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[Two primary malignant neoplasms and recurrent neoplasms in patients treated at the Regional Cancer Center in Lodź in 1976-1989].

In 1976-1989, 90, 128 patients with malignancies were recorded at the Regional Cancer Center in Lódź. Two different tumors have been diagnosed in 294 of these patients (0.31%), and the second pathologic growth corresponding to the secondary cancer criteria (occurrence within at least 6 months following radio- and/or chemotherapy) only in 148 of patients. Most frequently second tumors have been diagnosed in patients with: lip, skin, uterus and laryngeal cancers (2.8-0.8%). Relatively rare have been second tumors in patients with Hodgkin's disease and non-Hodgkin lymphomas (0.73%). The incidence of each type of the second tumors have been different than the types of neoplasma in all registered patients. Second tumors most frequently diagnosed in the same patient have been: skin cancer of different histological structure (two cases), breast cancer and tumors of the reproductive tract as well as laryngeal or lip cancer, and carcinoma of the lungs. A risk of the secondary malignancy in patients treated with radio- and chemotherapy in comparison with the risk of the second cancer in patients treated with chemotherapy only have been 2.71% and 1.36%, respectively.

Adult↗

[Laryngeal edema after radiotherapy--radiation reaction or a property of the neoplasm (recurrence, residual neoplasm)].

The authors discuss occurrence of post-radiation laryngeal oedema in the cases of patients with laryngeal cancer. The examination was carried out in 69 cases of patients on whom laryngectomy had been performed after failure of radiotherapy. In 65 out of these cases patients suffered from oedema of larynx with 57 cases classified as persistent or progressive post-radiation oedema (lasting for over three months inspite of application of pharmacological treatment), and 8 cases identified as fluctuating (receding after application of treatment and periodically reoccuring). Analysing the microscopic material of the specimens of the post-radiation oedema, the authors differentiated the stasis, inflammatory oedema and that causes by the presence of cancer infiltration. Basing on their own research data and the contemporary literature, the authors conclude, that the occurrence of persistent post-radiation oedema of the larynx lasting for the three months without reaction to the applied pharmacotherapy should be regarded as an important symptom signalling the presence or the recurrence of tumour after radiotherapy.

Biopsy↗

Urothelial neoplasms of the upper urinary tract. A correlation between cytologic and histologic findings in 43 patients with urothelial neoplasms of the renal pelvis or ureter.

The present study elucidates the possibilities to diagnose and classify urothelial tumors of the upper urinary tract by means of exfoliative cytology on voided urine using a membrane filter method. In a series of 30 patients with renal pelvic tumors and 13 patients with ureteral tumors an overall agreement between cytology and histopathology was obtained in 25 cases (58%). None of the Grade 1 tumors or of the non-invasive Grade 2 tumors were regarded as positive by cytology whilst two out of five invasive Grade 2 tumors had positive cytologic reports. The series included 24 patients with poorly differentiated or anaplastic tumors, 17 of whom had positive cytology (71%). By excluding from the series 13 patients with obstructed urinary passages or radiologically non-functioning kidneys on the tumor side an agreement between cytology and pathology was reached in 83 per cent of the cases, regardless of tumor grade, and in 17 out of 18 patients with Grade 3-4 tumors (94%).

Aged↗

[Neoplasm markers useful for diagnosis and monitoring of colonic neoplasms].

Serum tumor markers: CEA, CA 19-9, AFP, TPS may be helpful in early diagnosis of colorectal cancer, in the initial assessment of the extent of the disease, and in monitoring of the tumor growth or tumor volume reduction once cancer has been diagnosed and treatment started. Recent studies have focused on a new substances (candidates for tumour markers) of colorectal cancer.

Antigens, Neoplasm↗