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Results for “Genetic Load”

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At least 109 records · Page 6Linked to original sources
PubMed2002

[Helper cells, viral load, genetic factors, co-infections. Prognostic factors in HIV-1 infection].

The ideal time to initiate antiretroviral therapy in asymptomatic patients with chronic HIV infection remains to be defined. The most relevant laboratory parameter is the CD4 cell count. Therapy should be started before the CD4 cells drop below 200/microliter and the immune system becomes compromised. In contrast to past recommendations, viral load should not be used as a single laboratory parameter for initiation of antiretroviral therapy in asymptomatic untreated patients. The determination of genetic factors to assess the prognosis of HIV patients has not yet been incorporated into daily clinical practice. While co-infection with GBV-C is a prognostically favorable factor for the course of the HIV infection, replicative hepatitis C is associated with increased mortality.

AIDS-Related Opportunistic Infections↗
PubMed1980

Platelet monoamine oxidase activity: relation to genetic load of schizophrenia.

Platelet monoamine oxidase (MAO) activity is significantly lower in chronic schizophrenic patients with a family history of schizophrenia compared to schizophrenics with no affected relatives and normal controls. These results are consistent with the concept of genetic and biologic heterogeneity in schizophrenia and suggest that the lack of uniformity across previous MAO studies of schizophrenia may be explained in part by the presence of biochemically normal phenocopies.

Blood Platelets↗
PubMed1970

Senescence and genetic load: evidence from Tribolium.

After 40 generations in which young adults were killed shortly after the onset of reproduction, strains of Tribolium castaneum with significantly decreased median longevity evolved. These findings support the hypothesis that the longevity of a species is controlled by genetic factors, and represents a compromise between selection for longer reproductive period and the limit set by environmental hazards.

Aging↗
PubMed1982

[The role of genetic load in the development of reactive psychotic states leading to severe violence. Study of a case of "homicide arson" double and extended suicide].

Using the casuistic presentation of a case of arson with ensuing double murder and extended suicide by jumping over a rock face, we discuss to what extent genetic disposition is important for the formation of reactive-psychotic states that lead to crimes of extreme violence. From the results of protracted research on the previous history of the perpetrator and of his relatives, a multifactorial disposition toward affective psychoses, alcoholism, epilepsy, and suicide was discovered. On the other hand, in the long-term longitudinal observation of the perpetrator, manic depressiveness was diagnosed, which was characterized by a rapid bi-polar phase shift. This supports the opinion of the authors--partially contradictory to the literature--that such affective outbursts, which have apparently arisen purely reactively, but which lead to murder and suicide, in most cases arise on an endogenic basis. In such cases one should not speak of an exclusively reactive depression (mania) before the possibility of an endogenic component has been excluded. The latter, however, can only be detected through precise long-term longitudinal diagnosis and data on the family's psychiatric history. Otherwise, an endo-reactive depression (mania) must be diagnosed. This implies in these cases at least an "irresistible impulse" (Dispositionsunfähigkeit) of the perpetrator.

Adult↗
PubMed1987

[Demographic consequences of genetic load: a model of the origin of the incest taboo].

The prohibition of copulations among near relatives may raise the fitness of population. This effect being irregular and insignificant for a distinct generation, becomes apparent in evolutionary time intervals through the natural selection of populations with incest-taboo. The "characteristic selection time" theta depends on typical population size, genetic damage and the mean rate of population growth. The estimation obtained for theta permit us to assert that the model describes the phenomenon of "socio-cultural selection" in prehistory. The model shows the demographic specificity of small populations. The problem of the number of consanguineous marriages is considered in detail. New explanation for deviation of the observed frequency of consanguineous marriages from classical estimations is proposed.

Genes, Lethal↗