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Results for “IRITIS”

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PubMed1978

Iritis in patients with cutaneous melanoma and vitiligo.

Two patients with cutaneous malignant melanoma, vitiligo, and uveitis are described. The occurrence of vitiligo following cutaneous melanoma is not uncommon and has been interpreted to result from cellular and humoral factors directed against melanoma cells that also destroy normal cutaneous melanocytes. The present cases raise the possibility that melanocytes in the eye as well as the skin may be affected.

Aged↗
PubMed1980

Inhibition of prostaglandin-induced iritis. Topical indoxole vs indomethacin therapy.

Rat eyes pretreated with 10 microL of topically applied indoxole or 14C-indomethacin, both drugs as 0.5%, 1.0%, and 2.0% solutions in polysorbate 80, were subjected 60 minutes later to an intravitreal injection of 5 microL of 5.0% sodium arachidonate. Following a 30-minute interval, the iris vascular pattern was photographed under the same standardized conditions as in the preinjection control photographs. Comparison of the average diameters of preselected vessels showed indoxole to be more effective than indomethacin in inhibition of iris vascular dilation at all concentrations tested. Intracameral unbound indomethacin concentration was a whole order higher than that of indoxole after comparable doses. The difference in relative effect of the two drugs is neither a function of aqueous concentration nor of aqueous protein binding.

Animals↗