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PubMedDate not supplied

Clofazimine as elective treatment for granulomatous cheilitis.

Cheilitis granulomatosa (CG) is a rare, idiopathic inflammatory disorder that usually affects young adults and clinically is characterized by diffuse, non-tender, soft to firm swelling of one or both lips. A variant of granulomatous cheilitis is Melkersson-Rosenthal syndrome when associated with facial paralysis and furrowed tongue. Several treatments have been used with variable success. We report 3 cases of GC treated with oral clofazimine 100 to 200 mg daily for 3 to 6 months obtaining regression of lesions in all treated cases. Hyperpigmentation and elevation of liver enzymes were observed as side effects.

Adult↗
PubMed1989

[Miescher's granulomatous cheilitis].

Two patients with Miescher's cheilitis are described, with different disease length and histologic picture in involved foci. The essence of granulomatous cheilitis is still to be found, this being confirmed by the literature reviewed by the authors. Further accumulation of thoroughly verified data is necessary to solve this problem.

Adult↗
PubMed1984

[Cheilitis granulomatosa (Melkersson-Rosenthal syndrome): treatment with clofazimine].

A pilot study with the anti-leprosy agent clofazimine was conducted on seven patients with cheilitis granulomatosa or complete Melkersson-Rosenthal syndrome. Beneficial effects were observed in all patients, dependent on the degree of the clinical expression of the disease: the variable attacks of lip swelling, characteristic for the edematous phase of this disease, were suppressed promptly and completely in all patients. Persistent residual swelling of the lips, caused by cellular inflammatory infiltrates, which was present in four patients prior to therapy, responded much less rapidly and--in three out of four--only incompletely. After drug withdrawal, four patients remained free of symptoms for periods ranging from 5 to 45 months; the remaining three patients relapsed after intervals of 3-18 months. The mode of action clofazimine takes in cheilitis granulomatosa is not understood at the present time but is likely to be linked to the phagocytosis-stimulating effect of this drug on macrophages.

Adolescent↗
PubMed1978

Cheilitis granulomatosa. Successful treatment with combined local triamcinolone injections and surgery.

Cheilitis granulomatosa is a rare condition that has traditionally proved difficult to treat satisfactorily. Excellent results were obtained in our case with local triamcinolone acetonide injections and surgery. Histopathologic features of the classic, untreated condition were reviewed and compared to the histopathologic features of labial tissues after a seris of triamcinolone injections. It was found that the injected medication was effective in achieving some reduction of labial volume, apparently through a necrotizing effect of granulomas with subsequent replacement by fibrous scars. Discontinuation of local injections after initial surgery apparently contributed to an exacerbation, as shown by the histopathology of a second cheiloplastic procedure. We therefore recommended that patients with chelitis granulomatosa who are receiving combinaed triamcinolone-surgical therapy continue to receive local triamcinolone injections after surgery in order to minimize the tendency for recurrence.

Cheilitis↗
PubMed1989

Actinic cheilitis. A prospective study comparing four treatment methods.

Forty patients with actinic cheilitis were treated with one of four modalities: topical fluorouracil, chemical peel with trichloroacetic acid, lip shave, or carbon dioxide laser ablation of the vermilion. Patients treated with lip shave or carbon dioxide laser ablation had no recurrence of the problem during a 4-year period. While the lip shave procedure offers the advantage of histologic examination of the specimen, the patients treated with the laser ablation had fewer postoperative complications.

Aged↗
PubMed1991

Custom lip shield for chronic actinic cheilitis.

Chronic actinic cheilitis is a premalignant lesion related to excessive exposure to the sun. Those with fair complexions and blond hair, and those who work outside are susceptible to this disease. This article describes the fabrication of a custom lip shield to protect the lower lip from the sun in highly susceptible individuals.

Biocompatible Materials↗
PubMed1980

Actinic cheilitis. Report of a case.

Actinic cheilitis is not an uncommon disease and it can be an occupational hazard, particularly in those geographic areas with a great deal of sunshine. This condition has definite tendencies toward the development of carcinoma. Careful counseling and observation are necessary for good professional care of these patients, and occasionally vermilionectomy may be indicated.

Carcinoma, Squamous Cell↗
PubMed1986

Cheilitis glandularis: a case affecting the upper lip.

Cheilitis glandularis is a rare disorder characterized by enlarged mucous glands, usually in the lower lip, and possibly predisposing to squamous cell carcinoma. A case affecting the upper lip is presented, which appears to be the first report of the disorder in that site.

Cheilitis↗
PubMed1984

Antibiotic sensitivity and phage typing of Staphylococcus aureus isolated from non-hospitalized patients with angular cheilitis.

Strains of Staphylococcus aureus were isolated from 360 patients with angular cheilitis. Of these 24 per cent were sensitive to penicillin G, 74 per cent to tetracycline, 93 per cent to fusidic acid and 96 per cent to erythromycin. Twenty per cent belonged to bacteriophage Group I, 9 per cent to Group II, 13 per cent to Group III, 39 percent miscellaneous and 19 per cent were untypable. A number of phage typing patterns which have been reported for strains associated with specific forms of staphylococcal disease were present in the 360 isolates. In investigations involving cross infection of Staph. aureus, both patients and staff should be examined for evidence of infection at the angles of the mouth.

