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PubMed1998

[CIPA (Comprehensive Individualized Process Analysis)--a method for combining quantitative and qualitative individual case analysis].

The main question of psychotherapy research nowadays is how psychotherapy works. Hence, interest focuses mainly on the process of psychotherapy. General change mechanisms as well as the therapeutic interaction are in the center of research interest. On the basis of process outcome findings (Orlinsky, Grawe, Parks 1994) and the schema theory of Grawe (1987) we developed a research instrument allowing the analysis of therapies from a theoretically and quantitative approaches. The research instrument (CIPA-Comprehensive Individualized Process Analysis) consist of three parts: The scales of the first part assess the general working mechanisms and the therapeutic relationship. The second part allows a rating of the patient's interactions inside and outside the therapy. In the third part the individual schemata are rated. The instrument and the research strategy are being illustrated by means of a selected therapy recorded completely on video tape. The results are interpreted on the basis of the individual schema structure as well as the therapy outcome. The possibility offered by the new instrument to combine quantitative and qualitative research strategies is discussed.

Adult↗
PubMed1996

His and her individualisms? Sex bias and individualism in psychologists' responses to case vignettes.

Individualism and sexism have been identified as important and problematic biases in psychotherapy. The extent to which psychologists use individualist values differentially in their responses to clinical case vignettes describing men and women was examined. Two samples of practicing psychologists (N=229) responded to 14 clinical vignettes by choosing initial hypotheses about the client that reflected either a utilitarian, instrumental (traditionally masculine) perspective or expressive (traditionally feminine) themes. Two sex-of-client manipulations were conducted, one of which resulted in a sex-of-client effect. A loglinear logit analysis of repeated measures conducted with the non-manipulated vignettes indicated a marked preference for the utilitarian form of individualism for males in response to their clinical difficulties, whereas the responses for female clients were more balanced on the utilitarian and expressive alternatives. There was little evidence of a sex-of-respondent effect.

Adult↗
PubMed1992

Separation-individuation, family functioning, and psychological adjustment in college students: a construct validity study of the Separation-Individuation Test of Adolescence.

We evaluated the construct validity of the Separation-Individuation Test of Adolescence (SITA; Levine, Green, & Millon, 1986). Based on a review of the theoretical literature on separation-individuation issues during late adolescence, predictions were made as to how SITA scores would correlate with aspects of family functioning and psychological adjustment. The SITA and a battery of self-report family and adjustment measures were administered to 454 college students (272 females and 182 males; 74% White, 16% African American, and 10% Asian American or Hispanic). Correlational analyses offered partial support for the construct validity of the SITA. Cluster analyses revealed four distinct groups of subjects (anxious deniers, healthy separators, peaceful detachers, and succorance seekers), each with its own coherent set of scores on the SITA and instruments measuring family relations and positive and negative psychological adjustment. Criticisms concerning the labels and composition of the SITA scales are also discussed.

Adaptation, Psychological↗
PubMed1990

The third individuation. The effect of biological parenthood on separation-individuation processes in adulthood.

The subject of this paper is the Third Individuation, the continuous process of elaboration of the self and differentiation from objects which occurs in the developmental phases of early (20 to 40) and middle (40 to 60) adulthood. Although it is influenced by all important adult object ties, at its core are involvements with children, spouse, and parents, i.e., the family, the same psychological constellation that shaped the first (Mahler) and second (Blos) individuations.

Adult↗
PubMed1999

GBV-C/hepatitis G virus (HGV) RNA load in immunodeficient individuals and in immunocompetent individuals.

