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PubMed1976

[Transcortin binding capacity in the blood plasma of rats with a growing sarcoma 45].

It was shown that at the 10th day of sarcoma 45 growth the content of transcortine bound and free 11-oxycorticosteroids (11-OCS) in plasma of rat peripheral blood was increased. At the 30th day of the tumor growth the content of total and protein bound 11-OCS was decreased, accordingly by 57 and 61%. Following single hydrocortisone injections in intact rats and rats with sarcoma 45, on the 10th day of its growth, a marked increase in the content of bound 11-OCS was noted, as compared with animals receiving saline solution. On the 20-30th day of the tumor growth such effect was not observed. On the 20-30th day of sarcoma 45 growth 8-9% of the value of exogenic hydrocortisone, bound to blood plasma transcortins in intact rats, were found to be tracortin bound.

11-Hydroxycorticosteroids↗
PubMed1976

[Determination of free and protein bound cortisol, transcortin binding capacity and adrenocorticotropic hormone in the plasma of patients with hypertension].

The total non-conjugated plasma cortisol in 60 patients with hypertension disease (HD)is 17.5 mkg/ml. The free non-conjugated cortisol represents 8.45 per cent of the total - 1,5 mkg%, considerably (p less than 0.0001) higher than that in healthy subjects. Protein conjugated cortisol is 16.0 mkg%. The bounding capacity of transcortin the plasma of hypertonics is considerably decreased (p less than 0.0001) - 15.8 mkg (in healthy - 18.5 mkg) per 100 ml. ACTH level in the plasma of patients with HD is 32.0 pg/ml, considerably higher than that in healthy (25.8 pg/ml, p less than 0.0001). The elevation of the biologically active cortisol fraction in plasma of hypertonics is a function both of hypothalamo-hypopheseal stimulation and of transcortin level. That latent hypercortisolism is admitted to be manifestation of hypothalamo - hypopheseal superstimulation by increased ACTH secretion, in case of confirmed cerebro-hypothalamic disturbances in patients with hypertension disease.

Adolescent↗
PubMedDate not supplied

[Spectral-fluorescent characteristics of rat transcortin in normal conditions and during experimental circulatory insufficiency].

Spectral-fluorescent parameters of rat transcortin isolated from blood plasma of intact rats and rats with circulatory insufficiency were studied. The differences in the Schtern Folmer constants and the dissociation constants for the transcortin-corticosterone complex obtained during the protein titration by corticosterone may be due to different tryptophanyl surroundings in the molecules of the studied proteins. This may be a consequence of the conformational rearrangements of the corticosteroid-binding globulin molecules.

Animals↗
PubMed1989

[Characteristics of a transcortin-binding component of the plasma membrane of cells of the human decidual endometrium].

A sialoglycoprotein was isolated by affinity chromatography on immobilized transcortin from plasma membranes of human decidual endometrium cells, whose components were labeled with 125I and solubilized with sodium cholate. The apparent molecular mass of the monomer is 20.0 +/- 1.5 kDa, pI is at pH 3.3. The sialoglycoprotein specifically binds transcortin complexed to progesterone with Kd approximately 10(-10) M.

Cell Membrane↗
PubMedDate not supplied

Estrogen-induced transcortin increase and progesterone and cortisol interactions: implications from pregnancy studies.

The concentrations of progesterone, cortisol, estradiol, and transcortin binding capacity (TBC) were measured in plasma samples of women during normal pregnancy. Between 10 weeks and 20 weeks gestation, the mean of TBC increased linearly, and the mean increase in TBC for a given estradiol increment was constant until the estradiol concentrations reached approximately 30 nmol per liter. The results were consistent with the increase in TBC having been induced by estradiol; however, there was an inherent upper limit of response. Progesterone and cortisol were each linearly related to TBC, but the ratios of progesterone:TBC and cortisol:TBC showed no systematic trend throughout the period studied, and there was no systematic relationship between TBC and the progesterone:cortisol ratio. There was, however, a linear relationship between TBC and the progesterone + cortisol sum, such that a unit increase in TBC was accompanied by an approximate unit increase in the total concentration of the two main transcortin binding steroids. Some cases of spontaneous abortion or habitual abortion might be due to aberrant metabolic influence on progesterone of binding protein; in the instances studied, no evidence was found for this.

