximize the specificity (> 95%) without a significant loss of sensitivity.

CD4-Positive T-Lymphocytes↗