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PubMed1991

Spurious labor: a high risk factor for dysfunctional labor and fetal distress.

This is a retrospective case controlled study comparing the outcome of labor and neonates in pregnancies complicated by spurious labor at term. The first stage of labor was significantly longer and the proportion of cases requiring oxytocin augmentation was higher in the study group when compared to the controls. More infants in the study group displayed intrapartum CTG abnormalities and five had a depressed Apgar score at 5 min, compared to none in the controls. Of these five neonates, three were admitted to the neonatal intensive care unit and one died from meconium aspiration syndrome and asphyxia. The findings in this study support the view that spurious labor at term constitutes a high risk factor for the ensuing labor.

Adult↗
PubMed2004

The quality of intrapartum fetal heart rate monitoring.

OBJECTIVE: To determine the quality of fetal heart rate (FHR) recordings during the first and second stage of labor by quantifying the amount of fetal signal loss in relation to the method of monitoring: external ultrasound or directly via a scalp electrode. STUDY DESIGN: Analysis of 239 intrapartum recordings stored between 1 January 2001 and 1 July 2001 from consecutive deliveries at the Vrije Universiteit Medical Center in Amsterdam. Singletons delivered via the vaginal route were included in the study. FHR recordings had duration of at least 1h prior to birth of the infant. Subdivision in three groups took place on the basis of the recording technique which had been used; i.e. ultrasound, scalp electrode or a combination of both methods. FHR data was obtained using HP-M1350 cardiotocographs. The status (pen on, pen off, maternal signal) and the mode of the signals were acquired. The duration of pen lifts and maternal signals was divided by the total duration of the recording. Statistical analyses were performed with the Mann-Whitney U-test and the Wilcoxon signed ranks test. RESULTS: Recordings obtained via ultrasound demonstrated significantly more fetal signal loss than those obtained via the direct mode, particularly in the second stage. The FIGO criteria for fetal signal loss with external ultrasound were not fulfilled during this stage for about half the cases. CONCLUSION: Intrapartum FHR monitoring via a scalp electrode provides far better quality FHR signals than external ultrasound and deserves a more prominent position in fetal surveillance than it currently has.

Cardiotocography↗
PubMed2006

Maternal and neonatal infections and obstetrical outcome in water birth.

OBJECTIVES: The goal of our study was to assess the effect of water birth on obstetrical outcome, the maternal and neonatal infection rate in a selected low risk collective. STUDY DESIGN: In this prospective observational study (1998-2002) 513 women, wished to have a water birth. The study was approved by the local ethical committee, informed consent was obtained. According to the course of delivery, we compared three groups: woman who had a water birth, a normal vaginal delivery after immersion and a normal vaginal delivery without immersion. Outcome measurements were maternal and fetal infection rate, obstetrical outcome parameters and relevant laboratory parameters. RESULTS: The groups were comparable in terms of demographic and obstetric data. The maternal and neonatal infection rate and laboratory parameters showed no significant difference among the groups. There was no maternal infection related to water birth. There were five water born neonates and three neonates after normal vaginal delivery preceded by immersion with conjunctivitis. Significant differences were observed in obstetrical outcome parameters: less use of analgesia, shorter duration of first and second stage of labor, smaller episiotomy rate in water birth. In contrast no differences were seen in all observed fetal outcome parameters: APGAR score, arterial and venous pH, admission rate to neonatal intensive care unit. CONCLUSIONS: Water birth is a valuable alternative to traditional delivery. The maternal and fetal infection rate was comparable to traditional deliveries. A careful selection of a low risk collective is essential to minimize potential risks.

Adult↗
PubMed2001

Immersion in water in the first stage of labor: a randomized controlled trial.

