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A review of the evolution of the Library Association Medical Health and Welfare Libraries Group relating its organization, administration and activities to its key objectives.
In mid-1996, the FDA called for discussions on regulation of clinical software programs as medical devices. In response, a consortium of organizations dedicated to improving health care through information technology has developed recommendations for the responsible regulation and monitoring of clinical software systems by users, vendors, and regulatory agencies. Organizations assisting in development of recommendations, or endorsing the consortium position include the American Medical Informatics Association, the Computer-based Patient Record Institute, the Medical Library Association, the Association of Academic Health Sciences Libraries, the American Health Information Management Association, the American Nurses Association, the Center for Healthcare Information Management, and the American College of Physicians. The consortium proposes four categories of clinical system risks and four classes of measured monitoring and regulatory actions that can be applied strategically based on the level of risk in a given setting. The consortium recommends local oversight of clinical software systems, and adoption by healthcare information system developers of a code of good business practices. Budgetary and other constraints limit the type and number of systems that the FDA can regulate effectively. FDA regulation should exempt most clinical software systems and focus on those systems posing highest clinical risk, with limited opportunities for competent human intervention.
As incorporated in Healthy People 2010 objectives, data and information systems and a skilled workforce are 2 of the critical components of the public health infrastructure. The National Library of Medicine (NLM) and the National Network of Libraries of Medicine (NN/LM) are important resources for improving Internet access and providing related training to the public health workforce and to those in training for public health careers. The NLM and the NN/LM have joined forces with the Centers for Disease Control and Prevention, the Health Resources and Services Administration, the Association of State and Territorial Health Officials, the National Association of County and City Health Officials, and the Public Health Foundation. The goal of this collaboration is to improve electronic resources useful in public health practice and increase awareness of them, to train public health professionals to use electronic information services, and to help public health agencies obtain the equipment and Internet connections needed to use these services effectively. The databases, outreach programs, and connection grants available to public health professionals from the NLM, and the training and ongoing support available from the NN/LM for accessing these programs and services, are described.
Acquisitions-Cataloging records stored on magnetic tape by the Washington University School of Medicine Library were examined to determine frequency and average length of record components and their alphabetization requirements in a book catalog. Data from this study of 4,708 records will be used in adaptation of the Library's computer-based cataloging system to greater machine capabilities. The first of these two papers compares measurements found for WUSML records with those reported in studies of conventional catalog cards. The number of sorting positions used to alphabetize entries and causes of sort failure are examined in the second paper (Number V) which will be found on page 71 of this issue of the BULLETIN.
Library instruction and library orientation goals, techniques, and programs are reviewed. These programs are a responsibility of the information specialist. Existing programs use varied means to accomplish these educational goals.
A survey of automated records management in the United States and Canada was developed to identify existing on-line library systems and technical expertise. Follow-up interviews were conducted with ten libraries. Tables compare the features and availability of four main frame and four minicomputer systems. Results showed: a trend toward vendor-supplied systems; little coordination of efforts among schools; current system developments generally on a universitywide basis; and the importance of having the cooperation of campus computer facilities to the success of automation efforts.
Descriptive cataloging practices for serial differ significantly in some respects between the Library of Congress and the National Library of Medicine. This paper compares some of these differences and indicates the impact they can have on the development of on-line cooperative data bases such as OCLC. Attention is also given to the possible impact of the second edition of the Anglo-American Cataloguing Rules on serials cataloging. The need for standardization is stressed.
The Program Planning Model (PPM) is a planning and management tool that facilitates development and acceptance of significant programs. PPM assists program planning by systematically involving consumer or user groups in the development and review of new programs. While user participitation is important throughout PPM, this involvement is especially important during the problem exploration phase, when the problems or needs of these users are surveyed. The Nominal Group Technique (NGT), a variation of the "brainstorming" process, is a structured but flexible group process used in the problem exploration phase to generate a high number of useful responses concerning problem areas. NGT ensures maximum contribution of ideas by all participtants. NGT and its application in the planning and management efforts of several libraries and library networks are described in detail.
