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Validation of the Luria-Nebraska Intellectual Processes Scale as a measure of intelligence in male alcoholics.

This study investigated the Luria-Nebraska Intellectual Processes Scale (IPS) as a predictor of Wechsler Adult Intelligence Scale (WAIS) IQs among alcoholic inpatients. Strong correlations were found between the IPS and WAIS Verbal IQ and Full Scale IQ; however, the correlation with Performance IQ was only -.41. IQ estimates based on Prifitera and Ryan's (1981) regression equations derived on psychiatric inpatients differed significantly from obtained IQs in the current alcoholic sample. The importance of adequately assessing Performance IQ among patients with alcohol-related problems is discussed.

Adult↗

Mutation analysis and haplotype correlation for 139 cystic fibrosis patients from the Nebraska Regional Cystic Fibrosis Center.

Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasian populations with an approximate frequency of one in 2,500 live births and a carrier frequency of one in 25. We studied 400 individuals seen at The Nebraska Regional Cystic Fibrosis Center that included 139 CF patients, 206 parents, and 55 unaffected siblings to determine the frequency of the delta F508, R117H, G542X, S549R/N, G551D, R553X, R560T, and W1282X mutations. In addition, we determined haplotypes on each of these individual's chromosomes using four markers that included XV-2c, KM-19, pMP6d.9, and G2. Results from this study showed that the delta F508 mutation was present in 70% of CF chromosomes. Of the 139 CF patients 74 (53%) were homozygous for the delta F508 deletion, 47 (34%) were heterozygous for the delta F508 deletion and an unknown mutation, and 18 (13%) carried two unknown mutations. Four additional mutations were also found in our population and included G542X (6%), G551D (5%), R553X (4%), and R560T (1%). One patient was documented to be a compound heterozygote for G542X/G551D. A polymorphism, F508C, that has previously been reported in several families was also present in our study. The most common haplotype associated with the delta F508 deletion in our CF patients was the E haplotype (CF Consortium B) while other mutations were associated with a variety of haplotypes.

Base Sequence↗

Implementation of the Patient Self-Determination Act: a survey of Nebraska hospitals.

The purpose of this survey of Nebraska hospitals (N = 79) was to describe the planning, implementation, and evaluation of the Patient Self-Determination Act (PSDA) and to explore the role of the nurse in these processes. Results indicate nurses were very involved in the planning phase but rarely in the implementing phase. Few evaluation strategies were utilized and only some respondents identified problematic issues related to the implementation of the PSDA. Clinical implications for issues related to the PSDA are discussed and framed within the American Nurses' Association Position Statement on the PSDA (1991). Future studies are suggested, especially related to evaluation of PSDA implementation.

American Nurses' Association↗

Systems planning for the 80s: the Nebraska Mental Health Desired Service System model.

In an effort to address the complex realities of mental health service delivery in the 1980s, a systems model for planning and policy making has been developed. The model, called "the Nebraska Mental Health Desired Service System," can serve as a template for future service delivery system design. The development of the model and issues attendant to it are presented. Application of the model to planning, fiscal management, system management, politics, human resources development, and services coordination is presented.

Health Planning Organizations↗

Training Ph.D. psychologists for rural service: a report from Nebraska.

The Clinical Psychology Training Program at the University of Nebraska-Lincoln developed a rural mental health specialty to train psychologists to work in rural settings. Preliminary data indicate that the project was relatively successful in placing graduates in rural practice. But the needs for practitioners in rural communities clearly are greater than training programs can meet. Relying on doctoral psychologists for clinical work in rural communities may not be the best strategy in workforce planning.

Community Mental Health Services↗

Dietary factors and non-Hodgkin's lymphoma in Nebraska (United States).

