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PubMed2005

Pupil campimetry in patients with visual field loss.

Pupil campimetry is an objective test of the visual field. In pupil campimetry, the pupil light response elicited by focal light stimuli at different locations within the visual field is measured. Pupil campimetry was performed in patients with visual field loss because of different pathologies. The match between reduced pupil response and visual field loss was assessed. The pupil field of 23 patients was recorded by infrared video-pupillography with light stimuli generated on a computer screen. A visual field was obtained on the same day with the Tuebingen Automated Perimeter. Both fields were compared by subjective judgement. Six of nine patients with large, two of five patients with incomplete, and three of six patients with minor field loss showed matching defects in their pupil and their visual fields. In functional loss of visual field sensitivity, no pupil field defect was seen (three patients). In most patients, the loss of visual field sensitivity could be revealed objectively by pupil campimetry.

Adolescent↗
PubMed2005

Characteristics of pupil responses during far-to-near and near-to-far accommodation.

The static and dynamic aspects of the pupil response associated with various amplitudes of far-to-near (accommodation) and near-to-far (disaccommodation) focusing responses were evaluated in this study. Dynamic refractive and pupillary changes were measured simultaneously during focusing responses to targets at real distances in 12 young (23-26 years) emmetropic subjects. The targets were presented alternately at far (6 m) and at one of six near positions from 1 D (1 m) to 6 D (16.7 cm) in 1 D steps. The latency, magnitude and peak velocity of pupil changes associated with accommodation and disaccommodation responses were calculated. The latency of refractive changes was shorter than that of pupillary changes. In general, the pupil constricted with accommodation and started dilating while accommodation was still maintained, resulting in reduced pupil dilation with disaccommodation. The magnitude of the pupil response increased linearly with that of accommodation and disaccommodation. The amount of pupil change per dioptre of refractive change was invariant with various amplitudes of refractive change. The peak velocity of pupil constriction was greater than that of pupil dilation for corresponding amplitudes. The pupil response is more closely associated with accommodation than with disaccommodation.

Accommodation, Ocular↗
PubMed2006

Influence of pupil diameter on the relation between ocular higher-order aberration and contrast sensitivity after laser in situ keratomileusis.

PURPOSE: To investigate the influence of pupil diameter on the relation between induced changes in ocular higher-order wavefront aberrations and changes in contrast sensitivity by conventional laser in situ keratomileusis (LASIK) for myopia. METHODS: In 215 eyes of 117 patients (age, 33.2 +/- 8.3 years) undergoing LASIK for myopia of -1.25 to -13.5 D (-5.28 +/- 2.55 D), ocular wavefront aberrations and contrast sensitivity function were determined before and 1 month after surgery. Preoperative photopic pupil diameter was measured with a digital camera. Ocular higher-order aberrations were measured for a 4-mm pupil with a Hartmann-Shack wavefront analyzer. The root-mean-square (RMS) of the third- and fourth-order Zernike coefficients was used to represent coma- and spherical-like aberration, respectively. From the contrast-sensitivity data, the area under the log contrast sensitivity function (AULCSF) was calculated. RESULTS: One hundred five eyes had a photopic pupil diameter of 4 mm or larger, and the remaining 110 had a photopic pupil diameter smaller than 4 mm. There were no statistically significant differences in the background clinical data between these two groups. In the eyes with a photopic pupil diameter of 4 mm or larger, the changes in third-order comalike aberrations did not correlate with the changes in AULCSF (Pearson correlation coefficient, r = -0.037, P = 0.723) and 10% low-contrast visual acuity (r = 0.125, P = 0.224), but fourth-order spherical-like aberrations correlated significantly with the changes in AULCSF (r = -0.229, P = 0.024) and 10% low-contrast visual acuity (r = 0.221, P = 0.038). In the eyes with photopic pupil size smaller than 4 mm, there were significant correlations between the changes in comalike aberrations and the changes in AULCSF (r = -0.487, P < 0.001) and 10% low-contrast visual acuity (r = 0.310, P = 0.003), but spherical-like aberrations showed no correlation with the changes in AULCSF (r = -0.078, P = 0.485) and 10% low-contrast visual acuity (r = 0.208, P = 0.158). CONCLUSIONS: In eyes with larger photopic pupil diameter, increases in spherical-like aberration dominantly affect contrast sensitivity, whereas in eyes with smaller pupil size, changes in coma-like aberration exert greater influence on visual performance.

