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Effect in vitro of Tifell (formocresol-eugenol) on macrophage adhesion.

The purpose of this study was to investigate the effect in vitro on macrophage adhesion of Tifell (formocresoleugenol), used as an intracanal medicament and in therapeutic pulpotomies in primary teeth, Macrophages were obtained from Wistar rats. As a test of macrophage phagocytic function the adherence capacity of macrophages to a plastic surface was determined. Assays were carried out in Eppendorf tubes after 15 min of incubation at 37 degrees C in a humidified atmosphere of 5% carbon dioxide. The adherence index (AI) was calculated. Results showed that Tifell decreased significantly (P < 0.05) the AI of macrophages. Half maximal inhibition of AI was obtained at 1:334.5 Tifell dilution (AI = 27.75; P < 0.05). Taking into account that substrate adherence is the first step in the phagocytic action of macrophages and in antigen presentation, Tifell could inhibit macrophage function and modulate immune and inflammatory responses in dental pulp and periapical tissues.

Analysis of Variance↗

Treatment of vital and non-vital primary molar teeth by one-stage formocresol pulpotomy: clinical success and effect upon age at exfoliation.

The clinical success and effect upon the age at which teeth exfoliated was prospectively observed in 175 primary molars that had received formoceresol pulpotomies performed by one operator. The success rate among 142 vital teeth was 99.3% and among 33 non-vital teeth 84.8%. There was no significant effect upon age at exfoliation after either type of pulpal treatment.

Child↗