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At least 109 records · Page 6Linked to original sources
PubMed1989

[Hepatic mesenchymal hamartoma].

A case is presented of a 10-year-old female twin with a cystic liver mass that debuted as a painless epigastric mass. The lesion was excised by hepatectomy of segments II and III, confirming in the review of the cavity the presence of a common mesentery with cecocolonic malposition. The postoperative course was normal and clinical and echographic study of her twin sister disclosed no anomalies. The anatomopathologic study of the lesion revealed a tumor of difficult filiation that presented features of mesenchymal hamartoma together with others of biliary cystadenoma. The amount and nature of the stromal component, together with the patient's age at appearance, made us classify the case as mesenchymal hamartoma. The morphologic findings observed seem to support the histopathologetic theory of a congenital origin.

Child↗
PubMedDate not supplied

[Mandibular metastasis as the first manifestation of adenocarcinoma of the prostate].

We present a case of mandibular metastasis as the first manifestation of a disseminated prostate carcinoma. After commenting on the exceptional nature of the case, we underline the importance of histochemical markers (Acid phosphatase. PSA) to determine the non-filiated origin of a metastasis. It is advisable for this to be carried out systematically in all cases of metastasis of indeterminate origin.

Adenocarcinoma↗
PubMedDate not supplied

[Wunderlich syndrome: presentation of a case].

We present a case of spontaneous renal bleeding due to renal neoplasia. We analyse other causes of Wunderlich's syndrome and, following Kendall, we defend the indication of radical nephrectomy especially of non-filiated etiology in the cases in which other causes have been discounted and the contralateral kidney is sound.

Carcinoma, Renal Cell↗
PubMed1986

[Towards a genealogy of chromosome Y].

Taq I restriction polymorphisms of the 49 f genomic probe are used to establish a possible filiation of the Y chromosome in human populations. Relationships between alleles at the five polymorphic loci revealed by the probe allow the description of 17 haplotypes. Simulations are used to construct a plausible genealogy of these various haplotypes, on the basis of a limited set of basic hypotheses concerning polymorphic alleles evolution.

Biological Evolution↗
PubMed1988

[Calculation of the proportion of men excluded from paternity by HLA typing of the mother and child].

When filiation research shows that paternity is possible, French legislation recommends the calculation of two coefficients: 1. paternity probability (CP); 2. percentage of random men excluded from paternity by genetic markers of the mother and the child (PEme). A method is proposed, allowing the determination of PEme for the HLA system and PEme for the various systems employed. The calculations, relatively simple, can be worked out quickly and without risk of error, using a computer. We successively look at simple cases, complex cases and unusual cases: maternal death, consanguinity problems, racial problems. HLA-A, B, C, DR, DQ typing almost always leads to the exclusion of more than 98% of innocent men (PEme greater than 0.98). The HLA system clearly appears to be the most conclusive of the systems utilized by experts.

Chromosomes, Human, Pair 6↗
PubMed1985

[Alder's anomaly in mucopolysaccharidosis type VI. Cytological, cytochemical and ultrastructural study].

A cytological study of the blood and bone marrow of a child with mucopolysaccharidosis with Alder's anomaly was analysed at the optical and ultrastructural level. Morphological abnormalities of the blood and bone marrow leucocytes are defined; cytochemical and cytoenzymological abnormalities are indicated, allowing a differential diagnosis with "toxic granulations". The ultrastructural patterns of the storage cells are described compared to descriptions in the literature and the question of their mastocytic or macrophagic filiation is discussed.

Bone Marrow↗
PubMed1985

[Use of skull radiography in craniocerebral injuries in childhood].

Authors review the usefulness of radiographic skull examination in childhood head injury. Two hundred and forty-two patients assisted at the emergency area were prospectively recorded during one year. Data of filiation and epidemiology and symptoms and signs posed by Leonidas as "high risk criteria" to have a skull fracture, were registered. AP and L X-Ray skull were performed in all patients. Thirteen (5.37%) of them had a fracture. Blood discharge from the ear and skull depressed fracture were more frequently found in the fracture group with statistically significant difference (p less than 0.05 and p less than 0.01, respectively). The probability of positive finding was 8.8 for blood discharge from the ear, 17.6 for skull depressed fracture and 4.4 for bilateral black eyes. Because of no correlation between clinical and radiological findings, the radiographic skull examination must be systematically performed in every head injury if the purpose is to diagnose a fracture.

Adolescent↗
PubMed1985

[The psychiatrist and his questions in the face of traditional practices in Northwest Africa].

Traditional practices remain frequent in such countries as Maghrab. They interfer with care as well as with clinic, as made evident by some observations. Their weight, shown by many authors, possibly indicates the position of cultural changes of the group and underlines the importance of the pathology of filiation relationship. Nevertheless, meeting them should favour a reflection on the humanism of present society.

Adult↗
PubMed1979

[Distribution of HLA antigens among the population of Finistère (France) (author's transl)].

