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At least 109 records · Page 6Linked to original sources

Regular and anomalous scaling of a randomly advected passive scalar.

Extending Kolmogorov's refined similarity hypothesis to study the inertial behavior <[T(x+r,t)-T(x,t)](2n)>~r(zeta(2n)) of a passive scalar T(x,t) advected by a rapidly changing incompressible velocity field, a random variable straight theta was introduced by Ching [Phys. Rev. Lett. 79, 3644 (1997)]. In this paper, the statistical distribution of the random variable X=straight theta/sqrt[ ] is investigated analytically for the scaling in two limits, n-independent scaling zeta(2n)=zeta(2) and regular scaling zeta(2n)=nzeta(2), and numerically for the scaling of the Kraichnan conjecture zeta(2n)=1 / 2[sqrt[4ndzeta(2)+(d-zeta(2))(2)]-(d-zeta(2))]. For n-independent scaling zeta(2n)=zeta(2), the statistical distribution of X tends to an exponential distribution when zeta(2)-->0 or d-->infinity and to a Gaussian distribution when zeta(2)-->2 and d=2. For regular scaling zeta(2n)=nzeta(2), the statistical distribution of X tends to a Gaussian distribution when zeta(2)-->0 or d-->infinity. In d=2, there seems to be a phase transition for the probability density function P(X) from a convex to a concave function when the value of zeta(2) is increased and the critical point is zeta(2)=4/3 where the random variable X has a uniform distribution in [-sqrt[3],sqrt[3]]. In d=3, P(X) is a convex function for all 0 2. For the scaling of the Kraichnan conjecture, P(X) has two peaks in d=2 for zeta(2)>1.33, but, in d=3, it has only one peak for all 0 2.

Journal Article↗

Effects of visual angle on perspective reversal for ambiguous patterns.

Reversal rates of an ambiguous figure (the Necker cube) were studied for different pattern sizes covering a range of visual angles theta from approximately 1 to 62 deg. A large number of reversals was obtained for each observer and each pattern in order to examine the statistical distributions of reversal times. A pronounced flattening of the statistical distributions (represented throughout by a gamma distribution) and a growth of the mean duration of each percept, with increasing pattern size was found. A plateau in the range of theta between 5 and 20-30 deg was observed. For larger values of theta two kinds of observers have been identified: for 'fast' observers the inversion rate is little affected by theta, whilst for 'slow' observers, the mean reversal time increases strongly with theta. A tentative model, based on three different contributions to the duration of the alternation process, is proposed: a constant term, independent of theta, and two terms dependent on theta--a retinal term, and a cortical one. The last term is interpreted as due to the spreading of excitation with the characteristic of a filling-in process.

Adult↗

Analysis of finite mixture of distributions: a statistical tool for biological classification problems.

A microcomputer program to analyze finite mixtures of normal, binomial, Poisson or exponential distributions by a maximum likelihood estimation procedure is described. The program is coded in Turbo Pascal. Some theoretical and practical aspects of the compound distributions are discussed, mainly mathematical characteristics, fitting procedures and tests of hypotheses. The statistical tool, which is a cluster analysis technique, is presented in a general context for applications in biology. In particular an ecological example is briefly described: the age class structure resolution of a white-tailed deer population. To improve the usefulness for classification purposes, the link with discriminant analysis is examined. For a successful analysis of finite mixture of distributions the need for a large sample size is emphasized.

Age Factors↗

Impact of isospin breaking on the distribution of transition probabilities

In the present paper we investigate the effect of symmetry breaking in the statistical distributions of reduced transition amplitudes and reduced transition probabilities. These quantities are easier to access experimentally than the components of the eigenvectors and were measured by Adams et al. [Phys. Lett. B 422, 13 (1998)] for the electromagnetic transitions in 26Al. We focus on isospin symmetry breaking described by a matrix model where both the Hamiltonian and the electromagnetic operator break the symmetry. The results show that for partial isospin conservation, the statistical distribution of the reduced transition probability can considerably deviate from the Porter-Thomas distribution.

Journal Article↗

Dimensions of homo- and heteropolymeric sections of DNA synthesized by reverse transcription from globin mRNA matrices.

