The representation of cutaneous sense in the thalamus of the cat and monkey.
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Optic nerve section or destruction of the lateral geniculate nucleus increased the amplitude and elevated the recovery cycle of the cortical response to lateral geniculate radiation stimulation in cats. The lesions may have acted by eliminating tonic inhibitory or occlusive volleys originating in the retina, or both.
The lateral geniculate nucleus is organized in such a way that, initially at least, information from the one eye is almost exclusively segregated from that from the other eye. Single-unit recording, however, confirms the histological evidence that bilateral integration does take place. A small number of cells (< 8.5 percent) receive afferents directly from both optic nerves and are discharged by stimulating either nerve (direct interaction). More common is delayed interaction, where the cells are discharged independently by either optic nerve but only after a relatively long latency. Indirect interaction effects also occur.
The effect of the synchronous discharge of a large population of corticothalamic neurons on activity within the somatosensory relay nuclei has been studied. Thalamic responses to peripheral nerve stimulation are depressed by activity in corticothalamic neurons. A subconvulsive dose of strychnine, given intravenously, changes this depression to enhancement.
A conditioned rise in blood sugar occurs in rats during a 10-mirational and provide an waiting period prior to nociceptive stimulation. This conditioned "preparatory hyperglycemia" is abolished after a bilateral lesion is produced in the mid-line thalamic nuclei; the experiments point to the importance of the thalamic reticular formation in adaptative metabolic reactions.
By electrocoagulation of the thalamic posterior commissure, the electroencephalographic arousal by high frequency stimulation of the thalamic unspecific nuclei was prevented, whereas the synchronizing influence on the cerebral cortex remained intact. On this ground, the role of the "thalamic reticular system" in the control of the cerebral rhythms is discussed.
Seven unique wavelength responses, two inhibitory and five excitatory, with sensitivity maxima from 435 to 635 millimicrons, have been recorded from light-adapted, non-albino rabbits. Several combinations, usually one excitatory with one inhibitory response, often having characteristics suggesting mutual antagonism between them, were observed from single lateral geniculate cells.