Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CLIMACTERIC”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 109 records · Page 6Linked to original sources
PubMed2006

[Complementary and alternative therapies for climacteric symptoms].

OBJECTIVE: Review on complementary and alternative therapies for climacteric symptoms. METHODS: Search for publications about complementary or alternative treatments for climacteric symptoms based on Cochrane Library and Medline (1966-2006) including the references from the identified clinical trials and reviews. RESULTS: Cimicifuga may influence climacteric symptoms, especially hot flushes. Results for phytoestrogens, hop and Salvia seem promising but are less convincing. St. John's wort is an option for the treatment of moderate depressive symptoms. Phytoestrogens seem to have some potential for the prevention of osteoporosis and cardiovascular diseases. Results for the influence of lifestyle on hot flushes are conflicting, but interventions have demonstrated their use for the prevention of osteoporosis and cardiovascular diseases. CONCLUSIONS: Lifestyle modifications, Cimicifuga and phytoestrogens may relieve climacteric symptoms. Phytoestrogens and Cimicifuga should not be given to breast cancer survivors.

Acupuncture↗
PubMed1980

[The correlation between climacteric symptoms and plasma levels of catecholamines (author's transl)].

Although climacteric symptoms, particularly, vasomotor symptoms such as hot flushes, have been suggested to correlate with depletion of ovarian estrogen secretion, its precise mechanism to producing these symptoms has still remained unknown. On the other hand, catecholamines have been presumed to be related to an onset of the climacteric symptoms. This study was carried out to elucidate the correlation between the climacteric symptoms and plasma levels of catecholamines. Thirty-eight women complaining of climacteric symptoms were studied. These subjects were evaluated for their symptoms and the severity of the symptoms was expressed in numerical figure, 0 to 3, according to its degrees: none, slight, moderate, and marked, respectively. At the same time venous blood samples were drawn to determine the plasma levels of catecholamines, using an Renzini's fluorimetric assay method improved by Miura. Eventually, a correlation between severities of the symptoms and plasma catecholamines was made. Plasma epinephrine levels were found to be elevated as the severity of the hot flush progressed from none to marked. No symptoms other than hot flush showed such significant correlation with plasma epinephrine or norepinephrine levels. This result suggests that the onset of hot flush is closely related with an increased activity of the adrenomedullary sympathetic nervous system.

Adult↗
PubMed2003

[Climacteric syndrome: a population-based study in Campinas, SP, Brazil].

OBJECTIVES: To study the prevalence of climacteric, urogenital and sexual symptoms in a population of Brazilian women. METHODS: A cross-sectional descriptive population-based study was conducted. The selection of 456 women aged 45-60 years, living in Campinas, SP, in 1997, was done through area cluster sampling, according to data from the Brazilian Institute of Geography and Statistics. Data were collected via home interviews, using structured pretested questionnaires. Data were analyzed using the chi-squared test and the nonparametric Kruskal-Wallis test; a probability of <0.05 was considered statistically significant. The degree of climacteric symptoms was analyzed through circulatory and psychological indices. Analysis of the main components was used to determine symptom interrelationships. RESULTS: The most prevalent symptoms were nervousness (82%), hot flushes (70%), headache (68%), irritability (67%) and sweating (59%). Hot flushes, sweating and insomnia were significantly more prevalent in the peri and postmenopausal phases. The frequency (severity) of vasomotor and psychological symptoms did not vary according to the menopause phase. The prevalence of urinary incontinence was 27.4%. Complaints of dyspareunia and vaginal dryness were infrequent. Decreased libido was the most frequent sexual complaint. It was observed that some climacteric complaints were interrelated. The first cluster included hot flushes and sweating (vasomotor cluster). The second cluster included nervousness, depression and irritability (psychological cluster). The third cluster included dizziness and palpitation (atypical cluster). CONCLUSION: Climacteric symptoms in this population were highly prevalent and similar to those described in developed Western countries.

Brazil↗
PubMed2006

Climacteric complaints among very low-income women from a tropical region of Brazil.

