Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “PESTICIDES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 109 records · Page 6Linked to original sources
PubMed2002

Reproductive outcomes in the women of the Red River Valley of the north. I. The spouses of pesticide applicators: pregnancy loss, age at menarche, and exposures to pesticides.

In the current study, there was a modest but significant increase in risk (1.6- to 2-fold) for miscarriages and/or fetal loss occurring throughout the year in the spouses of applicators who use fungicides. There is a surprisingly significant deficit in the number of male children born to the spouses of fungicide applicators. First-trimester miscarriages occur most frequently in the spring, during the time when herbicides are applied. Use of sulfonylurea (odds ratio OR = 2.1), imidizolinone (OR = 2.6) containing herbicides, and the herbicide combination Cheyenne (OR = 2.9) by male applicators was statistically associated with increased miscarriage risk in the spring. Limited survey data from women who are the spouses of applicators did not show major alterations of long-term endocrinologic status (menarche, menopause, endometriosis). With regard to personal pesticide exposures, only women who engaged in pesticide application where there is direct exposure to these products are at demonstrable risk (OR = 1.8) for miscarriage. It was hypothesized that the overall reproductive toxicity observed in this population is, for the greater part, a male-mediated event. Clarification of exposure events leading to reproductive toxicity through direct measurements of exposure in both men and women is needed to resolve this issue.

Abortion, Spontaneous↗
PubMed1993

Pesticide exposure assessment: a crop exposure matrix. The Working Group on Pesticide Exposure Assessment.

A crop exposure matrix (CEM) was developed in the context of two Italian case-control studies. The CEM relates agricultural practices to pesticide exposures taking into account change over time and the use of chemicals by geographical area for farming. The matrix is specific to 14 areas and to 10 major crops. The exposure axis is made up of 440 chemicals used in the last 40 years in the areas of interest. In the matrix the association between crop growing and pesticides is expressed in terms of presence or absence of exposure. Accuracy of the matrix was initially evaluated using 26 occupational histories collected within the two case-control studies. Sensitivity and specificity of CEM for some compounds were estimated versus assessment of exposure by experts. Sensitivity ranges from 83.3% to 100%, specificity from 66.2% to 95.8% depending on the chemicals.

Agriculture↗
PubMedDate not supplied

Chlorinated pesticide residues in testicular tissue samples. Pesticides in human testicles.

Residues of chlorinated pesticides--HCB, alpha-, beta-, gamma-, delta-, epsilon-HCH isomers, heptachlor epoxide, DDE and DDT isomers in bilateral testicular biopsy material were determined in gas liquid chromatography with electron capture detector (GLC-ECD). The average levels of chlorinated pesticides residues occurring in 36 men are presented. Alpha-, delta-HCH and p,p'-DDE were observed in nearly all analyzed samples. Other analyzed compounds were observed in lower percentages, whereas o,p'-DDT and p,p'-DDT were not detected.

Chromatography, Gas↗
PubMedDate not supplied

Association of pesticide safety beliefs and intentions with behaviors among farm pesticide applicators.

Telephone interviews were conducted on a random sample of 164 dairy farmers knowledge and beliefs about pesticide hazards, intentions to use precautions, perceptions of pesticide safety peer norms, perceived self-efficacy to prevent personal exposure, and use of protective equipment. Self-efficacy and risk perception appear less relevant to safety behavior than other variables. Future research should focus prospectively and on national samples.

Adult↗
PubMed1991

Chronic central nervous system effects of acute organophosphate pesticide intoxication. The Pesticide Health Effects Study Group.

Acute organophosphate pesticide poisonings cause substantial morbidity and mortality world wide; however, whether organophosphates cause chronic neurological sequelae has not been established. To see whether single episodes of acute unintentional organophosphate intoxication lead to chronic neuropsychological dysfunction, we carried out a retrospective study of agricultural workers in Nicaragua who had been admitted to hospital between July 1, 1986, and July 31, 1988, for occupationally related organophosphate intoxication. This "poisoned" group (36 men) was tested on average about two years after the episode of pesticide poisoning and compared with a matched control group. The poisoned group did much worse than the control group on all neuropsychological subtests, with significantly worse performance on five of six subtests of a World Health Organisation neuropsychological test battery and on 3 of 6 additional tests that assessed verbal and visual attention, visual memory, visuomotor speed, sequencing and problem solving, and motor steadiness and dexterity. Differences in neuropsychological performance could not be explained by other factors. The findings of a persistent decrease in neuropsychological performance among individuals with previous intoxication emphasise the importance of prevention of even single episodes of organophosphate poisoning.