The lengths of globin messenger RNAs, isolated from rabbit and pigeon reticulocytes, and single-stranded complementary DNAs, synthesized from mRNA in presence of RNA-directed DNA-polymerase and oligo(dt) have been investigated by polyacrylamide gel electrophoresis under denaturing conditions. The cDNA preparations contained a fraction which corresponded in length to the alpha and beta chains of the mRNA used as a matrix. The lengthwise distribution of poly(A) sequences, isolated from globin mRNAs, corresponded to a statistical distribution, with a maximum at 75-80 nucleotides and with a maximum length of approximately 150 nucleotides. The lengthwise distribution of poly(dt) sequences, isolated from cDNA, corresponded to the poly(A) sequence distribution. It was concluded that: 1) cDNA is heterogeneous with respect to the length of poly(dt) sequences located at the 5' end of the molecule; 2) there was no selective use as primer of only that oligo(dt) which was located within the complex formed with the 5' end of the mRNA poly(A) sequence; 3) the heterogeneity of poly(DT) corresponded qualitatively to two models of template-primer interaction: selective use as a true primer of the oligonucleotide located in the complex formed with the 3' end of mRNA, and a statistical distribution of primer along the poly(A) sequence; and 4) the heterogeneity of the homopolymeric section of the cDNA may affect the kinetics of hybridization with mRNA, which possibly explains the previously observed [1] anomalous dependence of the hybridization rate on time.

Animals↗

Simple diagnostic statistical tests of models for DNA substitution.

The accuracy of models for DNA substitution used in phylogenetic analyses is becoming more important with the increasing availability and analysis of molecular sequence data. It is natural to look for ways of improving these models, and to do this in a planned manner it is useful to be able to identify features of sequences that may not be described adequately. In this paper, I describe three statistics which may give useful diagnostic information on departures from models' predictions. The statistical distributions of these statistics are discussed and simple significance tests are derived. These tests are based on the (estimated) phylogeny of the sequences and so have the advantage of using the information contained in this tree. Examples are given of the application of the new tests to Markov chain models describing the evolution of primate pseudogene sequences and small-subunit RNA sequences.

Animals↗

Statistical comparison of power spectra: a computer program.

A general computer program, of interest to neurobiologists, for comparison of uncorrelated power spectra is presented. The program, ALPHAF, is written in Fortran V language and is easily compiled and executed in any computer with a Fortran software package. The purpose of the program is to read power spectral density (PSD) values into a computer from digital tape and then perform the following functions: (1) compute and report power; (2) compute and report averages of the computed power values over selected frequency bands and (3) compute and report statistical standardised normal distributions for a frequency spectrum of interest. The standardised normal distribution statistic is derived by using equation 7.20, page 250 of Random data: Analysis and measurement procedures (Bendat and Piersol, 1971).

Computers↗

Postnatal development of the mouse temporal muscle and effects of a fine-grained diet on the muscle spindle.

The postnatal development of the mouse temporal muscle and effects of a fine-grained diet on muscle spindles were investigated. On d 25 after birth, 3 types of extrafusal muscle fibers could be distinguished on the basis of SDH activity, but not on the basis of their diameters. And in 50-d-old mice, 3 types of the muscle fibers had different diameters each other. In intrafusal muscle fibers, the postnatal changes of the SDH activity were similar to those of extrafusal muscle fibers, but the diameter distribution showed unimodal statistical distribution from 10th to 50th postnatal day. On the other hand, in control 180-d-old mice, 80 percent of muscle spindles in the temporal muscle had complete annulospiral endings, but the ratio of muscle spindles with complete annulospiral endings was decreased significantly in mice fed a fine-grained diet. The diet also decreased the diameter of the endings significantly. These results suggest that the main changes in the morphological and functional properties of the mouse temporal muscle occur in during and early after weaning period, and that normal mastication is needed to maintain the homeostatic condition of the mouse temporal muscle.

Animals↗

Relevant parameters for describing the oxygenation status of solid tumors.