Adolescent↗
PubMed2001

The pupil in dominant optic atrophy.

PURPOSE: To compare visual and pupil afferent function in dominant optic atrophy (DOA). METHODS: Patients with DOA who belonged to families showing evidence of linkage to the locus on chromosome 3q28-qter were recruited from the Moorfields Genetic Register. Patients and healthy control subjects underwent visual and pupil perimetry using a modified automated perimeter (Octopus 1-2-3; Interzeag, Schlieren, Switzerland). Five stimulus locations were tested: fixation, and at 17 degrees eccentricity along the 45 degrees and 135 degrees meridians in all four quadrants. The visual deficit (difference in decibels between the patient's luminance threshold and that in age-matched healthy control subjects) was compared directly with the pupil deficit (difference in decibels between the stimulus intensity giving the patient's pupil response and that giving an equivalent pupil response in healthy control subjects) at each test location. RESULTS: Visual deficits and pupil afferent deficits were found at all five locations. The visual deficits were significantly greater than the pupil deficits at the four peripheral locations (median difference = 6.3 dB, P: < 0.001). At fixation, the difference was not significant (median difference = 2.3 dB, P: = 0.407). CONCLUSIONS: Pupil function appears less affected than visual function at four of five locations tested. This result provides evidence that the retinotectal fibers serving the pupil light reflex are less susceptible to damage from the OPA1 genetic defect than the retinogeniculate fibers serving vision.

Adolescent↗
PubMed1996

Endogenous circadian rhythm of basal pupil size in rabbits.

PURPOSE: The authors examined the circadian change of basal pupil size in light-dark entrained normal rabbits and in entrained rabbits with unilaterally decentralized ocular sympathetic nerves. The pattern of the circadian pupillary rhythm was compared with the circadian patterns of intraocular pressure (IOP) and body temperature in the same rabbits. METHODS: Adult male New Zealand albino rabbits were entrained to a daily 12-hour light-12-hour dark cycle. Using an infrared camera recording system, basal pupil sizes in seven entrained rabbits were videotaped under a constant dark environment at 1-hour intervals for 24 hours. Hourly IOP and rectal temperature in the same rabbits were measured separately under both the regular light-dark cycle and constant dark. In 10 entrained rabbits that underwent unilateral transection of the cervical sympathetic trunk, measurements of pupil size and IOP in constant dark were performed. RESULTS: In normal rabbits, a smaller basal pupil size in the subjective light phase and a consistently larger pupil size in the subjective dark phase were observed. Notably, pupil size increased sharply at the beginning of the subjective dark phase and peaked shortly. Circadian rhythms of IOP and body temperature were present under the regular light-dark cycle and in constant dark. As did pupillary enlargement, IOP rose sharply at the beginning of the subjective dark phase and peaked shortly thereafter. Body temperature, however, increased gradually and peaked in the late subjective dark phase. In rabbits with unilaterally decentralized ocular sympathetic nerves, the circadian rhythm of pupil size was present only in the intact eye. In addition, the circadian IOP elevation in the decentralized eye was reduced significantly. CONCLUSIONS: In light-dark entrained rabbits, basal pupil size changes in a circadian pattern and peaks at the beginning of the dark phase. The circadian pupillary rhythm disappears after ocular sympathetic decentralization. There are similar characteristics in the circadian rhythm of IOP. The increase of basal pupil size in the early dark phase is not related to the nocturnal increase of body temperature.

Animals↗
PubMed2002

The nature, extent and effects of emotional abuse on primary school pupils by teachers in Zimbabwe.

