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PubMed1997

Bacteriological evaluation of 194 adult patients with acute frontal sinusitis and findings of simultaneous maxillary sinusitis.

In a prospective study bacteriological findings from frontal and maxillary sinus secretes were analyzed. Frontal sinus trephination was performed to 103 and maxillary irrigation to 192 patients. Main pathogens in the frontal as well as in the maxillary sinus secretes were Haemophilus influenzae and Streptococcus pneumoniae. beta-lactamase production of H. influenzae was found in 17% of frontal and in 16% of maxillary sinus samples. Bacteriological findings were supported by the staining results. The portion of anaerobic pathogens in cultures were poor, though Bacteroides fragilis antigen was detected in 8 frontal and 6 maxillary sinus samples. The acute frontal sinusitis should be treated with respective antibiotics. Complications seem not to develop in the acute phase and the disease can primarily be treated conservatively. It should however be controlled properly to avoid prolonged disease and late complications.

Acute Disease↗
PubMed1984

[Bacteriological study of maxillary sinusitis].

Suppurated maxillary sinusitis are frequent diseases. Diameatic puncture allows bacteriological investigations. Our results are positive in two thirds of cases. The bacterial flora is very varied, whose identification and antibiograms involve efficient treatment with daily washing and in situ antibiotherapy.

Adolescent↗
PubMed1998

Cefuroxime axetil versus clarithromycin in the treatment of acute maxillary sinusitis.

Acute maxillary sinusitis is a common condition requiring broad-spectrum therapy to prevent development of chronic disease. A randomised, double-blind, multicentre study was performed to compare the efficacy and safety of cefuroxime axetil 250 mg twice daily (n = 185) and clarithromycin 250 mg twice daily (n = 185), both administered for 10 days, in the treatment of patients with acute sinusitis. Efficacy was determined by assessment of clinical response at post-treatment and follow-up, and by radiological assessment at pre-treatment and follow-up. Assessment of days absent from work due to illness was also made. In the cefuroxime axetil group, 169/185 (91%) patients were cured/improved at post-treatment, as were 172/185 (93%) patients receiving clarithromycin and, of these, 137/169 (81%) and 143/172 (83%) maintained their response at follow-up. Follow-up radiography showed a reduction in incidence of air fluid level and/or opacification from 96% to 15% (cefuroxime axetil) and from 96% to 11% (clarithromycin), and a decrease in frequency of mucosal thickening from 58% to 28% (cefuroxime axetil) and from 56% to 29% (clarithromycin). Only 10% of patients in either group experienced adverse events and days absent from work were comparable. This study demonstrated clinical equivalence between twice-daily cefuroxime axetil and clarithromycin, both treatments being effective and well tolerated.

Absenteeism↗
PubMed1997

Quantification of X-ray opacity of the maxillary sinus in the Waters' view.

Plain X-ray filming such as that in the Waters' view is a simple and inexpensive method used in daily practice to briefly evaluate the severity of inflammation of the paranasal sinuses. The maxillary sinus is the largest and simplest in shape among all sinuses and is usually clearly observed on a film in the Waters' view. We attempted to obtain a quantitative index of the X-ray opacity of the maxillary sinus using X-ray films in the Waters' view. A copper wedge was placed to the left side of the subject's face and was filmed simultaneously. The X-ray film was digitized with an image digitizer. The X-ray density of each pixel was then converted to an absolute value for the copper thickness with a medical image processor. The mean pixel value in the region of interest at the maxillary sinus (M(R)) and that at the ipsilateral orbit (O) were determined. The difference, M(R) - O, was found to have a significant correlation with the average visual grading of the severity of inflammation of the maxillary sinus by 10 otolaryngologists. Thus M(R) - O Can serve as an objective measure of the X-ray opacity of the maxillary sinus. The use of this index during the follow-up period is advisable, especially in children, because of greatly reduced amount of X-ray exposure compared with that in computed tomography.

