[Larva currens--characteristic manifestations of strongyloidosis].
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Adult↗
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[Strongyloidosis. I. Specific and nonspecific skin lesions].
Specific, recurrent, tortuous or linear serpiginicus urticarial rash and nonspecific, stationary urticarial skin lesions appearing during infection with Strongyloides stercoralis and concomitant clinical manifestations in human were presented. Pathognomic form of larva currens in primary infection with S. stercoralis and in already allergic host during exo-autoinfection of the parasite, and similar skin lesions appearing during the endo-autoinfection but without the presence of S. stercoralis larvae in skin were described. Nonspecific urticarias were set against the pathognostic lesions.
Humans↗
[Use of a simplified method of detecting the larvae of the causative agent of strongyloidosis].
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Feces↗
[Immunogenic value of larval somatic antigen of Strongyloides papillosus in experimental strongyloidosis in rabbits].
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Animals↗
[Strongyloidiasis in Volyn Province].
82 cases of strongyloidosis have been recorded in the district over the period of 1971-1988. In 1977 an outburst of strongyloidosis was registered in a hospital for patients with chronic mental disorders. A great number of invaded patients identified accidentally during screenings suggests that the genuine infectivity of the population with strongyloidosis in Volyn Province is higher than the recorded one.
Humans↗
Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis.
We examined the effects of isoquinoline alkaloids in vitro in an effort to identify a treatment for Strongyloides stercoralis larva migrans in humans. Infective third-stage larvae of S. ratti and S. venezuelensis were used as model nematodes for S. stercoralis. Nematocidal activity was evaluated by the 50% paralysis concentration (PC(50)). Most of the tested isoquinoline alkaloids had activity for S. ratti and S. venezuelensis. We then evaluated in vitro cytotoxicity, which was the 50% inhibition concentration (IC(50)) of the compounds using HL60 tissue-culture cells. Three of the compounds (protopine, D-corydaline, and L-stylopine) which exhibited strong nematocidal activity, showed little cytotoxicity. In addition, we examined the relationship between nematocidal activity and cytotoxicity using the PC(50)/IC(50) ratio. A ratio equivalent to or lower than that calculated for the currently prescribed strongyloidosis treatments, ivermectin, albendazole and thiabendazole, was observed for allocryptopine, protopine, dehydrocorydaline, D-corydaline, L-stylopine, and papaverine. In contrast, the PC(50)/IC(50) ratios for protopine, D-corydaline, and L-stylopine were substantially more favorable. Therefore, protopine, D-corydaline, and L-stylopine were identified as potential effective treatments for strongyloidosis.
Alkaloids↗
[Fatal "overwhelming" strongyloidiasis in an immunosuppressed patient].
The increased use of immunosuppressants in the treatment of malignant and non-malignant diseases in today's medicine has significantly contributed to the increased interest in infections caused by opportunistic microorganisms and rare parasites. A fifty-eight-year old male patient, professor, born in Bosnia, was admitted to the Institute due to poor general condition and decompensated steroid diabetes. He had been under immunosuppressant therapy for the previous 5 weeks. Six months before, he noticed squamous and crusted changes on capilli, and afterwards on his body too. As these changes did not respond to local therapy he was admitted to the Department of Dermatovenereology, Zagreb University School of Medicine. Histologic analysis indicated pemphigus erythematosus. He was treated with immunosuppressants (methylprednisolone + azathioprine). Endoscopic examinations revealed duodenal ulcer, in addition to diabetes which could not be regulated by oral hypoglycemics. He received antiulcerative therapy for ulcer treatment. Several hours upon admission the patient became highly febrile, and vomited a sanguinolent content. In spite of intensive therapy, he became comatose and died 20 hours later. On autopsy, generalized strongyloidosis of the lungs, liver, duodenum and small intestine, and a bleeding duodenal ulcer due to strongyloidosis were found. This review should remind us that hyperinfestation with strongyloides is a rare and severe complication, and could be expected in immunocompromised patients.
Animals↗
Lung radiology in the tropics.
A high-quality chest radiograph and a timely, accurate report are often impossible in the tropics. Rationale matching of service to need, enthusiasm, commitment, and exploitation of information technology all go some way toward enabling patients with pulmonary disease to be imaged. The radiologic findings reflect the high preponderance of infectious disease. TB, HIV, and TB modified by HIV may be "routine" features in some parts of the tropics. Elsewhere, infestation with ameba, hydatid, and strongyloidosis, paragonimiasis, and melioidosis accounts for radiographic signs. The key is to have these conditions firmly in mind when reading tropical radiographs and be aware that the pattern of disease may be different between the patient from the tropics and the more familiar patient from downtown New York.