OBJECTIVE: The study seeks to determine the nature, extent and effects of emotional abuse; and who the perpetrators are in Zimbabwean primary schools. METHOD: Data collection was twofold because this involved reported cases of emotional abuse and the use of two questionnaires to collect data on the forms of emotional abuse perpetrated on pupils by teachers. First, data of reported cases of emotional abuse were collected from six regional offices of the Ministry of Education, Sport and Culture in Zimbabwe. The rationale was to determine forms of emotional abuse perpetrated on pupils by teachers in Zimbabwean primary schools. Second, the Teacher Trainees Questionnaire and the Teacher Questionnaire were administered to randomly selected samples of 150 primary school teacher trainees and 300 primary school teachers. Random numbers were used in the selection of the teachers and teacher trainees. The rationale for using teachers and teacher trainees was to make an in-depth analysis of the forms of emotional abuse perpetrated on pupils by teachers and to determine who the perpetrators are in this form of child abuse. In this study, emotional abuse shall refer to constant belittling of a pupil, the absence of a positive emotional atmosphere, verbal abuse, shouting, scolding, use of vulgar language, humiliation and negative labeling of pupils, and terrorizing of pupils by teachers in schools. RESULTS: The study found that the majority of teacher trainees and teachers believe that shouting, scolding, use of vulgar language, humiliation and negatively labeling of pupils as stupid, ugly, foolish is mainly done by female teachers in schools. However, 52.7% of the teacher trainees indicated that it is the male teachers who "use vulgar language on pupils." This study found some of the forms of emotional abuse that are perpetrated on pupils by teachers in schools. The findings seem to be consistent with the literature available on the gender of perpetrators associated with this form of child abuse. CONCLUSION: It is clear that emotional abuse exists in Zimbabwean primary schools and female teachers appear to be the main perpetrators of this form of child abuse. This form of child abuse may involve one perpetrator and a series of victims.

Child↗
PubMed2000

Knowledge and attitudes of high school pupils towards children with special health care needs: an Israeli exploration.

One hundred seventy-one pupils of a high school in Holon (Israel) were questioned regarding their attitudes towards chronically disabled individuals who have special health-care needs. The level of pupils' knowledge concerning the etiology, symptoms and complications of these chronic conditions was approximately 72%; it did not increase in four years of study. Previous personal knowledge of a child or adolescent with a chronic disease or handicap influenced the understanding of that particular ailment. The pupils' attitude towards handicapped individuals become more positive and tolerant with increasing age (and class level). A correlation was found between the level of knowledge about special medical-health needs and tolerant attitudes toward chronic patients. Most of the pupils think that the following occupational and recreational interests for the disabled will help to increase their self-image and improve their feelings of acceptance: computers, music (playing and listening), sports and domestic pets. The pupils believe the topics of chronic diseases and patients should be studied as a regular part of the school curriculum and these subjects should be taught with the participation of both physicians and teachers. The pupils stressed the role of the teacher in handling children with the chronic disease. Only half of the pupils think that their class peers should also know about the chronic disease of this individual pupil. The information sources of pupils concerning chronic disease are mainly TV, newspapers, adolescent periodicals, books, physicians and nurses, and lastly, the school. Conclusions are presented concerning health promotion activities in the school.

Adolescent↗
PubMed2006

Cochlear implanted pupils in Scottish schools: 4-year school attainment data (2000-2004).