BACKGROUND: Current forms of analgesia often have significant side effects for women in labor. Bathing in warm water during labor has been reported to increase a woman's comfort level and cause a reduction in painful contractions. The objective of this trial was to compare immersion in warm water during labor with traditional pain management for a range of clinical and psychological outcomes. METHODS: A prospective randomized controlled trial of 274 pregnant women, who were free from medical and obstetric complications and expecting a singleton pregnancy at term, was conducted at the Women's and Children's Hospital, a maternity tertiary referral center in Adelaide, South Australia. Women in labor were randomized to an experimental group who received immersion in a bath or to a nonbath group who received routine care. Pharmacological pain relief was the primary outcome that was measured, and secondary outcomes included maternal and neonatal clinical outcomes, factors relating to maternal and neonatal infectious morbidity, psychological outcomes, and satisfaction with care. RESULTS: The use of pharmacological analgesia was similar for both the experimental and control groups; 85 and 77 percent, respectively, used major analgesia. No statistical differences were observed in the proportion of women requiring induction and augmentation of labor or in rates of perineal trauma, length of labor, mode of delivery, or frequency of cardiotocographic trace abnormalities. Neonatal outcomes (birthweight, Apgar score, nursery care, meconium-stained liquor, cord pH estimations) revealed no statistically significant differences. Infants of bath group women required significantly more resuscitation than routine group women. Routine group women rated their overall experience of childbirth more positively than bath group women. Psychological outcomes, such as satisfaction with care or postnatal distress, were the same for both groups. CONCLUSION: Bathing in labor confers no clear benefits for the laboring woman but may contribute to adverse effects in the neonate.

Analgesia, Obstetrical↗
PubMed1997

Urinary retention in the post-partum period. The relationship between obstetric factors and the post-partum post-void residual bladder volume.

OBJECTIVE: The three objectives of this study are: to investigate the incidence of post-partum urinary retention after vaginal delivery, to investigate the relationship between various obstetric parameters and the post-partum post-void residual bladder volume and to study the natural progression of the post-void residual bladder volume in patients with covert post-partum urinary retention. METHODS: Women who had a vaginal delivery (n = 691) in a teaching hospital during a 2-month period were studied. They were classified into three groups: normal patients, those with overt urinary retention, and covert urinary retention. Their day 1 post-partum post-void residual bladder volume were recorded and analyzed with respect to the obstetric parameters. Patients with covert retention were followed up daily with ultrasound to monitor their post-void residual volume. RESULTS: The incidences of overt and covert retention in our unit were 4.9% and 9.7%, respectively. The overall incidence of post-partum urinary retention after vaginal delivery was 14.6%. The duration of the first and second stages of labor were significantly associated with the post-partum post-void residual bladder volume. In all patients with covert retention, their post-void residual volume returned to normal within 4 days. CONCLUSION: Post-partum urinary retention is a common phenomenon that may be related to the process of parturition. Covert retention is a self-limiting phenomenon and specific treatment is unnecessary.

Adult↗
PubMed1977

[Pharmacokinetic of piracetam during labour influence to acid-base-status in maternal and fetal blood (author's transl)].

PIRACETAM concentrations in fetal and maternal blood were measured during the first and second stage of labor and the elimination in maternal and fetal blood was studied. Fetal heart-rate, pH- and base-excess of the maternal and fetal blood were investigated to evaluate the influence of PIRACETAM on the acid-base-status of mother and child. PIRACETAM was administered intravenously to 43 patients in a dosage 2 g, 4 g and 6 g. The concentration in the maternal and fetal plasma was measured by gaschromatography. Before and after the injection of PIRACETAM and at delivery, blood was sampled from the mother's earlobe and the umbilical artery and vein, respectively. The results were compared with a control group. There was an exponential fall of PIRACETAM concentration in maternal and fetal blood. Maternal and fetal elimination half-life of PIRACETAM was about 112-98 minutes and 200 minutes, respectively. A fairly good correlation between the concentration of PIRACETAM in maternal and fetal blood was found. The fetal PIRACETAM concentration was about 50% below the maternal values. Fetal heart-rate, maternal and fetal pH- and base-excess-values were not significantly altered following PIRACETAM infusion. It may be concluded, that there exists a transfer of PIRACETAM across the placental barrier. However, the cytoprotective effect of PIRACETAM, as described in animal observations and by investigations in human, could not be verified by the methods and technology used in this study.

