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Results for “Leukemic Infiltration”

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PubMed1976

Radiation therapy in the treatment of leukemic infiltrates of the testes.

Testicular infiltration developed in 6 of 56 boys with lymphoblastic leukemia. All exhibited platelet counts under 100,000, indicating poor prognosis. Patients were treated with vincristine, prednisone, and craniomemingeal prophylaxis (2,400 rads/12 fx) extending to the C2 level. Only 3 patients did not suffer recurrence of testicular disease during their multiple leukemic relapses. Alternate treatment courses are suggested.

Acute Disease↗
PubMed1984

Leukemic infiltration of the testes in acute nonlymphocytic leukemia.

Two children with ANLL in complete remission developed testicular relapse 18 and 34 months after diagnosis. Their clinical presentation was similar to that observed in patients with ALL. Although the testicular leukemia responded to between 2,400 and 3,000 rads, bone marrow relapse occurred within 4 months and death within 6 months of the testicular relapse. This points out the need for surveillance of the testicles in males with ANLL, and raises the question of need for testicular biopsy among long-time male survivors.

Acute Disease↗
PubMed1985

Lack of mast cell reactivity during leukemic infiltration of the rat mesentery under syngeneic and allogeneic conditions. A study by transmission electron microscopy (TEM).

The ultrastructural morphology of mast cells localized in rat mesenteries was studied after intraperitoneal implantation of L5222 rat leukemia cells in syngeneic and allogenic hosts. It became evident that the mast cells in the syngeneic (BDIX rat) as well as the allogeneic system (BN rat) showed nor morphological alterations. Degranulation was never observed. This is in contrast to the behavior of macrophages which displayed a strong phagocytotic activity in allogeneic hosts. Thus, it seems that mast cells, under the present experimental conditions, remained inactive during a phase of intense tumor rejection.

Animals↗
PubMed2005

Corneal pseudomembrane from acute inflammatory response and fibrin formation to acute myeloid leukemic infiltrate.

PURPOSE: To describe an unusual ocular manifestation of a patient with acute myeloid leukemia (AML). DESIGN: Observational case report. METHODS: A 59-year-old woman with a history of preleukemic myelodysplastic syndrome (MDS) and status post bone marrow transplant (BMT) complained of a sudden onset of poor vision associated with a corneal pseudomembrane. Ocular graft vs host disease was suspected, and the pseudomembrane was excised for histopathologic examination. RESULTS: The pseudomembrane showed myeloblasts admixed with an acute inflammatory response suggestive of the development of AML, a complication of MDS. Bone marrow examination confirmed the diagnosis of relapsing AML. CONCLUSIONS: Acute myeloid leukemia could present as a pseudomembrane; thus, examination of relevant ocular tissue is recommended.

Acute Disease↗
PubMed1978

Leukemic infiltration of the testis during long-term remission.

Of 33 boys with acute lymphocytic leukemia treated at the Cincinnati Children's Hospital during 1971--1974, 14 remained in clinical and bone marrow remission for periods longer than 2.5 yr. Of these 14 patients, 8 then developed testicular leukemia. In 7 of these 8 patients, testicular infiltration was the first or only evidence of relapse. In 2 of the patients the gonads were not grossly abnormal, and testicular relapse was discovered as a result of routine wedge biopsy before therapy was to have been stopped. This experience has led to our policy of routine testicular biopsy in boys with acute lymphocytic leukemia who have had continuous remission for 3 yr and who are otherwise candidates for discontinuance of maintenance therapy.

Adolescent↗
PubMed1980

Leukemic infiltration of the prostate: a case report.

A successful transurethral resection of the prostate was performed without complication in a 66-year-old man who presented with acute urinary retention, anemia, leukemia and thrombocytopenia. Preoperative treatment with red cell and platelet transfusions, HLA typing for white cell transfusions and preventative antibiotics made surgical treatment successful. With continued improvement in therapy for hematologic tumors and the improvement in survival, catheter drainage with its concomitant chance for sepsis is not a viable alternative to surgical therapy for prostatism.

Acute Disease↗