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PubMed1980

ACAC (albumin-collodion coated activated charcoal) hemoperfusion: in-vitro removal and clearance of theophylline.

This study was designed to evaluate the effectiveness of ACAC charcoal to remove theophylline. Activated charcoal prepared according to Chang's technique was used in in vitro batch and clearance experiments. Theophylline was removed with a T1/2 of less than 5 minutes in the stirred batch experiments. The clearance studies showed values of 102, 145, and 208 ml/min (extrapolated to 300 g of ACAC charcoal), for extrapolated flow rates of 120, 240, and 360 ml/min. The ACAC charcoal is very efficient in removing theophylline in vitro from an aqueous solution. The efficiency of ACAC hemoperfusion for the treatment of severe, acute theophylline intoxication has also been demonstrated here.

Albumins↗
PubMed1987

Effect of membrane thickness of collodion coated activated charcoal on adsorption of small and middle molecules.

Different thicknesses of a cellulose nitrate (CN) coating were applied to petroleum pitch bead activated charcoal. The effect of this on the adsorption of small and middle molecules in vitro was studied. This was done by measuring the rate of adsorption of Vitamin B12, creatinine and uric acid from aqueous solution by activated charcoal having CN coatings of varying thickness (0.1% to 4.0% by weight). A CN coating weight of up to 0.2% caused negligible or no decrease in the rate of adsorption of all three solutes as compared with uncoated charcoal. Coating weights greater than 0.2% caused a significant decrease in the rate of adsorption of Vitamin B12, and uric acid but had little effect on the rate of adsorption of creatinine. Coating weights greater than 1.8% caused a significant decrease in the rate of adsorption of creatinine.

Adsorption↗