The aim of this study was to establish the mean plasma GBV-C/hepatitis G virus (HGV) RNA load in groups of GBV-C/HGV-infected individuals with varied immune status and to determine the most frequent patterns of evolution of the plasma GBV-C/HGV RNA load over time during the natural history of infection. The mean plasma GBV-C/HGV RNA load observed was, from the lowest to the highest: 5.21 log in immunodepressed multiply-transfused patients, 6.45 log in HIV-positive individuals, 6.66 log in immunocompetent multiply-transfused patients, and 6.71 log in blood donors. The difference was significant between the four groups (P < 0.0001). The most frequent pattern of evolution of the plasma GBV-C/HGV RNA load was as follows: after the primary GBV-C/HGV infection, the viral load was elevated from the onset; then, a high, persistent and relatively steady viral RNA level was the rule; and when it occurred, the loss of viremia was not preceded by a decrease before recovery from GBV-C/HGV infection.

Adolescent↗
PubMed2005

Towards a molecular code for individuality in the absence of MHC: screening for individually variable genes in the urochordate Ciona intestinalis.

Urochordates possess several well described allorecognitions systems, the molecular nature of those is not yet understood. A prerequisite for any self-/nonself discimination system is the presence of a group of highly variable molecules, which should vary between individuals. Using suppression subtractive hybridisation (SSH) we surveyed Ciona intestinalis for individually variable genes. Our search so far identified two genes, ciS7 and ciMETA2, which both display an unexpected high degree of intra- and interindividual variability, code for secreted proteins, and contain multiple domains suitable for protein-protein interactions. The possible role of these molecules in allorecognition is discussed.

Amino Acid Sequence↗
PubMed2004

Interfacial activity of copper(II) complexes with chelating ligands and individual hydrophobic extractants in model extraction systems I. Study of equilibrium interfacial tension at the hydrocarbon/water interface for systems with copper(II) complexes with chelating ligands and individual hydrophobic extractants.

The equilibrium interfacial tensions at the hydrocarbon/water interfaces, as measured at 20 degrees C for copper(II) complexes with the chelating ligands beta-diketone (1-phenyl-1,3-decanedione), 2-hydroxy-5-t-nonylacetophenone oxime, 2-hydroxy-5-t-octylacetophenone and 2-hydroxy-5-t-octylbenzophenone oxime, as well as for individual extractants, are discussed. The interfacial tension and surface excess isotherms were determined and interpreted. The experimentally obtained curves were successfully matched with the Szyszkowski and Frumkin equations. It was found that the tendencies of interfacial tension to be lower at the hydrocarbon/water interfaces for copper(II) complexes and individual chelating ligands are similar. However, the effectiveness and efficiency of adsorption for chelating extractants and copper(II) complexes are quite different, irrespective of the type of hydrocarbon used as the organic diluent. On the other hand, the type of organic phase affects the interfacial activity of the investigated compounds. Moreover, it was shown that the way of preparing the measurement systems with the copper(II) complex influences the results of its interfacial activity.

Journal Article↗
PubMedDate not supplied

Treating individuals 3: from subgroups to individuals: general principles and the example of carotid endarterectomy.

Clinicians often have to make treatment decisions based on the likelihood that an individual patient will benefit. In this article we consider the relevance of relative and absolute risk reductions, and draw attention to the importance of expressing the results of trials and subgroup analyses in terms of absolute risk. We describe the limitations of univariate subgroup analysis in situations in which there are several determinants of treatment effect, and review the potential for targeting treatments with risk models, especially when benefit is probably going to be dependent on the absolute risk of adverse outcomes with or without treatment. The ability to systematically take into account the characteristics of an individual patient and their interactions, to consider the risks and benefits of interventions separately if needed, and to provide patients with personalised estimates of their likelihood of benefit is shown using the example of endarterectomy for symptomatic carotid stenosis.

Carotid Stenosis↗
PubMedDate not supplied

Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit?

