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At least 109 records · Page 6Linked to original sources
PubMed1994

Electrophysiological studies on light damage in the mouse retina after sodium iodate injection.

Acute experimental retinal degeneration was induced in 3-month-old mice with sodium iodate (NaIO3) injection to investigate the effect of bright light with electroretinography (ERG). Eight C 57 black male mice were anesthetized. The ERG was recorded before and 24 h after the injection of NaIO3. Next, only one eye of each mouse was exposed to a bright light of 3.0 x 10(4) lx white light for 30 min. Ten hours later, ERGs of both the light-exposed and the unexposed eye were recorded. The amplitudes and peak latencies of the a wave and b wave were measured. The ERG was recorded as both eyes were exposed to stimulating flashes that were given in an increasing order of 0.6 log unit steps from the dimmest flash to produce a detectable ERG. The ERG from the light-exposed eye showed a distinctly elevated threshold (approx 2.0 log), while the contralateral unexposed eye did not. The peak latencies of both waves were significantly prolonged by exposure to light. In conclusion, light exposure affected ERG thresholds in mice with experimentally induced acute retinal degeneration.

Animals↗
PubMed2003

Quantum yield of the iodide-iodate chemical actinometer: dependence on wavelength and concentrations.

The quantum yield (QY) of the iodide-iodate chemical actinometer (0.6 M KI-0.1 M KIO3) was determined for irradiation between 214 and 330 nm. The photoproduct, triiodide, was determined from the increase in absorbance at 352 nm, which together with a concomitant measurement of the UV fluence enabled the QY to be calculated. The QY at 254 nm was determined to be 0.73 +/- 0.02 when calibration was carried out against a National Institute of Standards and Technology traceable radiometer or photometric device. At wavelengths below 254 nm the QY increased slightly, leveling off at -0.80 +/- 0.05, whereas above 254 nm the QY decreases linearly with wavelength, reaching a value of 0.30 at 284 nm. In addition, the QY was measured at different iodide concentrations. There is a slight decrease in QY going from 0.6 to 0.15 M KI, whereas below 0.15 M KI the QY drops off sharply, decreasing to 0.23 by 0.006 M KI. Calibration of the QY was also done using potassium ferrioxalate actinometry to measure the irradiance. These results showed a 20% reduction in QY between 240 and 280 nm as compared with radiometry. This discrepancy suggests that the QY of the ferrioxalate actinometer in this region of the spectrum needs reexamination.

Iodates↗
PubMed2004

Cyclodextrin-aided determination of iodate and bromate in drinking water by microcolumn ion chromatography with precolumn enrichment.

A selective and simple method for the determination of iodate (IO3-) and bromate (BrO3-) by microcolumn ion chromatography (IC) is presented. In this study, IO3- and BrO3- were determined as IBr2- and tribromide (Br3-), respectively, via a postcolumn reaction with bromide (Br) under acidic conditions with the aid of alpha-cyclodextrin (alpha-CD) in microcolumn IC. IO3- and BrO3- were selectively detected by the present method at a wavelength of 253 or 265 nm. The present system achieved good selectivity for IO3- and BrO3- as well as good repeatability under suitable conditions. Precolumn enrichment improved the detection limit, and allowed the determination of BrO3- in bottled water as low as sub microg L(-1) level in microcolumn IC.

Bromates↗
PubMed2006

Indirect kinetic spectrophotometric determination of hydroxylamine based on its reaction with iodate.

A simple, precise and accurate method is proposed for rapid determination of trace amounts of hydroxylamine based on the reaction of hydroxylamine with iodate in acidic media. The reaction of neutral red by the produced nitrite ion was used to monitor the reaction spectrophotometrically at 525 nm by a fixed time method. Hydroxylamine in the range of 0.0400-1.200 microg mL(-1) could be determined. The relative standard deviation for 10 determinations of 0.500 microg mL(-1) hydroxylamine was 1.81% and the limit of detection was 0.010 microg mL(-1). The proposed method was applied to the determination of hydroxylamine in water samples with satisfactory results.

Alcohols↗
PubMed1994

[A procedure for recording electroretinogram (ERG) with a contact lens-type electrode, and effect of sodium iodate on ERG in rats].