Initiated to increase space, renovation planning for Northwestern University's Galter Health Sciences Library evolved into a process for developing a more technology-centered library. Design focused on correcting structural problems and providing greater access to technology. Space was redesigned for functionality and flexibility. Design features included a new entrance, relocated and expanded learning resource center; certain limitations remained. The planning process involved all major groups on campus; construction will be phased.
A general approach for sorting antibodies (Abs) to a restricted protein domain was developed using phage-displayed peptide libraries. The method is demonstrated by fractionating polyclonal antibodies (pAbs), raised against a short peptide derived from the extracellular, juxtamembrane region of fibroblast growth factor receptor 1 (FGFR1) into fractions with distinct chemical and biological characteristics. Screening two combinatorial peptide libraries, with the pAb, several sequences, homologous to different regions within the original peptide, were identified. Four of the corresponding peptides were synthesized and used as peptide-conjugated affinity columns for the fractionation of the pAbs. The fractions obtained were unique in their recognition patterns and in their capacity to immunoprecipitate and immunoblot, as well as to modulate the activity of FGFR1. This technique is, therefore, highly sufficient in separating pAbs to monospecific fractions and may also be used for fine mapping of different, even overlapping, sequences within a restricted peptide or protein domain.
We have established a method for selecting binding phages from a phage immunoglobulin heavy chain variable region (VH) library by panning with nitrocellulose membranes (membrane panning). To evaluate the concentrating ability of membrane panning for binding phages, a phage VH library containing clones that bind to hen egg white lysozyme (HEL) was used for panning against HEL. The efficiency of our method was as high as that of panning with magnetic beads. In addition, we performed membrane panning against target proteins and isolated the binding phages. The human VH genes of these phages were cloned and expressed as VH-bacterial alkaline phosphatase (PhoA) conjugates (VH-PhoA) in Escherichia coli. The dose-dependent binding of VH-PhoA to target proteins was confirmed by dot blotting. When applied to disease-associated antibodies, these methods will likely benefit clinical research. In addition, these techniques may be applicable to systematic analysis in proteome studies.
Why should librarians, including those in hospitals and corporations, build virtual libraries and create information visions? This question is explored in relation to the three themes of the 1991 White House Conference on Library and Information Services-Democracy, Productivity, and Literacy.
Main approaches and methods used for constructing "jamping" and cDNA libraries, including novel ones, that omit the employment of methylases and linkers, are presented. The advantages and drawbacks of the well-known and new lambda vectors, suitable for the purposes mentioned, are discussed. Special attention is paid to diphasmids lambda ZAP, lambda SK12, lambda SK15, that combine features of lambda and M13 phages and of plasmids. The convenience and difficulties of "jumping" libraries for physical mapping of chromosomes are briefly considered.
A brief sketch is given of the past history and present functions of the Bracken Library. Architectural and decorative features of the new library are described.
A history of the Wayne State University College of Medicine and its library is given along with a description and specifications of the new library building.
As part of Washington University School of Medicine Library's continuing use of computers in the library, a selective dissemination of information system was tested. The project was to evaluate the system in relation to its serving the needs of a specialized medical research group. Both the manual and computer operations of the system are described. After three months of operation, the results, including relevancy, effectiveness, and existing needs, are discussed and analyzed; modifications are suggested to improve the present system.
The University of Michigan opened a new medical library in July 1980. The five-story structure combines the library with a learning-resources center. Overall, the building has operated smoothly and has been well accepted. The combining of two facilities designed to support the teaching and learning objectives of the health sciences curriculum will ensure long-term cooperation between them.
Surveys of medical school libraries made over a twenty-year period (1960-61 through 1980-81) were analyzed. As indicated by growth in both number and support, medical school libraries have evolved from a period of stability through expansive growth and subsequent leveling off. Expenditures and resource development have been affected by historical developments, especially recent massive federal and state aid to medical education.