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Morphological characteristics of incrustates of intrauterine contraceptive devices.

The morphology of incrustates formed on intrauterine contraceptive devices (IUD) is described. It is demonstrated that due to manufacturing technology some IUDs have long, parallel excavations serving as sites for incrustate formation. A regional difference of incrustation on the different parts of IUD has also been observed. Electron microscopy was carried out in tissue fragments attached to removed IUDs. Alterations correspond to acute or chronic inflammation. Incrustate on the surface of IUD appears to have a primary role in induction of the process.

Calcium Carbonate↗

Pelvic actinomycosis and the intrauterine contraceptive device. A cyto-histomorphologic study.

In 350 pancervico-vaginal (Fast) smears obtained from women using intrauterine contraceptive devices, organisms consistent with Actinomycetes have been found. Actinomycetes, representing cervicitis, endometritis, and pelvic abscesses clinically, have been observed histologically in some of these cases. Special stains, immunofluorescence, and anaerobic cultures have confirmed these organisms to be Actinomyces israelii. Actinomyces in the Fast smear occur in isolated clumps, revealing branching, filamentous organisms, and sulfur granules. They can be detected and diagnosed in a Papanicolaou-stained routine pancervico-vaginal smear. This diagnosis in Fast smears can identify users of intrauterine contraceptive devices who may have Actinomyces infection in the genital tract and who are at risk of developing clinical disease related to this infection.

Abscess↗

[The problem of the lost intrauterine contraceptive device (author's transl)].

Report on 18 patients who were treated in hospital during the last 4 years because of a lost intrauterine contraceptive device. Carbon dioxide hysteroscopy was found to be a more advantageous diagnostic procedure in the search than radiography. In 14 cases, the intrauterine contraceptive device was grasped and removed under hysteroscopic control. In 4 cases the uterine cavity was empty on hysteroscopy. The device had perforated into the uterine muscle or into the peritoneal cavity. These 4 cases are reported in detail.

Abdomen↗

Pelvic colonization with Actinomyces in women using intrauterine contraceptive devices.

Recent reports suggest a relationship between intrauterine contraceptive device (IUD) use and colonization or infection of the genital tract with Actinomyces species. This prospective, case-controlled study was designed to determine the incidence of colonization or infection with Actinomyces in IUD users. None of 50 control patients and four of 50 study patients (8%) had Actinomyces identified. None of the patients with positive results had symptomatic pelvic infection. Cervical cytology was effective in detecting each of the four study patients with positive results. It appears that the presence of any type of IUD is a major predisposing factor to colonization with Actinomyces.

Actinomycosis↗

Retrieval of intrauterine contraceptive devices with missing tails, using Lamicel.

Preliminary cervical dilatation using Lamicel, followed by relatively painless uterine probing was successful in removing 30 of 31 contraceptive devices that had not been removable in the outpatient clinic. This technique is simple, safe, inexpensive and well tolerated. It can be utilized to retrieve intrauterine contraceptive devices with missing tails when other conventional clinic procedures fail.

Biocompatible Materials↗

Pelvic inflammatory disease and the intrauterine contraceptive device.

The relationship between the use of intrauterine contraceptive device (IUD) and pelvic inflammatory disease (PID) was examined in 1054 patients who were seen at the Family Planning Clinic of Jos University Teaching Hospital and were followed up. The overall risk of PID developing in women wearing the IUD was minimal: 62 out of 1054 (5.9%). The rates, however, varied for the 6-month periods studied. The incidence of PID decreased as the period of usage increased. The greater number of patients developed PID less than 3 months from the date of IUD insertion. When PID occurred it was usually of mild or moderate intensity and the response to antibiotic therapy was very encouraging. There was no relationship between the parity of the patients and the development of PID. Even though there is a definite link between the use of IUD and the development of PID it does not obliterate the benefits which the use of IUD provide for the majority of its patrons; and so the use of IUD should continue.

Female↗

Appendix perforation by an intrauterine contraceptive device.

Perforation of the uterus by an intrauterine contraceptive device (IUD) is a rare, and serious complication, occurring in 1/350 to 1/2500 insertions. Perforation by IUDs can involve several neighboring organs such as the bladder and rectosigmoid. We report two cases of IUD perforations involving the appendix, both inserted during lactation. The first case is an asymptomatic patient in early pregnancy and the second is a woman whose original presentation was chronic lower abdominal pain. The presence of copper in the abdominal cavity can lead to adhesion formation and subsequent abdominal pain, bowel obstruction or infertility. Thus, we believe that when an IUD is located in the abdominal cavity it should be removed even in an asymptomatic patient. In addition, these cases might suggest postponing the use of this contraceptive method in lactating women.

Abdominal Pain↗

Some aspects of oxidative metabolism in human endometrium after long time of applying the intrauterine contraceptive device.

The paper intends to study the variation of oxidative metabolism of human endometrium (all the components) after applying the intrauterine contraceptive device for a long period of time. The results of the study show that modifications "in situ" of the oxidative enzymes vary according to the: type of the enzymes (NADH2-cytochrome-c-reductase, Lactatdehydrogenase), the hormonal cyclic stage (proliferative phase, or luteal phase), epithelial or connective tissue structures, time of resting the intrauterine contraceptive device (DIU) in uterus.

Endometrium↗

Vesical calculus: a complication of intravesical migration of intrauterine contraceptive device.

