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PubMed1980

NLM's Medical Library Resource Improvement Grant for Consortia Development: a proposed outline to simplify the application process.

The National Library of Medicine's Resource Improvement Grant for Consortia is available to assist with developing hospital library consortia, and to support the development of basic healthy information collections. In an effort to simplify the grant application process, this paper presents suggestions for writing the narrative section of the first budget-period application, using the outline in NLM's Application Instructions for Consortium Applicants. Suggestions for writing the narratives of the second budget-period application and the collection development application are also included.

Financing, Government↗
PubMed1983

Development of a state-wide health sciences information network: a cooperative effort.

A cooperative effort by a regional medical library (RML) program, a college of human medicine, a university library system, and numerous individual health care institutions to develop a network for the delivery of health sciences information within the state of Wyoming is described. This development consisted of four phases: collection building, training of library managers, consortia formation, and establishment of a state-based network management mechanism. Significant characteristics of the project include the high level of cooperation exerted by many different agencies and institutions, the participation by all acute-care institutions within the state, the initial large expenditure of funds to build resources within individual institutions, and the system development approach to the delivery of RML services that this project represents.

Health Facilities↗
PubMed1991

Liaison services for a remotely located biotechnology research center.

In April 1989, the Houston Academy of Medicine-Texas Medical Center (HAM-TMC) Library initiated a prototype liaison program with the Baylor College of Medicine (BCM), Center for Biotechnology (CBT). The library was interested in examining the benefits and costs of the outreach concept and in supporting Houston's efforts to develop into a center for biotechnology research. Located thirty-five miles from the HAM-TMC Library, CBT was receptive to an outreach project that would improve its access to the library's collection and services. This article describes the objectives and development of the pilot project, the services provided, feedback from the biotechnologists, and program costs. Although limited in scope, the project has provided the HAM-TMC Library with useful data about the information needs of a particular group of biotechnologists and strengthened relationships with these scientists. In addition, the knowledge and experience gained from this effort are being used to plan outreach efforts for other client groups.

Biotechnology↗
PubMed1993

Expanding the DOCLINE network to include nonmedical libraries in the state of Nevada.

Most libraries cannot meet patron demands for biomedical information using only their in-house collections. Consequently, many types of libraries request biomedical information through interlibrary loan, and these include not only academic health sciences libraries, hospital and special libraries, but also general libraries. In Nevada, with its small population spread over a large geographic area, it has become critical to develop a statewide network for sharing biomedical information. As the state resource library, the Savitt Medical Library launched an effort to establish a network, via DOCLINE, of all Nevada libraries that have health-related collections. The process of convincing academic and community college libraries to join DOCLINE and the resulting benefits of improved resource sharing and cooperative collection development are discussed.

Computer Communication Networks↗
PubMed1977

A list of selected reference materials in clinical chemistry.

This is a compilation of reference materials suggested for scientists considering a laboratory reference collection in clinical chemistry, or for librarians seeking to develop or add to an up-t-o-date library collection. Nine areas are represented: general clinical chemistry; analytical methods, procedures, and techniques; calculations and statistics; the clinical laboratory; drugs and metabolism; enzymology; instrumentation, interpretation of data; and ready reference.

Bibliographies as Topic↗
PubMed1996

Influence of disease-suppressive strains of Streptomyces on the native Streptomyces community in soil as determined by the analysis of cellular fatty acids.

Analysis of cellular fatty acid profiles was used to distinguish among introduced pathogen- suppressive strains and indigenous strains of Streptomyces spp. isolated from soil of field plots established to test the efficacy of Streptomyces strains PonSSII and PonR in the biological control of potato scab. Reference libraries of fatty acid profiles were developed for a collection of known pathogenic strains and the introduced suppressive strains. Population densities of pathogen-related, suppressive, and saprophytic Streptomyces strains were determined from the relationship of field isolates to mean library profiles using cluster analysis and the unweighted pair-group method using arithmetic averages. Community diversity was similarly determined. Streptomyces strains PonSSII and PonR were distinguished from each other and from the pathogen group (which clustered together) based on fatty acid profiles. The introduced, suppressive strains successfully colonized the soil and represented 2-19% of the isolates sampled over 2 years. The introduction of the suppressive strains inhibited the population of strains related to the pathogen library at each sample date; the pathogen population was substantially lower in soil from treatments where the suppressive strains were introduced compared with the nonamended control. At harvest, the pathogen-related population was suppressed 85-93 and 36-44% in 1991 and 1992, respectively, in treatments with the suppressive strains compared with the nonamended control. Diversity of the community was not affected by the introduced strains, and diversity and equitability indices were similar among treatments at any sample time. The inhibition of the pathogen-related population was correlated with a reduction of scab symptoms observed in the field plots into which the suppressive strains were introduced. Implications of a fundamental shift in the pathogen-related population in response to the introduction of the suppressive strains for long-term biological control of potato scab are encouraging.