Acute Disease↗
PubMed2006

Gastric lavage in acute organophosphorus pesticide poisoning (GLAOP)--a randomised controlled trial of multiple vs. single gastric lavage in unselected acute organophosphorus pesticide poisoning.

BACKGROUND: Organophosphorus (OP) pesticide poisoning is the most common form of pesticide poisoning in many Asian countries. Guidelines in western countries for management of poisoning indicate that gastric lavage should be performed only if two criteria are met: within one hour of poison ingestion and substantial ingested amount. But the evidence on which these guidelines are based is from medicine overdoses in developed countries and may be irrelevant to OP poisoning in Asia. Chinese clinical experience suggests that OP remains in the stomach for several hours or even days after ingestion. Thus, there may be reasons for doing single or multiple gastric lavages for OP poisoning. There have been no randomised controlled trials (RCTs) to assess this practice of multiple lavages. Since it is currently standard therapy in China, we cannot perform a RCT of no lavage vs. a single lavage vs. multiple lavages. We will compare a single gastric lavage with three gastric lavages as the first stage to assess the role of gastric lavage in OP poisoning. METHODS/DESIGN: We have designed an RCT assessing the effectiveness of multiple gastric lavages in adult OP self-poisoning patients admitted to three Chinese hospitals within 12 hrs of ingestion. Patients will be randomised to standard treatment plus either a single gastric lavage on admission or three gastric lavages at four hour intervals. The primary outcome is in-hospital mortality. Analysis will be on an intention-to-treat basis. On the basis of the historical incidence of OP at the study sites, we expect to enroll 908 patients over three years. This projected sample size provides sufficient power to evaluate the death rate; and a variety of other exposure and outcome variables, including particular OPs and ingestion time. Changes of OP level will be analyzed in order to provide some toxic kinetic data. DISCUSSION: the GLAOP study is a novel, prospective cohort study that will explore to the toxic kinetics of OP and effects of gastric lavage on it. Given the poor information about the impact of gastric lavage on clinical outcomes for OP patients, this study can provide important information to inform clinical practice.

Journal Article↗
PubMed2001

Electrically driven microseparation methods for pesticides and metabolites: V. Micellar electrokinetic capillary chromatography of aniline pesticidic metabolites derivatized with fluorescein isothiocyanate and their detection in real water at low levels by laser-induced fluorescence.

Anilines are important pollutants occurring in the environment as industrial discharges as well as the transformation products (i.e., metabolites) of a wide variety of commonly used pesticides. In this report, we describe the precolumn derivatization of anilines with fluorescein isothiocyanate (FITC) and their subsequent separation and detection by capillary electrophoresis-laser induced fluorescence (CE-LIF) detection. The FITC-aniline derivatives were readily detected at the 10(-10) M level. This limit of detection (LOD) was achieved in the presence of glycosidic surfactants complexed with borate at alkaline pH yielding the so-called in situ charged micelles. The glycosidic surfactants evaluated were n-octyl- and n-nonylglucopyranoside. Furthermore, and under optimum conditions, the FITC precolumn derivatization of the anilines was performed in real water (e.g., tap and lake water) spiked with anilines at the LOD level. The water matrices showed marginal effects on the extent of derivatization at the LOD level, and the possible interferents in the water samples did not affect the FITC-solute signal due to the selectivity of the derivatization and detection schemes. Besides filtration from microparticles, the real water samples did not necessitate extensive sample cleanup prior to derivatization.

Aniline Compounds↗
PubMed1978

Residues of pesticides and PCBs in estuarine fish,1972-76--National Pesticide Monitoring Program.

This report summarizes 1524 analyses of juvenile fish collected semiannually in 144 estuaries nationwide from July 1972 through June 1976. Pooled samples of 25 whole fish were screened for 20 common pesticides and polychlorinated biphenyls (PCBs). The three most common residues, DDT, PCBs, and dieldrin, were found in 39, 22, and 5 percent of the samples, respectively. Data indicate that estuarine pollution levels continue to decline.

Animals↗
PubMed1979

Determination of chlorinated pesticide residues in foods. II. Simultaneous analysis of chlorinated pesticide and phthalate ester residues by using AgNO3-coated Florisil column chromatography for cleanup of various samples.