The Achievements of Deaf Pupils in Scotland (ADPS) project has been tracking the educational attainment of deaf pupils in Scotland's schools since 2000. At the time of writing, the database contains records for 1,752 deaf pupils (2000-2005). Here 4-year aggregate educational attainment data are reported for a subset of 152 school-aged deaf pupils with cochlear implants notified to the ADPS database between June 2000 and June 2004. The data describe primary and secondary school results in reading, writing, and math for this subgroup, as well as placement and communication characteristics. The educational attainment of the group of deaf pupils with cochlear implants is clearly marked when the deaf pupil population is disaggregated for hearing loss, achieving comparatively higher average attainment in both 5-14 Curriculum National Tests (Mathematics in particular) and Standard Grades. Therefore the gap in performance relative to the national population data is reduced for those deaf pupils, although it still widens at higher levels of achievement for the National Tests. Although most pupils with cochlear implants are placed in the mainstream, there is no pattern of migration toward mainstream schools. Some deaf pupils with cochlear implants moved out of mainstream to other types of placement, and this has implications for health-economic cost-utility assessments of cochlear implantation that favor mainstream education by drawing upon the relative cost of different placement types. These findings suggest that the ADPS program of research can contribute school outcome data as valuable real-life outcome measures in wider assessments of the benefit of cochlear implants to deaf children and deaf young people.

Adolescent↗
PubMed1995

Pupil adjustments in the eye of the common backswimmer

The pupil mechanism in the acone apposition eye of the semi-aquatic common backswimmer Notonecta glauca (Hemiptera) was investigated with infrared reflectometry of the pseudopupil. This method allows non-invasive continuous measurements of pupil responses in the living animal. The dynamic range of the pupil sensitivity is about 7 log units during daytime and 6 log units at night. During the day, the sensitivity range of the pupil covers the normal daylight intensities in the animal's habitat, just under the water surface (I50=10(19.2) photons m-2 sr-1 s-1). At night, the sensitivity is 1 log unit lower (I50=10(20.2) photons m-2 sr-1 s-1), ensuring that the pupil is maximally open when light intensities are low. During daytime, light adaptation is completed in slightly less than 40 min, and dark adaptation takes approximately 50 min. The pupil response is only slightly slower at night. The speed of the response as well as the pupil sensitivity are dependent on the preceding adaptation history. An endogenous circadian rhythm determines the control range of the pupil aperture. However, the rhythm is easily disturbed, especially within a 3 h period before dusk and dawn. The results are compared with corresponding results from other insects with the same type of pupil mechanism.

Journal Article↗
PubMed2005

Pupils' liking for school: ability grouping, self-concept and perceptions of teaching.

BACKGROUND: Research indicates that affective aspects of development provide a basis for autonomous learning. Pupils' liking for school may be a useful indicator of their relationships with teachers and the school. AIMS: The aim of the research reported in this paper is to establish the properties of a measure of pupils' liking for school and to examine associations between this measure, pupils' experiences in lessons, their self-concepts and the amount of setting implemented in school. SAMPLE: A stratified sample of 45 mixed secondary comprehensive schools was selected for the research. Schools represented a variety of ability-grouping practices in the lower school (Years 7-9), from completely mixed-ability to setting in all academic subjects. All Year 9 pupils were included in the sample. METHODS: Pupils completed a questionnaire containing items on their self-concept, liking for school, and their perceptions of teaching in English, mathematics, and science. Data on pupils' gender, ethnic origin, social disadvantage and attainment was also collected. RESULTS AND CONCLUSIONS: The properties and correlates of scales indicating pupils' liking for school and their perceptions of teaching in English, mathematics, and science are established. Liking for school is greater among girls, pupils with higher academic self-concepts, and those with more positive perceptions of teaching. Pupils are more positive about teaching they experience in English than in mathematics or science. When other variables are statistically controlled, there is no significant effect of the extent of ability grouping in the school as a whole. Affective aspects of learning should not be neglected in the drive to raise standards.

Achievement↗
PubMed2005

Attitudes of school environment towards integration of HIV-positive pupils into regular classes and knowledge about HIV/AIDS: cross-sectional study.