Little is known about dietary factors and non-Hodgkin's lymphoma (NHL) risk, although high intakes of animal protein and milk have been associated with NHL in two previous studies. As part of a population-based case-control study of agricultural and other risk factors for NHL in eastern Nebraska (USA), we examined the self- and proxy-reported frequency of consumption of 30 food items by 385 White men and women with NHL and 1,432 controls. Animal protein intake was not associated significantly with the risk of NHL, however, there was a nonsignificantly elevated risk of NHL among men with high milk consumption. Vitamin C, carotene, citrus fruit, and dark green vegetable intakes were inversely significantly related to the risk of NHL for men, but not for women. Among men, the odds ratios for the highest quartiles of both vitamin C and carotene intake were 0.6 (95% confidence intervals = 0.3-1.0). There were no meaningful differences in the associations of nutrient intakes and NHL risk between B- and T-cell lymphomas and histologic types. Risks for low intakes of vitamin C and carotene were greater among men and women with a family history of cancer, particularly a history of lymphatic or hematopoietic cancer among first-degree relatives.

Adult↗

The Nebraska Medicaid managed behavioral health care initiative: impacts on utilization, expenditures, and quality of care for mental health.

This study evaluates the impact of Nebraska's Medicaid managed care program for behavioral health services on mental health service utilization, expenditures, and quality of care. Implementation of the program is correlated with progressive reductions in both total (about 13% over 3 years) and per eligible per month (20%) expenditures and a rapid, extensive decline in inpatient utilization and admissions. The percentage of enrollees receiving any type of treatment for a mental disorder actually increased modestly. Most important, several indicators of quality of care (e.g., timely receipt of ambulatory care following discharge from inpatient care and readmission to inpatient care shortly following discharge) suggest that quality of care did not materially change under the carve-out. Although a thorough assessment of quality of care impacts is warranted, this study suggests implementation of a managed care program may allow states to reduce Medicaid expenditures without compromising quality of care.

Data Collection↗

A New York isolate of Soil-borne wheat mosaic virus differs considerably from the Nebraska type strain in the nucleotide sequences of various coding regions but not in the deduced amino acid sequences.

A wheat-infecting furovirus found in Tompkins County, New York, U.S.A. was identified as a strain of Soil-borne wheat mosaic virus (SBWMV) by means of sequence analyses of portions of its RNA 1 and 2. The nucleotide sequences of several of its genes differed by c. 9 to 12% from those of the corresponding genome regions of the Nebraska type strain of SBWMV. The deduced amino acid sequences of the putative translation products, however, suggested much closer relationships. Thus, the amino acid sequences of the coat proteins of the two virus strains were 100% identical despite the fact that their coding regions differed in as many as 68 nucleotide positions. The New York (NY) strain of SBWMV is possibly closely related to an isolate from Illinois for which so far only the nucleotide sequences of its coat protein gene and the 5' untranslated region of its RNA 2 are known.

Amino Acid Sequence↗

Hair dyes and risk of glioma among Nebraska women.

The etiology of brain cancer is not well understood. We conducted a population-based case-control study among 112 white women in Nebraska who were newly diagnosed with glioma between July 1988 and June 1993, and 215 controls, to identify risk factors for this disease. A 1.7-fold increased risk of glioma was observed for women who ever used hair coloring products (95% confidence interval (CI) = 1.0-2.9, 62 cases), and a 2.4-fold risk for those who used permanent hair coloring products (odds ratio (OR) = 2.4, 95% CI = 1.3-4.5, 39 cases). For women with the most aggressive form of glioma, glioblastoma multiforme, risk increased with duration of exposure to 4.9 (95% CI = 1.6-15.7, 10 cases) after 21 or more years of permanent hair coloring use. Higher risks were observed with earlier age at first use, but we did not see an exposure-response pattern with frequency of use of permanent dyes. No association was observed with use of non-permanent (sometimes called temporary or semi-permanent) hair coloring products. These suggestive findings need confirmation in future studies with larger sample sizes, fewer proxy respondents, and the ability to evaluate the effect of changes in formulations over time.

Adult↗

Left-handedness in male schizophrenic patients is associated with increased impairment on the Luria-Nebraska Neuropsychological Battery.