Meta-analyses of randomised trials aim to summarise the effects of interventions across many patients, and can seem remote from the clinical issue of how individual patients should be treated and which patient groups will benefit the most from treatment. One method that attempts to address this point entails relating the overall effect in every trial to summaries of patient characteristics. This is called meta-regression. The interpretation of such analyses is not straightforward, however, because of a combination of confounding and other biases. Much more useful is to compare the outcomes for patient subgroups within trials and combine these results across trials. Unfortunately this method is rarely possible using published information, so analyses of individual patient data from trials are necessary. Also, although meta-analyses generally summarise an intervention's effect as a relative risk reduction, the groups of patients with the greatest absolute risk reduction have the most to gain.

Age Factors↗
PubMed2003

Ecological and individual predictors of maternal smoking behaviour. Looking beyond individual socioeconomic predictors at the community setting.

The aim of this study is to examine the prevalence of smoking during pregnancy by the individual mother's sociodemographic characteristics and ecological factors at the community level (suburbs). This analysis combined 1996 Australia Census and data on 3424 women attending Well-Baby-Clinics (WBC) between January 1996 and February 1998 within a region in South Western Sydney (SWS), Australia. The prevalence of maternal smoking was 31%. Maternal factors such as marital status, country of birth, education, occupation, socioeconomic status (SES), and types of antenatal care (ANC) were independent risk factors for maternal smoking. Small area analysis revealed suburbs within SWS with high rates of maternal smoking (47-57%). Community level characteristics such as low income, low educational level, young mothers, and unemployment can explain 85.7% of the variation in maternal smoking in SWS. Smoking during pregnancy is recognised as a serious risk factor to the unborn child. The present study draws attention to local community level factors, other than individual SES, which may be important when developing strategies for maternal smoking prevention programs.

Adolescent↗
PubMed2001

Ochratoxin A in human serum samples collected in Isparta-Turkey from healthy individuals and individuals suffering from different urinary disorders.

Ochratoxin A (OA) is a nephrotoxic fungal metabolite (mycotoxin) occurring in foodstuffs. The compound is causally associated with mycotoxin porcine nephropathy, a disease comparable with a human kidney disease called endemic nephropathy. In this paper OA levels in the human serum samples collected from healthy individuals and individuals suffering from different urinary disorders in Isparta-Turkey are presented. OA was measured in serum samples of 40 healthy people and a total of 93 patients with different kinds of urinary disorders. Four different kinds of urinary disorders were represented: chronic renal failure treated by hemodialysis (35), chronic renal failure treated by peritoneal dialysis (28), patients with bladder cancer (15), patients with renal stones (15). Analysis of OA in human blood samples was performed using an analytical method based on the measurement of fluorescence spectra. The mean concentration of OA in the healthy group was 0.4 +/- 0.28 ng/ml. The highest mean concentration was found in the group of patients treated by hemodialysis, 2.1+/- 1.2 ng/ml. The mean concentrations of the toxin in all patients groups were higher compared to the control group. Also, a significant difference was found between the mean concentrations of the groups of patients treated by dialysis (hemodialysis or peritoneal dialysis) and of the patients with renal stones or bladder cancer, only with the exception of the difference between peritoneal dialysis and renal stones group. No other significant differences were found when comparing the two groups. The findings indicate that OA may have a role in the human urinary pathology considered herein. A higher level of OA in dialysis groups compared to the control, renal stones and bladder cancer groups could probably be explained by the reduced glomerular filtration rate of these patients.

Adult↗
PubMed2000

Behavioral couples therapy versus individual-based treatment for male substance-abusing patients. An evaluation of significant individual change and comparison of improvement rates.

Fals-Stewart, Birchler, and O'Farrell (1996) found that married or cohabiting substance-abusing men (n = 40) who participated in behavioral couples therapy (BCT) in addition to individual-based treatment (IBT) for substance abuse had fewer days of substance use and, along with their partners, reported higher levels of dyadic adjustment during and 1-year after treatment than husbands who received IBT only (n = 40). In the present study, significant individual change in posttreatment frequency of substance use and dyadic adjustment was evaluated and comparisons of the proportions of participants receiving IBT and BCT who were improved, unchanged, or deteriorated in these domains of functioning were made using data from Fals-Stewart et al. (1996). Growth curve analysis revealed that a larger proportion of husbands in the BCT condition showed significant reductions in substance use (n = 33, 83%) than husbands who received IBT (n = 24, 60%). Also, a larger proportion of couples who participated in BCT showed improvements in dyadic adjustment (n = 24, 60%) than couples whose husbands received IBT only (n = 14, 35%).