AIM: To estimate the attitudes of teachers, parents, and pupils in primary schools towards the integration of HIV-positive pupils into regular schools, and their knowledge about HIV/AIDS. METHODS: Teachers (n=64), seventh and eight grade pupils (n=108), and their parents (n=124) from a big city and a small town in Croatia were examined by two specially designed instruments which measured their attitudes towards the integration of pupils with HIV/AIDS and knowledge about HIV/AIDS. RESULTS: All three populations showed positive attitudes towards the integration of children with HIV/AIDS into regular schools. A group of parents had lower attitude score (mean-/+standard deviation, 3.1-/+0.6) compared with teachers or pupils (3.5-/+0.4 and 3.4-/+0.4 respectively, P<0.001, ANOVA, and post hoc Tukey test). Knowledge about HIV/AIDS was high in all three groups. Pupils scored lower (8.2-/+4.1 out of maximum 15) than their teachers or parents (11.2-/+3.8 and 10.3-/+3.5 respectively, P<0.001). In all three subsamples, groups with higher level of education had more positive attitudes towards the integration of children with HIV/AIDS into regular schools as well as higher knowledge scores. No significant correlation was found between participants' attitudes and knowledge. CONCLUSION: School environment - teachers, pupils, parents - had generally positive attitudes towards the integration of HIV positive pupils and high level of knowledge about HIV/AIDS. Generally, parents showed less favorable attitudes than teachers and pupils and this may be a possible obstacle to the integration of HIV positive students into regular schools. There is obviously a need for a coordinated public intervention aimed at informing the public about HIV/AIDS.

Adolescent↗
PubMed1995

The incidence of atonic pupil following cataract surgery.

OBJECTIVE: To determine and compare the incidence of atonic pupil following modern extracapsular cataract extraction and small-incision phacoemulsification with lens implantation in a large series of consecutive patients. PATIENTS AND DESIGN: A retrospective review was undertaken of 1283 consecutive cases of cataract surgery with posterior chamber intraocular lens implantation (919 extracapsular and 364 small-incision phacoemulsification) performed by two surgeons between October 30, 1991, and June 30, 1993. Postoperative atonic pupil was defined as a pupil that, following cataract surgery, was 6 mm or more in diameter and minimally or nonreactive to light, accommodation, or 1% pilocarpine hydrochloride. RESULTS: Postoperatively, 25 (1.95%) of 1283 eyes developed an atonic pupil following cataract extraction with posterior chamber intraocular lens implantation (21 [2.29%] of 919 extracapsular and four [1.10%] of 364 phacoemulsification procedures). When an atonic pupil was present following surgery, disturbing glare often resulted, despite a well-centered intraocular lens. CONCLUSIONS: To our knowledge, this is the first large, consecutive study of the incidence of atonic pupil following modern cataract surgery and the first study to compare the incidence of atonic pupil following extracapsular surgery vs small-incision phacoemulsification. Although the incidence of atonic pupil may be lower following phacoemulsification, caution is advised in the implantation of ever-smaller optic lenses.

Adult↗
PubMed2003

Scotopic pupil size in a normal pediatric population using infrared pupillometry.

PURPOSE: To determine scotopic pupil diameter in a normal pediatric population. METHODS: Scotopic pupil size was measured in 166 eyes of 83 children with a mean age of 6.01+/-4.11 years (range 0.51-14.26 years) using the light and hand-held Colvard infrared pupillometer. Measurements were performed under dim illumination after 2 min of dark adaptation. The Colvard infrared pupillometer utilizes light amplification technology to determine scotopic pupil size. RESULT: The mean scotopic pupil diameter was 6.06+/-0.95 mm (range 4.0-8.5 mm) in the right eyes (OD) and 6.11+/-1.02 mm (range 4.0-8.5 mm) in the left eyes (OS), and 6.09+/-0.98 mm (range 4.0-8.5 mm) for both eyes (OU). An increase in mean scotopic pupil size with age was detected, with a peak of 7.28+/-0.42 mm at the age of 10-11 years. The correlation coefficient for age and scotopic pupil diameter was 0.51 OU (OD 0.52, OS 0.51), and the correlation coefficient for objective refraction (spherical equivalent) and scotopic pupil diameter was 0.05 OU (OD 0.01, OS 0.08). CONCLUSIONS: The scotopic pupil diameter in a pediatric population increases with age until the age of 11 years and then decreases again.