CONTEXT AND OBJECTIVE: Climacteric symptoms may vary between different countries and cultures. Socioeconomic factors and climate may be implicated. The aim of this study was to identify climacteric symptomatology among very low-income Brazilian women, living in a hot and humid region. DESIGN AND SETTING: This cross-sectional population-based study was conducted in Cuiabá, at Júlio Müller University Hospital, a tertiary institution. METHODS: The study enrolled 354 climacteric women. The variables analyzed were social class, symptomatology and abnormal concurrent conditions. The study was approved by the hospital's research ethics committee. RESULTS: Sixty-five percent of the participants (232/354) were very poor and had had little schooling. The number of symptoms per woman was 8.0 +/- 5.7. Hot flushes, nervousness, forgetfulness and fatigue were each found in nearly 60.0%. Tearfulness, depression, melancholy and insomnia were also frequent. Sexual problems were reported by 25%. The most relevant concurrent abnormal conditions reported were hypertension (33.9%), obesity (26.5%), arthritis/arthrosis (15.0%) and diabetes mellitus (9.6%). Hot flushes were associated with tearfulness, nervousness and forgetfulness. CONCLUSION: Brazilian climacteric women of low income and low schooling present multiple symptoms. Vasomotor and psychosexual symptoms were the most prevalent disorders. Hot flushes were associated with nervousness, forgetfulness and tearfulness.

Adult↗
PubMed1996

The effects of estradiol valerate plus medroxyprogesterone acetate and conjugated estrogens plus medrogestone on climacteric symptoms and metabolic variables in perimenopausal women.

BACKGROUND: Two sequential hormone replacement regimens, containing either estradiol valerate plus medroxyprogesterone acetate (E2V/MPA) or conjugated estrogens plus medrogestone (CE/MED), were compared with respect to effects on climacteric symptoms, lipid metabolism, and hemostasis. METHODS: In an open, multicenter study, 51 perimenopausal women were randomized to E2V/MPA and 50 to CE/MED. Assessment of climacteric complaints was performed at baseline and at months 1, 3, and 6. The effects on lipid and hemostatic variables were measured at baseline and at month 6. Quantitative data were analyzed using analysis of variance, the paired t-test or the chi2 Mantel-Hanszel test, where appropriate. RESILTS: Efficacy regarding treatment of climacteric symptoms was with E2V/MPA as good as with CE/MED, with a statistically significant reduction of most symptoms in both groups. After 6 months, total cholesterol and triglycerides had remained unchanged in both groups. High-density lipoprotein cholesterol showed no significant change with E2V/MPA, whereas an increase was noted in the CE/MED group (p<0.05). Low-density lipoprotein cholesterol was decreased with E2V/MPA (p<0.01) and was unchanged in the CE/MED group. Hemostatic parameters showed no significant changes after 6 months, with the exception of a decreased prothrombin time with E2V/MPA (p<0.05). Acceptability was excellent, expressed by the low incidence of treatment-related drop-outs in both groups. CONCLUSIONS: E2V/MPA is a one tablet per day sequential HRT regimen, which is as effective and acceptable as hormone replacement therapy with CE/MED regarding treatment of climacteric symptoms. Neither preparation had negative effects on lipid metabolism and hemostatic variables.

Adult↗
PubMed2006

Developing an instrument to measure climacteric symptoms among Korean and Japanese women.

PURPOSE: The purpose of this study was to construct a measurement instrument for climacteric symptoms among Korean and Japanese women. METHODS: From Dec. 1st of 2003 to March 30th of 2004, in-depth interviews were made with 26 women (15 in Jinju, Korea and 11 in Nagasaki, Japan) aged from 45 to 59 years who had not taken hormone replacement therapy to relieve the climacteric symptoms. A draft questionnaire with 45 items was constructed on the basis of the interview data and literature review. Three obstetricians, three PhDs in nursing science, and a chief nurse who was exclusively in charge of the climacteric management, examined the draft questionnaire to evaluate content validity. After deletions 39 items remained for a preliminary questionnaire. A survey was conducted by using a convenient sampling method in Jinju of Korea and Nagasaki of Japan during the period from April 1st, 2004 to July 10th, 2005. RESULTS: Factor analysis identified 4 factors, which were "mental and psychological symptoms", "physical symptoms", "loss of autonomic nervous system symptoms", "sexual symptoms". These four factors explained 46.9% of total variance. CONCLUSIONS: The results demonstrated that climacteric symptom scale was multidimensional, and the reliability and validity of the scale was supported.

