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PubMed1990

Effect of water-soluble contrast medium on the lung in rats. Comparison of iotrolan, iopamidol, and diatrizoate.

Aspiration is a serious complication of oral contrast media (CM). The authors investigated the effects of iotrolan, iopamidol, and diatrizoate in rats' lungs. To quantify the lung damage induced by CM, pulmonary water and hemoglobin contents were determined. Arterial blood-gas exchange (pH, PCO2, and PO2) also was determined as an indicator of respiratory function. Iotrolan, iopamidol, or sodium/meglumine diatrizoate with a concentration of 300 mg I/mL was administered intrabronchially at a dose of 1 mL/kg. Physiologic saline was administered to the control group. Ten minutes after administration, arterial blood was collected and the lung was removed. Diatrizoate and iopamidol increased pulmonary water and hemoglobin contents and decreased blood PO2. The effect of iotrolan on these parameters was slight and no significant differences were observed between the iotrolan and saline groups. These results suggest that iotrolan is a preferable CM for gastrointestinal examination in the case of suspected aspiration.

Animals↗
PubMed1983

Diatrizoate CT distribution kinetics: a study of human tissue characterization.

Diatrizoate distribution volume (DDV) is a property of living tissue which characterizes the distribution of diatrizoate contrast material within the tissue. This study compiles DDV and enhancement data from computed tomography (CT) of normal human adults. Tissues examined include liver, spleen, muscle, fat, and renal cortex. Four abnormal tissues, a cirrhotic liver, a liver infiltrated with metastatic colon carcinoma, and two examples of renal malignant lymphoma, were used for comparison. Time-DDV and time-enhancement values were generated for the normal tissues after a bolus of intravenous diatrizoate. The CT-DDV appears to be a potentially reliable indicator of diffuse organ pathology.

Diatrizoate↗
PubMed1998

Transformation of the ionic X-ray contrast agent diatrizoate and related triiodinated benzoates by Trametes versicolor.

Iodinated X-ray contrast agents are considered to be nondegradable by microorganisms. The decomposition of the ionic X-ray contrast agents Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoic acid) and Iodipamide (3,3'-adipoyl-diimino-di(2,4,6-triiodobenzoic acid) and related triiodinated benzoates (Acetrizoate [3-acetylamino-2,4, 6-triiodobenzoic acid] and Aminotrizoate [3-amino-2,4, 6-triiodobenzoic acid]) by Trametes versicolor has been investigated. The fungus was able to transform all tested triiodinated benzoates cometabolically. During transformation of these compounds, iodide was released, but deiodination was not complete. T. versicolor liberated traces of 14CO2 from uniformly ring-14C-labeled Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoate). Various extracellular metabolites were detected during transformation of the different substances. In the transformation of Diatrizoate, the three main metabolites were identified as 3,5-di(acetamido)-2, 6-diiodobenzoic acid, 3,5-di(acetamido)-2,4-diiodobenzoic acid, and 3,5-di(acetamido)-2-iodobenzoic acid, suggesting reductive deiodinations in steps as initial transformation steps.

Benzoates↗
PubMed1989

Synergy of chymopapain and diatrizoate studied in an experimental model.

The effect of diatrizoate on the chronic toxicity of chymopapain in the epidural space was studied. Chymopapain was injected epidurally into four monkeys; chymopapain plus diatrizoate meglumine, into four. In 3 months, neither group developed significantly more arachnoiditis than a control group of animals that had received epidural injections of physiologic saline. No synergistic effect of chymopapain and diatrizoate on the meninges was detected.

Animals↗
PubMedDate not supplied

Ioxaglate versus diatrizoate in selective pulmonary angiography. I. Subjective reactions.

In selective pulmonary angiography, a low osmolality contrast medium, ioxaglate, was compared with diatrizoate from the aspects of subjective discomfort and angiographic information. A cross-over analysis was done in 40 cases. The intensity of local heat sensation during and after the injection of ioxaglate was significantly lower than with diatrizoate. With ioxaglate, no cough was experienced even in patients with subtotal atelectasis or massive pleurisy. The quality of the arterial phase was essentially identical, with both media, while in the venous ioxaglate series the quality was significantly superior to that of diatrizoate.

Adult↗
PubMed1976

Nephrographic density and renal diatrizoate content in experimental acute renal failure.

Reversible acute renal failure (ARF) was induced in rats by intramuscular injection of glycerol. In these animals and controls, renal concentrations of 125I-labelled sodium diatrizoate, injected intravenously in doses similar to those used clinically, were compared with the density of the nephrogram, subjectively assessed under carefully controlled conditions. Though a good statistical correlation existed between renal diatrizoate concentration and nephrographic density, individual variation was wide. At any given level of renal iodine concentration, nephrograms were judged to be denser in ARF than in controls. This was not due to differences in whole-body opacification or renal size, but was partly explained by the greater visibility of renal outlines on plain films in ARF. However, though at all doses of diatrizoate renal iodine concentrations were higher in controls, differences in nephrographic density were in general difficult to detect.