Fatty Acids↗
PubMed1983

Bibliographic control of medical illustrations--a case study in the development of a library subsystem: I. Project planning.

The need to provide bibliographic access to a collection of original medical illustrations led the Library of the University of California, San Francisco, to search for a bibliographic control system and, not finding a satisfactory one, to develop one of its own, Part 1 of the report details the planning for such a development, including the need for bibliographic control of illustrations, the goals of the proposed system, design decisions and changes required, the type of system chosen, special subjects indexing needs, the required output, and staffing and budgetary needs.

Abstracting and Indexing↗
PubMed1993

Citation patterns in the health sciences: implications for serials/monographic fund allocation.

This study sought to determine optimal serial-to-monograph ratios for collection development by comparing citation frequency with current library practice. Internal medicine literature cited an average of 88% serial references and 12% monographs. In an observational study, teaching physicians on internal medicine rounds cited 89.5% serials and 10.5% monographs to student teams. By contrast, health sciences libraries included in the Houston statistics spend an average of 79% of acquisitions budgets for serials and 21% for monographs. An 88:12 acquisitions budget ratio would be more appropriate, reflecting actual use of serials and monographs in the health sciences.

Budgets↗
PubMed1990

Book availability as a performance measure of a library: an analysis of the effectiveness of a health sciences library.

User satisfaction as a measure of library effectiveness has been studied by using Kantor's branching technique. Cleveland Health Sciences Library, Cleveland, Ohio, was used as the center of this study. The study measured independently the user bibliographic information performance, collection development policy performance, acquisition policy performance, user catalog performance, circulation performance, library operation/functioning performance, and the user search performance. Each of these categories represented one or more of the factors of library performance that could account for the possibility of users' failure. The sample size consisted of 1000 requests for book titles. The book availability rates were 59.60% without the help of the librarian and 63.50% with the help of the librarian. The results indicate that a dynamic study of library policies at regular intervals by using the Kantor's method, which is easily reproducible, can maximize library resources for the most effective fulfillment of user demand.

Consumer Behavior↗
PubMed1994

Random peptide libraries.

Over the past year, great strides have been made in the design of peptide libraries, and new approaches have been developed for identifying peptide ligands. The libraries comprise large collections of peptides, ranging from 1 million to 1 billion different sequences, which can be screened using monoclonal and polyclonal antibodies, receptors, enzymes or other target molecules. The power of this technology stems from the chemical diversity of the amino acids coupled with the large number of sequences in a library. As such, peptide libraries may be useful for finding ligands that can serve as leads for pharmaceutical development and other purposes.

Amino Acid Sequence↗
PubMed1968

Development of methodologic tools for planning and managing library services. I. Project goals and approach.

In July 1966, the Institute for Advancement of Medical Communication began work on a project aimed at developing methods for collecting objective data suitable for planning and guiding local, regional, and national programs to improve biomedical libraries and the biomedical information complex. This article constitutes an introduction to a series of reports on the methodologic tools that have been developed. It describes the overall purpose and initial goals of the project, gives the general plan of the work, and presents five basic concepts that underlie the project's approach and structure the entire effort.

Information Services↗
PubMed1981

Selective medical libraries and library networks for developing countries.

The growth and rising cost of bibliographic materials require that attempts to make all medical libraries comprehensive and self-contained be replaced by the provision of selective collections devoted to the most used and useful materials, particularly in developing countries with limited resources. Journals constitute the most important and expensive component of a biomedical collection. While use data are important, a method is presented to guide selection in the absence of this information. The method identifies 35 nucleus journals and uses citation analysis to generate a list of 92 journals, partitioned into 31 medical specialty classes. Local expert consensus can guide selection of important local or regional literature not in the international archives. Careful selection results in efficient collections. Access to less used materials can be provided to individual libraries through resource sharing networks with affiliations to major comprehensive international libraries.

Developing Countries↗
PubMed1991

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

The area of highest variability in the antibody-combining site is the third complementarity determining region or CDR3. Based on our preliminary observation of the tremendous variability of this region in the human system we have studied the potential of CDR3 regions for generating diversity in the human B cell repertoire. To this end we generated CDR3-specific cDNA libraries from tissues collected at several stages of human development. Detailed computer analysis of more than 500 sequences reveals that human CDR3 region have the potential to generate more than 10(14) different peptides. The mechanisms responsible for this diversity include rearrangement by inversion, D-D fusion, gene conversion and the frequent utilization of the recently described DIR genes. The specific recombination mechanisms which may explain aberrant rearrangements as well as differences between fetal and adult repertoires are discussed in detail.