Climacteric↗
PubMed2006

Age, pattern of menopause, climacteric symptoms and associated problems among urban population of Hyderabad, Pakistan.

OBJECTIVE: To analyze the physiology of menopause in the context of the age at menopause, its pattern, climacteric symptoms and associated problems of an urban cohort. DESIGN: Cross-sectional, analytical study. PLACE AND DURATION OF STUDY: Four urban sectors of Hyderabad city, from September to October 2004. SUBJECTS AND METHODS: In total, 800 women of age 45-59 years, who had reached a natural menopause were interviewed. The data were collected by simple random sampling method. A pre-tested questionnaire was administered to collect the data. Physical examination including height, weight and blood pressure check was also carried out at the same time. Data were statistically analyzed through software program SPSS 10.0. RESULTS: The mean age at menopause of subjects was 47.16 years. Duration of climacteric ranged from 2 - 36 months in majority of cases. The marked climacteric symptoms were low backache (75%), headache (70.25%), tiredness (67.75%), limb pain (59.25%), sleep disturbance (53.75%), lack of concentration (49.5%), hot flushes (55.5%) and night sweats (45%). Other associated problems were hypertension (31.5%), ischaemic heart disease (22.25%), diabetes mellitus (15.75%), postmenopausal bleeding (10.5%) and vaginitis (4.2%), respectively. CONCLUSION: The age and pattern of menopause, climacteric symptoms and associated problems in studied population were different from other studies reported from within the country and abroad. This may reflect as sociocultural and dietary differences.

Adult↗
PubMed1998

[Low-dose estrogens in the treatment of the climacteric syndrome].

UNLABELLED: The present prospective study is aimed to estimate the effect of a low-dose combined oestrogen drug Cyclo-Menorette on climacteric syndrome in women with early menopause. MATERIAL AND METHODS: The criteria for inclusion in the study were ac follows: 9-12 months of menopause, increased FSH levels, moderately expressed climacteric syndrome confirmed by the menopausal index of Kupperman and Hamilton-Anxiety-Scale /HAMA/. According to acceptance of hormone replacement therapy /HRT/ the women were divided into 2 groups--control T /n = 31/ and Cunder treatment T /n = 35/. The degree of climacteric syndrome expression after Kupperman and HAMA was estimated in all patients at the beginning as well as on the 3-d, 6-th 12-d months. The presence and dynamics of side effects were followed in the patients treated with HRT. RESULTS: Spontaneous improvement of complaints was found out in the control group with an increase of intragroup differences during the follow-up period. Most expressed improvement in the group under treatment was established during the first 3-6 months, the beneficial effect being preserved until the end of the study. CONCLUSION: The use of 1 mg oestradiol valerat in combination with 2 mg oestriol results in a significant decrease of climacteric syndrome manifestation with slightly expressed and transient side effects.

Climacteric↗
PubMed2000

Factors associated with climacteric symptoms and the use of hormone replacement therapy.

BACKGROUND: To investigate factors associated with climacteric symptoms and the use of hormone replacement therapy (HRT). METHODS: A random sample of women aged 46, 50, 54, 58 and 62 years resident in Goteborg, Sweden (n=5,990) were invited by letter to complete a postal questionnaire concerning the menopause and HRT use. RESULTS: The response rate was 76% (n=4,504). Women with a higher education, who exercised regularly and who had regular spare-time activities felt better and had fewer climacteric complaints (p<0.001) compared to lower educated women, women who exercised infrequently and women who had no spare-time activities. Climacteric symptoms were associated with dryness symptoms (dry eyes, skin, hair and mouth), bilateral salpingo-oophorectomy (SOE), use of psychotropical drugs and use of alternative remedies, previous hysterectomy and full-time occupation. Stepwise multiple regression analysis showed significant correlations between vasomotor symptoms and various dryness symptoms, no menstrual periods and use of alternative remedies. Current HRT-users (13%) had used estrogens for 4.0 years and past users (14%) for 4.3 years. A correlation (p<0.005) was found between HRT use and previous use of contraceptive pills, use of alternative remedies and hysterectomy. Education, occupation and the frequency of exercise did not influence the prevalence of HRT use. CONCLUSIONS: This study has shown that the experience of climacteric symptoms and well-being is associated with many different factors. Women with a higher education and those who exercised regularly were more often symptom-free. HRT use was associated with previous use of contraceptive pills, use of alternative remedies and hysterectomy.