Absorptiometry, Photon↗
PubMed1984

Renal toxicity of contrast agents: iopamidol, iothalamate, and diatrizoate.

As part of a general safety study of iopamidol, a nonionic iodinated contrast agent, urine N-acetyl-beta-glucosaminidase enzyme assays were done to compare the renal toxicity of iopamidol with that of iothalamate and diatrizoate. In a randomized study of 30 patients for computed body tomography and another 30 patients for angiography, 10 in each group were injected with iopamidol, 10 with iothalamate, and 10 with diatrizoate. After computed tomography or angiography with the three agents, there was no significant difference in urinary enzyme levels among the groups. The nephrotoxicity of iopamidol appears equivalent to that of diatrizoate and iothalamate.

Acetylglucosaminidase↗
PubMedDate not supplied

The effect of glucose and copper on the stability of diatrizoic acid.

Hypaque Sodium Oral Solution is used as a X-ray contrast agent. The active ingredient is diatrizoate sodium. Several bottles of drug product were found to contain elevated levels of inorganic iodide, ranging from 0.001% (w/v) to 0.036% (w/v). The USP specification is no more than 0.02% w/v. The formulation contains sucrose as a sweetener and as a viscosity modifier. It was found that elevated levels of iodide were directly related to the amount of glucose found in the formulation. Glucose is a reducing sugar which can be generated by the decomposition of sucrose. Solution stress studies containing diatrizoate sodium and varying amounts of glucose and copper were conducted at three different pH values: 6, 7 and 8 in phosphate buffer at 60 degrees C. The decomposition of diatrizoate sodium was monitored by HPLC. The greatest amount of decomposition occurred in those solutions prepared in pH 8 phosphate buffer and containing both copper and glucose. It is suggested that glucose reacts with copper to form an activated species, which reacts to displace an iodide.

Chromatography, High Pressure Liquid↗
PubMed1991

Powdered diatrizoic acid for radiography of the respiratory tract. Part II. Clinical application.

The diagnostic and clinical value of 41 examinations using insufflation and/or inhalation of powdered diatrizoic acid for tracheobronchography, tracheography, laryngography, nasopharyngography, and sinusography was investigated in 35 patients. Diatrizoic acid was found to be useful when applied by insufflation for demonstration of the nasopharynx, trachea and greater bronchi, especially in patients with airway stenosis and low pulmonary reserve. Double contrast images were obtained with good demonstration of anatomic details and adequate diagnostic value. Visualization of the peripheral bronchi by insufflation was satisfactory only when excessive secretions were not present. The inhalation method was adequate only for visualization of the trachea and main bronchi. The method was found to be safe since diatrizoic acid produced no toxic, allergic or febrile reactions and was given in relatively small amounts without impairment of respiratory function.

Administration, Inhalation↗
PubMed1990

Adriamycin nephrosis and contrast media. A comparison between diatrizoate and iohexol in rats.

Urine profiles (albumin, glucose, NAG, LDH, GGT and sodium) were followed for 9 days after intravenous injection of either diatrizoate, iohexol, or saline in 27 Wistar rats with nephrosis induced by Adriamycin 42 days before. Another 9 rats exposed to neither Adriamycin nor contrast media served as controls. None of the contrast media caused further increased albuminuria of significance, whereas both induced significantly increased excretion of all 5 tubular components. The excretion of NAG and sodium was significantly higher following diatrizoate than following iohexol. From 24 h post injection there was no significantly greater excretion of any of the components after either diatrizoate or iohexol than after saline among the rats given Adriamycin. At the end of day 9 after contrast medium injection neither serum sodium, potassium, glucose, urea, creatinine, nor albumin revealed any contrast media related changes. Kidney histology showed quantitatively larger lesions in kidneys exposed to Adriamycin and contrast media than in kidneys exposed to Adriamycin and saline. There were no differences between the two contrast media groups. It is thus concluded, that both high osmolar ionic and low osmolar non-ionic contrast media cause temporary tubular dysfunction but no further glomerular dysfunction in rats with nephrosis induced by Adriamycin. The histologic findings indicate that both media may worsen non-reversible renal lesions.

Animals↗
PubMed1989

[Comparative studies of diatrizoate, ioxaglate and iohexol as angiocardiographic contrast media].

We did 2 consecutive randomized studies to compare the effects of diatrizoate, ioxaglate, and iohexol. Sixty patients were studied: 15 with diatrizoate (group I) versus 15 with ioxaglate (IIA), and 15 with ioxaglate (IIB) versus 15 with iohexol (III). Group I had hypotension and severe increase in end-diastolic pressure. Severe bradycardia was seen in 27% of the cases. Group IIA and IIB had identical changes, with a moderate increase in systolic and end-diastolic pressure. Group III only presented a mild increase in end-diastolic pressure. None of the low-osmolar contrast media produced severe bradycardia, but ioxaglate induced frequent (20%) nausea. Our results suggest the best contrast media for angiocardiography is, in decreasing order: iohexol, ioxaglate, and diatrizoate.

