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At least 109 records · Page 6Linked to original sources
PubMed1991

Lateral retinaculum release in adolescent patellofemoral disorders: its relationship to peripheral nerve injury in the lateral retinaculum.

Adolescent patellofemoral disorders which are associated with recognizable change in the articular cartilage of the patella are called chondromalacia patellae. This is a clinical syndrome characterized by persistent retropatellar pain, but not always associated with histopathological changes of the articular cartilage. When lateral retinacular release is performed in such patients, pain is frequently eased even though lateral release does not always cause an appreciable change in patellofemoral contact pressure. This suggests that pain, at times, may emanate from the peripatellar retinacular supports themselves. Thirty-five knees of 22 patients suffering from anterior knee pain (with or without an unstable patella) were investigated histologically. Pathological changes in nerves were graded on a 0 to 3 + scale of severity. There was severe degenerative neuropathy in nine knees, moderate change in nine, and slight change in 11; the remaining six knees were normal. Histological investigation of the resected lateral retinaculum suggested that pain originated in the lateral retinaculum in many patients, and that degenerative changes in the nerves of the lateral retinaculum may be an important cause of pain in patients with patellofemoral disorders.

Adolescent↗
PubMed1989

[Lateral and lateral anterior approaches in tumors of the cervical vertebrae].

The limit of the standard anterior and posterior approaches on the cervical spine is a small area including the pedicle and transversary process. However, this area contains the vertebral artery and the merging cervical roots. The lateral-anterior route gives access to both structures while the lateral one leads mainly to the intervertebral foramen and nerve roots. Both techniques are described with stress on the great advantages of the lateral-anterior route: easy exposure, large operative field, possibility of complementary arthrodesis and venous graft by-pass on the vertebral artery. Experience on 14 cervical bony tumors resected through the lateral-anterior approach is reported. Complementary techniques were performed in 5 cases: carotid-vertebral artery by-pass in 1, laminectomy in 2 and bone grafting in 2. Therefore, the lateral anterior approach is considered a good way to deal with the intermediate part of the cervical spine.

Adolescent↗
PubMed1989

Unrecognized injuries of the lateral ligaments associated with lateral malleolar fractures of the ankle.

Of four patients who were treated between May 1985 and November 1987 and who had both a lateral malleolar fracture and a tear of the lateral ligaments of the ipsilateral ankle, three could be followed. The fractured malleolus was treated with rigid internal fixation, but the injury to the lateral ligaments was not diagnosed until the ankle was stressed to test for stability after the internal fixation. We believe that if disruption of the lateral ligaments is noted at operation, repair is indicated. This involves only a slight prolongation of time under anesthesia and markedly increases the chances for a stable ankle. It is important to check intraoperatively for a possible tear of the lateral ligaments in a patient who has a fracture of the ankle, especially when the injury was caused by high-energy trauma.

Adult↗
PubMed1983

Lateral retinacular release for intractable lateral retinacular pain.

Lateral retinacular release was performed in a series of patients with intractable lateral retinacular pain characterized by tenderness localized in some portion of the lateral retinaculum. Patients with other patellofemoral problems were excluded. Of 14 knees, 79% responded favorably. Lateral retinacular release may be best indicated in patients with less severe malalignment of the patella and intractable pain in the lateral retinaculum.

Adolescent↗
PubMed2000

Lateralized interhemispheric transfer of color cues: evidence for dynamic coding principles of visual lateralization in pigeons.

Visual feature discrimination tasks in pigeons reveal a right eye/left hemisphere dominance at the population level. Anatomical studies and lesion data show this visual lateralization to be related to asymmetries of the tectofugal system, which ascends from the tectum over the n. rotundus to the forebrain. Anatomically, this system is characterized by numerous morphological and connectional asymmetries which result in a bilateral visual representation in the dominant left hemisphere and a mostly contralateral representation in the subdominant right hemisphere. Ontogenetically, visual lateralization starts with an asymmetrical embryonic position within the egg, which leads to asymmetries of light stimulation. Differences in exposure to light stimulation between the eyes result in activity differences between the ascending tectofugal pathways of the left and the right hemisphere, which are transcribed during a critical time span into morphological asymmetries. The asymmetries established after this transient period finally start to determine the lateralized processes of the visual system for the entire life span of the individual. We now can show that these anatomical lateralizations are accompanied by asymmetries of interocular transfer, which enable a faster shift of learned color cues from the dominant right to the left eye than vice versa. In summary, our data provide evidence that cerebral asymmetries are based both on "static" anatomical and on "dynamic" process-dependent principles.

Animals↗
PubMed1994

Reciprocal connections of lateral septal neurons and neurons in the lateral hypothalamus in the rat: a combined phaseolus vulgaris-leucoagglutinin and Fluoro-Gold immunocytochemical study.