Climacteric↗
PubMed2000

[Climacteric--medicalization, minimalization or normalization?].

Women's experiences and ideas about the climacteric are not in accord with the biomedical model, in which the climacteric and the menopause are characterized as being a risk factor for various diseases and a cause of "estrogen deficiency", a hormonal disease which is assumed to persist during the rest of life. The biomedical model may lead to medicalization and pathologizing, increasing the subordination of women and making them dependent on the health care system. Women who use hormonal therapy during the climacteric have many characteristics differentiating them from women who do not use such therapy. Thus, epidemiological studies will be difficult to interpret with respect to the long term effects of hormonal therapy. It is argued that the consultation for women of middle-age should be characterized by a holistic view of the woman taking account of her gender identity, life conditions and life situation. Such a view should focus on the woman's own ideas as to diagnostic procedures, treatment and solutions. In view of the lack of knowledge about the pros and cons of hormonal therapy, women themselves should make the decision, and such decisions should be encouraged. Also, the efforts directed towards women's compliance to hormonal therapy can be questioned. Women's climacteric symptoms should neither be medicalized, pathologized or minimized.

Adult↗
PubMed2001

[Possibilities for an individualized approach to the treatment of climacteric symptoms with phytoestrogens].

UNLABELLED: In climacteric women with contraindications and fear or lack of compliance for taking hormonal replacement therapy as well as in those cases where risks exceed benefits, the use of phytoestrogens is appropriate having in mind their especially good effect on neurovegetative symptoms. AIM: The present randomized prospective study is aimed at estimating the possibility for ameliorating climacteric symptoms with Melbrosia and at assessment of its effect on different symptoms in order to individualize the therapeutical approach. PATIENTS AND METHODS: Two groups of women with climacteric complaints were followed-up--control group (n = 32) and treatment group (n = 34). Climateric symptoms were assessed in the beginning and at the end of the study using Kupperman menopausal index. The levels of FSH, LH, oestradiol as well as some parameters of lipid metabolism were determined. RESULTS: A significant decrease of Kupperman index was observed in Melbrosia treatment group in contrast to the control group. No significant changes in gonadotropins, oestradiol and lipid parameters were found in both groups. CONCLUSION: The preparation Melbrosia, consisting of phytoestrogens and amino acids exerts a good therapeutic effect on climacteric symptoms mainly on the nervousness, anxiety, irritability, headache, and hot flashes.

Amino Acids↗
PubMed1992

[Oral symptoms in the climacteric. A prevalence study].

The female climacteric is attributed to physiological ovarian failure with the consequent decrease in the secretions of oestrogen, progestones and androgens. Numerous metabolic, psychological and physical changes have been associated with this event. Oral discomfort, including the burning mouth syndrome and the dry mouth syndrome, has been described as a menopausal symptom. However, the relationship between the hormonal changes related to climacteric and the onset of oral discomfort is still controversial. The purpose of the present study was to evaluate the prevalence of oral symptoms, with particular regard to burning sensation, xerostomia, altered taste and recurrent oral ulcerations. The relationship between oral and climacteric symptoms and psychological status of the patients was also evaluated. A questionnaire was administered to 136 women (mean age: 51.2 years, range 40-62) being consecutively referred to the University Hospital Menopause Clinic from October 1991 to March 1992. The questionnaire included informations regarding menopausal state, oral symptoms, drug assumption, wearing of partial or total dentures, parafunctions (lip and cheek biting, bruxism, tongue thrusting). Climacteric symptoms including flushes/sweats, palpitations, headache, arthralgia/myalgia, vaginal dryness, decreased concentration, tiredness, decreased libido, insomnia, vertigo were evaluated. Visual analogue scale (VAS) was used where appropriate. Information regarding the alteration of the psychological status was collected by means of the Hospital Anxiety and Depression Scale Statistical analysis was performed by chi 2 test or Fisher's Exact Probability Test and Mann-Whitney U-test. The level of significance accepted was 5%. The subjects in this study were divided into two groups on the basis of their answers to the questionnaire: group I (no. 39), premenopausal women; group II (no. 97), menopausal women.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2004

[Evaluation of the quality of life of women in the climacteric period].

