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PubMed1993

[Fox-Fordyce disease (apocrine miliaria)].

A 1-year follow-up in a 12 year old girl suffering from Fox-Fordyce disease is reported. Reddish papules were found in the typical locations in the regions with a high density of apocrine glands. A biopsy specimen showed keratin plugs in the infundibula of apocrine glands. Since hormone therapy could not yet be given, external therapy only was performed, with good results.

Administration, Topical↗
PubMed1991

Predictive patch testing of "Medigloves" on humans using the repeated insult technique.

The predictive patch tests using the repeated insult technique with pieces of ETO sterilized "Medigloves" on 200 human subjects showed negative allergic reactions in all cases. Therefore, the sensitizing potential of "Medigloves" is quite low, if any. Mild to severe forms of miliaria rubra were occasionally observed in about one fourth of the subjects during the induction and challenge periods since the weather was quite warm and humid. However, three subjects who developed more pronounced miliaria rubra on the skin underneath rubber-glove squares were selected for provocative use tests. The results were negative in all cases. A subject who showed a false-positive allergic reaction also showed negative results in a provocative use test and in patch tests with standard rubber chemicals and pieces of "Medigloves" from various batches. Occlusive patch tests for 72 hours with Mediglove pieces from the same batch used in the initial test challenge phase were repeatedly negative when performed during the cool time of the year. In tropical countries, predictive closed patch tests employing solid occlusive materials should be done during cool weather in order to prevent or minimize the occurrence of miliaria. In hot weather, this is a common source of false positive reactions.

Adult↗
PubMed1994

[Pulmonary manifestations of tuberculosis in childhood].

We mention the major pathogenous characteristics of a tuberculosis infection. Immunity to tuberculosis and tuberculin allergy are connected with each other but are not identical reactions of the organism. We describe the well-known complications in primary infections, namely the primary focus and the formation of lymph nodes. The peripheral primary focus generally regresses after treatment. However, the hilar lymph nodes sometimes increase in size even after appropriate medication (autonomous activity of some lymph nodes). If x-ray films reveal segmental changes and if there is evidence of viral or mycoplasma infection, tuberculosis should be taken into consideration as a parallel disorder because these infections often pave the way for tuberculosis. In the stage of early generalisation miliaria may occur within 3 months of infection. In most cases miliaria escapes detection. Pleurisy involves tuberculosis bacteria entering the pleural cavity. One of the prerequisites of pleurisy is hyperergia of the pleura. If the patient has tuberculotic pleurisy it means that miliaria has already occurred and miliary tuberculosis need not be anticipated. We also mention secondary diffusion into the apex of the lung and its consequences.

AIDS-Related Opportunistic Infections↗
PubMed1978

Unilateral segmental hyperhidrosis. Response to 20% aluminum chloride solution and plastic wrap.

A young woman had unilateral dermatomal hyperhidrosis documented by a starch-iodine technique. Evaluation failed to reveal any associated causative conditions. She was treated with 20% aluminum chloride hexahydrate solution in absolute alcohol (Drysol) with a favorable response. With recurrent use, however, she developed miliaria following exertion. Aluminum chloride hexahydrate was shown to be an effective agent to treat this unusual condition, but miliaria with exertion secondary to its use may be a limiting factor.

Adult↗
PubMedDate not supplied

Neoprene splinting: dermatological issues.

Occupational therapists are expanding their use of custom and commercial soft splints fabricated from neoprene (polychloroprene), but little has been written regarding dermatological issues associated with this material. Skin contact with neoprene poses two dermatological risks: allergic contact dermatitis (ACD) and miliaria rubra (i.e., prickly heat). Allergic reaction to neoprene is generally ascribed to the accelerants used to manufacture the man-made rubber, specifically thiourea compounds and mercaptobenzothiazole (MBT). Symptoms of neoprene-related ACD include itching, skin eruptions, swelling, and hemorrhages into the skin. Miliaria rubra creates small, red, elevated, inflammatory papules and a tingling, burning sensation. Although neoprene hypersensitivity is rare, its incidence may grow as neoprene becomes a more commonly used material. It is recommended that therapists screen patients for a history of dermatological reactions to neoprene or other materials containing thiourea compounds or MBT and educate patients to discontinue splint use if dermatological symptoms develop. Therapists are also encouraged to notify splint manufacturers regarding all ACD reactions.

Adult↗
PubMed2004

Patterns histopathologic of Fox-Fordyce disease.

Fox-Fordyce disease is an uncommon condition that is biopsied even less commonly. Since the publication of Shelley and Levy, in 1956, the disease is regarded widely to be "apocrine miliaria", an analogue of eccrine miliaria. Histopathologically, an "intraepidermal sweat retention vesicle" is considered the only feature diagnostic of the condition. In this article, the entire literature devoted to the subject and reviewed features clinically and histopathologically as they were presented in those publications. Furthermore, observations in sections of tissue cut from 8 biopsy specimens taken from 4 patients with Fox-Fordyce disease are presented including correlation clinicopathologic. Changes histopathologically in Fox-Fordyce disease vary greatly. Apart from findings described previously as being typical (e.g., dilation, hyperkeratosis, and spongiosis of infundibula), there were vacuolar alteration at the dermo-epithelial junction of infundibula, dyskeratotic cells scattered in infundibula, and parakeratosis in the manner of cornoid lamellation within an orthokeratotic plug filling a dilated infundibulum. Infundibula and apocrine ducts were surrounded by numerous foamy macrophages. Despite that variation of features histopathologically, the appearance clinically, was similar in all patients, namely small infundibulocentric papules, sometimes with a keratotic plug in the center of it, and sometimes with a yellow cast. In conclusion, current concept of Fox-Fordyce disease is too restricted. All the different patterns histopathologically observed by us are manifestations of one single pathologic process named for Fox and Fordyce.

Dermatology↗