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[Localized loss of facial tissue. Criteria of use of extra-oral implants and clinical cases].

Osseointegrated maxillofacial epitheses are an interesting therapeutic response for rehabilitation after loss of facial tissue when reconstructive plastic surgery cannot be proposed. We analyzed the criteria used for deciding on this type of treatment for the loss of local areas of auricular tissue, the nasal pyramid and the orbitopalpebral region, presenting individual clinical examples.

Adolescent↗

[Basaliom. Case report and isolation of mesenchymal stroma cells in various growth conditions in vitro].

The case of a 54-year-old man with multiple basaliomas of the face but without any other symptoms of the Goltz-Gorlin syndrome is described. Obviously, there ist a family history of a tendency to develop basaliomas. One of the patient's three brothers, his mother, her sister and two of his six children were also affected. After removal of the tumor, electron microscopy revealed intranuclear crystal-like structures in some of the epithelial cells of the tumor tissue. The particular geometry of these structures suggests that these are papilloma viruses. The tumor stroma contained fibroblasts, fibrocytes and predominantly myofibroblasts. Tumor explants were cultured in vitro in Dulbecco-Vogt medium using 5 different supplements: 10% fetal calf serum (FCS), 10% fresh human serum with and without PDGF and CL (PDGF-CL, PDGF, CL, NULL). These cultures result in different rates of collagen gel contraction and binding of varying amounts of the "q" fraction of the first complement (C1q): PDGF CL-cells greater than PDGF cells greater than FCS cells greater than NULL cells. The culture of tumor tissue cells in different media thus seems to enhance the dominance of different cell subtypes.

Basal Cell Carcinoma↗

Factors leading to delay in the diagnosis and affecting survival of children with head and neck rhabdomyosarcoma.

Rhabdomyosarcoma of the head and neck often presents with vague symptoms which mimic other disease conditions. These factors lead to undue delay in the establishment of the correct diagnosis and the delivery of acceptable therapy, including surgery, radiation therapy, and chemotherapy. There is, however, evidence of improved results of treatment of these tumors since the addition of multiple drug chemotherapy to surgery and radiotherapy.

Adolescent↗

[Is Malherbe calcifying epithelioma in the ENT area of a rare tumor?].

The calcifying epithelioma (pilomatrixoma) is a benign tumour of the skin originating from hair sheath cells. The head, especially the cheek and preauricular region with the parotid gland, is a very common site (about 50%). The tumour arises predominantly in younger people, with a 2:1 female to male ratio. It is not so rare as suggested by the few ENT publications. The histologic picture shows two characteristic epithelial cells, the basophilic and ghost cell. Calcification is present in most cases. The prognosis after removal of the tumour is good. Two personal cases are reported, multiple pilomatrixomas on the cheek of an 12 year old girl, and a tumour on the auricle, an unusual site.

Adult↗

Chemosurgery for skin cancer: fixed tissue and fresh tissue techniques.

Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique.

Biopsy↗

Atypical fibroxanthomas of the skin: multiple primaries.

An 83-year-old man experienced, within a four-year span, two separate atypical fibroxanthomas occurring on the right ear and right forehead without any satellite lesions or obvious lymph node metastases. Such an occurrence has not been reported before.

Aged↗