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At least 109 records · Page 6Linked to original sources
PubMed1990

Spindle and epithelioid cell nevus (Spitz nevus). Natural history following biopsy.

A clinical follow-up study of 49 cases of spindle and epithelioid cell nevus is presented to address the question about the potential for local recurrence. Only 19 (39%) of the 49 lesions were initially excised en toto, and the remainder (30 cases) had positive margins; six of the latter spindle and epithelioid cell nevi were reexcised, and no evidence of a residual nevus was found in five of the six cases. There were no recurrences in the 49 patients during an average follow-up period of 5.0 years (range, 1 to 10 years). The rarity of recurrent spindle and epithelioid cell nevus would justify a conservative approach to management, with clinical follow-up alone recommended after a subtotal excision, when the pathologic diagnosis is unequivocal.

Adolescent↗
PubMed1987

Transepidermal elimination of nevus cells. A possible mechanism of nevus involution.

Nevus cell nests were seen histologically within the upper levels of the epidermis in biopsy specimens obtained from three patients with clinically banal-appearing nevi. Although the presence of melanocytes arranged as solitary units or grouped in nests in the upper layers of the epidermis is one histopathologic feature of malignant melanoma, we believe this finding represents transepidermal elimination of nevus cells and may be one mechanism of nevus involution.

Adolescent↗
PubMed1985

[The Spitz nevus. Spindle cell and/or epithelioid cell nevus--a histological analysis of 652 tumors].

652 Spitz' nevi have been histologically analysed and separated into epidermal and dermal changes. There are similarities between Spitz' nevus and melanocytic nevus. 44.9% of the examined Spitz' nevi consist of spindle cells only, 34% of spindle as well as epithelioid cells, and 21% of epithelioid cells only. We are going to discuss the difficulties in histological examination; more or less important signs are differentiated in detail. In some cases, Spitz' nevus will remain a somewhat dubious and disturbing tumor.

Adolescent↗
PubMed1997

Clinical review of 247 case records of Spitz nevus (epithelioid cell and/or spindle cell nevus).

BACKGROUND: Spitz nevus has clinically been described as a dome-shaped usually nonpigmented papular or nodular lesion variable in color from pink to red. OBJECTIVES: To give an exhaustive description of the clinical features of the Spitz nevus from a large series of 247 patients. METHODS: A retrospective analysis of the clinical features of 247 Spitz nevi excised from 1974 to 1993 has been performed. We evaluated the following features: age, sex, anatomical location, clinical and histopathologic features; descriptive statistics were calculated and relationships among the above variables were assessed. RESULTS: Most lesions were pigmented (71.7%), located on the lower extremities (43.3%), more frequent in the first decade (55.8%) and in females (57.9%). The nonpigmented type was more frequent in the head or neck region, whereas the pigmented types were more frequent on the lower extremities. Besides, these types showed different histopathologic features: the spindle cells usually predominated in the flat pigmented type, whereas dome-shaped types were usually composed of both spindle and epithelioid cells. CONCLUSIONS: In our patients, the pigmented Spitz nevi were more common than the nonpigmented ones; furthermore pigmented and nonpigmented Spitz nevi showed different anatomical locations and different histopathologic features.

Adolescent↗
PubMed1981

Nevus oligemicus. A variant of nevus anemicus.

A man had a long history of a persistent, fixed area of livid erythema on the trunk. The distribution of hair, sweat, and sensation were normal as were the histologic findings in the affected skin. The involved area had a decreased total skin blood flow and a lower surface temperature compared with surrounding uninvolved skin, but showed normal responses to vasoconstrictor and vasodilator stimuli. Incomplete sympathetic blockade partially abolished the erythema. We suggest that the appearance of the nevus is caused by increased vasoconstrictor tone in the thermoregulatory vessels of the involved skin, leading to relative stasis in the superficial "nutritional" vasculature. This would seem to be a new example of a "pharmacological nevus" showing similarities to and differences from nevus anemicus.

Hemangioma↗
PubMed1993

Acquired lateral telangiectatic nevus: port-wine stain or nevus flammeus.

Three adult patients (one man and two women) with acquired lateral telangiectatic nevus (acquired port-wine stain or acquired nevus flammeus) on the face are presented. One patient had no history of preceding trauma. However, in two others, chronic sun exposure probably caused actinic damage of the skin with telangiectasia. A review of the literature on acquired lateral telangiectatic nevus and its causative factors is presented.

Adult↗
PubMed1994

Plaque-type blue nevus on the face: a variant of Ota's nevus?

We describe a plaque-type blue nevus that had been present since birth on the right cheek of a 22-year-old man. It was characterized by several dark blue macules and papules with intervening areas of faint blue discoloration. Histologic examination showed a common blue nevus and a mongolian spot-like dermal melanocytosis in the dark blue and intervening faint blue pigmentary lesions, respectively.