Abortion, Spontaneous↗
PubMed1985

Serum transcortin levels in patients with chronic hemodialysis.

Patients with renal insufficiency who are hemodialyzed 3 times a week either through a cuprophane membrane or through a polyacrylonitrile (PAN) membrane have the same transcortin and cortisol levels as patients with renal insufficiency who are not dialyzed. Moreover, hemodialysis did not influence acutely the latter transcortin levels.

Acrylic Resins↗
PubMedDate not supplied

[Binding of glucocorticoids by a transcortin-like protein in the cytoplasmic fraction of rat myocardium].

Myocardial cytosol of adult adrenalectomized rats bound specifically 3H-corticosterone and 3H-hydrocortisone and did not bind the synthetic 9alpha-fluoroglucocorticoid (dexamethasone) in vitro at 0-4 degrees. The specific binding of dexamethasone was not also found in the cytosol of neonatal rats. Heating of myocardial cytosol of adrenalectomized rats within 10 min at 60 degrees led to the complete loss of the glucocorticoid-binding activity. Treatment of the cytosol within the same period but at the temperature lower than 55 degrees did not affect its binding capacity. 3H-corticosterone-cytoreceptor complex was precipitated by ammonium sulphate at 40-60% of saturation. The complex was eluted from a column of Sephadex G-150 by solutions with both low (0.015 M KCl) and high (0.4 M KCl) ionic strength as the alone peak. This fraction corresponded by molecular weight to the transcortin complex. The data obtained and the results of our previous investigations suggest that myocardial glucocorticoid-binding cytoplasmic protein is related to transcortin-like cytoreceptors.

Aldosterone↗
PubMed1980

Lymphopenic response of patients presenting with chronic lymphocytic leukemia associated with carcinoma of the prostate to diethylstilbestrol: correlation of response to the in vitro synthesis of RNA by patient lymphocytes and its relationship to transcortin.

Three patients with chronic lymphocytic leukemia (CLL) and carcinoma of the prostate were treated for the latter condition with diethylstilbestrol (DES). All three patients responded with rapid reductions in their peripheral white counts. The previously observed lymphocytic infiltration of the bone marrow of one patient was not evident after three months of DES treatment. The response of this patient to DES correlates well with the enhanced level of plasma transcortin subsequent to treatment. Treatment of this patient with DES alters the ability of peripheral lymphocytes to incorporate radioactive uridine into RNA as well as the in vitro response to either cortisol or beta-estradiol.

Carcinoma↗
PubMed1984

Pregnancy-associated molecular variants of human serum transcortin and thyroxine-binding globulin.

Affinity chromatography on immobilised concanavalin A revealed that transcortin and thyroxine-binding globulin isolated from human postpartum serum contained approximately 10% of molecular variants that did not occur in these glycoproteins isolated from normal donor serum (both male and female). The chromatographic behaviour of the pregnancy-associated glycoprotein variants, their monosaccharide compositions, and the results of methylation analysis indicated that these variants contained only triantennary oligosaccharide chains of the N-acetyl-lactosamine type.

Chromatography, Affinity↗
PubMed1984

C21 steroids and transcortin-type protein during delayed implantation in the European badger Meles meles L.

A high-affinity corticosteroid-binding protein (CBG) roughly resembling a transcortin-type protein is present in badger plasma. Plasma CBG, corticosteroid and progesterone (P) concentrations were measured in relation to delayed implantation, true progestation and gestation. Two significant CBG increases were observed during pregnancy. The first, in the second half of embryonic diapause coincides with an increase in plasma corticosteroid concentration and the second, during true progestation and gestation, with an increase in P concentration. Relationship of CBG increases with pregnancy in badger are discussed.

Adrenal Cortex Hormones↗
PubMed1984

Androgen control of transcortin binding capacity in adult male ducks.