Intravesical migration of an intra-uterine contraceptive device (IUCD) in a 28-year-old woman resulted in recurrent urinary tract infections. She received antibiotic treatment from her general practitioner but had no investigations done. Later on she became pregnant and investigations revealed that the thread of IUCD was missing and there was a vesical calculus. After she had delivered the baby, a pelvic X-ray was taken and showed a vesical calculus on the IUCD. Both calculus and IUCD were removed cystoscopically.

Adult↗

Two modifications of the intrauterine membrane contraceptive device.

The intrauterine membrane (IUM) is an intrauterine contraceptive device designed to be compliant with a range of uterine shapes and sizes and with transient dimensional changes resulting from uterine motility. This compliance was expected to contribute to low rates for removal due to bleeding and pain, but the use of the IUM resulted in heavy bleeding among its early users. Consequently, two modifications of the device were made to decrease bleeding. One group of IUMs was modified by using ethylene vinyl acetate to provide a high level of lateral compliance and another was modified by using a tissue-compatible Hydron coating in order to decrease the inflammatory response of the endometrium. One hundred of each of these modified IUMs were tested along with 100 of the standard IUMs in a double-blind study conducted at the Noi Klinika in Debrecen, Hungary. The findings of this study suggested that these two modifications did not improve the over-all performance of the IUM.

Adult↗

Microbial colonization of tailed and tailless intrauterine contraceptive devices: influence of the mode of insertion in the rabbit.

An experimental rabbit model was developed to study the microbial colonization of intrauterine contraceptive devices. Tailed and tailless devices were surgically inserted into into the uterus by two different routes: surgically, directly into the uterine horn, thus avoiding contact with the vaginal and cervical microfloras, or via the vagina and cervix. After 1 to 8 weeks the devices were recovered and prepared for scanning electron microscopy. The surfaces of surgically inserted devices remained uncolonized all through the experiment whereas in those inserted via the cervix microorganisms colonized the core surface as early as 2 weeks after insertion. Our data suggest that in our experimental conditions the mode of insertion appears to be the major factor influencing the microbial colonization of intrauterine contraceptive devices and that the presence of a tail does not seem to play a significant role.

Animals↗

[Pelvic inflammatory disease and the use of intrauterine contraceptive devices].

Pelvic inflammatory disease includes a group of different diseases such as: endometritis, salpingitis, oophoritis and peritonitis. The risk of pelvic inflammatory disease in intrauterine contraceptive devices--users is 7-9 times higher than in the general population, whereas the incidence of occurrence of these diseases in this certain group is 2-5%. During the period 1989-1993, 155 intrauterine contraceptive users with pelvic inflammatory disease, were treated at the Clinic, which makes 25% of all hospitalized female patients with pelvic inflammatory disease. Serious cases have been established in regard to the period 10 years ago. In order to prevent the occurrence of pelvic inflammatory disease in users of intrauterine contraceptive devices, health education is necessary to motivate regular controls and check-ups, preventive application of antiseptic vaginal tablets and detection of signs of the disease.

Female↗

A comparative analysis of the modification of sexual desire of users of oral hormonal contraceptives and intrauterine contraceptive devices.

OBJECTIVE: To compare the influence of oral hormonal contraceptives (OCs) and the use of intrauterine contraceptive devices (IUDs) on the modification of sexual desire. MATERIALS AND METHODS: A prospective observational study of 1073 women using OCs or an IUD at the Family Planning Center 'Marina Alta' in Alicante, Spain. In order to evaluate the relative risk regarding the decrease in libido attributed to each contraceptive method, a logistic regression analysis was undertaken which considered the factors of age adjustment, level of studies, family planning information, relationship with partner, age when sexual relationships were initiated, parity, contraceptive method previously used and the duration of use of the contraceptive method. RESULTS: No differences in the decrease of sexual desire were observed between the use of the OC and IUD (odds ratio (OR) 1.32; 95% confidence interval (CI) 0.70-2.49), yet differences were noted, however, in relation to age (OR 1.05; 95% CI 1.01-1.10). Although these differences were not statistically significant, a high level of awareness regarding family planning was shown to increase sexual desire when compared to a lower level of information on this subject (OR 0.64; 95% CI 0.41-1.01). Sexual desire was seen to decrease if the quality of the relationship with the partner was average (OR 2.24; 95% CI 1.36-3.69) or poor (OR 4.69; 95% CI 1.93-11.4). Nulliparous women showed a greater decrease in sexual desire in relation to women who had already given birth (OR 1.57; 95% CI 1.00-2.47). Sexual desire was greater if the contraceptive method had already been in use for 6-12 months (OR 0.41; 95% CI 0.17-0.98). CONCLUSIONS: Sexual desire does not vary in relation to the use of OCs or IUDs, yet it does decrease with age, in nulliparous women and in those with an average or poor relationship with their partner. Furthermore, sexual desire shows an increase between the first 6 and 12 months of contraceptive treatment.

Adolescent↗

Pain response following insertion of a Gravigard (Copper-7) intrauterine contraceptive device in nulliparous women.

A total of 33 nulliparous women aged between 18 and 35 have been observed for related symptoms following insertion of an intrauterine contraceptive device. Seventy-five percent suffered some abdominal pain initially but this was reduced to 1% by the end of the week. The symptoms of cramp and backache showed a similar trend. There was no relationship between symptoms and the day of the cycle on which insertion was performed. It is concluded that careful insertion of the Copper-7 in this group of patients is well tolerated irrespective of the day of cycle on which insertion is performed. The initial dynamic response following IUCD insertion may be an additional factor in the assessment of the performance of an individual intrauterine contraceptive device.

Abdomen↗