OBJECTIVES AND STUDY DESIGN: Evaluation of quality of life of women in the climacteric period with the use of an individually developed questionnaire of a transitory period. Evaluation of the effect of Hormonal Replacement Therapy (HRT) on health related quality of life. MATERIALS AND METHODS: A group of 190 women in the perimenopause period was subject to an analysis. The criterion of qualification for the investigated group was medical history of a patient, which revealed climacteric symptoms and age of women (from 45 to 60 years old). The patients were divided into two main groups depending on the use of HRT The first group--investigated group - adhibiting HRT consists of 76 patients, the second one--control group--114 patients. Within each of the groups, 5 subgroups were isolated basing on the moment of the menopause occurrence. The research tool was an individually developed questionnaire consisting of SF-36, Green Scale and Beck Depression Scale. RESULTS: Between the group subject to HRT and the control group, a statistically significant difference (p < 0.05) was observed concerning the quality of life parameters, intensification of depression connected with climacteric and symptoms of the climacteric syndrome. CONCLUSIONS: 1. The application of HRT in women after menopause contributes to an improvement of the general quality of life, of mood and vitality. 2. Women subject to the therapy constitute a minority. Thus, HRT should be promoted in order to improve the life quality of women in that period so difficult for them. 3. The transitory period questionnaire is a good work tool, which allows to determine the necessity of the therapy application and to monitor its course.

Attitude to Health↗
PubMed2005

[Progress on the research of prevention and treatment of female climacteric syndrome by traditional Chinese medicine].

Perimenopause syndrome, referred also to climacteric syndrome, results from the changing of relationship among hypothalamus, pituitary and ovary during women's aging process. Those changes take place first in overy, then in hypothalmus and pituitary, which are reflected as the functional changes in endocrinological and central nervous system, accompanied with a series of psychological symptoms. 90% of women with perimenopause syndrome show clinical symptoms. The clinical prevention and treatment of female climacteric syndrome by traditional Chinese medicine: traditional Chinese medicine attributes the various symptoms of female climacteric syndrome to a variety of syndromes of Chinese medicine, e. g. gradual consumption of kidney-Qi, emptiness of the Ren and Chong channels, gradual exhaustion of Tienqui, breakdown of Yin-Yang equilibrium in the body, disorders of Zang-Fu, Qi and blood. The treatment based on syndrome differentiation, modification of prescription according to the symptoms, special prescription and simple recipe and acupuncture were employed in treating Yin-deficiency of the kidney, Yang-deficiency of the kidney, Yin and Yang-deficiency of the kidney, breakdown of the normal physiological coordination between the heart and the kidney, deficiency of liver-Yin and kidney-Yin, insufficiency of both the spleen and the kidney, deficiency of Qi and blood in the heart and spleen, stagnation of the liver-Qi and deficiency of the spleen, stagnation of the liver-Qi, phlegm stagnancy and the upward invasion of heat-phlegm. The traditional Chinese medicinal had a satisfactory global regulating effect on the nervous system and immune- regulating network with multifunction and unique advantage, e.g. its regulating effect on FSH, LH, E2, 5-HT, 5-HIAA, free radical and adtonomic nervous system. Experimental studies have also been conducted, e. g. There were also systematic studies of the simple Chinese drugs' pharmacodynamics and drugs forms of prepared drugs. In the health care of female climacteric syndrome the traditional Chinese medicine has also its own features and advantages.

Animals↗
PubMed1975

Age at the menopause and onset of the climacteric in women of Martin District, Czechoslovkia. Statistical survey and some biological and social correlations.

