[Use of thrombotuffon in the treatment of duodenal and upper intestinal fistulas].
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Eight of 17 patients with necrotizing pancreatitis (47 percent) developed 12 intestinal fistulas. Pancreatitis occurred most often secondary to alcohol abuse, and fistula complicated controlled open drainage of the lesser sac more often than sump or Penrose drainage of the lesser sac. Fistulas appeared more often in patients with two or more drainage operations than in those with a single drainage procedure. Most duodenal fistulas closed with nonoperative therapy, whereas jejunal and colonic fistulas required operative closure. Operative techniques included both simple suture closure and resection with anastomosis. Five patients (29 percent) died. Thus, although frequent debridement and controlled open drainage may reduce the mortality rate of necrotizing pancreatitis, it appears to increase the likelihood of intestinal fistulas, which may require operative treatment.
Three cases are presented of a rare complication of abdominal aorta aneurysm, that is its rupture into the gastrointestinal tract. In two cases the aneurysm ruptured into the duodenum, and in one case into small intestine. The authors call attention to the variety of symptomatology and diagnostic difficulties with the primary aorto-intestinal fistula. This is true especially of cases in which the rupture is the first and not infrequently the only symptom of the aneurysm. The rupture of the abdominal aorta aneurysm into the gastrointestinal tract is still fraught with a very high mortality; out of three patients with primary aorto-intestinal fistula only one was saved.
In modeled experiments of 23 polyfistulous dogs with a reproduced high complete small-intestine fistula it was established that enteral compensation of water-electrolyte losses by means of a saline solution, isotonic and isoionic to the chyme, contributed to the maintenance of the water-salt balance for a prolonged period of time, kept up the animals' life and ensured the return to normalcy following the closure of the fistula. Preservation of the function of absorption by the small intestine was confirmed by the data of morphological investigations of 403 bioptic specimens of the mucosa from various parts of the small intestine repitedly taken in the course of the experiments. The data obtained testify to the absence of atrophy of villi and nakedness of their stroma, despite the intravital detachment of the epithelium into the lumen of the intestine, as well as to hyperproduction of the mucus, dilatation of the vessels of the circulatory and lymphatic systems, to retention of the mitotic activity.
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Results of treatment of 771 patients with external intestinal fistulas were analyzed. Duodenal fistulas were diagnosed in 47 patients, small-intestinal - in 366, large-intestinal - in 329, mixed - in 26, combined - in 3. Patients were divided into 2 groups: group 1 - 341 patients treated from 1983 to 1992, group 2 - 430 patients treated from 1993 to 2002. In group 1 - 294 (86.2%) patients underwent surgery, in group 2 - 405 (94.2%) patients. Differential approach to choice of treatment method, intraaortic therapy before and after surgery, use of developed devices for treatment of non-formed fistulas permitted to improve results of treatment and to reduce lethality from 10.3% in group 1 to 3,3% in group 2.
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