Adult↗
PubMed1997

A time course analysis of Stroop interference and facilitation: comparing normal individuals and individuals with schizophrenia.

Using randomized stimulus onset asynchrony (SOAs), the authors traced the time course of Stroop interference and facilitation in normal participants and participants with schizophrenia. Unlike earlier findings using blocked SOAs, singular peaks in interference, facilitation, or both occurred at particular SOAs. The peaks of normal participants and participants with schizophrenia differed. Findings are congruent with a model of Stroop performance that posits individual differences in processing speeds of target and nontarget stimulus dimensions, coupled with critical points in response selection. Participants with schizophrenia also showed more overall interference than normal control participants. A second experiment that added a temporal gap between the distractor word and target color obliterated Stroop effects only for individuals with schizophrenia. These findings provide a new empirical basis for models of Stroop effects. They are also consistent with hypotheses about the importance of the prefrontal cortex for working memory and prefrontal dysfunction in schizophrenia.

Adolescent↗
PubMed1998

Self-esteem as a mediator between spousal support and depressive symptoms: a comparison of healthy individuals and individuals coping with arthritis.

This study examined whether self-esteem mediated the effects of both self-reported positive and negative marital interactions on depressive symptoms and whether the relationships among marital interactions, self-esteem, and depressive symptoms were stronger for individuals (n = 90) coping with arthritis compared with individuals (n = 90) not coping with a chronic illness. Data were drawn from the 1986 Americans' Changing Lives national survey. The results of multigroup structural equation analysis suggest that mediation depends on the type of marital interaction being considered and the group being examined. For the arthritis group, self-esteem mediated the relationship between negative marital interactions and depressive symptoms, whereas for the healthy group self-esteem played no role in mediating the relationship between marital interactions and depressive symptoms. Findings underscore the importance of testing moderated-mediation models of social support.

Adaptation, Psychological↗
PubMed2000

Putting the individual back into individual growth curves.

Scaling of time (age) in latent growth curve (LGC) models has important implications for studies of development. When participants begin a study at different ages, sample means and covariance-based structural equation modeling (SEM) approaches produce biased estimates of the variance of the intercept and the covariance between the Intercept and Slope factors. However, individual data vector-based SEM approaches produce proper estimates of these parameters that are identical to those produced by multilevel modeling (MLM). Scaling of the time variable also raises issues regarding the interpretation of within- and between-persons effects of time that parallel those associated with centering of predictor variables in MLM. A numerical example is used to illustrate these issues, and an Mx script for fitting individual data vector-based LGC models is provided.

Adolescent↗
PubMed2002

[Variability according to the individual of the efficacy of repellents with a base of vegetable oils in the individual protection against Simulium damnosum s. l. bites].

In Ivory Coast, treatments against black flies larva are interrupted since December 1998 and these flies are back everywhere in abundance. They are now a severe source of discomfort, so it is therefore very important to propose to rural populations a personal protection method against their bites. This article is about the individual attraction of fly boys on the efficiency of lotions and creams of the different repellents (coconut, palm nut, gobi). Our works were carried out in savanna zone (Niakaramandougou) and in forest zone (Soubré) in Ivory Coast. The methodology consisted in capturing black flies on volunteers whose legs were rubbed with repellent. Coconut, palm nut and gobi formulas (lotions and creams) were tested on Simulium damnosum s.l. During each session, which lasted from 07:00 am to 12:00 and from 03:00 pm to 06:00 pm, one person without repellent was used as a control person. The results show that the least efficient repellent (gobi) ensures nonetheless a reduction of 90% of the number of bites that an individual would have received if he was not protected by the repellent. Experimentations allows to say that for a given repellent and formulas (lotion and cream), there is no significant difference between the number of Simulium damnosum s. l. bites received by fly boys.