We have studied by using HLA system, 200 people, without filiation but having the same geographic origine (Finistère). The results have been compared with those measured for Parisian and Basque population. A significantly decrease of antigen A29, B18 and BW16 frequency have been observed in the population from Finistere. But, antigen B8 and B27 seems to be more frequent than in population from Paris. A linkage desequilibrium is described for A1-B8 and A3-B7 haplotypes as in population from Paris; but the desequilibrium for A11-B5 seens to be characteristic of population from Finistere.

France↗
PubMed1982

[Currently recommended use of the Hemoccult for the detection of rectocolic tumors].

Because colorectal carcinoma is both very frequent and extremely serious, diagnosis and treatment of this cancer are a major Public Health issue in France. The recognition of the filiation between polyps and cancer has led to considering prevention of colorectal cancer through the detection of polyps. The usefulness of the hemoccult test is discussed. Reported results warrant the rejection of this method for the individual detection of colorectal tumors because of poor sensitivity. Conversely, there are grounds for advocating the use of the hemoccult test for mass screening on certain conditions; the most important of these is that a negative test must not be considered as sufficient to eliminate the diagnosis. If screening plans with the hemoccult test are implemented, they will have to be coordinated with an important health education program to promote individual prevention using endoscopy, particularly in high risk and symptomatic subjects.

Colonic Neoplasms↗
PubMed1983

[Richter's syndrome. A morphological study apropos of 3 cases].

The occurrence of a large cell lymphoma in the course of chronic lymphocytic leukemia is rare and its evolution is fatal at short term. This is the definition of Richter's syndrome. The authors report three cases documented by cytology, histology. The immunological study was performed for one of these by typing on a suspension of fresh bone marrow and lymph node cells. It showed the immunological identity of the chronic phase and the transformation phase (Richter's syndrome). These findings are in line with recent studies showing the immunocellular filiation of the two hemopathies despite the morphological differences, the transformation phase showing the differentiation of the B clone of the chronic phase.

Aged↗
PubMed1983

Correlation of alkaline phosphatase activity to normal T-cell differentiation and to radiation leukemia virus-induced preleukemic cells in the C57BL mouse thymus.

Cytochemical methods at the light and electron microscopic level were used to define the pattern of alkaline phosphatase (APase) activity in normal thymus and to study its modifications after inoculation with the thymotropic leukemogenic radiation leukemia virus in correlation with the emergence of preleukemic cells and their thymus dependency. APase was found in numerous lymphoblasts of the fetal thymus. The enzyme was also detected in a few lymphoid blast cells of the normal young adult thymus, which were closely associated with thymic nurse cells. The observed distribution of APase in normal thymus suggests that its expression could be limited to an early stage of the T-cell differentiation pathway. After inoculation with radiation leukemia virus, APase activity remained normal for almost the entire latency period, during which virus replication spread to the cortex and thymus-dependent preleukemic cells appeared. An important increase in the number of APase-positive cells occurred later, i.e., at the end of the latency period, in nontumoral thymus, which displayed lymphocytic depletion and contained autonomous thymus-independent preleukemic cells. These latter features obviously reflected the malignant transformation of thymus lymphoblasts, which eventually led to the development of the thymic lymphomas. The results raise the question of the possible filiation between the thymic nurse cell-associated APase-positive lymphoid cells of the normal thymus and the target cells susceptible to productive infection and to neoplastic transformation after radiation leukemia virus infection.

Alkaline Phosphatase↗
PubMed1978

[Histochemical and histoenzymatic study of experimental endarteritis in rabbits. II. Aortic endarteritis].

The placement of a polyethylene cuff around the abdominal aorta of 20 male rabbits 2,5 to 3 months old induce an adventitial reaction characterized by edema (7th day), fibroblastic proliferation (7th - 15th day), fibrosis and sclerosis (2nd - 3rd month), changes in the media including cytoenzymatic activation (1st - 3rd week), signs of hypoxia, degenerative and productive processes leading to intimal tickening. Histoenzymatic characteristics of the intimal thickening cells look like activities of smooth muscle cells, while the activities of some cellular areas recalled those of endothelial cells (high aerobic oxydoreductases and ATP/ase activities). This histoenzymatic duality is perhaps related to the histogenetic filiation of the intimal thickening cells. Histochemical data (metachromasia, alcianophilia, APS +) suggest that these cells are able to synthesize different elements of the extracellular matrix. All these features resemble femoral endarteritis obtained by the same process; moreover, in aorta the endarteritis evolves more slowly, the cellular proliferation is later and focused, the signs of hypoxia and necrosis and more pronounced. These differences are probably related to structural and metabolic dissimilarities of the two vessels, and to differences in their cellular reactivity.

Animals↗
PubMed1982

[Ultrastructural evolution of fetal germinal cells to adult spermatogonia in Macaca fascicularis monkeys].

