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Results for “Calcium Gluconate”

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PubMed2006

Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation.

Sodium fluoroacetate (SFAC) or Compound 1080 is a potent rodenticide, largely used after 1946 for rodent and home pest control. The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to citrate accumulation and resulting in interference in energy production by Krebs cycle blockade. In the present study, domestic cats were intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The intoxicated animals presented emesis, diarrhea with abdominal pain posture and an abdominal palpation, tachypnea, bilateral midriasis, hypothermia, hyperexcitability and convulsions. Blood gas analysis indicated decreased pH and bicarbonate levels. Serum ionized calcium was also decreased. ECG showed non-specific changes in ventricular repolarization and ventricular arrhythmias. The survival rate was 75% in the treated group with calcium gluconate and sodium succinate and 37.5% in the nontreated group.

Animals↗
PubMed1975

[Value of calcium gluconate labelled with 99mTc in the detection of intracranial tumors].

In a preliminary communication, the authors compare the success coefficients of pertechnate 99m-Tc and of a new labelled molecule: calcium gluconate 99m-Tc, in a group of 32 patients. The results obtained showed the undoubted superiority of the gluconate in comparison with the pertechnate in the detection of intracranial metestases, and in particular those of the posterior fossa. It proved equally effective as bleomycin labeled with 57-Co. Amongst the other types of tumour studies, the use of the gluconate seems to be particularly indicated for neoplasms of the posterior fossa and in those close to the base of the skull and venous sinuses, given the marked reduction in "background noise" obtained when this method is used.

Bleomycin↗