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At least 109 records · Page 6Linked to original sources
PubMed1987

The impact of colonoscopy on the early detection of colonic neoplasms in patients with rectal bleeding.

A retrospective analysis was made of 372 consecutive patients who underwent colonoscopy because of rectal bleeding. The three distinct patterns of bleeding studied were chronic (224 cases), recent major (93 cases), and acute bleeders (55 cases). In 50% of the cases, colonoscopy detected a lesion other than diverticula. These lesions consisted of several forms of colitis, arteriovenous malformations (AVMs), ulcers, and most importantly, neoplasms in 34% of the cases. In 13% of the cases, an invasive neoplasm was detected and 76% of them were early stage (Dukes A or B). A third of the neoplasms were located proximal to the splenic flexure. Among patients with a negative barium enema, 35% had a neoplasm detected on colonoscopy. These findings were similar for the three distinct patterns of rectal bleeding studied. These data support the need for colonoscopy in all types of rectal bleeders, regardless of the results obtained by BE.

Acute Disease↗
PubMed1986

Colonoscopy findings in symptomatic patients without X-ray evidence of colonic neoplasms.

Colonoscopy was carried out in 97 patients with persistent large-bowel symptoms in whom double-contrast barium enemas were either normal or showed diverticular disease alone. In 37 the X-ray was normal, but colonoscopy showed 9 polyps and 3 carcinomas. In 60 patients with barium enemas showing diverticular disease alone colonoscopy revealed 13 polyps and 1 carcinoma. Of the 4 carcinomas 1 was Dukes' A, 2 Dukes' B, and 1 Dukes' C. 23 of the 26 patients with a neoplastic lesion at colonoscopy had rectal bleeding, compared with only 40 of the 71 without a lesion. The frequency of neoplasia in those with a normal barium enema was 32%, compared with 23% in those whose X-ray showed diverticular disease. Colonoscopy, rather than double-contrast barium enema, should be the first line of investigation in patients with persistent large-bowel symptoms, especially rectal bleeding.

Adult↗
PubMedDate not supplied

[Colonoscopy as primary procedure in the diagnosis of colonic neoplasms].

Experience with colonoscopy as an initial procedure in the study of the colon is presented. 3.450 colonoscopies in patients with GI symptoms were performed by trained endoscopists using the intermediate length scopes (130cm) without fluoroscopy. In 90% of the cases the whole colon was studied in a mean time of 20 minutes. 382 neoplasms (11.07%) were diagnosed. Polips represented 90% of the lesions and 34.3% of them were adenomas. 30% of the adenomas and 34.4% of the malignant tumors were localized in the right colon. We emphasise that 82.7% of the polips found in the right colon were adenomas. As a side effect we had a sigmoid perforation, it represents 0.03%. Colonoscopies performed by a trained endoscopist is a highly diagnostic method with low degree of complications, making it the procedure of choice in the study of the colon in specialized centers.

Adenoma↗
PubMed1996

Technical report: spiral CT pneumocolon for suspected colonic neoplasms.

Abdominal spiral computed tomography (CT) pneumocolon is performed after cleansing the colon, using a smooth muscle relaxant and rectal air insufflation. Rapid dynamic scanning is undertaken with intravenous contrast to give optimal hepatic and vascular enhancement, and 5-10 mm contiguous slices. The area of interest in the colon is reconstructed every 2.5 mm. This technique was performed in four patients with colorectal cancer and the CT findings were compared with the barium enema and pathology following surgical resection. Spiral CT pneumocolon clearly showed the primary tumour in all cases as an enhancing soft tissue mass, and was able to detect local extension and lymphadenopathy as well as assess the liver, peritoneum and remaining abdomen. CT depicted the morphology of the primary tumour more clearly than barium enema, and in one case also detected a 1 cm polyp which was not seen on the barium study because the patient was incontinent of barium and views were limited. There was good correlation between the CT and pathological findings. Compared to a barium enema, spiral CT pneumocolon is quick, with minimal patient discomfort, no risk of barium incontinence, and there is good assessment of the local and distant abdominal disease. Multiplanar formatting is possible and 3-D reconstruction gives intra- and extra-luminal views.

Aged↗
PubMed1975

[Antigenic translocation of the "carcinoembryonic antigen" in colonic neoplasms].

The localization of the carcinoembryonic antigen (CEA) in the colon tumours was studied with the indirect Coons test. The localization of CEA in malignant cells was different from that in the normal colon mucosa. In addition, an essential secretion of this antigen may occur in neoplasms. The alteretion of the antigen position in pathologically changed cells or its secretion, differing from that in normal tissue, is referred to as the antigenic translocation.

Carcinoembryonic Antigen↗
PubMed1990

Immunohistochemical demonstration of human papilloma virus antigen in human colon neoplasms.

The presence of human papilloma virus (HPV) has recently been demonstrated in colon tumors, but the incidence of HPV infection in normal colon mucosa or in benign or malignant neoplasms of the mucosa is unknown. We studied both neoplastic and normal human colon tissue for the presence of HPV antigen using immunohistochemical techniques. Ninety colon specimens were studied. Three consecutive series of normal colon mucosa (N = 30), single benign tubulovillous adenomas (N = 30), and invasive carcinomas (N = 30) were selected and confirmed histologically. Formalin-fixed paraffin-embedded samples of each tissue were prepared using immunohistochemical techniques and resultant slides were read blindly and graded simply as positive or negative for HPV antigen. The presence of HPV antigen varied dramatically between groups, with 97% of the invasive carcinomas, 60% of the benign tubulovillous adenomas, and 23% of the normal mucosa positive for HPV antigen. Groups were statistically significant using chi 2 analysis (P less than 0.001). We conclude that an association exists between the human colon neoplasia and the presence of HPV antigen. This may suggest an etiologic role of the virus in colon cancer.

Adenoma↗
PubMed1986

Computed tomographic air enema technique to demonstrate colonic neoplasms.

The use of intravenous glucagon and the judicious introduction of air into a clean colon offer additional help in the confirmation of the larger intracolonic tumors on computed tomographic examination. The procedure is simple and may aid in the differentiation of an intrinsic colonic tumor from other pathologic conditions, particularly those that are extracolonic in origin.

Adenocarcinoma↗