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Abnormal electrical brain responses to pitch in congenital amusia.

Congenital amusia is a lifelong disability that prevents afflicted individuals from enjoying music as ordinary people do. The deficit is limited to music and cannot be explained by prior brain lesion, hearing loss, or any cognitive or socio-affective disturbance. Recent behavioral results suggest that this disorder is critically dependent on fine-grained pitch discrimination. Here, we present novel electrophysiological evidence that this disorder can be traced down to a right-lateralized N2-P3 response elicited by pitch changes. This abnormal brain response begins as early as 200 milliseconds after tone onset and may serve as a marker of an anomaly in music acquisition.

Acoustic Stimulation↗

Effects of spectral complexity and sound duration on automatic complex-sound pitch processing in humans - a mismatch negativity study.

The pitch of a spectrally rich sound is known to be more easily perceived than that of a sinusoidal tone. The present study compared the importance of spectral complexity and sound duration in facilitated pitch discrimination. The mismatch negativity (MMN), which reflects automatic neural discrimination, was recorded to a 2. 5% pitch change in pure tones with only one sinusoidal frequency component (500 Hz) and in spectrally rich tones with three (500-1500 Hz) and five (500-2500 Hz) harmonic partials. During the recordings, subjects concentrated on watching a silent movie. In separate blocks, stimuli were of 100 and 250 ms in duration. The MMN amplitude was enhanced with both spectrally rich sounds when compared with pure tones. The prolonged sound duration did not significantly enhance the MMN. This suggests that increased spectral rather than temporal information facilitates pitch processing of spectrally rich sounds.

Adult↗

Coding of the fundamental frequency in continuous interleaved sampling processors for cochlear implants.

In this study the perception of the fundamental frequency (F0) of periodic stimuli by cochlear implant users is investigated. A widely used speech processor is the Continuous Interleaved Sampling (CIS) processor, for which the fundamental frequency appears as temporal fluctuations in the envelopes at the output. Three experiments with four users of the LAURA (Registered trade mark of Philips Hearing Implants, now Cochlear Technology Centre Europe) cochlear implant were carried out to examine the influence of the modulation depth of these envelope fluctuations on pitch discrimination. In the first experiment, the subjects were asked to discriminate between two SAM (sinusoidally amplitude modulated) pulse trains on a single electrode channel differing in modulation frequency ( deltaf = 20%). As expected, the results showed a decrease in the performance for smaller modulation depths. Optimal performance was reached for modulation depths between 20% and 99%, depending on subject, electrode channel, and modulation frequency. In the second experiment, the smallest noticeable difference in F0 of synthetic vowels was measured for three algorithms that differed in the obtained modulation depth at the output: the default CIS strategy, the CIS strategy in which the F0 fluctuations in the envelope were removed (FLAT CIS), and a third CIS strategy, which was especially designed to control and increase the depth of these fluctuations (F0 CIS). In general, performance was poorest for the FLAT CIS strategy, where changes in F0 are only apparent as changes of the average amplitude in the channel outputs. This emphasizes the importance of temporal coding of F0 in the speech envelope for pitch perception. No significantly better results were obtained for the F0 CIS strategy compared to the default CIS strategy, although the latter results in envelope modulation depths at which sub-optimal scores were obtained in some cases of the first experiment. This indicates that less modulation is needed if all channels are stimulated with synchronous F0 fluctuations. This hypothesis is confirmed in a third experiment where subjects performed significantly better in a pitch discrimination task with SAM pulse trains, if three channels were stimulated concurrently, as opposed to only one.

Acoustic Stimulation↗

A dual-task investigation of automaticity in visual word processing.

An analysis of activation models of visual word processing suggests that frequency-sensitive forms of lexical processing should proceed normally while unattended. This hypothesis was tested by having participants perform a speeded pitch discrimination task followed by lexical decisions or word naming. As the stimulus onset asynchrony between the tasks was reduced, lexical-decision and naming latencies increased dramatically. Word-frequency effects were additive with the increase, indicating that frequency-sensitive processing was subject to postponement while attention was devoted to the other task. Either (a) the same neural hardware shares responsibility for lexical processing and central stages of choice reaction time task processing and cannot perform both computations simultaneously, or (b) lexical processing is blocked in order to optimize performance on the pitch discrimination task. Either way, word processing is not as automatic as activation models suggest.

Adolescent↗

Present status and future development of the cochlear prosthesis.