A simplified method suitable for simultaneous analysis of chlorinated pesticide and phthalate ester residues in various foods was developed. Chemical residues were quantitatively extracted from fatty and vegetable samples with acetonitrile as follows: Chemical standard in 0.5 mL ethanol solution was added to 10 g homogenized sample. After 3 hr, pork and beef were extracted 3 times with 20 mL portions of acetonitrile. The acetonitrile layers were diluted with water and extracted with n-hexane. Rice samples were combined with 10 mL water, 5 mL acetonitrile and 1 mL ethanol and extracted 3 times with 20 mL portions of n-hexane. The n-hexane concentrate from each sample was submitted to AgNO3-coated Florisil column chromatography. The AgNO3 coating adequately adsorbed interfering coextractives. Extracts of fish and vegetable samples were separated into 2 fractions by the above column chromatography. Supplemental cleanup procedures were also developed to accurately determine phthalate esters eluted in the second fraction. Satisfactory gas chromatograms were obtained for most samples.

Animals↗
PubMedDate not supplied

Accumulated pesticide and industrial chemical findings from a ten-year study of ready-to-eat foods. KAN-DO Office and Pesticides Team.

This report lists the pesticide and industrial chemicals found in the ready-to-eat foods tested repetitively for 10 years through the U.S. Food and Drug Administration's Revised Market Basket Study. The study operated from 1982 to 1991. During that time 37 market baskets, each containing 234 food items that represented about 5000 food types in American diets covering all age groups, including infants and children, were collected. Each food item was individually prepared for eating; that is, it was opened, unwrapped, washed, peeled, sliced, formulated by recipe, or cooked. Each item was then composited and analytically screened for about 300 different chemicals, including chlorphenoxy acids, ethylenethiourea, methyl carbamates, organochlorines, organophosphates, organosulfurs, phenylureas, and pyrethroids. Overall, less than 1% of the potential of 2.5 million findings occurred for the 10-year study period. In total, 138 different chemical residues accounted for 17 050 accumulated findings. Most findings were less than 1 microgram/g, which is considered a low-level finding. Each food item averaged about 2 low-level findings per analysis.

Chromatography, Gas↗
PubMed1995

Pesticide effects on eel metabolism pesticide; levels did not decline at any time when animals were exposed to 4.1 mg/liter.

Previous works on endosulfan eel toxicology in this laboratory demonstrated that 0.041 mg/liter of endosulfan was the 50% lethal concentration of 96 hr exposure. Eels of species Anguilla anguilla were exposed to two sublethal endosulfan concentrations: 8.2 micrograms/liter (1/5 LC50) and 4.1 micrograms/liter (1/10 LC50), and the experiment was done at different exposure times: 12, 24, 48, 72, and 96 hr. Muscle glycogen content decreased significantly (p < 0.05) at 24, 48, 72, and 96 hr exposure to 8.2 micrograms/liter. Muscle lactate levels in fish did not change significantly while lactate levels in eel blood increased at 12, 24, 48, 72, and 96 hr exposure to 8.2 micrograms/liter. Mean blood glucose values were elevated after exposure to both endosulfan concentrations. The results are discussed in relation to the stress effect produced by the pesticide and the related responses of the fish.

Analysis of Variance↗
PubMed1975

Confirmation of pesticide residue identity: part IX. Organophosphorus pesticides.

This paper describes a confirmation procedure for residue levels of dyfonate, dichlorofenthion and cyanox. After extraction and quantitation by flame photometric detector (FPD)-gas liquid chromatography (GLC), the organophosphorus pesticides are hydrolyzed in a 10% methanolic-potassium hydroxide solution. The phenolic hydrolysis products are then extracted from this solution and reacted with pentafluorobenzyl bromide to produce the pentafluorobenzyl (PFB) ether derivatives. These PFB ethers are subsequently cleaned-up and fractionated on a silica gel micro-column and analyzed by electron capture (EC)- GLC.

Chromatography, Gas↗
PubMed1988

Studies on contamination of vegetable drugs with halogen derivative pesticides. Part 2: Concentrations of halogen derivative pesticides in vegetable blends and herbal granulated products produced in Poland in 1980-1984.

Changes in concentration levels of halogen derivative pesticides (p,p'-DDT and its metabolites p,p'-DD and p,p'-DDE, as well as HCH, DMDT, aldrin, dieldrin) in vegetable blends and granulated products produced in Poland were studied in the period 1980-1984. By means of GLC and TLC methods it has been found, that as in the case of raw materials, contamination levels of these materials increased from 1980 up to the maximum values for vegetable blends in 1982 and in granulated products in 1983. Generally, concentration levels in vegetable blends and in raw material were similar over the same periods of time, whereas concentrations in granulated products were considerable lower.

Chromatography, Gas↗