Adult↗
PubMedDate not supplied

[Experience with evacuable maxillary sinus endothesis for orbital and maxillary trauma].

Results with a deflatable anatomically designed Endothesis for the reduction of fractures of the antral walls, especially the orbital floor. For the treatment of the fractures of the antral walls, especially of the extended fractures of the orbital floor, after repositioning through the maxillary sinus, treatment is necessary which supports the maxillary sinus and which, being effective in all directions, protects the ciliated epithelium and guaranties the drainage of secretions. After anatomical preexaminations three differently large hollow models for the maxillary sinus made of thin-walled silicon were developed. These "Endotheses" were implanted through a facial window into the maxillary sinus and are to be filled by way of nasal drain with contrast fluid. 51 patients were subjected to clinical, x-ray and, in selected cases, endoscopic post-control.

Facial Injuries↗
PubMed1993

Maxillary sinus augmentation: histomorphometric analysis of graft materials for maxillary sinus floor augmentation.

This study used histomorphometric analysis to quantitate the bone composition of four different sinus grafting materials biopsied at the time of implant installation. The study consisted of five patients in whom eight bone biopsies were obtained from seven grafted sites. The grafting materials consisted of hydroxylapatite (HA) granules mixed with cortical chin bone, HA mixed with demineralized bone powder, HA alone, and cortical chin bone alone. Histomorphometry was performed using backscattered scanning electron microscopy images and a computerized image analysis system. The biopsy cores yielded 46 sections from which a total of 255 fields, measuring 2.0 mm x 2.0 mm each, were imaged and analyzed. The biopsy cores contained 44.4% bone after grafting with HA granules and chin bone, 59.4% bone after grafting with chin bone alone, 20.3% bone after grafting with HA granules alone, and 4.6% bone after grafting with HA granules and demineralized bone powder. The small number of biopsies did not permit analysis of statistical significance. However, this study demonstrated the feasibility of correlating mineralized tissue composition of different sinus grafting materials with clinical outcome after dental implant installation.

Aged↗
PubMedDate not supplied

[Ultrasound examination in presentation A for diagnosis of maxillary sinusitis in childhood].

Maxillary sinusitis is frequent in childhood. This study aimed at evaluating the value of ultra sound in presentation A in the diagnosis of maxillary sinusitis in childhood. Altogether 324 maxillary sinuses in 162 children were examined. A value of ultra sound examination was verified comparing the obtained results with the results of X-rays, considering three classifications of the latter. Besides the attempt of correlation of the results, ultra sound specificity and sensitivity were evaluated. Relatively high sensitivity and relatively low specificity of ultra sound technique were noted. It seems that ultra sound examination in presentation A may serve as a screening technique in children. Being sensitive and safe, this technique may be used in patients who require frequent examinations in persisting chronic disorders or recurrent maxillary sinusitis. However, the obtained results should be verified with X-rays because of the low specificity of ultra sound examination, especially prior to therapy of patients with unclear clinical picture of the disease.

Child, Preschool↗
PubMed1999

Bacteriology of endoscopically normal maxillary sinuses.

The bacteriology of maxillary sinuses with normal endoscopic findings is reported in this study. When transantral sinoscopy was used to examine the maxillary sinuses, the whole maxillary sinus was inspected with different-angle endoscopes. If no lesion was seen over the whole maxillary sinus mucosa, no secretion existed in the maxillary sinus cavity, and the maxillary sinus ostium was wide open, the maxillary sinus was considered endoscopically normal. The bacteriology of these endoscopically normal maxillary sinuses was studied by passing cotton-tipped sticks through the cannula to collect swab specimens. In some cases, a biopsy forceps was also passed to obtain mucosal specimens. The specimens were sent to the laboratory for aerobic and anaerobic cultures. Between July 1990 and May 1998, 83 swab and 31 mucosal specimens were collected from 69 patients who had not taken any antibiotic within 10 days before endoscopy. The culture rates were 62.3 per cent (35/53) from swab specimens and 57.1 per cent (eight out of 14) from mucosal specimens in patients with the diagnosis of chronic paranasal sinusitis, and were 46.7 per cent (14/30) from swab specimens and 41.2 per cent (seven out of 17) from mucosal specimens in patients without this diagnosis. This study shows that endoscopically normal maxillary sinuses are not sterile.

