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At least 109 records · Page 6Linked to original sources
PubMed1967

Sporicidal activity of peracetic acid and beta-propiolactone at subzero temperatures.

A method was developed to evaluate and measure the sporicidal activity of peracetic acid (PAA) and beta-propiolactone (BPL) at subzero temperatures as low as -40 C. Bacillus subtilis var. niger spores were used as the test organism. Both PAA and BPL were sporicidal at low temperatures, with PAA the more active. The temperature coefficients of the two chemicals are generally low over a range of 20 to -20 C, but increase significantly at temperatures below this. Results showed an initial lag in the PAA death rates that was directly dependent on the temperature. BPL did not show this lag time.

Acetates↗
PubMed1968

Effect of bacterial cell moisture on the sporicidal activity of beta-propiolactone vapor.

The activity of a vapor-phase disinfectant is usually expressed in terms of the atmospheric relative humidity (RH). This study shows that, in beta-propiolactone (BPL) vapor disinfection, the important factor is really the moisture content and location of water in the cell, and not necessarily the atmospheric RH. Previous studies revealed that only about 50% of the bacterial spores equilibrated to 45% RH were killed when exposed to the same RH to BPL vapor. On the other hand, all the spores equilibrated to and then exposed at 75% RH to BPL were readily killed. The present study shows that spores equilibrated to 98% RH are readily killed by BPL at 45% RH, but only 99% of the spores equilibrated to 75% RH are killed by BPL at 45% RH. Also, in order to be killed, desiccated spores must be exposed to BPL at higher humidities than would be required if the spores had not been previously desiccated.

Bacillus subtilis↗
PubMed1970

Effect of formalin, beta-propiolactone, merthiolate, and ultraviolet light upon influenza virus infectivity chicken cell agglutination, hemagglutination, and antigenicity.

Four strains of influenza virus were treated with Formalin, Merthiolate, Merthiolate and Formalin, ultraviolet light, and beta-propiolactone (BPL) for 18, 48, and 72 hr. Infectivity, chicken cell agglutination (CCA), hemagglutination (HA), and antigenicity determinations were made. Except for Merthiolate, each method of inactivation was equally effective in reducing infectivity. Loss of infectivity was related to length of treatment. CCA determinations were higher for all treated groups except for BPL-treated samples; these had lower determinations. BPL treatment also lowered the HA titer. Antigenicity was lessened by BPL treatment and by Merthiolate and Formalin treatment. Generally, the length of inactivation up to 72 hr did not affect CCA, HA, or antigenicity determinations. For the most part, there was no significant differences in the reactivity of the four strains.

Agglutination↗
PubMed1984

Neurological complications due to beta-propiolactone (BPL)-inactivated antirabies vaccination. Clinical, electrophysiological and therapeutic aspects.

Seventy six patients with neuroparalytic accidents due to antirabies vaccination (ARV) with BPL vaccine were studied. The mean age of incidence was 26.9 +/- 15.7 years. The suspected source of infection was by the bite of a dog in 72 (97.3%) out of 74. The mean duration of interval between the first dose of ARV and onset of neurological deficits was 12.2 +/- 8.4 days. The number of doses was 7 or less in 49 (65.3%) cases and more than 7 in 26 (34.7%) cases. With regard to neurological deficits, 6 (7.9%) had encephalopathy, 23 (30.3%) had encephalomyeloradiculopathy, 7 (9.2%) had myelopathy, 21 (27.6%) had myeloradiculopathy, 18 (23.7%) had polyradiculopathy and one had bilateral 7th cranial nerve palsies. Lumbar CSF analysis was done in 67 patients and was abnormal in 47 (70.1%) patients in the form of pleocytosis or raised protein or both. EEG, done in 30 patients, was abnormal in 13 (43.3%) and the abnormalities were not related to clinical features in 6. Electroneuromyography (ENMG) was done in 25 and was abnormal in 21 cases. Visual evoked potentials (VEP) was done in 11 cases and was abnormal in two. Sixty eight patients received steroids and 17 patients received cyclophosphamide in addition to steroids, 14 during the first admission and 3 during follow up when the recovery with steroids was not satisfactory. The therapeutic results were better in those who received cyclophosphamide and was statistically significant. Fourteen (18.4%) patients died and 6 were autopsied. The pathological features were essentially myeloradiculopathies, with variable degree of encephalic involvement. Two showed distinct necrotising myelopathy of immune type.

Adult↗