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Results for “OSTEOSCLEROSIS”

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At least 109 records · Page 6Linked to original sources
PubMed2006

A case of hepatitis C-associated osteosclerosis in an elderly Japanese man.

Hepatitis C-Associated Osteosclerosis (HCAO) is characterized by a marked increase in bone mass with deep bone pain. Since 1992, eleven cases of HCAO have been reported. This report describes an elderly Japanese man with HCAO, whose clinical course we followed for 3 years. A 68-year-old man developed pain in both pretibial regions in June 2000, and he had frequent episodic loss of muscular strength in his hands. He had recieved blood transfusion for a bleeding ulcer 43 years before and was seropositive for hepatitis C virus. His serum alkaline phosphatase (ALP) level was markedly increased, while his serum calcium was slightly decreased and serum phosphate was normal. Skeletal radiographs of the lower extremities showed a progressive increase in skeletal density, but did not show any apparent deformity. Administration of nonsteroidal anti-inflammatory drugs led to a reduction in bone pain. Treatment with vitamin D3 and calcium decreased the number of episodes of sudden muscular weakness and maintained serum calcium within the normal range. Three years after the onset of the disease, bone mineral density of his lumbar vertebrae and left hip rose from 0.963 g/cm2 to 1.096 g/cm2, and from 0.938 g/cm2 to 1.383 g/cm2, respectively. His serum ALP level decreased from 2889 to 277 IU/L (normal range: 104-338) and serum calcium normalized. These findings were accompanied by a decrease in bone pain. This case and previous reports suggest that the skeletal tissue of this disease appears to be of good quality.

Aged↗
PubMed1975

Pyruvate kinase deficiency anemia with terminal myelofibrosis and osteosclerosis in a beagle.

A 15-month-old male Beagle with chronic hemolytic anemia was found to have erythrocytic pyruvate kinase deficiency and, terminally, myelofibrosis and osteosclerosis. The dog's erythron was studied by procedures that enabled close comparison with congenital hemolytic anemia (pyruvate kinase deficiency) of Basenji dogs. The affected dog's sire, dam, and one littermate--each clinically and hematologically normal--were found to have 50% reduction in erythrocytic pyruvate kinase (PK) activity.

Ancylostomiasis↗
PubMedDate not supplied

[Total hypertrophy of 1 lower limb associated with/banded osteosclerosis, vascular flat nevus and acrocyanosis].

Forty years have gone by since the first case of total hypertrophy of the lower limb, associated with plane vascular naevus and partial "banded" osteosclerosis, was published, in 1935 by Al Rădulescu. No similar case was found in this time. The authors present now two cases of Rădulescu syndrome, identical with the first case, demonstrated with clinical, radiological and morphopathologic elements. A detailed differential diagnosis is made, which confirms the Rădulescu syndrome, a separate, well-defined morbid entity.

Adult↗
PubMed1989

Hexachlorobenzene-induced hyperparathyroidism and osteosclerosis in rats.

Hexachlorobenzene (HCB) exposure has been shown to alter the normal concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D3 in rats and to result in osteoporosis in humans. Experiments were undertaken to investigate the effects of HCB on the homeostatic mechanism of calcium metabolism and to determine its effect on bone in rats. Fischer 344 rats were dosed 5 days/week for 5, 10, or 15 weeks with 0, 0.1, 10.0, or 25.0 mg HCB/kg body wt. Body weight was not affected by any of the exposure conditions. Liver weight was significantly elevated above control values at the two higher dose levels at all three time periods. Kidney weight and kidney-to-body weight ratio were significantly elevated at the highest dose level after 10 weeks and at the two higher dose levels after 15 weeks of exposure. Serum alkaline phosphatase was significantly decreased at the two higher dose levels after both 10 and 15 weeks of exposure. 1,25-Dihydroxyvitamin D3 was measured in the 5-week exposure group only and was significantly elevated in the three higher dose levels. After 5 and 15 weeks of HCB exposure, parathyroid hormone concentration was significantly elevated at the two higher dose levels at both time periods. Wet femur density was significantly increased at the two higher dose levels of HCB after 10 weeks of exposure and the three higher dose levels after 15 weeks of exposure. Dry femur density was also increased in the cases where wet femur density was increased. However, femur weight was not affected at any dose level. The results from this study indicate that HCB induces hyperparathyroidism in rats, as demonstrated by increased serum parathyroid hormone levels and osteosclerosis of the femur.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1977

[Osteosclerosis in the phalanges in sarcoidosis (author's transl)].

Osteosclerosis in the phalanges is a frequent finding in sarcoidosis and its incidence appears higher then that of the osteolytic lesions. Of 19 patients with histological diagnosis of sarcoidosis areas of bone sclerosis in the phalanges were found in 6 cases (31, 5 percent).

Female↗
PubMed1980

[Osteosclerosis associated with systemic mastocytosis].

Case report of a 60-year-old man who had suffered from urticaria pigmentosa for the last 18 years of his life. The main autopsy finding was systemic mastocytosis of the bone marrow accompanied by severe osteosclerosis of the axial skeleton. Histologic examination revealed a characteristic pattern of the bone marrow; it contained foci of mast cells surrounded by a dense network of reticulin fibers, inducing a pathologic structure of spongy bone. A review of the literature confirms the high incidence of osteosclerotic alterations in patients with mastocytosis. These may be considered a sign of bone marrow involvement in urticaria pigmentosa.

Autopsy↗
PubMed1997

Changes in osteosclerosis of the osteoarthritic knee after high tibial osteotomy.

Radiographically demonstrated osteosclerosis was quantitatively evaluated in knees with medial compartmental osteoarthritis by dual xray absorptiometry. Bone density was measured in various areas of 144 knees with medial compartmental osteoarthritis, 23 knees of which were treated with high tibial osteotomy. The bone mineral density of the medial femoral and tibial condyles was greater than that of the lateral femoral and tibial condyles in all knees with medial compartmental osteoarthritis. The ratios of bone mineral density of the medial condyles to that of the lateral condyles were found to increase significantly with the progression of osteoarthritis. There was a significant positive regression line correlation between those ratios and the increase of varus deformity as expressed by the standing femorotibial angle. The former were calculated to be 1.0 when the latter was nearly 170 degrees (10 degrees anatomic valgus angulation). The ratio of bone mineral density of the medial femoral condyles to the lateral femoral condyles decreased sharply in all 23 knees within 1 year after high tibial osteotomy.

Absorptiometry, Photon↗