AIM: Several studies using different methods of pO2 measurement have shown that in many tumor entities tissue oxygenation is quite heterogeneous and thus cannot be sufficiently described by a single value. This study presents those distribution parameters which are mandatory to describe the complete oxygenation status of a solid tumor. METHODS: In determining the oxygenation status different aspects of relevancy have to be taken into account. First, several parameters are necessary to characterize the location, the spread, and the shape of the pO2 distribution from a statistical point of view (statistical parameters). In addition, parameters for the description of the biological relevance of the tumor oxygenation have to be considered (biological parameters). These parameters reflect the role of oxygenation for the metabolic microenvironment and the biological behavior of the tumor as well as the significance under therapeutic and diagnostic aspects. Finally, some parameters are necessary to assess the quality of pO2 measurement itself (quality parameters). RESULTS: By combining all pO2 readings from one tumor a statistical distribution is obtained, which is in many tumors asymmetrically shifted towards low pO2 values. In order to describe the location, spread, and shape of this distribution the following parameters should be stated: median, mean, 10% and 90% percentile, minimum, maximum and 10 to 90% interpercentile range. For data presentation these values can be combined in a box-whiskers plot. In order to reflect the importance of tumor oxygenation under diagnostic, therapeutic or cell-biological aspects the fraction of pO2 readings < or = 2.5 mm Hg, < or = 5 mm Hg, and < or = 10 mm Hg should be stated. Where negative pO2 readings occur in a study, the fraction of pO2 readings < 0 mm Hg as well as the most negative pO2 value should be presented in order to assess the quality of the pO2 measurement. CONCLUSIONS: For a comprehensive description of the oxygenation status of solid tumors the following distribution parameters should be stated: median, mean, 10% and 90% percentile, minimum, maximum, 10 to 90% interpercentile range, fraction of pO2 readings < 0 mm Hg, < or = 2.5 mm Hg, < or = 5 mm Hg, and < or = 10 mm Hg as well as the most negative pO2 reading.

Humans↗

How should we estimate confidence intervals for a ratio, for example, between counts of colony-forming cells?

When calculating a ratio, of colony counts, for example, experimental hematologists often provide no indication of the uncertainty of the estimates, or the uncertainty is computed using a method with partially unknown properties. We have used empirical data on survival of colony-forming cells after exposure to hydroxyurea to select assumptions regarding the statistical properties of the survival ratios. Then, we have evaluated four alternative methods for constructing confidence intervals for such ratios. With simulations, the adequacy of the methods is shown to depend on the assumed statistical distributions of the data and on the number of observations in the numerator and denominator. Especially with few observations, some methods may produce misleading results. An easily calculable confidence interval, formally based on lognormal distributions, seems to be applicable to a fairly wide range of other plausible statistical distributions as well; it may be a reasonable choice in many situations. Whatever method is chosen, the confidence intervals for ratios are wide, and more data than is generally appreciated are needed for a precise determination of a ratio.

Animals↗

Creation of the transformed Q statistic probability distribution to aid in the detection of abnormal computerized visual fields.

This paper describes the creation of a new Q statistic which can be calculated from the threshold data of a single computerized visual field. The Q statistic can then be used to decide, at a given significance level, whether the individual field is normal or abnormal. The Q statistic is constructed to be particularly sensitive to the situation in which only a small subset of the values in the field is depressed, making it particularly useful in the diagnosis of early glaucoma.

Adult↗

[Performance assessment of mammographic diagnostic systems: evolution of methods and their application to a digital image study].

INTRODUCTION: "Receiver Operating Characteristic" (ROC) curves are one of the most efficient analysis tools for the complete evaluation of a diagnostic system performance. However this method is limited in visualizing and locating abnormal structures, such as clusters of microcalcifications on mammographic images. Other more refined and complex techniques have also been suggested, where particular statistical hypotheses are assumed, namely the "Free-response ROC" (FROC), the "Alternative FROC" (AFROC) and the "Free-response Forced Error" (FFE) analyses. We studied the theoretical bases of these different methods and their experimental applications to assess the correctness of the hypothetical statistical distributions. MATERIAL AND METHODS: We considered two statistical hypotheses: first, that the false-positive response distribution follows the Poissonian statistics; second, that "signal" and "noise" distributions have a Gaussian trend with different means and variances. Thus, we applied the different methods to the responses given by 8 observers (5 radiologists and 3 medical physicists) who independently evaluated 3 digital mammographic samples. Every sample consisted of 39 images, with 1-15 clusters each (total: 100 clusters). The samples were obtained from 39 images available in an Internet database (sample 1); 2 different digital filters were applied to each image (samples 2 and 3). To collects responses, we provided for two phases: first, every observer visualized and located the clusters at a given confidence level; second, when a false-positive response was given, spontaneously or after forcing, the responses were ordered by decreasing conspicuity. Finally, data were analyzed with a "home-made" software by applying the FROC and AFROC analyses to the data collected in phase 1 and the FFE analysis to those collected in phase 2. RESULTS: We considered the area under the AFROC curve as the most important parameter: the values obtained with the 3 types of analysis are well in agreement within their uncertainties. In particular, the FROC-AFROC agreement did not exceed 5.9% (10 of 14 cases within 2.5%), while the FFE analysis had higher standard deviations associated with the area value (about 10%). The interpolated curves from both FROC and AFROC data were very similar. The three methods had various advantages: the FFE is very simple to calculate and makes the most of the information given by the observer; FROC and AFROC can provide true-positive and false-positive responses on the same image, which permits to optimize the evaluation of a diagnostic system performance. The statistical tools used in the simplest methods are usually integrated with the completeness characteristics of the location of multiple signals on mammograms. CONCLUSIONS: In theory, every method is necessary because it provides additional information to validate the statistical hypotheses under investigation. In fact, when the methods are used to evaluate and compare several diagnostic systems, the results of the three techniques are equivalent. Therefore, choosing a specific technique depends on both available resources and response type all the hypothetical statistical distributions in our study proved correct.

