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Generalizing, optimizing, and inventing numerical algorithms for the fractional Fourier, Fresnel, and linear canonical transforms.

By use of matrix-based techniques it is shown how the space-bandwidth product (SBP) of a signal, as indicated by the location of the signal energy in the Wigner distribution function, can be tracked through any quadratic-phase optical system whose operation is described by the linear canonical transform. Then, applying the regular uniform sampling criteria imposed by the SBP and linking the criteria explicitly to a decomposition of the optical matrix of the system, it is shown how numerical algorithms (employing interpolation and decimation), which exhibit both invertibility and additivity, can be implemented. Algorithms appearing in the literature for a variety of transforms (Fresnel, fractional Fourier) are shown to be special cases of our general approach. The method is shown to allow the existing algorithms to be optimized and is also shown to permit the invention of many new algorithms.

Journal Article↗

Nothing new under the sun: an examination of newly discovered inventions and techniques.

Dental practitioners of generations ago had the foresight and ingenuity to produce many useful ideas and techniques that, unfortunately, were forgotten. Great effort could have been spared had closer attention been given to the inventions and successes of our forebears. Perhaps, the status of dentistry might be even greater had we been more aware of our heritage and had we built on our history.

Anesthesia, Dental↗

[Health care: the place for the invention of a new scientific paradigm].

It is an essay about Care, basis of the practice and research, as place of invention, test, criticism and reconstruction of the Nursing specific knowledge. Health and well-being, quality, "L'état de l'art" and, yet, the experience of caring at the patients and Nurses' bodies are discussed.

Diffusion of Innovation↗

Predicting commercial success for Australian medical inventions patented in the United States: a cross sectional survey of Australian inventors.

OBJECTIVES: To examine the commercial development of Australian medical patents and identify the determinants of their being used in innovations (new or improved products or production processes). DESIGN: Cross-sectional survey with a nested case-control study. PARTICIPANTS AND SETTING: 177 inventors listed as the first Australian on medical patents granted in the United States between 1 January 1984 and 30 December 1994, and surveyed in 1998-1999. MAIN OUTCOME MEASURE: A series of predictor variables (including characteristics of the patents; characteristics of the inventors; ideas, advice and funding during commercialisation; and the process of commercialisation) for whether or not a patent became an innovation. RESULTS: Half (89/177) of the medical patents became innovations, with 34% generating a total of A $287 million (13% over $1 million) in annual sales a median of 8 years after the patent had been granted. A patent was more likely to become an innovation if the inventor was employed by industry at the time of invention (odds ratio [OR], 3.2; 95% CI, 1.1-9.2), had invested their own finances (OR, 2.8; 95% CI, 1.0-7.4), and if the patent had been licensed (OR, 4.6; 95% CI 1.7-12.7), led to further patents (OR, 3.2; 95% CI, 1.0-10.4) and involved an industry partner in its commercial development (OR, 10.1; 95% CI, 3.6-27.7). It was less likely to become an innovation if finance came from a research funding agency (OR, 0.3; 95% CI, 0.1-0.8) and if interest from Australian industry was judged by inventors as "poor" (OR, 0.6; 95% CI, 0.4-0.9). CONCLUSIONS: Medical patents in the US listing Australian inventors are more likely to become innovations if they originate from industry rather than the public sector, and if inventors are willing to invest their own finances.

Australia↗

Patenting inventions in combinatorial chemistry.

I have intended to provide an overview of some patent strategies for protecting intellectual property in the combinatorial chemistry arts, along with examples taken from recently issued patents. The opinions in this paper are those of the author, and are not intended to be relied upon as legal advice. Specific questions about any particular patent or invention should be discussed with competent counsel before action is taken. If you would like to look at the patents discussed in this article, they are available on-line at http:¿www.patents.ibm.com/boolquery and at other locations.

Combinatorial Chemistry Techniques↗

[Nullification appeal presented by the Dutch Kingdom against the Directive 98/44 on the legal protection of biotechnological inventions].

The author studies the Appeal of revocation by the Kingdom of Holland against the Directive 98/44 concerning the juridical protection of biotechnological inventions. The main reasons of the Appeal are: the election of a mistaken juridical base; the infraction of the principle of subordination; the violation of the principle of juridical security; the non-fulfillment of the obligations of the International Law; the violation of the fundamental rights; and the infraction of the principle of collegiality.

Biotechnology↗

[The European directive 98/44/CE on legal protection of biotechnologic inventions].

After a lengthy process, a full decade after work first commenced, at last the European Directive on legal protection of biotechnology inventions has been adopted (Directive 98/44/EC, by the European Parliament and Council, 6 July 1998. In this article the author provides an interesting study of the Directive, and discusses how the text arrived at its definitive version by comparing it with previous drafts and proposals put forward since the original one of 21 October 1988.

Bioethics↗

[Deposition of microorganisms at patenting the invention and results for the inventor].

The standards of the patent legislation of Ukraine and other countries concerning the deposition of microorganisms at patenting of the invention and conditions for the availability of the deposited samples have been considered. The questions connected to practice of strains deposition in Ukraine which require the normative decision or specification in view of the tendency of development of patent legislation in the countries advanced in the sphere of the industrial property have been outlined.

Microbiology↗

[The first invention patents in general anaesthesia].