Adolescent↗
PubMed2005

Pupil size and Perimetry--a pharmacological model using increment and decrement stimuli.

BACKGROUND: To assess the influence of natural and pharmacologically induced pupil size fluctuations on differential luminance sensitivity threshold (DLS) using bright (increment) and dark (decrement) stimuli. METHODS: Twelve healthy volunteers (20-30 years) were examined under the effect of phenylephrine 2%, dapiprazole 0.5%, and placebo. Pupil size was recorded by infra-red video camera in sessions without and with visual field examination (Tübingen Computer Campimeter). DLS was estimated at 9 locations within the central 20 degrees visual field, using bright and dark 26 min-of-arc-stimuli (10 cd/m(2) background, 4-2-1 dB thresholding strategy, four reversals). RESULTS: There were substantial inter-individual differences in pupil size and pupil size fluctuations. Intra-individual differences were small. Independently of medication, pupil size fluctuations were reduced by more than one-third when a subject was undergoing perimetric examination. Pupil size affected DLS on its own (slope 0.21 dB/mm; 95% CI: 0.09-0.33 dB/mm), differently at different stimulus locations, and to a greater extent with increment than with decrement stimuli (slope difference 0.13 dB/mm; 95% CI: 0.00-0.26 dB/mm). CONCLUSIONS: Campimetric examinations have a stabilising effect on pupil size fluctuations. Pupil size affects DLS with bright stimuli more than with dark stimuli; in normal young subjects this effect is not relevant for clinical or normative studies.

Adrenergic alpha-Agonists↗
PubMed1995

The form of the human pupil.

The purpose of this study was to characterize the form of the pupil in normal human subjects. Using a modified slitlamp, photographs of pupils were taken in steady illumination and 10-20 sec after darkness. Transparencies were projected and digitized, and the pupil margin was represented as a circular Fourier series. Best-fit ellipses were also determined. The placement of the pupil relative to the limbus was determined in a number of subjects. Results from 23 subjects indicated that in both darkness and light, average pupil noncircularity was 0.0166. (A value of 0.0200 is easy to detect with the unaided eye from the photographs.) On average, the best-fit ellipse accounted for about half of the noncircularity (59.6% in darkness; 47.7% in light). Most of the contribution to shape was made by the first 4 or 5 harmonics. Shapes were usually stable within a session and could remain fairly stable for at least a year; however, shapes for different subjects were not very similar, especially in the light. (Average pairwise similarity: 0.106 in darkness; 0.034 in light; similarity can have values from -1 to 1.) For a given subject, shapes in light and dark were often fairly similar (average similarity 0.260), but there were systematic differences: in eyes where the ellipse contributed > 20% of noncircularity, ellipse major axes clustered around vertical in darkness, and horizontal in light, implying greater contraction near the vertical meridian. Even pupils with little elliptical contribution turned out to contract more near the vertical meridian. There was some tendency for left and right eyes of an individual to show mirror symmetry of shape. In the dark, pupils were located 0.27 +/- 0.09 mm nasal and 0.20 +/- 0.15 mm superior to the limbus center, and usually moved slightly further nasal or superior in the light. Noncircularity increased with age (0.0015/decade). It was concluded that pupils show individuality of shape, with significant regularities within and across subjects.

Adult↗
PubMed1995

Oval pupil in patients with diabetes mellitus: examination by measurement of the dark-adapted pupillary area and pupillary light reflex.