In adult male ducks submitted to marked variations in plasma testosterone concentration, plasma transcortin (CBG) levels were shown to be closely related to the level of plasma testosterone. In connection with previous data on female ducks, the results strongly support the evidence that at least in this species, CBG is under a stimulatory control by testosterone.

Animals↗
PubMed1996

Lower serum transcortin (CBG) in major depressed females: relationships with baseline and postdexamethasone cortisol values.

This study has been carried out to examine (i) transcortin or corticosteroid binding globulin (CBG), the major glucocorticoid transport protein, in major depressed versus minor depressed and normal subjects; and (ii) the relationships between CBG and basal and postdexamethasone cortisol or adrenocorticotropic hormone (ACTH) values. Serum CBG was significantly lower in major depressed than in minor depressed subjects and normal controls. The significant decrease in serum CBG was observed in major depressed women but not in major depressed men. In depressed subjects, there was a significant and negative relationship between serum CBG and severity of illness. There were significant positive relationships between serum CBG and basal 8:00 a.m. plasma cortisol in normal volunteers (r = 0.87, P < 10(-4)) and depressed subjects (r = 0.40, P = 0.0002). There was no significant relationship between serum CBG and 24-h urinary cortisol. In depressed patients, there was a positive relationship between serum CBG and postdexamethasone cortisol (r = 0.31, P = 0.003). It is concluded that, in depression, serum CBG levels should be taken into consideration for the interpretation of baseline and postdexamethasone plasma total cortisol levels.

Adjustment Disorders↗
PubMed1982

Isolation and characterization of glycopeptides of human transcortin.

Pronase digestion of human transcortin yielded two major glycopeptides (GID3 and G2D2, in a molar ratio of approx. 1.0 to 1.5) which were isolated by gel and anion-exchange chromatography. Chromatography behaviour, methylation analysis and analytical chromatography on a Con A-Sepharose column suggested that both of the glycopeptides were N-linked asparaginyl oligosaccharides of the N-acetyllactosamine type, G1D3 and G2D2 being triantennary and biantennary isoglycans, respectively. Microheterogeneity in regard to the position of the linkages between sialyl and galactosyl residues occurred in the triantennary and, possibly, in biantennary isoglycans.

Amino Acids↗
PubMed1976

A putative glucocorticoid receptor and a transcortin-like macromolecule in pituitary cytosol.

This study describes the binding of [3H]corticosterone and [3H] dexamethasone to soluble macromolecules in the pituitaries of adrenalectomized rats perfused at sacrifice to remove blood contamination. (1) Unlabeled dexamethasone competes only slightly for [3H] corticosterone binding when the steroids are added to cytosol as well as when the steroids are present from the time of disruption of the tissue. In the latter case, corticosterone is as good a competitor as dexamethasone for [3H]dexamethasone binding. (2) Gel permeation chrmatography with BioRad A-5M reveals the presence of a [3H] corticosterone-macromolecular complex with an elution volume comparable to transcortin as well as a very large hormone-binding complex eluting in the void volume of the column...

Adrenalectomy↗
PubMed1988

More familial leukaemia in ALL patients with both unexplained high transcortin levels and an HLA antigen Cw3.

In a group of 74 adult ALL patients 25 had a transcortin level greater than or equal to 3 SD above the normal mean, 15 expressed an HLA-Cw3 antigen and 11 combined both characteristics. In this subgroup of 11 ALL patients, five had familial leukaemia, i.e. at least one relative with acute leukaemia or lymphoma. On the other hand, only three examples of familial leukaemia were found in a series of 59 ALL patients with one or none of these two characteristics (relative risk: 15.6; P less than 0.001).

Adult↗
PubMed1975

Effect of sample volume and column length on transcortin determination by sephadex G-25 gel filtration.

When Sephadex G-25 columns are used to separate transcortin-bound corticosterone from free corticosterone, there is a non-linear increase of total binding with increasing plasma volume filtered. However, the specific binding (total binding - unspecific binding) shows a linear relationship with the plasma volume filtered. Furthermore, the specific binding decreases with increasing Sephadex column length and absolute binding values are found by extrapolating to a zero length column.

Chromatography, Gel↗