[Simultaneous study of systemic and regional visceral hemodynamics in cirrhosis. II. Systemic and hepatosplanchnic hemodynamics in compensated alcoholic cirrhosis].
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The cardiac output (CO) and cardiac index (CI) were examined by echocardiography throughout pregnancy and 1 month of puerperium and the results were compared with fetal growth as determined by birth weight. The results are as follows. The changes in CO and CI during the pregnancy and puerperium of normal pregnant women (n = 48) were similar in all subjects, and reached the maximum at the 24th-31st week's of gestation. On the 5th day of puerperium, the CO and CI values were almost the same as those obtained at the 32nd-40th weeks of gestation, and after 1 month of puerperium the values were same as those obtained in the non-pregnant period. The CO and CI of HFD child-bearing group (n = 8), AFD child-bearing group (n = 30) and LFD child-bearing group (n = 10) were compared. The CO and CI values for the LFD group were lower than those for AFD group; particularly, significant differences (p less than 0.05) were observed in 24th-31st weeks and 32nd-40th weeks of gestation. The CO and CI values of HFD group tend to be higher than those for AFD group, but there is no statistical significance between the two groups. The birth weight correlated to the rate of increase in CO and CI during pregnancy with coefficients of correlation of 0.56 (p less than 0.05) and 0.54 (p less than 0.05), respectively. The rate indicates the ratio of maximum values of CO and CI obtained during pregnancy to the values after 1 month of puerperium, which have been shown to be consistent with those during the non-pregnant period. A significant correlation (r = 0.54, p less than 0.05) was found between placenta weight and birth weight. The correlations between placental weight and the rate of increase in CO and CI were also significant with coefficients of correlation of 0.40 (p less than 0.05), and 0.38 (p less than 0.05), respectively.
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INTRODUCTION: Pipecuronium bromide is a new non depolarising muscle relaxant with a long duration of action; we considered its haemodynamic effects during general anaesthesia. MATERIALS AND METHODS: Eight surgical patients (4 males, 4 females), mean age 44 years (range 29-65 years), ASA I-II, were studied. All patients were undergoing elective neurosurgical procedures (Hunt-Hess I-II). A radial artery-cannula was put in for blood pressure monitoring and a Swan-Ganz volumetric/ejection fraction fiber optic catheter was put in pulmonary artery via right internal jugular vein (EFV/OTDC-Baxter). A diazo-analgesic high dose fentanyl anaesthesia was given. All patients received pipecuronium bromide 0,1 mg/kg during stable haemodynamic conditions. Haemodynamic determinations were performed over following three times: T0 before the pipecuronium administration, T1 and T2, 3 and 15 minutes after administration respectively. These parameters were analysed: HR, MAP, MPAP, RAP, PCWP, CI RVEDVI, RVESVI, RVEF, SVRI, LVWI, RVWI, SvO2, DO2I, VO2I, O2ER, Qs/Qt (statistics: analysis of variance (two ways ANOVA) and orthogonal decomposition; for all statistical comparison, differences were considered significant when p < 0.05). RESULTS: Only MAP and SVRI showed significant changes (p = 0.02 and p = 0.04), even if clinically modest. No other parameter showed any change at all. CONCLUSIONS: Pipecuronium bromide did not show adverse haemodynamic effects; its haemodynamic repercussions are clinically negligible. The drug could be considered as first choice in long lasting operations for patients with potential cardiovascular instability.
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The application of absolute coronary velocity reserve, relative coronary velocity reserve, and pressure-derived fractional flow reserve of the myocardium may have influence on decision making for angioplasty and stenting in patients after myocardial infarction. This case highlights the use and limitations of these techniques in the setting of myocardial infarction where absolute coronary flow reserve may be commonly compromised. The role for absolute, relative coronary, and fractional flow reserve are discussed.
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