Presently devised single channel devices generate relatively primitive sensation of hearing. They provide some enhancement of communication skills for the totally deaf. Definite psychological advantages for the totally deaf have been observed. Pitch discrimination is by the mechanism of "periodicity pitch." No "place" pitch encoding is possible. The recognition of complex sounds is not possible. Multiple segments of auditory nerve must be stimulated in a manner which will stimulate the complex patterns of neural activity necessary for speech discrimination. Electrodes can be optimized and the pathophysiological consequences of electrical stimulation can be determined in experimental animals. The perceptual consequences of electrical stimulation, however, can best be determined in man himself. How much we will have to rely on known and future methods of aural rehabilitation will depend upon how well perceptual speech patterns can be generated by electrical stimulation of the auditory nerve.

Animals↗

Non-impaired auditory phase locking in dyslexic adults.

Dyslexic adults have profound difficulties in discriminating rapidly presented sound sequences. To test whether these deficits might be caused by impaired neuronal phase locking to the envelopes of the sound stimuli, 20 normal-reading and 13 dyslexic adults discriminated pitches of pure tones at approximately 1 kHz (producing spectral pitch due to place coding in the cochlea) and of approximately 80 Hz amplitude modulations of white noise (producing periodicity pitch based on temporal information only). We proposed that a specific deficit in phase locking would result in a worse ability to discriminate periodicity than spectral pitch. The dyslexics were significantly less accurate than the control subjects in discriminating both spectral and periodicity pitch stimuli but their performance was not disproportionally worse in the periodicity pitch task. Thus it seems that impaired neuronal phase-locking cannot explain the problems dyslexics face in processing of rapid sound sequences.

Acoustic Stimulation↗

Auditory information processing during acute insulin-induced hypoglycaemia in non-diabetic human subjects.

Acute insulin-induced hypoglycaemia impairs performance on tests of general mental ability in humans. It is recognized that different brain functions vary in their sensitivity to neuroglycopenia, but little is known about the effects of neuroglycopenia on specific brain processes. The effect of controlled hypoglycaemia on two aspects of auditory information processing (auditory temporal processing and simple auditory processing) was examined in a homogeneous group of 20 healthy non-diabetic human subjects. Auditory temporal processing (temporal order discrimination) and simple auditory processing (pitch discrimination, single-tone duration and single-tone loudness discrimination) tests were part of the Test of Basic Auditory Capabilities (TBAC). Two tests of general cognitive performance (Digit Symbol Substitution and Trail Making B) were included to provide a measure of general brain functioning during hypoglycaemia. Hypoglycaemia lead to a significant deterioration in auditory temporal processing (P < 0.01), and a deterioration in one of three tasks of simple auditory processing (discrimination of single-tone loudness, P < 0.05). Significant disruptions also occurred in both tests of general brain functioning. These results are congruent with other studies in human subjects, showing a disruptive effect of hypoglycaemia on visual information processing when examined under conditions of limited perceptual time, and they provide further evidence of the importance of sensory processing speed in basic perceptual and cognitive functions. The disruptive effect of moderate insulin-induced hypoglycaemia on auditory perception may have implications for insulin-treated diabetic humans exposed to this metabolic stress, because of the importance of hearing in everyday life.

Acoustic Stimulation↗

Higher order pattern structure influences auditory representational momentum.

Representational momentum refers to the phenomenon that observers tend to incorrectly remember an event undergoing real or implied motion as shifted beyond its actual final position. This has been demonstrated in both visual and auditory domains. In 5 pitch discrimination experiments, listeners heard tone sequences that implied either linear, periodic, or null motions in pitch space. Their task was to judge whether the pitch of a probe tone following each sequence was the same or different from the final sequence tone. Results suggested that listeners made errors consistent with extrapolation of coherent pitch patterns (linear, periodic) but not with incoherent (null) ones. Hypotheses associated with internalized physical principles and pattern-based expectations are discussed.

Attention↗

Auditory backward recognition masking with well-practiced listeners.