Mammography↗

On the distribution of fast-phase intervals in optokinetic and vestibular nystagmus.

Histograms of fast-phase intervals in human optokinetic and vestibular nystagmus were generated, and fitted to statistical distributions used in previous studies. The distributions did not depend on stimulation type (optokinetic or vestibular). An inverse Gaussian or a gamma distribution fitted the data better than did a reciprocal Gaussian distribution, but none fitted the data especially well. In some cases, however, the interpretation of these distributions is more physiologically satisfactory than in others. Recommendations are made on which class of models is preferred, and the experiments needed to support the particular models. Our results call into question the validity of previous studies that fit statistical distributions to data sets of a size comparable to ours.

Adult↗

Infant sensitivity to distributional information can affect phonetic discrimination.

For nearly two decades it has been known that infants' perception of speech sounds is affected by native language input during the first year of life. However, definitive evidence of a mechanism to explain these developmental changes in speech perception has remained elusive. The present study provides the first evidence for such a mechanism, showing that the statistical distribution of phonetic variation in the speech signal influences whether 6- and 8-month-old infants discriminate a pair of speech sounds. We familiarized infants with speech sounds from a phonetic continuum, exhibiting either a bimodal or unimodal frequency distribution. During the test phase, only infants in the bimodal condition discriminated tokens from the endpoints of the continuum. These results demonstrate that infants are sensitive to the statistical distribution of speech sounds in the input language, and that this sensitivity influences speech perception.

Attention↗

Applications and statistics for multiple high-scoring segments in molecular sequences.

Score-based measures of molecular-sequence features provide versatile aids for the study of proteins and DNA. They are used by many sequence data base search programs, as well as for identifying distinctive properties of single sequences. For any such measure, it is important to know what can be expected to occur purely by chance. The statistical distribution of high-scoring segments has been described elsewhere. However, molecular sequences will frequently yield several high-scoring segments for which some combined assessment is in order. This paper describes the statistical distribution for the sum of the scores of multiple high-scoring segments and illustrates its application to the identification of possible transmembrane segments and the evaluation of sequence similarity.

Amino Acid Sequence↗

Comparison between the phi distribution of the amino acids in the protein database and NMR data indicates that amino acids have various phi propensities in the random coil conformation.

It has been indicated that amino acids have various intrinsic phi and psi propensities, as demonstrated from the comparison between experimental secondary structure propensities and their relative statistical distribution in the protein database for the appropriate region of the Ramachandran plot. However, this does not eliminate the possibility that these experimental propensities are the result of context effects due to the secondary structure environment of the mutated position. To demonstrate that there are at least real intrinsic phi propensities, independent of context effects, we have used two different nuclear magnetic resonance parameters related to the phi dihedral angle (J3 alpha HN coupling constants and the chemical shift of the C alpha H proton), determined in random-coil tetra- and pentapeptides, and/or in proteins. Comparison of the experimentally determined values for these parameters with the theoretical ones determined from the analysis by different empirical and theoretical equations of the phi dihedral angle statistical distribution of the amino acids in the protein database, supports the idea that each amino acid has, at least, different phi intrinsic propensities. Consideration of all conformations, or only coil conformations, in the protein database produces similar results. The reasonable correlation between these experimental and theoretical data and the hydrogen-exchange data in random-coil peptides suggests that maximisation of hydrophobic surface-buried and hydrogen-bond formation with the solvent could be responsible for these different random-coil conformational preferences. Analysis of the intrinsic propensities for beta-strand, alpha-helix and polyproline II dihedral angles of the 20 amino acids in coil conformations, indicates that the side-chain of the amino acids is mainly determining the relative preferences for the phi angle.

Amino Acids↗