Reciprocal connections between lateral septal neurons and neurons in the lateral hypothalamus/lateral preoptic area were studied in the rat. The anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L) and the retrograde tracer Fluoro-Gold (FG) were simultaneously injected into the lateral septum. After double-immunocytochemistry, PHA-L-labeled terminals were found in synaptic contact with dendrites of retrogradely FG-labeled neurons in the lateral hypothalamic/lateral preoptic area.

Afferent Pathways↗
PubMed2006

Task-related laterality effects in the lateral occipital complex.

Using functional imaging, we investigated the effects of two different tasks on activation in the lateral occipital complex (LOC). Alternating blocks of intact and scrambled objects were presented. In one task, subjects responded when an object repeated (matching task). In a second task subjects silently named objects (naming task). Identical objects (tools, animals and letters) were presented for both tasks. A relative measure of the number of voxels activated in LOC in left and right hemispheres was calculated for each task across a range of thresholds. Also the effects of task demands on category specific areas in LOC were examined. The object matching task resulted in proportionally more activity in the right hemisphere. The object naming task resulted in proportionally more activity in the left hemisphere, most prominently in the anterior portion of LOC. Effectively, changing the task changed the lateralization of activation to intact objects in LOC. In contrast, changing the task did not change the lateralization of category-specific activations. The results suggest that there are task-related top-down influences on the activation of neural populations in LOC as a whole, but the lateralization of category-specific regions in LOC is independent of task demands and may reflect bottom-up processing.

Brain Mapping↗
PubMed2004

Sexual imprinting leads to lateralized and non-lateralized expression of the immediate early gene zenk in the zebra finch brain.

Sexual imprinting is an early learning process by which young birds acquire the features of a potential sexual partner. The physiological basis of this learning process is an irreversible reduction of spine densities in two forebrain areas, the lateral neo- and hyperstriatum (LNH) and the medial neo- and hyperstriatum (MNH). The aim of the present study was to investigate whether the immediate early gene zenk, which has been shown frequently to play a role in plastic processes in the song system of zebra finches, may also be involved in the structural changes observed in these areas. The first exposure to a female after an isolation period enhances zenk expression in a variety of brain areas including LNH, MNH, and optic tectum. In contrast to earlier results, it was only the neostriatal part of LNH which showed an enhancement on first courtship, while exposure to a nestbox enhanced the label within the entire LNH area. Unexpectedly, the IEG expression was clearly lateralized in some layers of the optic tectum. Because lateralization occurred independent of the experimental condition, our study adds to recent results which also support the idea of a lateralized organization of the avian visual system.

Animals↗
PubMed1999

Is there a sex difference in human laterality? III. An exhaustive survey of tactile laterality studies from six neuropsychology journals.

The contents of six neuropsychology journals (161 volumes, 612 issues) were screened to identify tactile laterality experiments. Of 73 experiments identified, 40% provided information about sex differences. Seventeen experiments yielded a total of 18 sex differences, of which 4 could be interpreted in terms of the hypothesis that functional cerebral lateralization is more pronounced in males. All 4 interpretable outcomes (constituting 5.5% of the population of experiments and 13.8% of the informative experiments) were found to be consistent with the differential lateralization hypothesis. The results, in isolation, do not justify rejecting the null hypothesis. However, when considered in conjunction with findings for auditory and visual laterality studies, the present results are compatible with a weak population-level sex difference.

Adult↗
PubMedDate not supplied

MRI versus lateral stress radiography in acute lateral ankle ligament injuries.

PURPOSE: Our goal was to compare the abilities of MRI and stress radiography to detect the extent of recent lateral ankle ligament inversion injuries. METHOD: In this prospective study, 60 athletically active patients (aged 18-45 years) with recent inversion trauma (< or = 7 days) underwent stress radiography and MRI. In 15 patients, the MR findings were reviewed at surgery. Patients were divided into three groups according to severity of ligament injury on MRI (no, one, or two to three ligament tears). Based on bilateral stress radiography, patients were classified into three groups according to the differential degree of talar tilt (< or = 5, 6-14, or > or = 15 degrees) and compared with patients from the MR groups. RESULTS: Surgery showed MRI to have 74% sensitivity and 100% specificity in the evaluation of complete lateral ankle ligament tears. Agreement between MR and stress radiography groups for the severity of recent lateral ankle ligament tears was poor (kappa = 0.030). CONCLUSION: MRI should be performed in young, athletically active patients if surgical intervention is contemplated, especially at 6-14 degrees talar tilt on stress radiography, since stress radiography tends to over- and underestimate the severity of lateral ligament trauma.

Acute Disease↗
PubMedDate not supplied

Interaction between lateralized systems: exploring the complexity of laterality.