Dra, Zimmer describes in this work the evolution of general anaesthesia for surgeries, quoting the recorded invention patents, since the 1st one performed in France - an ether anaesthesia - in 1846, 2 years after Wells had used nitrous oxide as gas for a surgery (december 1844).

Anesthesia, Dental↗

[Comment on the ruling about the appeal against the Directive on biotechnological inventions].

The author examines the content of the European Court of Justice ruling which dismisses the appeal lodged by the Netherlands against Directive 98/44 concerning the legal protection of biotechnological inventions. The main grounds for the appeal were as follows: inappropriate choice of points of law; breach of the principle of subsidiarity; violation of the principle of legal certainty; breach of International Law obligations; undermining of human dignity; breach of the principle of collegiality.

Biotechnology↗

Inventing the future of physicians and information technology: methods and results of the 1997 Lafayette Parish Medical Society Information Systems and Information Technology Project.

This paper challenges physicians to consider how to best invent a future in which they can personally leverage emerging information and communication technologies to maximize their effectiveness and efficiency as care givers. One Louisiana State Medical Society component medical society has already posed this challenge to its members. The paper describes the 1997 Lafayette Parish Medical Society Physicians' Information Systems and Information Project, conducted on behalf of the society by faculty of the Healthcare Administration MBA Program at the University of Southwestern Louisiana. Specific recommendations for application of health care information technologies by physicians and by health care institutions, based on findings and conclusions of the project, are highlighted.

Data Collection↗

[Endoscopic local ablation therapy (ELAT) for hepatocellular carcinoma--inventive approaches to achieve radical treatment and to expand the indication of ELAT].

We introduce some inventive approaches in endoscopic local ablation therapy (ELAT) for patients with hepatocellular carcinoma (HCC). ELAT is applied in cases of HCC when the tumor is smaller than 3 cm on the surface of the liver (smaller than 4 cm with extrahepatic growth), and tumor numbers < or = 3. Appropriate use of the laparoscopic, thoracoscopic and hand-assisted approaches, suitable preceding embolizations with the angiographic technique, a combination of ablation therapy, and the use of CO2-angio US, DIMON puncture system and cluster needle are important. If necessary, additional surgeries such as endoscopic hepatectomy, laparoscopic cholecystectomy or laparoscopic devascularization must be performed together. As a result, it will be possible to expand the indication of ELAT safely and radically.

Carcinoma, Hepatocellular↗

Systematic Inventive Thinking: a new tool for the analysis of complex problems in medical management.

The complexity of medical problems is a well-recognized phenomenon. In the presence of economic and cultural restrictions, medical decision-making can be particularly challenging. This paper outlines a system of analysis and decision-making for solving such problems, and briefly describes a case study in which the method was used to analyze the case of antibiotic overprescribing in a large health maintenance organization. The purpose of the study was to determine if a technique for problem-solving in the field of engineering could be applied to the complex problems facing primary care. The method is designated Systematic Inventive Thinking and consists of a three-step procedure: problem reformulation, general search-strategy selection, and an application of idea-provoking techniques. The problem examined is the over-prescribing of antibiotics by general practitioners working in Maccabi Healthcare Services, an HMO serving one and a half million patients in Israel. The group of healthcare professionals involved in the discussions generated 117 ideas for improving antibiotic use. Six of these ideas were then implemented in a national campaign in the winter of 2000/1 and 2001/2. During this period, a significant reduction in per-visit antibiotic purchasing was observed for influenza visits (from 79.2 per 1,000 to 58.1 per 1,000, P < 0.0001), but not for other categories of visits. The SIT methodology is a useful technique for problem-solving and idea generation within the medical framework.

Anti-Bacterial Agents↗

The invention of health law.

By default, the courts are inventing health law. The law governing the American health system arises from an unruly mix of statutes, regulations, and judge-crafted doctrines conceived, in the main, without medical care in mind. Courts are ill-equipped to put order to this chaos, and until recently they have been disinclined to try. But political gridlock and popular ire over managed care have pushed them into the breach, and the Supreme Court has become a proactive health policy player. How might judges make sense of health law's disparate doctrinal standards? Scholars from diverse ideological starting points have converged toward a single answer: the law should look to deploy medical resources in a systematically rational manner, so as to maximize the benefits that every dollar buys. This answer bases the orderly development of health care law upon our ability to reach stable understandings, in myriad circumstances, of what welfare maximization requires. In this Article, I contend that this goal is not achievable. Scientific ignorance, cognitive limitations, and normative disagreements yield shifting, incomplete, and contradictory understandings of social welfare in the health sphere. The chaotic state of health care law today reflects this unruliness. In making systemic welfare maximization the lodestar for health law, we risk falling so far short of aspirations for reasoned decision making as to invite disillusion about the possibilities for any sort of rationality in this field. Accordingly, I urge that we define health law's aims more modestly, based on acknowledgement that its rationality is discontinuous across substantive contexts and changeable with time. This concession to human limits, I argue, opens the way to health policy that mediates wisely between our desire for public action to maximize the well being of the many and our intimate wishes to be treated noninstrumentally, as separate ends. I conclude with an effort to identify the goals of health law, so constructed, should pursue and to suggest how a strategy of accommodation among these goals might apply to a variety of legal controversies.

Antitrust Laws↗