Animals↗
PubMed1991

Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis.

The most common mutation of the cystic fibrosis transmembrane conductance regulator gene, CFTR, associated with the clinical disorder cystic fibrosis (CF) is called "delta Phe508," a triple-base deletion resulting in loss of phenylalanine at residue 508 of the predicted 1480-amino acid CFTR protein. In the context that the lung is the major site of morbidity and mortality in CF, we evaluated airway epithelial cells for CFTR mRNA transcripts in normal individuals, normal-delta Phe508 heterozygotes, and delta Phe508 homozygotes to determine if the normal and delta Phe508 CFTR alleles are expressed in the respiratory epithelium, to what extent they are expressed, and whether there are relative differences in the expression of the normal and abnormal alleles at the mRNA level. Respiratory tract epithelial cells recovered by fiberoptic bronchoscopy with a cytology brush demonstrated CFTR mRNA transcripts with sequences appropriately reflecting the normal and delta Phe508 CFTR alleles of the various study groups. CFTR gene expression quantified by limited polymerase chain reaction amplification showed that in normal individuals, CFTR mRNA transcripts are expressed in nasal, tracheal, and bronchial epithelial cells at approximately 1-2 copies per cell, more than 100-fold greater than in pharyngeal epithelium. Importantly, allele-specific hybridization studies demonstrated that the normal and delta Phe508 CFTR alleles are expressed in the respiratory epithelium in similar amounts.

Base Sequence↗
PubMed2004

Vitamin K status of older individuals in northern China is superior to that of older individuals in the UK.

To explore whether differences in vitamin K nutrition might, at least in part, underlie differences in fracture incidence between Asian and European populations, the vitamin K status of older individuals in Shenyang, China (eighty-six men, ninety-two women) and in Cambridge, UK (sixty-seven men, sixty-seven women) was compared. Dietary information was collected by food questionnaire in Shenyang and food diary in Cambridge and used to estimate the intake and sources of phylloquinone. Fasting blood was analysed for phylloquinone, triacylglycerol, total osteocalcin (tOC) and undercarboxylated osteocalcin (expressed as percentage of tOC; %ucOC). The mean intakes of green leafy vegetables were 127 (SD 90) g/d in Shenyang and 39 (SD 48) g/d in Cambridge. The estimated phylloquinone intakes (geometric means) were 247 (95% CI 226, 270) microg/d in Shenyang and 103 (95% CI 94, 112) microg/d in Cambridge. Plasma phylloquinone concentrations (geometric means) were significantly higher in the Shenyang subjects (2.17 (95% CI 1.95, 2.42) nmol/l) than in the Cambridge subjects (0.69 (95% CI 0.63, 0.76) nmol/l; P<0.001). Plasma phylloquinone concentration was positively related to phylloquinone intake in both the Shenyang (coefficient 0.17 (SE 0.08); P=0.03) and Cambridge subjects (coefficient 0.29 (SE 0.10); P=0.005). tOC concentration and %ucOC (after adjusting for tOC) were significantly lower in the Shenyang than in the Cambridge subjects (tOC 25.2 (SE 4.2)% and %ucOC 68.5 (SE 10.0)% lower respectively; P<0.001). After adjusting for tOC and triacylglycerol, %ucOC was negatively related to plasma phylloquinone concentration in both the Shenyang (coefficient -0.41 (se 0.11); P=0.0003) and Cambridge subjects (coefficient -0.17 (SE 0.07); P=0.02). The present study demonstrates that older individuals in northern China have a better vitamin K status compared with their British counterparts in Cambridge, UK.

Aged↗