To assess the extent of interaction between lateral biases in response systems at different levels of the neuraxis and detect the possible presence of different patterns of interaction related to population subgroups, we investigated laterality in hand reaching, whole-body turning and eye use in 20 bushbabies (Otolemur garnettii). Two subgroups were clearly identified: the STABLE group was composed of subjects, mainly females, that were consistent in hand preference and had correlation of hand/eye bias; the UNSTABLE group included subjects, mainly males, that showed instability in hand preference as a function of change in test conditions and had correlation of hand/turning bias. Results are interpreted to support the value of the study of interaction between lateral biases as a way of gaining a deeper understanding of the complexity of laterality.

Animals↗
PubMed1994

A molecular marker for lateral root initiation: the RSI-1 gene of tomato (Lycopersicon esculentum Mill) is activated in early lateral root primordia.

The frequency of lateral root initiation in tomato (Lycopersicon esculentum Mill cv. VFN8) seedling roots is increased over eightfold in response to 1.6 microM alpha-naphthalene-acetic acid (NAA). To identify genes that are activated during lateral root initiation, a cDNA library was made with RNA from roots treated with auxin and differentially screened with radioactive probes made from RNA isolated from treated and untreated roots. A cDNA clone, TR132, was identified that hybridized to a transcript that was induced within 4 h of auxin treatment and increased tenfold by 72 h. A gene (RSI-1) corresponding to the TR132 cDNA was cloned and characterized with regard to its nucleotide sequence, transcription start site and chromosomal map position. Approximately 1 kb of the 5' flanking DNA was linked to the beta-glucuronidase (GUS) protein coding region and tested for expression in transgenic tomato seedlings. GUS activity was observed in both lateral and adventitious root initials, including very early initials, and persisted until shortly after the lateral emerged from the parent tissue. In roots from seedlings with high activity, GUS expression was also observed in the root cap and vascular tissue. The predicted RSI-1 protein is rich in cysteine, lysine and proline, and includes an N-terminal region with characteristics of a signal peptide. The putative mature protein exhibits 79% amino acid identity to a protein encoded by a gene (GAST1) that is induced by gibberellic acid in tomato shoots.

Amino Acid Sequence↗
PubMed1996

Microsurgical management of lateral lumbar disc herniations: combined lateral and interlaminar approach.

Seventy-three patients presenting either with biradicular symptoms caused by involvement of the upper and lower root or with monoradicular symptoms caused by affection of the upper root were treated between January 1993 and July 1995 in our department. An interlaminar and lateral access was used to decompress both the upper and lower root by combining the conventional interlaminar approach and a lateral partial facetectomy. With this technique, satisfactory to excellent results were obtained in 92% of the patients. The advantages of the combined approach are (i) optimized visualization of the disc and surrounding anatomical structures, (ii) improved exposure of the lateral foramen and thorough removal of disc material, (iii) minimal risk of root injury by improved visualization, (iv) preservation of a functional facet joint and thereby reduction of postoperative instability with persistent back pain. Since occasionally lateral disc herniations are poorly visualized by computed tomography or magnetic resonance imaging, the decision to use the combined approach should be guided by the patient's clinical presentation rather than by radiological findings.

Female↗
PubMed1987

Lateralized functional relationship between the preoptic area and lateral hypothalamic reinforcement.

Electrical self-stimulation in the lateral hypothalamus of both hemispheres was recorded in 14 rats before and after administration of a unilateral ibotenic acid lesion of the cell bodies in the region of the lateral preoptic area. A significant decrease in the rate of self-stimulation at each of two stimulation intensities was found when the electrode was placed in the hemisphere in which the ibotenic acid lesion was made. This decrease remained constant over 21 days of testing. No changes were detected in rate of self-stimulation in the intact contralateral hemisphere. These results provide evidence for a role in lateral hypothalamic self-stimulation of intrinsic neurons located in the region of the lateral preoptic area.

Animals↗
PubMed2006

A working-side change to lateral tooth guidance increases lateral pterygoid muscle activity.

UNLABELLED: The inferior head of lateral pterygoid (IHLP) is thought to play a critical role in the generation and control of lateral jaw movements. AIM: The aim was to test the hypothesis that a change to the lateral tooth guidance (working-side occlusal alteration, OA) results in a significant change in the electromyographic (EMG) activity of the IHLP during standardised lateral jaw movements (laterotrusion) tracked by a jaw-tracking system. METHODS: Ten trials of right laterotrusion were repeated under: control 1 (before occlusal alteration), OA (after occlusal alteration placement), and control 2 (after occlusal alteration removal) conditions in 14 subjects while recording left IHLP, bilateral anterior and posterior temporalis, masseter and submandibular muscles. RESULTS: IHLP activity was significantly (p<0.05) increased with the occlusal alteration during the outgoing (movement from intercuspal position to approximately 5mm right) and return phases of laterotrusion. The other muscles demonstrated no change or a significant decrease in activity. CONCLUSIONS: These findings suggest that a change to the occlusion on the working-side in the form of a steeper guidance necessitates an increase in IHLP activity to move the mandible down the steeper guidance. It must be emphasised that these data cannot be used as justification for occlusal therapy.