A procedure for recording the electroretinogram (ERG) in rats with a contact lens-type electrode was developed in order to examine visual toxicity overtime. Rats received a single intravenous injection of sodium iodate (SI), a retinotoxic compound, via the tail vein at a dose of 12.5, 20, 25 or 50 mg/kg, and the ERG was recorded for 10 days after dosing. Histopathologic examination of the retinas was then conducted. 1. The rats were anesthetized with ketamine hydrochloride (50 mg/kg, i.m.) after 90 to 120 min of dark-adaptation. Thirty-two responses to repetitive 1.2 joule light stimuli at 0.5 Hz interstimulus intervals were averaged by a microcomputer. Under these conditions, stable ERG a-wave, b-wave and oscillatory potentials could be recorded for 10 days. 2. At 12.5 mg/kg of SI, no treatment-related abnormalities were observed on the ERG. Doses of 20 mg/kg or more of SI caused depression of the amplitudes of the ERG a-wave and oscillatory potentials 2 hrs or 1 day after dosing. Following these changes, the amplitude of the ERG b-wave decreased 1 or 2 days after dosing. 3. Upon histopathologic examination of the retina, folding of the outer nuclear layer, disarrangement of the rods and cones and swelling and decrease of the pigment epithelial cells were observed at 20 mg/kg or more. The severity of the retinal lesions correlated well with the changes in the ERG. 4. Using this recording technique, it was confirmed that a stable ERG could be recorded repeatedly in rats, and the effects of SI on the ERG could be detected. Furthermore, histopathologic examination revealed that the severity of the retinal lesions correlated well with the changes in the ERG. These results indicate that the ERG recording technique employed in this study is useful for evaluating retinal toxicity in rats.

Animals↗
PubMed1996

[A procedure for recording electroretinogram (ERG) and effect of sodium iodate on ERG in mice].

A procedure for recording the electroretinogram (ERG) in mice with a coiled stainless steel-type electrode was developed in order to examine retinal toxicity. Mice received a single i.v. of sodium iodate (SI), a retinotoxic compound, via the tail vein at a dose of 12.5, 25, or 50 mg/kg, and the ERG was recorded periodically for 28 days after dosing. In addition, the retina was examined histopathologically on day 30 after dosing. 1. The mice were anesthetized with mixed anesthetics of urethane, xylazine and ketamine after 30 to 60 min of dark-adaptation. Sixteen responses to repetitive 1.2 J light stimuli at a frequency of 0.2 or 0.1 Hz were averaged by a microcomputer. Body temperature of the mice was kept constant at 37 to 38 degrees C using a thermostatically controlled heating mat. Under these conditions, stable ERG a-wave, b-wave, oscillatory potentials and c-wave could be recorded for 28 days. 2. SI at doses of 25 mg/kg or more caused depression of the amplitudes of the oscillatory potentials, and enhancement of the a- and b-wave amplitudes, while the c-wave was already extinguished on day 1 after dosing. Following these changes, the amplitudes of the a- and b-wave decreased from day 3 or 7 after dosing. These changes did not recover until day 28 after dosing. 3. Upon histopathologic examination of the retina, folding of the outer nuclear layer, disarrangement of the rods and cones, decrease of the visual cells and swelling and decrease of the pigment epithelial cells were observed with SI at 25 mg/kg or more. 4. Using this recording technique, it was confirmed that a stable ERG was recorded repeatedly for 28 days in mice, and the effects of SI on the ERG could be detected. Histopathologic findings in the retina revealed the abnormal portions were correlated well with the changes in the ERG. These results indicate that the ERG recording procedure developed in this study is useful for evaluating retinal toxicity in mice.

Animals↗
PubMed1984

[Effects of sodium iodate, iodoacetic acid and ethambutol on electroretinogram and visual evoked potential in rats].

The effects of sodium iodate (SI), iodoacetic acid (IAA) and ethambutol (EB) on the electroretinogram (ERG) and the visual evoked potential (VEP) were examined in unrestrained rats. A single intravenous dose of SI at 25 mg/kg caused depression of amplitudes of the ERG a-wave and oscillatory potentials 24 hrs after dosing. Following these changes, the amplitude of the ERG b-wave decreased. The depression of the VEP was observed in parallel with the depression in amplitude of the ERG. A single intravenous dose of IAA, even at a dose of 60 mg/kg which induced death of the rats, did not cause any significant abnormality in the ERG and VEP. Repeated subcutaneous dose of EB at 500 mg/kg/day depressed the amplitude of the P1-N1 wave and prolonged the peak latency of the P1 and N1 waves of the VEP without affecting the ERG after administration for 5 to 6 weeks. These abnormalities of the VEP appeared almost in parallel with ataxic gait. Neither gross behavioral changes suggesting visual disturbances nor abnormal ocular fundus was revealed in any rat receiving SI or EB even when marked depression of the ERG and/or VEP was observed. These results indicate that SI damages retinal function and EB does the conduction pathways from the retina to the visual cortex. In addition, the simultaneous recordings of both the ERG and VEP in unrestrained rats were found to be useful for evaluating the visual toxicity, and to furnish useful information on the site of toxic action of drugs.

