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At least 109 records · Page 6Linked to original sources
PubMed1992

[Evaluation of the fluidifying effect on nasal mucus of physiologic solution combined with increasing concentrations of polysorbates].

Nasal decongestants are widely used in the treatment of rhinitis. Decongestant drugs are one of the main components, but numerous reports gave been made concerning side, local and general effects. The problem is particularly important in the treatment of infantile rhinitis for which the use of saline solution alone is often preferred. The paper evaluates the fluidifying action of a saline solution and polysorbate 20, a tensioactive molecule, on nasal mucous. Changes in mucous viscosity were assessed using a "filancemeter" and thromboelastograph. At the same time a clinical study on the efficacy of treatment and the possible presence of side effects was carried out in a population of rhinitic subjects. The study highlighted the fluidifying effect of the preparation on nasal mucous and the complete absence of side effects.

Administration, Intranasal↗
PubMedDate not supplied

[Antiamnesic activity of nerve growth factor adsorbed on poly(butyl) cyanoacrylate nanoparticles coated with polysorbate-80].

The antiamnesic activity of nerve growth factor (NGF) in various medicinal forms [aqueous NGF solution with and without polysorbate-80 (PS-80) additives, NGF adsorbed on poly(butyl) cyanoacrylate (PBCA) nanoparticles with and without PS-80 coating] has been studied in rats with model amnesia induced by scopolamine (2 mg/kg, s.c.). The antiamnesic activity was evaluated by the ability of subsequently introduced drugs (5 microg NGF per animal, i.p.) to inhibit the amnesic action of scopolamine as manifested by retrieval of the passive avoidance reflex (PAR) learned using the Lafayette Instruments USP system 30 min after drug injection. The PAR memory trace was evaluated as an increase in the latent time before visiting the dark compartment 24 h after drug injection. In the untreated amnesia control group, the scopolamine amnesia was manifested by the absence of any increase in the PAR latent time. In the form of an aqueous solution, NGF did not inhibit the scopolamine-induced amnesia. NGF adsorbed on uncoated PBCA and in the form of solution with PS-80 produced an antiamnesic action manifested by a reliable increase in the PAR latent time as compared to that in the untreated control group. NGF adsorbed on PBCA nanoparticles coated with PS-80 not only exhibited a significant antiamnesic effect, but even stimulated the cognitive function and increased the PAR latent time above the value in the learned control group.

Amnesia↗
PubMedDate not supplied

Determination of polysorbates in foods by colorimetry with confirmation by infrared spectrophotometry, thin-layer chromatography, and gas chromatography.

A method is presented for the detection of polysorbates (PSs) in 8 kinds of processed foods by colorimetric and thin-layer chromatographic (TLC) techniques. The PSs are extracted from processed foods with a mixture of methylene chloride and ethanol by using an Extrelut column. The extract is further purified by using a silica gel column. The PS extract is complexed with cobalt-thiocyanate (Cothiocyanate) reagent and is determined spectrophotometrically at 620 nm. The recoveries and coefficients of variation for 8 kinds of processed foods fortified with 0.1% PS 80 were 67.9-94.6% and 4.0-11.3%, respectively. The detection limit of TLC corresponded to 50 mg PS 80/kg. PS identity was confirmed by infrared spectrophotometry of PS extract, and gas chromatography of fatty acids and thin layer chromatography of POE-sorbitan residues after saponification.

Chromatography, Gas↗
PubMed2005

Meniscal repair using the Polysorb Meniscal Stapler XLS.

We present our technique of repair of meniscal tears in 11 patients using a newly designed stapler, the Polysorb Meniscal Stapler XLS (USS Sports Medicine, Norwalk, CT), to increase the effectiveness and ease of repair of tears in the vascular zone while limiting potential complications. The low-profile stapler comes with a reloadable pistol grip device and a disposable straight or 15 degrees upcurved shaft with a single preloaded 10-mm staple. Standard anteromedial and anterolateral portals were used, along with a superomedial portal for inflow. The portal was enlarged slightly to facilitate introduction of the cannula or the stapler directly into the knee. The nose of the stapler was applied to the superior surface of the inner edge of the meniscal tear. The sharp points on the tip of the nose were used to manipulate the inner edge and coapt the tear site. Firm pressure was applied to the meniscal tissue, and the nose of the stapler was embedded in the inner edge of the meniscus no more than 2 to 3 mm from the tear (as measured along the meniscal surface). The handle was pulled slowly as the staple engaged the meniscal tissue. This step was repeated every 3 to 4 mm to ensure ideal tear stabilization.

Adolescent↗
PubMedDate not supplied

[Pulmonary microembolism with particles of synthetic polymer "Polysorb"in the treatment of postpartum endometritis].