Ultrastructural changes in the spermatogonial line of the macaque, Macaca fascicularis, were studied during foetal development (from day 37), childhood and puberty. The different cell types and their distinctive morphological characteristics have been identified by studying adjacent thick and thin sections under light and electron microscopy. The main criteria used were: organization of the rough endoplasmic reticulum (RER) and its relation to mitochondria, chromatin distribution, stainability and perichromatin granule content, nucleolar organization and differentiation of the nuclear membrane including the lamina and nuclear vacuoles or cisternae. According to their ultrastructure, the following main cell classes were distinguished: gonocytes (37 to 43-day foetuses), prespermatogonia (50 to 110-day foetuses), pale type A (Ap) and dark type A (Ad) adult-type spermatogonia which differentiated progressively in 120 to 140-day foetuses. During childhood, the testis contained only Ap and Ad spermatogonia. At the onset of meiosis (about 48 months after birth), type B spermatogonia appeared, and the different classes of spermatogonia were found lying directly on the basal lamina of the sex cords. The filiation of the spermatogonial line during development has been discussed.

Aging↗
PubMed1981

[The infundibular adenoma: a follicular poroma with sebaceous and apocrine differentiation (author's transl)].

Tricholemmal adnexal pilar tumors may be classified according to the tricholemmal zone whose structure they reproduce and according to their degree of maturation or dedifferentiation. The pilar sheath acanthoma (dilated pore of Winer), the tumor of follicular infundibulum and the follicular poroma (inverted follicular keratosis) are related to the infundibulum and keratinize according to the epidermal pattern. The tricholemmal cysts (of simple or proliferating type) and the keratinizing tricholemmoma are related to the upper part of the isthmus of the anagen hair and keratinize according to the specific pattern of the outer root sheath at this isthmic level. The tricholemmoma is related to the lower tricholemma which does not keratinize and the cells of which are glycogen-rich. In this vertical didactic classification, there exist combinations and filiations of the different tumors. In a serial analysis of 68 skin adnexal tumors diagnosed as follicular poromas, we observed 6 cases with sebaceous and apocrine differentiation. For this organoid tumor issued from the infundibular epithelium we propose the term of "infundibular adenoma".

Adenoma↗
PubMed1981

[Confabulatory anomia from visual and tactile agnosia in a case of multi-infarct dementia. Neuropsychological study (author's transl)].

Observation of a patient suffering from a double softening of the brain (inner side of right temporal lobe, left occipital lobe). Clinically, Korsakoff's syndrome, right quadranopsia, pure alexia, tactile and visual agnosia concerning objects, colors and faces. Relative integrity of elementary perceptions (matching tests), impairments of stimulus identification (Lissauer's associative agnosia). Phenomena of sensoriphasic interactions are reported: normal speech in conversation, contrasting with confabulant anomia when naming or describing visual or tactile stimuli: then, escaping the control of sight, a relative "autonomy" of speech appears, with word perseverations and semantic "slipping" and filiations. Discussion of optical aphasia.

Agnosia↗
PubMed1978

[Distribution of HLA antigens among the population of Finistère (France) (author's transl)].

We have studied by using HLA system, 200 people, without filiation but having the same geographic origine (Finistère). The results have been compared with those measured for Parisian and Basque population. A significantly decrease of antigen A29, B18 and BW16 frequency have been observed in the population from Finistere. But, antigen B8 and B27 seems to be more frequent than in population from Paris. A linkage desequilibrium is described for A1-B8 and A3-B7 haplotypes as in population from Paris, but the desequilibrium for A11-B5 seens to be characteristic of population from Finistere.

France↗
PubMed1995

Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia. Evidence for somatic mutations and intraclonal diversity of the expressed VH region gene.

Mixed cryoglobulinemia is usually considered to be a nonmalignant human B cell proliferation that produces a monoclonal IgM rheumatoid factor (RF). Important immunologic similarities and differences were described between the monoclonal B cells during mixed cryoglobulinemia and during malignant chronic lymphocytic leukemia (CLL):high frequency of the same VH and V kappa gene usage by both types of monoclonal B cells producing IgM with RF activity, apparent intraclonal homogeneity, but different expression of the pan T cell CD5 Ag. The description of an unusual CD5-negative B cell CLL case secreting a mutated IgM RF led the authors to suggest that the usage of non-mutated germline Ig genes is a property of cells derived from the CD5 lineage or stage of differentiation, rather than an intrinsic property of CLL or of IgM RF-producing cells in general. Because mixed cryoglobulinemia cells are usually CD5-negative, it was of interest to test for the existence of mutations in the VH and V kappa regions, as well as for the intraclonal homogeneity of the expressed Ig genes. In this study, we used the PCR technique to analyze the monoclonal rheumatoid factor (mRF) V genes from a patient with mixed cryoglobulinemia. We show that the CD5-negative monoclonal B cells express a slightly mutated V kappa 3 gene, but a more mutated VH1 gene whose genomic counterpart was shown to be the 51p1 germline gene. The sequence analysis of several independent clones shows some degree of intraclonal diversity, suggesting the existence of a clonal filiation. These results are discussed in terms of the origin of the monoclonal B cell during mixed cryoglobulinemia and CLL.

Antibodies, Monoclonal↗