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Results for “Prostaglandins--analysis”

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PubMed1979

Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: effect on prostaglandin levels in menstrual fluid.

The prostaglandin synthetase inhibitor ibuprofen was evaluated for relief of severe primary dysmenorrhea in a controlled, double-blind, cross-over study in seven patients for a total of 23 menstrual cycles. In eight untreated cycles, the amount of prostaglandin (PG) in the menstrual fluid was higher than in nondysmenorrheic subjects. There was good to excellent relief of dysmenorrhea in seven ibuprofen-treated cycles, which was associated with a threefold to fourfold reduction in menstrual PG released. When a placebo was given in five cycles, only poor or minimal relief of dysmenorrhea was obtained and the menstrual PG released was similar to that in control cycles. In individual patients, there was a remarkable correlation between the severity of menstrual pain as assessed daily by the patient and the level of menstrual PG released during the corresponding period. The effect of ibuprofen therapy on menstrual fluid volume was inconsistent. The study shows that in severe primary dysmenorrhea there is increased release of PG in the menstrual fluid; this can be effectively suppressed with ibuprofen, which provides excellent relief from the symptoms of dysmenorrhea.

Adult↗
PubMed1973

[Prostaglandins].

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Abortion, Spontaneous↗
PubMed1984

Decidual morphology and F prostaglandin in amniotic fluid in stretch-induced abortion.

Two to four stems of Laminaria were inserted into the cervixes of seven healthy women at second trimester. Forty-eight hours later, the Laminaria in each patient were replaced with a rubber balloon (100 mL capacity) that was inflated with 150 to 180 mL of physiologic saline solution, and traction of 800 to 1000 g was applied for an additional 24 hours. During Laminaria application, marked cervical softening was noted in all cases, and weak but definite uterine contractions were initiated in three women. During the balloon application regular uterine contractions were initiated or increased in all patients, with three late second trimester patients aborting within 24 hours. Light and electron microscopic studies of the decidua parietalis obtained during apparent uterine activity and after abortion revealed normal cell morphology. A significant increase in amniotic fluid F prostaglandin was noted after the balloon treatment (P less than .05). The authors conclude that uterine stretching induces uterine activity and a rise of prostaglandin in amniotic fluid without disfunction of decidual cells.

Abortion, Induced↗