Acid-Base Equilibrium↗
PubMed1986

Maternal upright posture and mobility in labor--a review.

There has been a relatively recent interest in alternative birthing techniques, including increased maternal mobility during labor. This literature review was pursued to evaluate the effect of upright maternal posture and ambulation on the first stage of labor. Although previous reviews frequently assume that maternal ambulation speeds labor progress, the data presented in this review are not conclusive as to whether the upright maternal posture or ambulation during the first stage of labor shortens labor length or improves fetal outcome. However, it is clear that ambulation in labor is not harmful either to the mother or fetus. In addition, many investigators have reported that mobility in labor results in greater maternal comfort and ability to tolerate labor and decreased use of anesthesia and analgesia. Thus, acceptance of mobility in labor by patients and staff is generally reported. This information can serve as a guide to clinical management. However, there is a need for further analysis of the effect of maternal ambulation during labor, and specific suggestions for research are presented.

Clinical Trials as Topic↗
PubMed2006

Complications associated with cesarean section in the second stage of labor.

OBJECTIVE: To determine maternal and neonatal complications associated with cesarean section done in the second stage of labor. METHOD: Cohort study comparing cesarean sections done in the second stage of labor (cases) with those done for poor progress in the first stage (controls). Only singleton cephalic live pregnancies at 36 weeks or more, without previous cesarean section, were included. RESULT: There were 39 cases and 39 controls. Cesarean section in the second stage of labor took significantly longer (median 45 vs. 30 min; P<0.001), and was associated with more frequent postoperative pyrexia (10 vs. 2; P=0.012). There were more neonatal admissions in the case group (17 vs. 3; P<0.001). Hypoxic ischemic encephalopathy was more frequent in infants following second-stage cesarean section (8 vs. 1; P=0.013), as was subaponeurotic hemorrhage (6 vs. 0; P=0.012). CONCLUSION: Cesarean section in the second stage of labor is associated with significant intraoperative and neonatal morbidity.

Adolescent↗
PubMed1994

Vaginal prostaglandins for the ripe cervix.

OBJECTIVES: To assess the efficacy of vaginal prostaglandin (PGE2) tablets for induction of labor in the presence of a ripe cervix. METHODS: A randomized controlled trial was performed. Two hundred and nine consecutive women undergoing induction of labor with a Bishop Score > or = 5 were randomly assigned to (a). Study group receiving PGE2 tablets (n = 106) and (b). Control group having artificial rupture of membranes only (n = 103). The duration of labor, oxytocin and analgesia requirements, the mode of delivery, complications and duration of confinement were recorded. RESULTS: Mean duration of first stage of labor was shorter in parous patients in the study group (194 min v. 319 min), as was the mean induction delivery interval in primigravidas. Oxytocin was used in 75% of primiparas and 40% multiparas in the study group compared with 100% and 80%, respectively, in the controls. Epidural analgesics and instrumental delivery rates were also reduced. CONCLUSIONS: The use of vaginal PGE2 tablets for induction of labor with a ripe cervix is associated with a shorter first stage of labor and with reduced requirements for oxytocin, analgesia and instrumental delivery.

Administration, Intravaginal↗
PubMed2002

Fetal blood saturation during the 1st and 2nd stage of labor and its relation to the neonatal outcome.