Several studies suggest increased mixed and left-handedness in schizophrenia. This is of interest as early cerebral injury can result in increased left-handedness and some investigations have suggested a role for early developmental insult (e.g., birth complications) in schizophrenia. We administered the Luria-Nebraska Neuropsychological Battery (LNNB) to 24 left-handed male schizophrenic patients and a separate group of 24 right-handed schizophrenic patients who were age and education matched to the left-handed patients. The test protocol also was administered to 15 left-handed non-psychiatric control subjects and 15 right-handed controls. Direct comparisons (t-test) of the left- to right-handed schizophrenics revealed that the left-handed patients showed significantly greater impairment on several LNNB measures sensitive to cognitive deficits in schizophrenia. There were no differences between left- and right-handed control subjects. A further 2 X 2 ANOVA pooling all subjects noted several significant interactions between handedness and diagnostic group. The findings suggest a unique interaction between left-handedness and neuropsychological impairment in schizophrenia and could support a relationship between left-handedness, early cerebral insult, and cognitive deficits.

Analysis of Variance↗

Comparison of cognitive performance in RDC-diagnosed schizoaffective and schizophrenic patients with the Luria-Nebraska Neuropsychological Battery.

Controversy continues regarding the differential diagnostic distinction between schizoaffective disorder and schizophrenia, and there are few published studies that examine the neuropsychological performance of schizoaffective patients. We evaluated 52 RDC-diagnosed schizophrenic and schizoaffective patients with equal numbers of medicated and unmedicated patients using the Luria-Nebraska Neuropsychological Battery and additional cognitive measures. Both groups performed at cognitively impaired levels. The cognitive performance level of schizoaffective patients was indistinguishable from that of the schizophrenic patients. The RDC subtype of schizoaffective disorder (depressed or manic) also was not related to cognitive performance level. Findings are consistent with the notion that cognitive impairment is found in a significant portion of schizophrenic (and possibly schizoaffective) patients and that the presence of this deficit may characterize a specific subgroup of patients.

Adult↗

Luria-Nebraska performance and symptomatology in unmedicated schizophrenic patients.

Recent attempts at subgrouping schizophrenia have emphasized negative symptoms (e.g., blunted affect, emotional withdrawal), and several works have suggested that patients with negative symptoms show greater cognitive deficits and structural brain abnormalities. However, many of these studies have relied on screening devices or single measures of neuropsychological performance. Accordingly, the present study used the Luria-Nebraska Neuropsychological Battery (LNNB) in assessing 38 unmedicated inpatients with a diagnosis of schizophrenia. The results found no relationship between LNNB performance and symptom ratings derived from clinical interviews using the Brief Psychiatric Rating Scale. The findings show that cognitive performance may be unrelated to symptomatology when a complex battery type test is used.

Adult↗

Interpretation and use of the Luria-Nebraska Battery.

In a recent article, T. V. Akhutina and L. S. Tsvetkova (1983, Brain and Cognition 2, 129-134) presented an analysis of the Luria-Nebraska Neuropsychological Battery. Along with their generally positive review, they raised questions regarding the importance of the qualitative aspects of patients' performance in the interpretation of the battery. We agree with the authors that any interpretation of the battery which does not consider qualitative performance can limit the power and applicability of the battery. The procedures of item analysis and qualitative analysis are discussed as essential to a comprehensive interpretation of the battery. Also discussed are comments on additional scaling for the battery and the development of a standardized qualitative scoring system.

Brain Damage, Chronic↗

Recovering staff and smoking in chemical dependency programs in rural Nebraska.

The problem of cigarette smoking among those who are recovering from alcohol dependence is becoming more apparent as chemical dependency units (CDUs) are beginning to restrict smoking for clients and staff and more actively encourage nicotine abstinence. To date, little is known about effective smoking cessation techniques for people with a history of alcohol problems. To obtain new data, a survey of personal experiences with smoking cessation and professional recommendations about nicotine dependence was administered to 124 recovering treatment professionals in CDUs in rural Nebraska. Among the 99 staff with a history of smoking, 81 (80%) had tried to quit smoking and 38 were former smokers at the time of the survey. Quitting "cold turkey" was the most popular smoking cessation method. Reliance on AA principles was second. The results suggest that recovering staff can successfully quit smoking by applying their professional practice guidelines for alcohol treatment to their personal problems with tobacco.

Adult↗

Hospital recruitment for the Smallpox Pre-Event Vaccination Program: experiences from Florida, Nebraska, New Jersey, and Tennessee, December 2002-June 2003.