Five adult listeners who had extensive previous practice on a pitch discrimination task participated in an auditory backward recognition masking (ABRM) experiment. S identified the relative pitch "higher"-"lower" of a test tone. A standard tone of 20 msec duration at 800 c/s was followed after 500 msec by a similar 20-msec test tone at 800 +/- delta f. delta f varied from 3.3-11.4 c/s across Ss, adjusted for each S to yield approximately 75%-correct performance. The test tone was followed, after a silent interval of 20-250 msec, by a 100-msec mask, either a tone of 800 c/s or white noise. All stimuli were approximately equal to 77 dbA. All Ss exhibited substantial ABRM when the backward mask was a tone but substantially less when it was white noise. Evidently it is not necessary to use relatively naive listeners to demonstrate ABRM. The performance of most Ss was reduced by the tone masker (i.e., ABRM was in evidence) to chance or nearly chance levels (i.e., little or no ABRM) until the ISI exceeded 80 msec, and for 3 of the Ss ABRM with the tone masker was still evident after 250 msec. It was concluded that a backward mask interferes with test-tone information held in a multichannel preperceptual store and that such interference depends, in part, on the degree to which the properties of the test tone and mask overlap.

Acoustic Stimulation↗

The influence of linguistic experience on the cognitive processing of pitch in speech and nonspeech sounds.

In the present experiment, the authors tested Mandarin and English listeners on a range of auditory tasks to investigate whether long-term linguistic experience influences the cognitive processing of nonspeech sounds. As expected, Mandarin listeners identified Mandarin tones significantly more accurately than English listeners; however, performance did not differ across the listener groups on a pitch discrimination task requiring fine-grained discrimination of simple nonspeech sounds. The crucial finding was that cross-language differences emerged on a nonspeech pitch contour identification task: The Mandarin listeners more often misidentified flat and falling pitch contours than the English listeners in a manner that could be related to specific features of the sound structure of Mandarin, which suggests that the effect of linguistic experience extends to nonspeech processing under certain stimulus and task conditions.

Adolescent↗

Pitch processing in the human brain is influenced by language experience.

Positron emission tomography (PET) was used in a cross-linguistic study to compare pitch processing in native speakers of English, a nontone language, with those of Thai, a tone language. When discriminating pitch patterns in Thai words, only the Thai subjects showed activation in the left frontal operculum. Activation of this region near the classically defined Broca's area suggests that the brain recognizes functional properties, rather than simply acoustic properties, of complex auditory cues in accessing language-specific mechanisms in pitch perception.

Acoustic Stimulation↗

Computerized testing of signal-encoding strategies with round-window implants.

After extensive testing of a patient with two bipolar modiolar electrodes connected to a percutaneous plug in 1977, we provided four patients with a single-channel monopolar round-window electrode connected to a tuned radio-frequency receiver coil. Loudness and pitch discrimination and results of psychophysical scaling experiments of extracochlear electrodes are comparable to those with intracochlear stimulation. Extensive testing with a computerized test system and with tape-recorded and live speech material showed that accurate vowel and speaker identification by stimulation alone is possible and that discrimination by lipreading is considerably improved. Interactive training sessions further improve discrimination results. Different signal-encoding algorithms can be used to generate in real time stimulation signals from prestored speech parameters (such as pitch, gain, formants, and zerocrossing intervals).

Adult↗

Cochlea of the dolphin, Tursiops truncatus: the basilar membrane.

In the dolphin Tursiops truncatus, the basilar membrane over its course its course from basal to apical ends shows a systematic variation in width and in the manner and rigidity of its suspension. The suspension is by bony laminae on both the outer and inner edges in the basal region, and by progressively less rigid attachments in the more apical regions, until near the apex the membrane is held only by connective tissue. The basilar membrane shows an unusual variation in width of 14 times, ranging from an astonishingly small value of 25 mum at the basal end to a value toward the apex of about 350 mum. This structural variation is in harmony with the extension of sensitivity of the dolphin ear into the very high frequencies, and suggests unusual capabilities of pitch discrimination in this high range.

Animals↗

Psychophysical judgment: electro-cortical and heart rate correlates of accuracy and uncertainty.

The relationship between perceptual accuracy and physiological response amplitude was investigated in an auditory pitch discrimination experiment. Confidence ratings were obtained from all subjects following each trial. The stimulus set consisted of three tones of different frequencies spaced in a manner to provide both easy and difficult discriminations. Heart rate, EEG and vertical eye movement were recorded throughout the experiment. The results of the experiment indicated that the largest evoked cardiac rate response was elicited by the stimulus which produced the fewest errors in judgment; larger auditory evoked potentials, particularly the late positive component (P300), were associated with the 'easy' stimulus; greater cortical negativity was associated with the difficult stimuli. Eye activity was found to covary with judgmental accuracy; cortical slow wave activity was particularly sensitive to the confidence, or 'uncertainty' parameter. A 'decision tree' model was hypothesized to describe the processing mechanism involved in solving the discrimination problem.

Acoustic Stimulation↗