Adult↗
PubMed1996

Comet assay demonstrates a higher ultraviolet B sensitivity to DNA damage in dysplastic nevus cells than in common melanocytic nevus cells and foreskin melanocytes.

We used the single cell gel electrophoresis assay (comet assay) to study ultraviolet B (UVB)-induced DNA damage in pigment cells. This assay detects DNA damage, mainly DNA strand breaks and alkali labile sites in the DNA molecule. We studied the effect of biologically relevant doses (comparable to 2-3 MED (minimal erythemal dose) for in vivo irradiated full-thickness skin) of monochromatic UVB light of 302 nm on cultured melanocytes derived from foreskin, common melanocytic nevi, and dysplastic nevi. We were able to demonstrate a linear dose-response relationship between UV dose and the migration coefficient of the comet tail in all three types of pigment cells. Nevus cells originating from dysplastic nevi showed the highest sensitivity to UVB irradiation: 65% higher induction of DNA damage compared to the induction in foreskin melanocytes. Common melanocytic nevus cells were most resistant and showed a 30% lower induction of DNA damage in comparison to foreskin melanocytes. Differences in chromatin structure and cell cycle profile may influence the results of the comet assay. Control experiments with x-ray irradiation, which is well known to produce direct DNA strand breaks via radical formation, revealed only small differences between the three types of melanocytic cells. It is unlikely, therefore, that intrinsic nuclear characteristics may account for the observed differences.

Cell Movement↗
PubMed1980

Desmoplastic nevus: a distinct histologic variant of mixed spindle cell and epithelioid cell nevus.

From a series of 75 cases of mixed spindle cell and epithelioid cell nevi, 14 were designated as desmoplastic nevi. Junctional activity, theque formation, and pigmentation were uncommon features. As a result, desmoplastic nevi may be confused with a variety of fibrohistiocytic lesions. Well defined intranuclear invaginations of cytoplasm occurred in 12 cases, and were helpful in differentiating desmoplastic nevi from these lesions. Desmoplastic malignant melanoma must also be considered in the microscopic differential diagnosis, but distinguishing features of desmoplastic melanoma include the presence of preexisting lentiginous melanoma, and necrosis of tumor cells and collagen. Desmoplastic nevus was compared to the ordinary variants of mixed spindle cell and eipthelioid cell nevus in an attempt to define etiologic factors responsible for a desmoplastic reaction. No satisfactory explanation could be found since the clinical variables examined were not statistically different.

Adolescent↗
PubMed1998

[Corymbiform nevus cell nevus].

There is a wide morphological variety in the appearance of melanocytic nevi. We report a case of a 77-year-old woman with a pedunculated, lobulated intradermal nevus on her trunk. For this grape-like clinical variant, we propose the term "corymbiform nevus".

Aged↗
PubMed1991

Multiple granular cell tumors associated with giant speckled lentiginous nevus and nevus flammeus in a child.

We describe an 11-year-old girl in whom multiple cutaneous granular cell tumors were associated with a giant speckled lentiginous nevus and an extensive nevus flammeus. An association between granular cell tumors and pigmented skin lesions has been reported twice previously and supports a neural origin for these tumors. An abnormality of neural crest development is proposed to explain the coexistence of three uncommon and unusually extensive cutaneous disorders in this patient. This case may represent a further variant of phakomatosis pigmentovascularis.

Child↗
PubMed2000

Melanocytic nevus with pregnancy-related changes in size accompanied by apoptosis of nevus cells: a case report.

Melanocytic nevi are commonly believed to undergo changes during pregnancy. This is probably related to hormonal influences; however, few studies have been able to prove it. We observed a case of a benign melanocytic nevus, which showed significant enlargement during pregnancy and immediate postpartum regression associated with increased apoptosis of nevus cells. Estrogen and progesterone receptors were not found in our case, although the clinical course still suggested a close association with hormonal influences.

Adult↗
PubMed1993

Proliferative activities in Spitz nevus compared with melanocytic nevus and malignant melanoma using expression of PCNA/cyclin and mitotic rate.

Proliferative activity in Spitz nevus (SN) was determined using proliferating cell nuclear antigen (PCNA) immunostaining and by assessing the mitotic rate. It was compared with that in compound melanocytic nevus (MN) and in malignant melanoma (MM). The PCNA index (number of positive cells/1,000 tumor cells) in SN was 72.8 +/- 45.5% (mean +/- SD), which was statistically significantly higher than that in MN (7.2 +/- 2.7%) and lower than that in MM (248.5 +/- 110%). The PCNA-positive cells in SN and MM were found both in dermal and junctional nests, while those in MN were found almost exclusively in the dermal nests. The mitotic rate in SN was 1.4 +/- 0.96%, while it was nothing in MN and 5.4 +/- 4.2% in MM. There was a statistically significant correlation between the PCNA index and the mitotic rate at r = 0.8946, p < 0.001. The PCNA index, however, appeared to show the proliferative activity of SN more clearly than did the mitotic rate.

Adolescent↗