Amino Acid Sequence↗
PubMed2000

Electronic reserves: copyright and permissions.

Electronic reserves present a new service option for libraries to provide needed materials during hours that the library is not open and to user groups located some distance from library collections. Possible changes to current copyright law and publishers permissions policies have delayed the development of electronic reserves in many libraries. This paper reviews the current state of electronic reserves materials in the publishing and library communities and presents the results of a survey of publishers to determine permissions policies for electronic materials. Issues of concern to both libraries and publishers are discussed.

Computer Communication Networks↗
PubMed1980

A simple objective method for determining a dynamic journal collection.

In order to determine the content of a journal collection responsive to both user needs and space and dollar constraints, quantitative measures of the use of a 647-title collection have been related to space and cost requirements to develop objective criteria for a dynamic collection for the Treadwell Library at the Massachusetts General Hospital, a large medical research center. Data were collected for one calendar year (1977) and stored with the elements for each title's profile in a computerized file. To account for the effect of the bulk of the journal runs on the number of uses, raw use data have been adjusted using linear shelf space required for each title to produce a factor called density of use. Titles have been ranked by raw use and by density of use with space and cost requirements for each. Data have also been analyzed for five special categories of use. Given automated means of collecting and storing data, use measures should be collected continuously. Using raw use frequency ranking to relate use to space and costs seems sensible since a decision point cutoff can be chosen in terms of the potential interlibrary loans generated. But it places new titles at risk while protecting titles with long, little used runs. Basing decisions on density of use frequency ranking seems to produce a larger yield of titles with fewer potential interlibrary loans and to identify titles with overlong runs which may be pruned or converted to microform. The method developed is simple and practical. Its design will be improved to apply to data collected in 1980 for a continuous study of journal use. The problem addressed is essentially one of inventory control. Viewed as such it makes good financial sense to measure use as part of the routine operation of the library to provide information for effective management decisions.

Humans↗
PubMed2000

The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries.

A unique separator was developed which allowed automatic separation and peak collection using semi-preparative supercritical fluid chromatography (SFC). A peak detector switched the effluent between waste and special collection cassettes. Up to 50 mg of various solutes were injected onto a 21-mm I.D. Cyano column. The entire flow path was contained and no aerosols were generated. Collection efficiency was as high as 95%. Peak purity was often greater than 99. 9%. Typical run times were less than 10 min. An analytical SFC was used to screen the performance of a wide range of mobile and stationary phases for the elution of more than 60 miscellaneous small drug compounds. The best 'universal' gradient employed 0.4% isobutyl or isopropylamine dissolved in methanol, then mixed from 5 to 55% into carbon dioxide at 10%/min. Flow rate was 50 ml/min. The analytical SFC was shown to be a good predictor of the semi-prep instrumental performance.

4-Aminobenzoic Acid↗
PubMed1990

Teaching reprint file management: a hands-on approach.

The development of user-friendly search systems has enabled physicians to perform their own MEDLINE searches These physicians are recognizing a need to learn how to organize their growing reprint collections. Librarians at the University of Michigan, Alfred Taubman Medical Library have developed a unique course that presents a variety of techniques to meet the needs of a wide audience. For some users, such as students or house officers who have limited funds or lack support devices, a variety of manual methods are presented. Advantages and disadvantages of using manual versus computerized systems are discussed. Following the illustration of the manual methods, users are introduced to a simple computerized method using a utility type database management package, PC-FILE. Hands-on training under the direction of librarians allows students to develop and use a practice database while having experts available to answer questions. Users are encouraged to take a copy of PC-FILE (shareware) with them to experiment with before committing themselves to a more expensive database management software package. Before the class ends, those interested in a more sophisticated package with specialized report formats and downloading/uploading capabilities are given a brief demonstration of PRO-CITE. Evaluations have shown that there is interest in all three methods.

Computer User Training↗
PubMed1993

The Houston Academy of Medicine--Texas Medical Center Library management information system.

A management information system (MIS) provides a means for collecting, reporting, and analyzing data from all segments of an organization. Such systems are common in business but rare in libraries. The Houston Academy of Medicine-Texas Medical Center Library developed an MIS that operates on a system of networked IBM PCs and Paradox, a commercial database software package. The data collected in the system include monthly reports, client profile information, and data collected at the time of service requests. The MIS assists with enforcement of library policies, ensures that correct information is recorded, and provides reports for library managers. It also can be used to help answer a variety of ad hoc questions. Future plans call for the development of an MIS that could be adapted to other libraries' needs, and a decision-support interface that would facilitate access to the data contained in the MIS databases.

Academic Medical Centers↗