The Smallpox Pre-Event Vaccination Program (SPVP) for public health and hospital-based health care workers began on January 24, 2003. This report summarizes efforts made by health officials in Florida, Nebraska, New Jersey, and Tennessee to facilitate the voluntary participation of acute care hospitals in the SPVP. Seven common characteristics contributed to the success of programs in these four states: (1) early planning, building on existing competencies, and state government support, (2) carrying the program forward on a planned timeline with experienced vaccination staff, (3) use of multifaceted training activities, (4) use of mock scenarios and field exercises to avoid early problems, (5) establishment and fostering of good relationships and lines of communication with stakeholders and the mass media, (6) addressing liability and workers' compensation concerns prior to initiation of the SPVP, and (7) attention to vaccination clinic logistics.

Bioterrorism↗

"Ready to quit chew? " Smokeless tobacco cessation in rural Nebraska.

A quit-chew media campaign was conducted in a 10-county region of south-central Nebraska. The campaign involved television and radio appearances, newspaper articles, and paid billboard advertisements. Smokeless tobacco users who called a toll-free helpline were provided quitting resources. Twelve months after the campaign ended, follow-up contact was completed with 104/205 (51%) of chewers who received the quit kits. A majority (70%) reported making some change, such as using less or switching brands, and 49% had made a quit attempt. The point prevalence quit rate was 11.5%.

Adult↗

Diet and risk of adult glioma in eastern Nebraska, United States.

OBJECTIVE: To investigate potential associations between diet and adult glioma. METHODS: We conducted a population-based case-control study of adult glioma in eastern Nebraska. Nutrient and food group intakes were estimated for 236 glioma cases and 449 controls using information obtained from a food-frequency questionnaire. RESULTS: After adjusting for potential confounders, inverse associations with risk of adult glioma were observed for intakes of dark yellow vegetables (highest quartile versus lowest: OR = 0.6, Ptrend = 0.03) and beans (OR = 0.4, Ptrend = 0.0003), but no associations were seen for dietary sources of preformed nitrosamines or high-nitrate vegetables. Our nutrient analysis revealed significant inverse associations between risk of adult glioma and dietary intake of pro-vitamin A carotenoids (highest quartile versus lowest: OR = 0.5, Ptrend = 0.005), a-carotene (OR = 0.5, Ptrend = 001), beta-carotene (OR = 0.5, Ptrend = 0.01), dietary fiber (OR=0.6, Ptrend = 0.048) and fiber from beans (OR = 0.5, Ptrend = 0.0002). We observed no significant associations with risk of adult glioma for intakes of other nutrients or compounds including nitrate, nitrite, vitamin C, vitamin E, saturated fat, cholesterol, dietary fiber from grain products, or fiber from fruit and vegetables. CONCLUSION: Our study does not support the N-nitroso compound hypothesis, but suggests potential roles for carotenoids and possibly other phytochemicals in reducing risk of adult glioma.

Adult↗

Children of Latino immigrants, 4-8 years, in rural Nebraska are adequate in vitamin B-6.

Plasma concentrations of B-6 vitamers and homocysteine as well as erythrocyte alanine aminotransferase activity coefficients and vitamin B-6 (dietary + supplement) intakes of apparently healthy young Latino children of immigrant parents living in rural Nebraska were determined and differences determined by gender. Thirty-five Latino children (16 males and 19 females), aged 4-8 years, were included in the study. Nutrient intake information was obtained from the children's parents utilizing two nonconsecutive 24-hour food recalls. No differences were observed by gender with regard to vitamin B-6 intakes, plasma concentrations of B-6 vitamers and homocysteine, and erythrocyte alanine aminotransferase activity coefficients. The intakes of all children met the Recommended Dietary Allowance for vitamin B-6. Plasma pyridoxal 5'-phosphate concentrations, plasma homocysteine concentrations, and erythrocyte alanine aminotransferase activity coefficients of the children were (mean +/- SD) 83.71 +/- 37.35 nmol/L, 6.81 +/- 1.63 micromol/L, and 1.08 +/- 0.06, respectively. All the Latino children of immigrant parents in this study had values indicative of adequate vitamin B-6 status.

Alanine Transaminase↗