Determination of the dark-adapted pupillary area (DAPA) by infrared photography revealed that some diabetic patients show corectopia (oval pupil) in addition to the small DAPA as pupillary abnormalities. The prevalence and clinical details of oval pupil were compared between diabetic patients and healthy subjects. Pupillary light reflexes were also analyzed with an infrared videopupillography in some of the diabetic patients. The healthy subjects were examined for the influence of age on the ratio of the pupillary diameter of the major and minor axes. The ratio was 1.04 +/- 0.02 (mean +/- S.D.) in the healthy subjects, and cases in which the ratio was +2 S.D. or higher than the mean ratio were defined as oval pupil. Oval pupil was observed in 21 (24%) of 86 diabetic patients, and was correlated with heart rate variation (P < 0.05) and DAPA (P < 0.01), which represent an autonomic dysfunction. Quantitative analysis of pupillary light reflexes with an infrared videopupillography revealed that the dark-adapted pupillary area before photic stimulation (P < 0.01) and the maximum %-velocity of constriction (P < 0.05) were significantly less in the oval pupil group than in the round pupil group. Cranial magnetic resonance imaging revealed no abnormalities in the oval pupil group. From these results, a peripheral autonomic disorder was implicated in the etiology of oval pupils in diabetic patients.

Adult↗
PubMed2004

Effect of brimonidine tartrate 0.2% ophthalmic solution on pupil size.

PURPOSE: To evaluate the effect of brimonidine tartrate 0.2% ophthalmic solution on pupil size under scotopic and photopic luminance conditions in persons considering laser refractive surgery. SETTING: Ophthalmic Health Center, Tel Aviv, Israel. METHODS: The pupil size was measured in 36 eyes of 36 participants under scotopic and photopic conditions using the Colvard pupillometer (Oasis Medical) before and after brimonidine tartrate drops were administered. The pupil size was subsequently measured after 30 minutes and 4 and 6 hours. RESULTS: No difference was found in pupil size before brimonidine tartrate instillation in eyes with light or dark irides. Before instillation, the mean photopic pupil size was 4.81 mm +/- 0.54 (SD) (range 4.0 to 6.0 mm). At 30 minutes, all pupils became miotic, with a mean size of 3.77 +/- 0.51 mm (range 3.0 to 5.0 mm) (P<.0001). After 6 hours, 27.8% of the pupils had returned to their previous size. Before brimonidine tartrate administration, the mean scotopic pupil size was 6.22 +/- 0.73 mm (range 5.0 to 8.0 mm). There was significant miosis to 4.57 +/- 0.84 mm (range 3.0 to 6.5 mm) (P<.0001) that continued for at least 6 hours. The miotic effect of brimonidine tartrate was stronger in eyes with light irides. CONCLUSIONS: Brimonidine tartrate caused significant miosis, especially under scotopic conditions, most likely from its alpha-2 adrenergic effect. Under photopic luminance conditions, the miotic effect was pronounced.

Adrenergic alpha-Agonists↗
PubMed2006

Intraindividual comparison of higher-order aberrations after implantation of aspherical and spherical intraocular lenses as a function of pupil diameter.

PURPOSE: To compare intraindividual higher-order wavefront aberrations after implantation of aspherical and spherical intraocular lenses (IOLs) as function of pupil diameter. SETTING: Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. METHODS: In this prospective study, wavefront measurements of 21 patients after implantation of a spherical IOL (AMO AR40e) in 1 eye and an aspherical IOL (AMO Tecnis) in the contralateral eye were analyzed. Third-, 4th-, 5th-, total higher-order aberration (HOA) root-mean-square (RMS), and primary spherical aberration (Z(4)(0)) were compared at different virtual pupil diameters of 3 to 6 mm. RESULTS: For both IOLs and each higher order analyzed, values increased with increasing pupil diameter. Fourth-order RMS and Z(4)(0) in the aspherical IOL group were significantly lower than with the spherical IOL at all analyzed pupil diameters. The total HOA RMS of the aspherical IOL was significantly lower than the spherical IOL only at 6 mm pupil diameter. For 3rd- and 5th-order RMS, no significant difference was found between the tested IOLs at any pupil diameter. CONCLUSION: In comparison to a spherical IOL, the aspherical Tecnis IOL reduced Z(4)(0) and 4th-order RMS significantly for pupil diameters of 3 to 6 mm, whereas total HOA RMS was only significantly reduced for a pupil diameter of 6 mm.

Aged↗