Humans↗
Nematocidal activities of thiabendazole and ivermectin against the larvae of Strongyloides ratti and S. venezuelensis.
With the aim of developing therapeutic agents for strongyloidosis, the disease caused by infection with Strongyloides stercoralis, we established a novel assay technique using S. ratti and S. venezuelensis as models for S. stercoralis. The newly developed assay technique was found to more accurately represent treatment-induced larval paralysis than existing assays. Our method uses paper disks impregnated with the test solution, which even allows materials that are sparingly soluble in water to be tested. An inverted microscope was used to observe the larval states, and these states were recorded using a digital camera. We observed the activities of ivermectin and thiabendazole against larvae and calculated larval motility and velocity. These two factors were then combined to determine the overall viability of larvae at selected concentrations. The activities of the anthelmintics were compared by calculating the concentrations at which 50% viability was demonstrated, or in other words, the concentration at which paralysis was caused in 50% of the individuals (50% paralysis concentration; PC(50)). Evaluations after 24h of exposure yielded the following reproducible PC(50) values for ivermectin and thiabendazole, respectively: S. ratti, 2.4 and 140 microM; and S. venezuelensis, 2.3 and 190 microM. After treatment with ivermectin, there was a tendency for larval motility to be greater than that of the controls at low concentrations, a result that might be associated with its mechanism of action.
Animals↗
[Ivermectin use in tropical medicine].
Ivermectin is a major breakthrough for the treatment of onchocerciasis, strongyloidosis, scabies and cutaneous larva migrans. Combined with albendazole, ivermectin is highly efficient for treating lymphatic filariasis and intestinal worms. Ivermectin shows very few side-effects but its use in children below 5 and during pregnancy is discussed. Ivermectin tolerance could be related to mdr1 gene expression. Additional studies are needed to assess its efficiency for pediculosis.
Antiparasitic Agents↗
Species-specific amplification by PCR of ribosomal DNA from some equine strongyles.
The first and second internal transcribed spacer sequences of 28 morphologically-defined species of horse strongyle were characterized, and specific oligonucleotide primers were designed for some species based on the nucleotide differences. Utilizing these primers, a PCR approach was developed for the specific amplification of ribosomal DNA of Strongylus vulgaris, Cyathostomum catinatum, Cylicocyclus nassatus, Cylicostephanus longibursatus or Cylicostephanus goldi. The method allowed the species-specific amplification of parasite DNA derived from faecal samples and/or copro-cultures, demonstrating the potential of the approach for the diagnosis of equine strongyloidosis. The establishment of this PCR assay also has implications for studying the biology and epidemiology of equine strongyles and anthelmintic resistance using faecal egg count reduction tests.
Animals↗
[Eosinophilia and hepatopathy].
We present the case of a 70-year old Patient with diffuse abdominal pain, severe eosinophilia, and increased liver parameters hospitalized for further evaluation. An idiopathic hypereosinophilic syndrome was postulated and the patient was treated with highdose methylprednisolone with rapid normalisation of the eosinophil numbers and decrease of the liver parameters. Later on strongyloidosis could be diagnosed (positive ELISA Test) as the cause of eosinophilia, and the patient was successfully treated with mebendazole. Blood eosionophilia most commonly reflects an allergic, infectious or neoplastic process; increased blood and/or tissue eosinophilia range in severity from self-limited to life-threatening conditions. Strongyloides infection can persist for years without prominent symptoms and should be suspected in any patient with unexplained eosinophilia.
Abdominal Pain↗
[First case of human toxocariasis (?) with adult worms in the circulatory system, detected by the presence of embryonated eggs in hemolysis concentration].
Ascarids's eggs were found by blood concentration in a Cameroonese patient with hypereosinophilia. Eggs, similar to those of Toxocara canis or cati, were present in 6 blood concentrations carried out during 7 weeks. These eggs (70-75 x 100-112 microns) contained embryos and hatching of 437-504 microns long larvae was sometimes observed. The presence of adult worms in a well oxygenated localization (e.g.; the left ventricle) was supposed. A pleural effusion was also observed but the low number of eosinophils in the pleural fluid (3%) eliminated the responsibility of the parasite. The treatment by thiabendazole for an associated strongyloidosis was well tolerated but inefficient. On the contrary, the treatment by diethylcarbamazine, well tolerated, induced the disparition of the circulating eggs. This result was confirmed by 6 blood concentrations carried out during 6 months.