Angiocardiography↗
PubMedDate not supplied

Effects on urine profiles of diatrizoate in hydrated and dehydrated rats. A double cross-over study.

Effects of intravenous diatrizoate on urine profiles in hydrated and dehydrated rats were compared. In 12 normal rats albumin, glucose, sodium, and the enzymes LDH and GGT were followed twice over 3 hours. The 6 rats being dehydrated at the first examination were hydrated 28 days later and vice versa. At both examinations diatrizoate affected all profile components significantly during the first two hours and caused a 3 per cent weight loss in both groups. Only one significant difference between the hydrated and dehydrated rats was found: The excretion of the brush border enzyme GGT was 1.5 times higher in the dehydrated than in the hydrated rats in both series. Thus, the effect of diatrizoate on the tubular brush border seems to depend on the state of hydration in normal rats.

Albuminuria↗
PubMedDate not supplied

Effect of iohexol and diatrizoate on pulmonary arterial pressure following pulmonary angiography. A clinical comparison in man.

A clinical comparison of the effects on pulmonary arterial pressure produced by iohexol and diatrizoate, following selective pulmonary angiography, was made in 17 patients with a normal pressure before the injection of the contrast medium. A double blind crossover study was performed and each contrast medium was administered in random order. The pulmonary arterial pressure was continuously recorded before, during and after the injection for 3 minutes. The effect of iohexol on the pulmonary arterial pressure was significantly less than that of diatrizoate. The results indicated that iohexol should be better tolerated than diatrizoate and therefore a safer contrast medium for selective pulmonary angiography.

Adult↗
PubMed1990

Cytogenic effects of diatrizoate and ioxaglate on patients undergoing excretory urography.

Possible cytogenic alterations due to radiologic contrast medium in patients undergoing a common radiologic examination is studied. Two groups of 20 patients each were used. Group I consisted of patients undergoing excretory urography, using sodium and meglumine diatrizoate as contrast. A different agent, sodium and meglumine ioxaglate, was used with group II. Three blood samples were taken from each patient before urography, immediately after urography, and 1 week later. The frequency of sister chromatid exchanges (SCE) and chromosomal aberrations (CA) were found to increase significantly in the B samples from both groups, that of group I being higher (P less than .01 compared with P less than .05). Furthermore, these alterations were found to persist in the C samples from group I. No modification of the Proliferating Rate Index (PRI) was found. The osmolarity or other components of the contrast media studied could be involved in the process. The results indicate that ioxaglate produces less cytogenic damage than diatrizoate.

Adult↗
PubMed1984

Pediatric urography: comparison of metrizamide and methylglucamine diatrizoate.

A non-ionic contrast medium (metrizamide) was compared to an ionic agent (methylglucamine diatrizoate) for pediatric urography. Fifty children were divided into two age groups: under 5, and 5 to 10. In younger children, metrizamide gave more excellent images (19% vs. 0%) and fewer inadequate images (0% vs. 18%) than methylglucamine diatrizoate (p = 0.06). In older children, metrizamide likewise gave more excellent images (44% vs. 14%) and fewer inadequate images (0% vs. 7%). The same pattern was seen when the two groups were combined (excellent, 28% vs. 8%; inadequate, 0% vs. 12%) (p = 0.05). Differences with respect to changes in hematocrit, serum osmolality, serum sodium, and SGOT were statistically significant, but not adverse reactions. In terms of both efficacy and safety, the authors conclude that metrizamide is preferred for pediatric urography.

Child↗
PubMed1981

Morphologic endothelial response to meglumine diatrizoate: an electron-microscopic study.

Ultrastructural changes in vascular endothelium after an intra-aortic injection of 65% meglumine diatrizoate, 10 ml/kg, and equiosmolal hypertonic saline were observed using electron microscopy in the rat. Cell shrinkage and expansion of intercellular clefts were found in all specimens from a large artery at 5 and 20 minutes after injection. Some destroyed cells were seen at all times after contrast and hypertonic saline administration, but one-half of the specimens taken at 1 hour were otherwise nearly normal in appearance. In muscle capillaries, the changes were less severe than in the large artery. Despite the large dose, equiosmolal meglumine diatrizoate and saline solutions produced identical vascular lesions as detected with electron microscopy.

Animals↗
PubMed1977

Intra-arterial bolus of 125I labeled meglumine diatrizoate. Early extravascular distribution.

A mixture of 125I labeled meglumine diatrizoate and 131I labeled human serum albumin was injected into the lower abdominal aorta of 30 anesthetized, laparotomized male rats. Measurements of the activities in cardiac blood and in different tissues of the hindlimbs and tests were perfomed at six time intervals ranging from 5 seconds to 2 minutes after injection, the determine early uptake and distribution volumes of diatrizoate. Concentrations and distribution volumes were initially much greater than values obtained after intravenous injection, but these differences had considerably decreased or disappeared by 2 minutes.

Animals↗