Adolescent↗
PubMedDate not supplied

A comparison of lateral popliteal versus lateral midfemoral sciatic nerve blockade using ropivacaine 0.5%.

BACKGROUND AND OBJECTIVES: The midfemoral approach to the sciatic nerve (MF) is a new technique that has been used for postoperative analgesia after knee surgery. The aim of the present study was to compare efficacy, performance time, and patient acceptance of the midfemoral approach to that of the lateral approach at the level of the popliteal fossa (popliteal block [PB]). METHODS: Sixty-three patients were enrolled in this prospective, randomized study. Thirty-two patients received a lateral sciatic nerve block (group PB) and 31 patients a midfemoral block (group MF). Ropivacaine 0.5% (30 mL) was used in both groups. RESULTS: The quality of nerve blockade was comparable in both groups. Onset of sensory block for peroneal and tibial nerves was significantly shorter in group MF than in group PB, 5 (1-20) minutes and 5 (1-20) minutes versus 10 (1-40) minutes and 10 (1-45) minutes, respectively. Onset of motor block in both territories was also shorter in group MF compared with PB, 6 (2-35) minutes and 5 (2-55) minutes versus 15 (2-60) minutes and 15 (2-60) minutes, respectively (P <.05). There was no difference in duration of sensory and motor blockade, 16 (7-32) hours versus 16 (6-43) hours and 16 (8-32) hours versus 16 (6-25) hours. There was no significant difference between both groups with respect to difficulty of nerve block performance. Patient discomfort during needle puncture was also similar. CONCLUSIONS: The midfemoral approach to the sciatic nerve for ankle and foot surgery resulted in a reliable anesthetic, comparable to that of the lateral popliteal approach. This technique is simple, safe, and provides postoperative analgesia as effective as that obtained with the lateral approach.

Adult↗
PubMed1999

Transverse and lateral mobility in outer hair cell lateral wall membranes.

Cochlear outer hair cell (OHC) electromotility is associated with the cell's lateral wall. The lateral wall contains two distinct membranes: the plasma membrane (PM) and the subsurface cisternae (SSC). We explored biophysical characteristics of these lipid structures using membrane-specific fluorescent dyes. We have previously demonstrated that di-8-ANEPPS stains the PM while NBD-C6-ceramide partitions to the SSC. In this report we show that NBD-cholesterol also partitions to the SSC. Transmigration of the SSC dyes across the PM was visualized under confocal microscopy, after separating the two membranes using the micropipette aspiration technique. The transverse mobility of NBD-cholesterol was faster than that of NBD-C6-ceramide. We then measured the lateral mobility of the dyes within both the PM and the SSC using fluorescence recovery after photobleaching (FRAP). The diffusion coefficients at 12 37 degrees C and the activation energies for diffusion were found to be similar to those of other biological membranes. These data indicate that both the PM and the SSC are membranes in the fluid phase, with no evidence of temperature-dependent phase transitions. Our observations are consistent with a fluid-mosaic model of the lateral wall membranes.

4-Chloro-7-nitrobenzofurazan↗
PubMedDate not supplied

Lateral division of the lateral posterior region: connections with area 18 in cats.

To establish the topography of the lateral division of the lateral posterior region (LP1) projections to area 18, up to five different anatomical tracers were injected in separate rostrocaudal locations in area 18 of four adult cats, and patterns of retrogradely labeled LP1 cells were identified. LP1 inputs to area 18 arose from both caudal and rostral nuclei and were topological, organized in patterns that indicate that lower visual space is represented anteroventrally, and more central and upper visual space is represented caudodorsally. In the caudal LP1 nucleus, patches of labeled cells formed bands that ran parallel to the medial and lateral LP1 borders and encompassed medial portions of the nucleus. In rostral LP1, the patches of labeled cells formed clusters giving the connections with area 18 a more modular appearance, and were nearer the lateral LP1 border. Injections made nearest area centralis representations in area 18 labeled more neurons than injections in cortex representing more peripheral visual space. Also, neighboring injections in area 18 labeled overlapping patches of cells, but no double-labeled cells were observed. These findings are consistent with previous conclusions based on electrophysiological mapping studies, that two retinotopically organized nuclei constitute LP1.

Animals↗