Adult↗
[Parasitological evaluation of the stool].
The parasitologic investigation performed without clinical orientation in a routine laboratory allowed to identify the most common parasites, often cysts of protozoa, using a minimal technique. A more accurate investigation (e.g.: concentration, extraction and flotation) was hampered by a too large number of systematic specimens. The use of an immersion objective improves the detection and identification of cysts of protozoa. There is still some controversy on the virulence of small amoebae, flagellates, Blastocysts and Entamoeba coli, the infection being often massive. AIDS should predispose to new parasitic diseases such as cryptosporidiosis and strongyloidosis. A careful examination of stools for parasites has become mandatory in view of the wide geographical origin of patients with a parasitic disease.
Animals↗
Detection of antibodies against glycolipids of Echinococcus multilocularis metacestodes in sera of patients with alveolar hydatid disease.
Glycosphingolipids extracted from Echinococcus multilocularis metacestodes were tested against sera from patients with alveolar hydatid disease (AHD). The tests were performed first by ELISA then by immunostaining on thin layer chromatography. A binding between the parasite glycolipids and antibodies of AHD human sera was observed by ELISA. The glycolipids related to this binding were specifically parasite neutral glycosphingolipids. No reaction was observed with parasite acid glycolipids nor with neutral glycolipid extracts from human or mongolian gerbil erythrocytes. Comparison between absorbance values of 25 AHD sera and 20 control sera showed significant differences. Similar results were obtained with sera from hydatid cyst patients. Sera from patients with other parasitoses (schistosomiasis, strongyloidosis or paludism) were also tested. The reactive fractions were identified by immunostaining on thin layer chromatography with AHD sera, they were neutral glycosphingolipids containing at least two carbohydrate residues. These results were compared with chromatograms obtained with hydatid cyst human sera and discussed.
Animals↗
Development and evaluation of a Western blot kit for diagnosis of human trichinellosis.
We evaluated industrially prepared Western blot strips designed to avoid the cross-reactions observed with indirect immunofluorescence and enzyme-linked immunosorbent assays used for the serodiagnosis of trichinellosis. The antigen preparations were crude extracts of Trichinella spiralis. The Western blot profile characteristic of trichinellosis was characterized by comparing 60 sera from patients infected by Trichinella to 11 sera from healthy subjects, 51 sera from patients with other proven parasitic diseases (cysticercosis, schistosomiasis, strongyloidosis, fascioliasis, toxocariasis, liver amebiasis, anisakiasis, filariasis, toxoplasmosis, hydatidosis, or malaria), and 23 sera from patients with autoantibodies. Specific 43- to 44-kDa and 64-kDa bands were obtained with all of the sera from 51 patients with acute trichinellosis, in 4 out of 9 patients at the early stages of the disease, and in only 1 control patient, who had suspected anisakiasis and in whom trichinellosis could not be ruled out by muscle biopsy.
Animals↗
Significance of Salmonella typhi bacteriuria.
Bacteriuria due to Salmonella typhi usually occurs following recent typhoid fever or in chronic carrier states. Data from 18 patients with S. typhi bacteriuria, seen during 5 years, were analyzed. Fourteen patients had localized urinary tract infection due to S. typhi. Four others had bacteriuria, probably associated with typhoid fever. Localized abnormalities of the urinary tract and kidneys and also systemic diseases were found to predispose patients to S. typhi bacteriuria. Local abnormalities encountered included urolithiasis (n = 3), prostatic hypertrophy (n = 1), and tuberculosis (n = 1). One renal transplant recipient and another with lupus nephritis had S. typhi bacteriuria. One had associated strongyloidosis, and another was pregnant.
Bacteriuria↗
[Urticaria and parasites].
Urticaria has many etiology and during its exploration, it's important to mind about parasitic disease. The authors present briefly ten of them potentially associated with this eruption. For each disease (ascaridiosis, trichinellosis, fasciolosis, giardiosis, toxocarosis, anisakidosis, cercarial dermatitis, schistosomiasis, strongyloidosis, hydatidosis), they precise epidemiological situation for contamination and simple diagnosis approach.
Humans↗