Effect of beta adrenergic receptor stimulation on integrated systemic venous bed.
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Repeated drug administration readily produces classically conditioned responses in animal and human experimental studies. The majority of patients applying for treatment of drug dependence show both autonomic and subjective responses when exposed to drug-related stimuli. These responses are presumed to have been conditioned during a period of active drug use, persist after traditional treatment for drug dependence, and may constitute one of several factors which predispose to relapse. Preliminary data are presented from a novel treatment approach which is designed to test whether drug-conditioned responses can be reduced or extinguished by systematic exposure to drug-related cues and whether such extinction improves the overall results of treatment.
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A computer-based system termed MBIS (the Molecular Biological Information Service), written in FORTRAN77 and Digital Command Language (DCL) and running on a Digital Equipment Corporation VAX computer under the VMS operating system (V4.1) is in use at the Division of Molecular Biology. MBIS consists of three main sections: 1) The utility section, used by the system's manager to tailor the five commonly available databases so that they are useable by the applications programmes running on the system; 2) The retrieval section, used to find and extract specific sequences or bibliographic information, and 3) The analytical section, used to analyse and compare sequences either extracted from the databases or input by the user. The nucleotide databases maintained are GenBank, EMBL and PIR (Protein Identification Resource, National Biomedical Research Foundation) and the peptide databases are PIR and NEWAT. In addition, users can originate and maintain their own databases. Those programmes which feature graphics output are compatible with most emulators of the Tektronix 4010 terminal.
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