In this study, 6877 women were analysed whose ages ranged between 38 and 58 (born between 1909 and 1929) and who had had no artificial menopause. This is 88.04% of the total female population in this actual period of life, living in Martin District in 1967. The mean age at the menopause was found, by status quo method, to be 51.21 years (standard deviation 4.4), and by the method of weighted arithmetical means, 48.81 years, (standard deviation 3.9). The mean age at the onset of the climacteric, calculated by the same methods, was 47.55 years, or 46.74 years, respectively. The mean age at menarche was 14.6 years. The average birth-rate was 2.8. The mean period of fertility for the series as a whole was 36.6 years. Women with menstrual disturbances had their menopause about 1 year earlier. We have noted a similar tendency in nulliparas and primiparas. We could find no great difference in the age at menopause between those who had had an early or a late menarche. Menstrual disturbances also influenced the onset of the climacteric. It was at least one year earlier than with regular menstruation. Age at menarche and parity had no effect on the age at the onset of climacteric. Women working in agriculture and housewives had their menopause a little later than mean age of the series, whereas manual workers and those in other occupational categories had their menopause and onset of the climacteric about 1 year earlier. Furthermore, single women had their menopause about one year earlier than the married ones. Widows had their menopause twice so often as the married women and they got it very soon after the husbands's death.

Adult↗
PubMed1979

[Use of the bicycle ergometric test in the differential diagnosis of climacteric cardiopathy].

Bicycle ergometry on the "Elema" electrical bicycle ergometer was conducted on 6, patients of climacteric age (41 to 55 years) with pain in the region of the heart and ECG changes. The method made it possible to confirm the diagnosis of climacteric cardiopathy in 39 and to reveal climacteric cardiopathy and concurrent ischemic heart disease in 23 patients. It was noted that physical load had a favourable effect on processes of repolarization in the myocardium of patients with climacteric cardiopathy.

Adult↗
PubMedDate not supplied

[Use of a new steroid (Org OD 14) in the climacteric syndrome].

A double-blind study was carried out in 60 women with climacteric symptoms: 30 women were given Org OD 14 (2.5 mg) and 30 were given a placebo to be taken daily for six weeks. The effects of the medication on the climacteric symptoms, the subjective sensations, the plasma FSH levels and endometrial histology were studied. In the treated group compared with the control group the relief or improvement of the following climacteric symptoms were recorded: perspiration, palpitations, irritability and backache. A favourable effect on the subjective sensations was noted in both groups, although no significant difference for the group which received Org OD 14 was found. At the end of the treatment with Org OD 14, the FSH levels were found to be greatly reduced in comparison with the basal values; this, however, was not the case with the placebo group. With regard to endometrial histology, no sign of hyperplasia was found in any of the patients. No relevant side effects or symptoms of estrogenic or androgenic stimulation were recorded. For the climacteric patient needing estrogen therapy, it can be concluded that Org OD 14 is an effective and innocuous medication in the doses used.

Adult↗
PubMed1995

Efficacy and safety of estriol replacement therapy for climacteric women.

BACKGROUND: As an estrogen derivative, estriol is rather effective in the relief of climacteric symptoms due to estrogen deficiency. When given one dose a day, it will not provoke endometrial proliferation and shedding. Thus, it is suitable for postmenopausal women who no longer want to have uterine bleeding and for those with comparatively higher risk of endometrial hyperplasia. In the aspect of postmenopausal osteoporosis, the prevention of further bone loss due to estrogen deficiency is also important and to be evaluated. METHODS: We collected 20 patients, aged 44-62 years, who had undergone either natural or surgical menopause and were treated with estriol succinate (Synapause; Organon; Holland 2 mg/tab) 2 mg/day for 2 years, with relief of climacteric symptoms evaluated after the first 3 months of treatment. Bone mineral density (BMD) of lumbar spine was measured using quantitative computed tomography (QCT) after one and two years of treatment, respectively. RESULTS: Estriol was very effective in the improvement of major subjective climacteric complaints in 86% of patients, especially hot flush and insomnia within 3 months. The atrophic genital changes caused by estrogen deficiency were also improved satisfactorily. No subjective symptoms induced by the therapy were seen. The rate of uterine bleeding was low, complained by only one patient. However, our study did not show the preventive effect of estriol against osteoporosis. CONCLUSIONS: Estriol can be a safe and effective alternative in the relief of climacteric symptoms for postmenopausal women, but it cannot prevent the bone loss.

Adult↗