Animals↗
PubMed1975

[The time course of radioiodine distribution in chicks after iodate treatment].

The radioiodine (131Jodine) excretion in chicken is increased after the treatment with iodate, the radioiodine uptake in the thyroid gland is decreased. The percentage of intra- and extrathyroidal radioiodine 24 hours after the injection is similar in all groups. It seems that these findings are due to isotopedilution effects.

Animals↗
PubMed1956

The stability of potassium iodate in crude table salt.

An experiment carried out by the authors confirms that the addition, under commercial conditions, of potassium iodate to crude sea salt is a reliable method for the iodization of salt, a fact of particular significance to countries in which iodization by potassium iodide is unsatisfactory owing to adverse environmental conditions.

Environment↗
PubMed1992

Transient increase of b-wave in the mouse retina after sodium iodate injection.

Twenty C57 black mice received an injection of 40 mg/kg of sodium iodate through the caudal vein. The electroretinograms (ERGs) were recorded before and after injection. Flash stimuli with the maximum illuminance, 30,000 lux, were given at increasing levels of illuminance in 0.6 log U steps for 13 levels of intensity. The a- and b-wave amplitudes increased linearly with increased stimulus intensity for approximately 5.0 log U before being saturated. Twenty four hours after injection, the intensity-amplitude curve shifted toward the higher intensity region. It was calculated that the sensitivity loss of the b-wave after injection was 2.0 log U, although the maximum amplitude was larger and the peak latency was delayed. The same results were seen less obviously in the ERGs 48 hr after injection. After 96 hr, both waves were greatly attenuated and even abolished. At the time the increased ERGs were recorded, the histopathologic findings exhibited severe damage of the retina in the pigment epithelium and in the outer layer.

Animals↗
PubMed1991

[Participation of sodium iodate in the induction of experimental autoimmune uveoretinitis (EAU)].

It is known that Brown Norway (BN) rats show resistance to the development of experimental autoimmune uveoretinitis (EAU). Although BN rats don't develop EAU easily when they were immunized with S antigen containing emulsified complete Freund's adjuvant, this paper reports on the development of EAU at the rate of 40-60% in BN rats when immunization is preceded by an injection of more than 0.5 mg (1.79 mg/kg of body wt) of sodium iodate which leads to the destruction of retinal pigment epithelium (RPE). It was thought that the destruction of RPE participated in the induction of EAU. Therefore, it is considered that the existence of RPE may play an important role in the induction of EAU.

Animals↗
PubMed1990

[Early effects of sodium iodate shown by detection of the destruction of anionic sites in outer blood-retinal barrier].

In order to demonstrate the early effect of sodium iodate (NaIO3) on retinal pigment epithelium (RPE), Bruch's membrane and choriocapillaries, we examined the alteration of their anionic sites using a cationic probe, polyethyleneimine (PEI). We injected 10 microliters of 3% NaIO3 solution into the vitreous of pigmented rabbits and after thirty minutes or one hour, administered 0.5% PEI intravenously. In the eyes injected with intravitreously saline solution or without injection, PEI-positive particles (diameter 15-20 nm) were located in a row on both sides of the basement membrane of the RPE and choriocapillaries and periodically at the collagen fiber of inner and outer collagenous zone of Bruch's membrane. However no particle was observed on the cell membrane of the basal infolding of the RPE. Thirty minutes after injection of NaIO3, PEI particle positive sites were reduced at the basement membrane of the RPE. One hour after injection they reduced in number but remained at the basement membrane of choriocapillaris and collagens in Bruch's membrane. We showed the early effect of NaIO3 to the RPE by examining the alterations of the anionic sites.

Animals↗
PubMed1986

Sucrose permeability of the blood-retinal and blood-brain barriers. Effects of diabetes, hypertonicity, and iodate.