OBJECTIVE: The aim of this study was to evaluate fetal blood oxygenation (SpO(2)) by means of continuous pulse oximetry during labor and its relation to the neonatal outcome. MATERIALS AND METHODS: Fetal SpO(2) was measured continuously during labor with a noninvasive pulse oximetry for fetal application. The average, minimum and maximum SpO(2) levels were evaluated separately for the 1st and 2nd stage of labor. The average SpO(2) of the fetus was compared to the neonatal outcome assessed by the levels of pH, pO(2) and pCO(2) in the fetus' umbilical blood and to the Apgar score. RESULTS: Twenty-eight patients were monitored by fetal pulse oximetry. All the patients had normal, vaginal delivery. During the 1st stage of labor, the average fetal SpO(2) was 51.78 +/- 8.00%, the minimum SpO(2) level was 37.61 +/- 9.86%, and the maximum level of SpO(2) was 63.82 +/- 7.37%; in the 2nd stage of labor, the average SpO(2) level was 44.91 +/- 8.28%, the minimum level was 35.00 +/- 9.22%, and the maximum SpO(2) was 52.30 +/- 9.36%. A significant decrease in the fetal average and maximum SpO(2) levels was observed between the 1st and the 2nd stages of labor (the average SpO(2) was 51.78 +/- 8.00% vs. 44.91 +/- 8.28%, p = 0.00029; the maximum SpO(2) was 63.82 +/- 7.37% vs. 52.30 +/- 9.36%, p < 0.00001). A significant correlation between the average SpO(2) level during the 1st and 2nd stage of labor and the Apgar score at the first minute of outcome was observed (R = 0.43, p = 0.031). No relationship between the fetal SpO(2) during the 1st and the 2nd stage of labor and the pH, pCO(2), and pO(2) in the fetal umbilical blood were observed. CONCLUSIONS: During the 2nd stage of labor, a significant decrease in the fetus' SpO(2) can be observed. The fetus' SpO(2) level >30% in the 1st and 2nd stage of labor was related to the good neonatal outcome. The assessment of the fetal SpO(2) during the 1st stage of labor seems to be important in predicting neonatal outcome.

Adult↗
PubMed1983

Fetal activity acceleration during early labor.

Altogether 59 women (53 normal and 6 high-risk pregnancies) underwent a fetal activity acceleration determination (FAD) during the first stage of labor. 52 FAD were considered reactive, while 5 were non-reactive and 2 technically inadequate. Four of the 5 fetuses with a non-reactive FAD showed signs of fetal compromise during labor and 1 died intra-uterinely. There were significantly more normal births and non-compromised fetuses in the FAD reactive group than in the non-reactive (p less than 0.002, chi 2-test), while there were significantly more acute cesarean sections in the non-reactive group (p less than 0.001, chi 2-test). Of the 12 vacuum extractions (all in the FAD reactive group) 4 were performed because of prolonged 2nd stage and 8 because of suspected because of prolonged 2nd stage and 8 because of suspected intra-uterine asphyxia, but all infants did well after delivery, and the umbilical arterial pH was in all cases above 7.15. It is concluded that when a FAD test is reactive in the first stage of labor, one can expect a positive outcome of the birth, whereas a non-reactive test arouses suspicion of fetal compromise and implies that one must carefully monitor the progress of the birth so that the fetus can be delivered promptly if any sign of late decelerations should appear. A reactive FAD is, on the other hand, rather reassuring for the fetal state.

Delivery, Obstetric↗
PubMed1996

The effect of epidural fentanyl on the minimum local analgesic concentration of epidural chloroprocaine in labor.