A case of fatal massive pulmonary microembolism with particles of the synthetic polymer preparation in a female of 26 early after delivery is reported. The case is interpreted as a maternal death of the 1st group due to occasional damage in the process of uterine cavity washing with a suspension of a synthetic polymer preparation polysorb in the treatment of purulent postpartum endometritis.

Adult↗
PubMedDate not supplied

[Changes of biochemical blood parameters under conditions of treatment with vaulen and polysorb enterosorbents].

Alteration of the biochemical blood indices has been studied in patients with rheumatoid arthritis and lupus erythematosus that were treated with vaulen (V) and polysorb (P) enterosorbents. It was determined that alanine aminotransferase activity grew and albumin, urea, uric acid levels enhanced after the V treatment. Glucose level and alanine-, asparagine aminotransferases activities decreased after the P treatment. It is necessary to take into consideration these results when choosing an enterosorbent for treatment of patients with the immunocomplex rheumatic diseases accompanied by the liver parenchyma lesion and hyperuricemia.

Adult↗
PubMed1994

[Proposal for using mechanical staplers with Polysorb in creation of orthotopic neobladder].

After radical cysto-prostatectomy the bladder substitute is made from an ileal segment, opened along its antimesenteric border and folded; the results are in general good. The success of this procedure demands attention to detail, hemostasis and gentle handling of tissue so this surgery depends an unusual degree of commitment to meticulous technique. The very low rate complications, obtained with mechanical sutures in gastrointestinal surgery, incited the Authors using the staplers GIA and TA Polysorb for detubularized ileal segment. They are very manageable, easy to use and the follow-up shows the absence of urinary stone; so the team approach is less tedious and strenuous. The Authors present their results of 11 neobladder-staplers made with 35 cm of detubularized ileal segment without folding.

Aged↗
PubMedDate not supplied

[The use of antioxidants together with polysorb enterosorption in the combined treatment of patients with III-IV-stage ovarian cancer].

Studied in the course of a multiple-modality treatment of patients with stage III to IV ovarian cancer were effects of retinol and tocopheroli acetas and enterosorption with a silicone sorbent polysorb on the processes of lipid peroxidation and indices for the antioxidant system, for which purpose 75 female subjects were examined. The results obtained showed that retinol and tocopheroli acetas and enterosorption combined in treatment of patients with stage III-IV ovarian cancer made for stabilization of the processes of lipid peroxidation as well as for normalization of blood plasma content of factors of the antioxidant defence.

Antioxidants↗
PubMed2005

Polysorbate 80 and Cremophor EL micelles deaggregate and solubilize nystatin at the core-corona interface.

The extent and the location of nystatin solubilization by nonionic surfactant micelles were determined. The critical aggregation concentrations (CAC) of nystatin in 4 x 10(-3) M surfactant were determined by dynamic light scattering. The resulting CAC values for nystatin in Cremophor EL (CrEL), Tween 80 (T80), and Nofable ESO-9920 (NOF) were 150, 150, and 300 microM compared to 10 microM for the phosphate-buffered saline (PBS) control. The surfactants were able to solubilize and deaggregate nystatin from 50 to 75 times more than the PBS control. The core polarity of CrEL micelles, determined by pyrene fluorescence, was significantly lower than T80 and NOF micelles. The micelle-water partition coefficients (P) of nystatin and pyrene were determined by fluorescence spectroscopy. The partition coefficient values of 7.5 microM nystatin in CrEL and NOF micelles were 1100 +/- 60 and 1000 +/- 110, an insignificant difference (p > 0.1). However, there was a significant increase in pyrene partitioning in micelles with lower core polarity. Additionally, the P of nystatin decreased when the nystatin concentration was increased, whereas the pyrene P did not. The unusual partitioning behavior of nystatin revealed a good fit with the Langmuir adsorption isotherm, indicating solubilization at the micellar core-corona interface.

Antifungal Agents↗
PubMed1975

In vivo method for monitoring polysorbate 85 effect on epidermal permeability.

An in vivo method of monitoring the rate of water desorption from human forearms, using "dry" nitrogen gas passed over approximately 1 cm-2 of skin was investigated with the aid of a commercial electrolytic moisture analyzer. The assembled apparatus was used to evaluate the differences in water loss rates from treated and untreated (control) forearms following surfactant application. The changes in the differences were also monitored after cessation of treatment, i.e., during the healing process. The apparatus provided an accurate, rapid, and painless method of monitoring relative water loss rates and, as such, could prove a useful tool in routine testing in experimental dermatology and cosmetology. The results confirm the earlier finding from an in vitro method with excised rabbit skin that the tested surfactant increases the permeability of the epidermis.

Adult↗