Adolescent↗
PubMed2006

Mucosal healing and mucociliary transport change after endoscopic sinus surgery in children with chronic maxillary sinusitis.

OBJECTIVES: The aim of the study was to evaluate the effects of endoscopic sinus surgery for chronic maxillary sinusitis in children by investigating ultrastructure element changes in the sinus mucosa and nasal mucociliary clearance before and after operation. METHODS: Twenty-five children with chronic maxillary sinusitis scheduled to undergo functional endoscopic sinus surgery and another five controls were enrolled. A saccharin transit test was performed before and after the operation for each subject. Forty specimens of diseased maxillary sinus mucosa were classified into edematous and polypoid types, with 20 specimens in each type. The mucosal specimens were taken from the superolateral wall of each maxillary sinus during surgery and at post-operative follow-up when the mucosal recovery had begun and the symptoms had subsided. The specimens were examined with a scanning electron microscope. RESULTS: A significant increase in number of the submucosal gland openings (GO) was noted for the sinusitis group, of both edematous and polypoid types. In post-operative cases, the number of gland openings decreased, however, it remained higher than for the control group. The number of goblet cells (GC) decreased in the sinusitis cases, and significant difference was not demonstrated compared to postoperative and control groups. After endoscopic sinus surgery, the cilia in both types of antral mucosa were significantly regenerated compared to preoperative variants. Significant differences in postoperative saccharin transit time were demonstrated for both types of antral mucosa compared to the preoperative values. CONCLUSION: After endoscopic sinus surgery for chronic pediatric sinusitis, the antral mucosa recovered and mucociliary clearance improved for both types of antral mucosa, with improved ventilation and drainage demonstrated for our patients. Based on our specimens, the edematous mucosa appear to regenerate sooner than the polypoid variant, with close post-operative follow-up for more than 2 and 4 months for the edematous and polypoid types of antral mucosa, respectively, necessary to prevent sinusitis relapse.

Adolescent↗
PubMed1999

A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients. Influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumonia.

The objective of this randomized study was to compare the occurrence of nosocomial pneumonia in nasotracheally intubated patients who were randomly allocated either to a systematic search of sinusitis by CT scan (study group) or not (control group). A total of 399 patients were included: 272 male and 127 female; mean age, 61 +/- 17 yr; SAPS: 12.6 +/- 4.9. The study group consisted of 199 patients and the control group consisted of 200. In the study group, sinus CT scans were performed in case of fever at Days 4 and 8 and then every 7 d. Nosocomial sinusitis was defined as follows: fever of >/= 38 degrees C, radiographic (sinusal air-fluid level or opacification on CT scan) signs, and presence of purulent aspirate from the involved sinus puncture with >/= 10(3) cfu/ml. Patients with sinusitis received sinus lavage and intravenously administered antibiotics. In the study group, 80 patients experienced nosocomial sinusitis. In the control group, no patient was treated for a sinusitis. Ventilator-associated bronchopneumonia (VAP) was observed in 88 patients: 37 in the study group (1 mo Kaplan-Meier estimate, 34%) versus 51 in the control group (1 mo Kaplan-Meier estimate, 47%); (p = 0.02, log-rank test; relative risk [RR] = 0.61; 95% confidence interval [CI], 0.40 to 0.93). Two months overall mortality was estimated at 36% in the study group versus 46% in the control group (p = 0.03, log-rank test; RR = 0.71; 95% CI, 0.52 to 0.97). We conclude that the occurrence of VAP in patients undergoing prolonged mechanical ventilation via a nasotracheal intubation can be prevented by the systematic search and treatment of nosocomial sinusitis. The effect on mortality should be confirmed.

Cross Infection↗