The permeabilities of the blood-retinal (BRB) and blood-brain (BBB) barriers to sucrose were determined simultaneously using an intravenous injection technique in the rat. The method involved direct sampling of retinal tissue in order to avoid errors caused by sucrose penetration across other components of the blood-ocular barrier. The permeability X surface area (PS) product for the BRB was approximately four times greater than for the BBB. Intracarotid infusion of a hypertonic arabinose solution resulted in a dose-dependent increase in the permeability of both barrier systems. In contrast, 24 hr after treatment of animals with iodate, the PS product for the BRB but not the BBB was increased. The permeability of the blood-retinal barrier to sucrose was measured in normal and 2-, 6-, and 20-week streptozocin diabetic rats. The BRB was unaffected at 2 and 6 weeks of diabetes, and showed only a small increase in permeability at 20 weeks. Our results suggest that alterations in the blood-ocular barrier in early diabetes do not result from an increased passive permeability of the BRB. The method described should permit direct comparison of BRB and BBB permeabilities to a variety of compounds under various conditions.

Animals↗
PubMed1984

[Adsorption behavior of radioactive iodide and iodate in soil].

The adsorption behavior of radioiodine on soils has been studied. Soils were collected in Tokai, Ibaraki Pref . and classified with soil texture and contents of organic matter. Carrier-free radioiodine in iodide form is adsorbed on soil independent of soil properties, while radioiodine in iodate form is more readily adsorbed on soil which is abundant in organic, matter.

Adsorption↗
PubMed1994

[Scanning electron microscopic observation on altered fenestration of the choriocapillaris in sodium iodate-treated rats].

Fenestration of the choriocapillaris may be lost and regained in various pathologic conditions. The purpose of this study was to observe the gradual disappearance of fenestrae with the scanning electron microscope. Pigmented rats were treated with an intravenous injection of sodium iodate. Changes in the choriocapillaris were produced by damaging retinal pigment epithelium. The eyes were processed for styrene embedded cracking on the third, fifth, and seventh days. Dense clusters of fenestrae were seen at the luminal surface facing retina on the third day. These clusters were surrounded by protrusion of cellular surface. The clusters of fenestrae were smaller with some variation in size on the fifth and seventh days. The protrusion between the clusters became flatter and wider. Some endothelial cells had a flat surface with tiny clusters of fenestrae. Although there was loss of fenestrae with smaller clusters and some variation in size, the tendency of the fenestrae to cluster was sustained in the same way as during the reformation of fenestrae in the choriocapillaris after laser photocoagulation.

Animals↗
PubMed2005

New d0 transition metal iodates: synthesis, structure, and characterization of BaTi(IO3)6, LaTiO(IO3)5, Ba2VO2(IO3)4.(IO3), K2MoO2(IO3)4, and BaMoO2(IO3)4.H2O.

Five new d0 transition metal iodates, BaTi(IO3)6, LaTiO(IO3)5, Ba2VO2(IO3)4.(IO3), K2MoO2(IO3)4, and BaMoO2(IO3)4.H2O, have been synthesized by hydrothermal methods using Ba(OH)2.8H2O, La2O3, K2CO3, TiO2, V2O5, MoO3, and HIO3 as reagents. The structures of these compounds were determined by single-crystal X-ray diffraction. All of the reported materials have zero-dimensional or pseudo-one-dimensional crystal structures composed of MO6 (M = Ti4+, V5+, or Mo6+) octahedra connected to IO3 polyhedra. Infrared and Raman spectroscopy, thermogravimetric analysis, and UV-vis diffuse reflectance spectroscopy are also presented. Crystal data: BaTi(IO3)6, trigonal, space group R-3 (No. 148), with a = b = 11.4711(10) A, c = 11.1465(17) A, V = 1270.2(2) A3, and Z = 3; LaTiO(IO3)5, monoclinic, space group P2(1)/n (No. 14), with a = 7.4798(10) A, b = 18.065(2) A, c = 10.4843(14) A, beta = 91.742(2) degrees , V = 1416.0(3) A3, and Z = 4; Ba2VO2(IO3)4.(IO3), monoclinic, space group P2(1)/c (No. 14), with a = 7.5012(9) A, b = 33.032(4) A, c = 7.2150(9) A, beta = 116.612(2) degrees , V = 1598.3(3) A3, and Z = 4; K2MoO2(IO3)4, monoclinic, space group C2/c (No. 15), with a = 12.959(2) A, b = 6.0793(9) A, c = 17.748(3) A, beta = 102.410(4) degrees , V = 1365.5(4) A3, and Z = 4; BaMoO2(IO3)4.H(2)O, monoclinic, space group P2(1)/n (No. 14), with a = 13.3368(17) A, b = 5.6846(7) A, c = 18.405(2) A, beta = 103.636(2) degrees , V = 1356.0(3) A3, and Z = 4.

Journal Article↗