The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration (EC50) in a 20-mL volume in the first stage of labor. The aim of this study was to determine the local anesthetic sparing efficacy of epidural fentanyl by its effect on the MLAC of chloroprocaine. Fifty-six parturients, not exceeding 7 cm cervical dilation, who requested epidural analgesia were allocated to one of two groups in this double-blind, randomized, prospective study. After placing a lumbar epidural catheter, 20 mL of the solution being tested was given: chloroprocaine (n = 28) or chloroprocaine with fentanyl 3 micrograms/mL (60 micrograms) (n = 28). The concentration of chloroprocaine was determined by the response of the previous patient to a higher or lower concentration using up-down sequential allocation. Analgesic efficacy was assessed using 100-mm visual analog pain scores with 10 mm or less within 30 min defined as effective. The MLAC of chloroprocaine was reduced from 0.43% wt/vol to 0.26% wt/vol by fentanyl (P = 0.023). Thus, the addition of epidural fentanyl 3 micrograms/mL (60 micrograms resulted in a significant 40% reduction in the MLAC of chloroprocaine in the first stage of labor.

Adult↗
PubMed2006

Oral misoprostol for induction of labor in prelabor rupture of membranes (PROM) at term: a randomized control trial.

OBJECTIVE: To compare the efficacy of two different dosages of oral misoprostol (50 and 100 microg) with control, in medical induction of labor for patients with prelabor rupture of membranes (PROM) at term. METHODS: One hundred women with PROM at term were randomized to receive placebo (vitamin B6 50 mg, control), 50 microg (treatment group 1), or 100 microg (treatment group 2) of oral misoprostol every 4 h to a maximum of six doses. The main outcome measures included time interval from onset of PROM to delivery, duration of first stage of labor, and occurrence of vaginal delivery within 24 h from PROM. RESULTS: The time intervals from PROM to delivery were significantly reduced in both treatment groups compared to control (control, 25.1+/-10.5 h; treatment group 1, 14.5+/-6.2 h; and treatment group 2, 13.0+/-6.1 h, p<0.0001 for both). The duration of the first stage of labor was significantly shortened only in treatment group 2 compared to control (3.3+/-2.5 versus 6.2+/-3.4 h, p=0.01). Of those who delivered vaginally (93% in treatment group 1 and 97% in treatment group 2), significantly more women delivered within 24 h of PROM in the treatment group compared to the control group (50%, p<0.05). CONCLUSIONS: Oral misoprostol 50 microg every 4 h is safe, cheap, and as effective as 100 microg in reducing the PROM to delivery time interval and labor duration in primiparous women. The same effect is not observed in a multiparous group.

Administration, Oral↗
PubMed2003

Analgesic efficacy of intramuscular opioids versus epidural analgesia in labor.

OBJECTIVES: To compare analgesic efficacy of intramuscular opioids: meperidine and tramadol with epidural analgesia. METHODS: One hundred and twenty-eight term nulliparous women with singleton pregnancy and vertex presentation were randomized to receive either epidural (n=43), meperidine (n=39) or tramadol (n=44). A visual analog scale (VAS) was used to assess the severity of pain. The parameters analyzed were analgesic efficacy, effect on labor, other maternal side effects, perinatal outcome and maternal satisfaction. RESULTS: Median VAS scores following first dose were 0 (0-5), 5 (3-8) and 5 (3-8) in epidural, meperidine and tramadol groups, respectively. Ninety percent of women rated analgesia as good to excellent in the epidural group as compared with 72% of women in the meperidine group and 65% in tramadol group. However, epidural caused a significant prolongation of first (P<0.05) and second (P<0.01) stage of labor with an increased number of operative deliveries (27% in the epidural, 7.6% in the meperidine, and 11.4% in the tramadol groups, P<0.05). In the epidural group 40% women had urinary retention and 16% had motor weakness, whereas sedation was the only side effect seen in the meperidine (41%) and tramadol groups (9%). Respiratory depression was noted among three neonates in the meperidine group, two in the tramadol group and none in the epidural group. CONCLUSIONS: The analgesic efficacy and maternal satisfaction is better with epidural analgesia than with opioids. Analgesia provided by meperidine and tramadol is comparable and approximately 50% of women rated the analgesia as good. Meperidine is better in the second stage than tramadol. Hence in developing nations where availability of facilities is the main limiting factor, intramuscular opioids can be considered suitable alternatives.

Adult↗