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[Setting a maximum allowable concentration for urea in reclaimed potable water and evaluating the nature of its biological action].

The purpose of the study was to identify maxim allowable concentrations of urea in reclaimed potable water. The urea concentration equal to 80 mg/l is the threshold dose influencing the taste and flavor of water. Urea is a low toxicity substance (LD50 = 14,300 mg/kg), the effect of which is not cumulative. However, when used in high doses it affects bioenergetic and cholinergic processes and causes changes in ECG, higher nervous activity and visceral structure. It has been shown that when applied to warm-blooded animals the acting dose of urea is 14.3 and 1.43 mg/kg (1/1000 and 1/10000 LD50), the threshold dose is 0.72 mg/kg (1/20000 LD50), and the ineffective dose is 0.36 mg/kg (1/40000 LD50) which amounts to the concentration of 10 mg/l. In terms of toxic effects the dose equal to 10 mg/l is taken to be the maximally allowable concentration of urea. It is recommended to use the Laham biotest for measuring urea in water.

Animals↗
PubMed1991

[Experimental substantiation of maximum allowable concentration of phosphoric acid in the water of reservoirs].

It has been found out on the basis of experimental studies, that the threshold concentration of phosphorous acid is 85.7 mg/l according to the influence on organoleptic water properties, I mg/l--according to the influence on the sanitary regimen of water reservoirs. The preparation is of low toxicity when administered perorally to laboratory animals, cumulation degree is medium. Embryotoxic and gonadotoxic effects, mutagenic and allergic properties have not been detected. The maximum no-effect dose in the chronic experiment is 1.4 mg/kg. MAC is recommended on the level of I mg/l according to the general sanitary indicator of harmfulness (the 3-d class of danger).

Animals↗