Anti-Bacterial Agents↗
PubMed2005

Aphthous ulcers associated with imiquimod and the treatment of actinic cheilitis.

Our case series report is the first documented depiction of the appearance of aphthous ulcers secondary to imiquimod application. This case series presentation discusses the underlying pathophysiology of aphthous ulcer development and imiquimod therapy in terms of the stimulation of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha). The literature review suggests more than just a mere coincidence for the development of aphthous ulcers subsequent to the treatment of actinic cheilitis with imiquimod application.

Adjuvants, Immunologic↗
PubMed1988

Carbon dioxide laser treatment of chronic actinic cheilitis.

The carbon dioxide laser in both conventional and superpulsed modes was used to treat 13 patients with chronic actinic cheilitis. The procedure was well tolerated. Focal, but not functionally restricting, scarring developed in three patients. The cosmetic result was otherwise excellent. No recurrences have been noted.

Aged↗
PubMed1986

Exfoliative cheilitis--a factitious disorder?

Exfoliative cheilitis is an uncommon lip lesion usually of great concern to the patient and quite refractory to treatment. The available literature was surveyed, and 3 cases have been described to illustrate various aspects of the condition. The difficulty of treating such lesions has been discussed, and a proposition put forward that the lesions are of a factitious nature.

Adult↗
PubMed1989

Oral medicine in practice: angular cheilitis.

In a series of twelve articles the authors aim to cover the more common oral medicine problems likely to be encountered in dental practice. Whenever possible, clinical photographs have been used to illustrate important points, and the text is deliberately succinct and without references. In the first article, the pathogenesis, investigation and management of angular cheilitis is reviewed.

Cheilitis↗
PubMed2003

Altered cytokeratin expression in actinic cheilitis.

BACKGROUND: Actinic cheilitis (AC) is a widely recognized precancerous lesion of the lip. Varying degrees of epithelial dysplasia may be present. However, no studies have correlated epithelial changes with cytokeratin expression that might reflect the disordered maturation that is probably occurring. METHODS: Thirty-four cases diagnosed as AC were classified according to dysplasia degree, and submitted to immunohistochemical staining for the detection of cytokeratins (CKs) 7, 8, 13, 14, 16 and 19. Normal mucosa adjacent to the lesions was also evaluated. RESULTS: The results obtained showed that CK10 immunostained only superficial keratinized epithelial layers in 11 cases, and also intermediate spinous layers in 18 cases. Cytokeratin 14 was expressed in all epithelial layers of 31 cases, in two cases its expression was in the basal and intermediate layers, and one case was negative. Cytokeratin 13 immunostained 26 cases and was negative in eight cases. In these eight cases, CK13 was apparently replaced by CK16. Cytokeratin 16, besides these eight cases, was also expressed in the spinous intermediate layers of a further eight cases. The remaining CKs tested were all negative. No relation between the degree of dysplasia and the CK expression was noted. CONCLUSIONS: Cytokeratin expression in AC is different from that of normal oral mucosa, and is not related to the degree of dysplasia.

Adult↗
PubMed2001

Treatment of Miescher's cheilitis granulomatosa in Melkersson-Rosenthal syndrome.

Cheilitis granulomatosa is the most frequent dermatological sign in the Melkersson-Rosenthal syndrome. We reviewed 27 cases of this syndrome diagnosed and treated in the last 20 years. All the patients were surgically treated and received intralesional corticosteroids during surgery and tetracycline hydrochloride (500 mg, twice daily) after the operation to prevent recurrence.

Administration, Oral↗
PubMed2003

Cheilitis glandularis: an unusual histopathologic presentation.

Cheilitis glandularis (CG) is an uncommon disease that usually affects the lower lip of adults. It is characterized by enlargement and eversion of the lip in association with excretory duct dilatation. The presence of minor salivary gland hyperplasia is controversial. Three types of CG have been described in the literature; the classification is based on the common clinical and histopathologic findings (ie, simple, superficial, and deep). This report is of an unusual case of CG simplex for which the initial histopathologic diagnosis was papillary cystadenoma, a neoplastic process. The lesion was completely excised, and final microscopic review of a larger specimen revealed chronic sclerosing sialadenitis, dilated salivary secretory ducts with oncocytic change and periductal inflammation, and foci of adenomatous hyperplasia consisting of enlarged ducts exhibiting squamous epithelial metaplasia and hyperplasia with papillary architecture. The latter proliferative pattern is an unusual finding in what is otherwise clinically diagnosed as CG.

Cheilitis↗
PubMed2006

Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa.

Polyvinylpyrrolidone (PVP), a polymer of the monomer N-vinylpyrrolidone with various molecular weights, was originally developed as a plasma expander. Currently, it is widely used in hair sprays, skin care products, fruit juices, and as a retarding agent in drugs such as procaine and hormones. PVP polymers with a molecular weight greater than 20,000 cannot be excreted by the kidneys and therefore are phagocytosed and permanently stored in the reticular endothelial system, leading to the so-called PVP storage disease. We report a case of localized cutaneous PVP storage disease presenting with persistent upper lip swelling and mimicking cheilitis granulomatosa, which has never been reported before.

Cheilitis↗